The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

FEBS Letters

Volumn 585, Issue 3, 2011, Pages 539-544

  Da Silva, Wagner S ^a,c   Ribich, Scott ^a   Drigo, Rafael Arrojo E ^a   Castillo, Melany ^a   Patti, Mary Elizabeth ^b   Bianco, Antonio C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Instituto de Bioquímica Médica   (Brazil)

Author keywords

Chemical chaperone; Deiodinase; Metabolism; Oxygen consumption; Thyroid hormone

Indexed keywords

4 PHENYLBUTYRIC ACID; CHAPERONE; MESSENGER RNA; TAUROURSODEOXYCHOLIC ACID; THYROID HORMONE; THYROXINE; THYROXINE DEIODINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CELL CULTURE; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GLUCOSE INTOLERANCE; HORMONE ACTION; LIPID DIET; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RESPIRATORY QUOTIENT; WEIGHT GAIN;

MUS;

EID: 79551501758     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.12.044     Document Type: Article

References (32)

1. J.E. Silva Thermogenic mechanisms and their hormonal regulation Physiol. Rev. 86 2006 435 464
2. A.C. Bianco, A.L. Maia, W.S. da Silva, and M.A. Christoffolete Adaptive activation of thyroid hormone and energy expenditure Biosci. Rep. 25 2005 191 208
3. B. Gereben, A.M. Zavacki, S. Ribich, B.W. Kim, S.A. Huang, W.S. Simonides, A. Zeold, and A.C. Bianco Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling Endocr. Rev. 29 2008 898 938
4. J.A. Hall, S. Ribich, M.A. Christoffolete, G. Simovic, M. Correa-Medina, M.E. Patti, and A.C. Bianco Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis Endocrinology 151 2010 4573 4582
5. R. Grozovsky, S. Ribich, M.L. Rosene, M.A. Mulcahey, S.A. Huang, M.E. Patti, A.C. Bianco, and B.W. Kim Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes Endocrinology 150 2009 1976 1983
6. R. Friedlander, E. Jarosch, J. Urban, C. Volkwein, and T. Sommer A regulatory link between ER-associated protein degradation and the unfolded-protein response Nat. Cell Biol. 2 2000 379 384
7. D. Botero, B. Gereben, C. Goncalves, L.A. de Jesus, J.W. Harney, and A.C. Bianco Ubc6p and Ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase Mol. Endocrinol. 16 2002 1999 2007
8. B.W. Kim, A.M. Zavacki, C. Curcio-Morelli, M. Dentice, J.W. Harney, P.R. Larsen, and A.C. Bianco ER-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2 Mol. Endocrinol. 17 2003 2603 2612
9. U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, R.O. Smith, C.Z. Gorgun, and G.S. Hotamisligil Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 313 2006 1137 1140
10. L. Ozcan, A.S. Ergin, A. Lu, J. Chung, S. Sarkar, D. Nie, M.G. Myers Jr., and U. Ozcan Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metab. 9 2009 35 51
11. P.A. Hansen, A. Waheed, and J.A. Corbett Chemically chaperoning the actions of insulin Trends Endocrinol. Metab. 18 2007 1 3
12. M.A. Christoffolete Mice with impaired extrathyroidal thyroxine to 3,5,3′-triiodothyronine conversion maintain normal serum 3,5,3′-triiodothyronine concentrations Endocrinology 148 2007 954 960
13. M. Castillo Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity Thyroid 20 2010 545 553
14. C. Curcio, M.M. Baqui, D. Salvatore, B.H. Rihn, S. Mohr, J.W. Harney, P.R. Larsen, and A.C. Bianco The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line J. Biol. Chem. 276 2001 30183 30187
15. W.S. da-Silva The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation Diabetes 56 2007 767 776
16. A.C. Bianco, and J.E. Silva Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue J. Clin. Invest. 79 1987 295 300
17. N.Y. Kalaany LXRx regulate the balance between fat storage and oxidation Cell Metab. 1 2005 231 244
18. M. Watanabe Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Nature 439 2006 484 489
19. C. Fekete Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome Endocrinology 145 2004 1649 1655
20. G. Canettieri, F.S. Celi, G. Baccheschi, L. Salvatori, M. Andreoli, and M. Centanni Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element Endocrinology 141 2000 1804 1813
21. A.C. Bianco, X. Sheng, and J.E. Silva Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis J. Biol. Chem. 263 1988 18168 18175
22. G.D. Sagar Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity Mol. Cell. Biol. 27 2007 4774 4783
23. M. Dentice The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate Nat. Cell Biol. 7 2005 698 705
24. A.M. Zavacki The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase Mol. Cell. Biol. 29 2009 5339 5347
25. A.K. Kurz, C. Block, D. Graf, S.V. Dahl, F. Schliess, and D. Haussinger Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver Biochem. J. 350 Pt. 1 2000 207 213
26. M.H. Schoemaker Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways Hepatology 39 2004 1563 1573
27. X. Zhang, L. Wei, Y. Yang, and Q. Yu Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway J. Cell. Biochem. 93 2004 819 829
28. P. Mally, R. Mishra, S. Gandhi, M.H. Decastro, B.B. Nankova, and E.F. Lagamma Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells Pediatr. Res. 55 2004 847 854
29. R.C. Rubenstein, and B.M. Lyons Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation Am. J. Physiol. Lung Cell Mol. Physiol. 281 2001 L43 L51
30. J. Steinmann, S. Halldorsson, B. Agerberth, and G.H. Gudmundsson Phenylbutyrate induces antimicrobial peptide expression Antimicrob. Agents Chemother. 53 2009 5127 5133
31. M. Kars Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women Diabetes 59 2010 1899 1905
32. P. Arner, J. Bolinder, A. Wennlund, and J. Ostman Influence of thyroid hormone level on insulin action in human adipose tissue Diabetes 33 1984 369 375