Development and characterization of a three-dimensional co-culture model of tumor T cell infiltration

Biofabrication

Volumn 8, Issue 2, 2016, Pages

  Alonso Nocelo, M ^a   Abuin C ^a   Lopez Lopez R ^a   De La Fuente, M ^a  

^a Instituto de Salud Carlos III   (Spain)

Author keywords

3D cell culture; anticancer drug; infiltrated T lymphocytes; inflammation; secretome; tumor microenvironment

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; CROSSTALK; DIAGNOSIS; ENZYME ACTIVITY; PATHOLOGY; T-CELLS; TUMORS;

3-D CELL CULTURE; ANTICANCER DRUG; INFLAMMATION; SECRETOME; TUMOR MICROENVIRONMENT;

CELL SIGNALING;

PROTEIN;

BIOLOGICAL MODEL; CELL COMMUNICATION; CELL PROLIFERATION; COCULTURE; EVALUATION STUDY; GENETICS; HUMAN; IMMUNOLOGY; NEOPLASM; PATHOPHYSIOLOGY; PROCEDURES; T LYMPHOCYTE; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

CELL COMMUNICATION; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PROTEINS; T-LYMPHOCYTES; TUMOR MICROENVIRONMENT;

EID: 84987619049     PISSN: 17585082     EISSN: 17585090     Source Type: Journal    
DOI: 10.1088/1758-5090/8/2/025002     Document Type: Article

References (76)

