β-Lapachone prevents diet-induced obesity by increasing energy expenditure and stimulating the browning of white adipose tissue via downregulation of MIR-382 expression

Diabetes

Volumn 65, Issue 9, 2016, Pages 2490-2501

  Choi, Won Hee ^a,b   Ahn, Jiyun ^a,b   Jung, Chang Hwa ^a,b   Jang, Young Jin ^a   Ha, Tae Youl ^a,b  

^a Korea Food Research Institute   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LAPACHONE; CHOLESTEROL; CITRATE SYNTHASE; GLUCOSE; INSULIN; LEPTIN; MICRORNA; MICRORNA 382; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; PROTEIN DIO2; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; BETA-LAPACHONE; MICRORNA 382, MOUSE; NAPHTHOQUINONE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEIGE ADIPOCYTE; BODY MASS; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET INDUCED OBESITY; DOWN REGULATION; DRUG MECHANISM; DRUG MEGADOSE; ENERGY EXPENDITURE; FAT MASS; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INSULIN SENSITIVITY; LIPID DIET; LIPID STORAGE; LOW DRUG DOSE; MALE; METABOLIC PARAMETERS; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMOGENESIS; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENERGY METABOLISM; GENETICS; GLUCOSE TOLERANCE TEST; INDIRECT CALORIMETRY; METABOLISM; OBESITY; OXYGEN CONSUMPTION;

ADIPOCYTES; ADIPOCYTES, BROWN; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CALORIMETRY, INDIRECT; CELLS, CULTURED; DIET, HIGH-FAT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; NAPHTHOQUINONES; OBESITY; OXYGEN CONSUMPTION; THERMOGENESIS;

EID: 84987642034     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1423     Document Type: Article

References (43)

1. Galgani J, Ravussin E. Energy metabolism, fuel selection and body weight regulation. Int J Obes 2008;32(Suppl. 7):S109-S119
2. Rao RR, Long JZ, White JP, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 2014; 157:1279-1291
3. Roberts LD, Boström P, O'Sullivan JF, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab 2014;19:96-108
4. Liang H, Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ 2006;30:145-151
5. Shabalina IG, Petrovic N, de Jong JM, Kalinovich AV, Cannon B, Nedergaard J. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Reports 2013;5:1196-1203
6. Keipert S, Jastroch M. Brite/beige fat and UCP1-is it thermogenesis? Biochim Biophys Acta 2014;1837: 1075-1082
7. Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011;121:96-105
8. Trajkovski M, Ahmed K, Esau CC, Stoffel M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat Cell Biol 2012;14:1330-1335
9. Qiu Y, Nguyen KD, Odegaard JI, et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 2014;157:1292-1308
10. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297
11. Xu P, Vernooy SY, Guo M, Hay BA. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol 2003;13: 790-795
12. Wienholds E, Plasterk RH. MicroRNA function in animal development. FEBS Lett 2005;579:5911-5922
13. Kim HJ, Cho H, Alexander R, et al. MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes. Diabetes 2014;63:4045-4056
14. Sun L, Trajkovski M. MiR-27 orchestrates the transcriptional regulation of brown adipogenesis. Metabolism 2014;63:272-282
15. Chen Y, Siegel F, Kipschull S, et al. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun 2013;4: 1769
16. Hwang JH, Kim DW, Jo EJ, et al. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes 2009;58: 965-974
17. Quiñones M, Al-Massadi O, Fernø J, Nogueiras R. Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis. Mol Cell Endocrinol 2014; 397:42-50
18. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122
19. Aune UL, Ruiz L, Kajimura S. Isolation and differentiation of stromal vascular cells to beige/brite cells. J Vis Exp 2013;50191
20. Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 2012; 26:271-281
21. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 2012;15:395-404
22. Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376
23. Dempersmier J, Sambeat A, Gulyaeva O, et al. Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol Cell 2015;57:235-246
24. Hao Q, Yadav R, Basse AL, et al. Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism. Am J Physiol Endocrinol Metab 2015;308:E380-E392
25. Labbé SM, Caron A, Bakan I, et al. In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis. FASEB J 2015;29:2046-2058
26. de Jesus LA, Carvalho SD, Ribeiro MO, et al. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 2001;108:1379-1385
27. Christoffolete MA, Linardi CC, de Jesus L, et al. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes 2004;53:577-584
28. Mentuccia D, Proietti-Pannunzi L, Tanner K, et al. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes 2002;51:880-883
29. Bi P, Shan T, Liu W, et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 2014; 20:911-918
30. Pfannenberg C, Werner MK, Ripkens S, et al. Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes 2010;59:1789-1793
31. 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011;96:192-199
32. Gburcik V, Cawthorn WP, Nedergaard J, Timmons JA, Cannon B. An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. Am J Physiol Endocrinol Metab 2012;303:E1053-E1060
33. Lo KA, Sun L. Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes. Biosci Rep 2013;33: e00065
34. Becerril S, Gómez-Ambrosi J, Martín M, et al. Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity. Histol Histopathol 2013;28:1411-1425
35. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013;19:1252-1263
36. Lee JS, Park AH, Lee SH, et al. Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One 2012;7:e47122
37. McAninch EA, Bianco AC. Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci 2014;1311:77-87
38. Bianco AC, Sheng XY, Silva JE. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 1988;263:18168-18175
39. López M, Alvarez CV, Nogueiras R, Diéguez C. Energy balance regulation by thyroid hormones at central level. Trends Mol Med 2013;19:418-427
40. Hall JA, Ribich S, Christoffolete MA, et al. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology 2010;151:4573-4582
41. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett 2011;585:539-544
42. Seok JK, Lee SH, Kim MJ, Lee YM. MicroRNA-382 induced by HIF-1α is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog. Nucleic Acids Res 2014;42:8062-8072
43. Ortega-Molina A, Efeyan A, Lopez-Guadamillas E, et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab 2012;15:382-394