1. Stratton M R, Campbell P J and Futreal P A 2009 The cancer genome Nature 458 719-24
2. Sounni N E and Noel A 2013 Targeting the tumor microenvironment for cancer therapy Clin. Chem. 59 85-93
3. Quail D F and Joyce J A 2013 Microenvironmental regulation of tumor progression and metastasis Nat. Med. 19 1423-37
4. Junttila M R and de Sauvage F J 2013 Influence of tumour micro-environment heterogeneity on therapeutic response Nature 501 346-54
5. Balkwill F and Mantovani A 2001 Inflammation and cancer: back to Virchow? Lancet 357 539-45
6. Mueller M M and Fusenig N E 2004 Friends or foes - bipolar effects of the tumour stroma in cancer Nat. Rev. Cancer 4 839-49
7. Burkholder B et al 2014 Tumor-induced perturbations of cytokines and immune cell networks Biochim. Biophys. Acta 1845 182-201
8. Daniel D, Meyer-Morse N, Bergsland E K, Dehne K, Coussens L M and Hanahan D 2003 Immune enhancement of skin carcinogenesis by CD4+ T cells J. Exp. Med. 197 1017-28
9. de Visser K E, Korets L V and Coussens L M 2005 De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent Cancer Cell 7 411-23
10. Gajewski T F, Schreiber H and Fu Y-X 2013 Innate and adaptive immune cells in the tumor microenvironment Nat. Immunol. 14 1014-22
11. Borchers A H, Powell M B, Fusenig N E and Bowden G T 1994 Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures Exp. Cell Res. 213 143-7
12. Sasano H et al 2012 The advantages of co-culture over mono cell culture in simulating in vivo environment J. Steroid Biochem. Mol. Biol. 131 68-75
13. Elliott N T and Yuan F 2011 A review of three-dimensional in vitro tissue models for drug discovery and transport studies J. Pharm. Sci. 100 59-74
14. Yamada K M and Cukierman E 2007 Modeling tissue morphogenesis and cancer in 3D Cell 130 601-10
15. Cvetković D, Goertzen G-F and Bhattacharya M 2014 Quantification of breast cancer cell invasiveness using a three-dimensional (3D) model J. Vis. Exp.
16. Sung K E, Su X, Berthier E, Pehlke C, Friedl A and Beebe D J 2013 Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models PLoS One 8 e76373
17. Zhao Y et al 2014 Three-dimensional printing of Hela cells for cervical tumor model in vitro Biofabrication 6 035001
18. Liu T et al 2007 Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device Lab Chip 7 302-9
19. Ho C M B, Ng S H, Li K H H and Yoon Y-J 2015 3D printed microfluidics for biological applications Lab Chip 15 3627-37
20. Rimann M, Bono E, Annaheim H, Bleisch M and Graf-Hausner U 2015 Standardized 3D Bioprinting of soft tissue models with human primary cells J. Lab Autom.
21. Wüst S, Müller R and Hofmann S 2011 Controlled positioning of cells in biomaterials-approaches towards 3D tissue printing J. Funct. Biomater. 2 119-54
22. Dolznig H et al 2011 Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction Am. J. Pathol. 179 487-501
23. Sugihara H et al 2013 Identification of miR-30e∗ regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer PLoS One 8 e81839
24. Florczyk S J, Liu G, Kievit F M, Lewis A M, Wu J D and Zhang M 2012 3D porous chitosan-alginate scaffolds: a new matrix for studying prostate cancer cell-lymphocyte interactions in vitro Adv. Healthc. Mater. 1 590-9
25. He W et al 2014 Proteomic comparison of 3D and 2D Glioma models reveals increased HLA-E expression in 3D models is associated with resistance to NK cell-mediated cytotoxicity J. Proteome. Res.
26. Hirt C et al 2014 'In vitro' 3D models of tumor-immune system interaction Adv. Drug Deliv. Rev.
27. Barak V, Goike H, Panaretakis K W and Einarsson R 2004 Clinical utility of cytokeratins as tumor markers Clin. Biochem. 37 529-40
28. Unger C, Kramer N, Walzl A, Scherzer M, Hengstschläger M and Dolznig H 2014 Modeling human carcinomas: physiological relevant 3D models to improve anti-cancer drug development Adv. Drug Deliv. Rev.
29. Knight E, Murray B, Carnachan R and Przyborski S 2011 Alvetexdr: polystyrene scaffold technology for routine three dimensional cell culture Methods Mol. Biol. 695 323-40
30. Wang X-Y et al 2013 Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer Oncotarget 4 739-50
31. Amann A et al 2014 Development of an innovative 3D cell culture system to study tumour - stroma interactions in non-small cell lung cancer cells PLoS One 9 e92511
32. Colom A, Galgoczy R, Almendros I, Xaubet A, Farré R and Alcaraz J 2013 Oxygen diffusion and consumption in extracellular matrix gels: implications for designing three-dimensional cultures J. Biomed. Mater. Res. A
33. Stratmann A T et al 2014 Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model Mol. Oncol. 8 351-65
34. Murray J C et al 2004 Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism J. Immunol. 172 274-81
35. Chen J, Wu X-J and Wang G-Q 2008 Hepatoma cells up-regulate expression of programmed cell death-1 on T cells World J. Gastroenterol. 14 6853-7
36. Jevnikar Z, Obermajer N, Bogyo M and Kos J 2008 The role of cathepsin X in the migration and invasiveness of T lymphocytes J. Cell Sci. 121 2652-61
37. Kwasny D, Kiilerich-Pedersen K, Moresco J, Dimaki M, Rozlosnik N and Svendsen W E 2011 Microfluidic device to study cell transmigration under physiological shear stress conditions Biomed. Microdevices 13 899-907
38. Lin Y, Liu L, Zhang T and Liu J 2013 Functional investigation of Fas ligand expressions in human non-small cell lung cancer cells and its clinical implications Ann. Thorac. Surg. 95 412-8
39. Huang H et al 2015 VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-B-induced endothelial activation FASEB J. 29 227-38
40. Linde N, Gutschalk C M, Hoffmann C, Yilmaz D and Mueller M M 2012 Integrating macrophages into organotypic co-cultures: a 3D in vitro model to study tumor-associated macrophages PLoS One 7 e40058
41. Eruslanov E B et al 2014 Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer J. Clin. Invest. 124 5466-80
42. Ghosh S et al 2005 Culture of melanoma cells in 3-dimensional architectures results in impaired immunorecognition by cytotoxic T lymphocytes specific for Melan-A/MART-1 tumor-associated antigen Ann. Surg. 242 851-7 discussion 858
43. Kenny H A et al 2009 Organotypic models of metastasis: a three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis Cancer Treat. Res. 149 335-51
44. Campbell J J, Davidenko N, Caffarel M M, Cameron R E and Watson C J 2011 A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology PLoS One 6 e25661
45. Pavlou M P and Diamandis E P 2010 The cancer cell secretome: a good source for discovering biomarkers? J. Proteomics 73 1896-906
46. Baker B M and Chen C S 2012 Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues J. Cell Sci. 125 3015-24
47. Croci D O, Zacarías Fluck M F, Rico M J, Matar P, Rabinovich G A and Scharovsky O G 2007 Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment Cancer Immunol. Immunother. 56 1687-700
48. Filipazzi P, Bürdek M, Villa A, Rivoltini L and Huber V 2012 Recent advances on the role of tumor exosomes in immunosuppression and disease progression Semin. Cancer Biol. 22 342-9
49. Kahlert C and Kalluri R 2013 Exosomes in tumor microenvironment influence cancer progression and metastasis J. Mol. Med. 91 431-7
50. Chen S-T, Pan T-L, Juan H-F, Chen T-Y, Lin Y-S and Huang C-M 2008 Breast tumor microenvironment: proteomics highlights the treatments targeting secretome J. Proteome Res. 7 1379-87
51. Zeng X et al 2013 Quantitative secretome analysis reveals the interactions between epithelia and tumor cells by in vitro modulating colon cancer microenvironment J. Proteomics 89 51-70
52. Laffin B and Petrash J M 2012 Expression of the aldo-ketoreductases AKR1B1 and AKR1B10 in human cancers Front. Pharmacol. 3 104
53. Fukumoto S et al 2005 Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas Clin. Cancer Res. 11 1776-85
54. Tammali R, Reddy A B M, Srivastava S K and Ramana K V 2011 Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo Angiogenesis 14 209-21
55. Zablocki G J, Ruzycki P A, Overturf M A, Palla S, Reddy G B and Petrash J M 2011 Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens Chem. Biol. Interact. 191 351-6
56. Yadav U C S, Ramana K V, Aguilera-Aguirre L, Boldogh I, Boulares H A and Srivastava S K 2009 Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice PLoS One 4 e6535
57. Chen W-D and Zhang Y 2012 Regulation of aldo-keto reductases in human diseases Front. Pharmacol. 3 35
58. Ramana K V 2011 Aldose reductase: new insights for an old enzyme Biomol. Concepts 2 103-14
59. Reuter S, Gupta S C, Chaturvedi M M and Aggarwal B B 2010 Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol. Med. 49 1603-16
60. Muinelo-Romay L, Alonso-Alconada L, Alonso-Nocelo M, Barbazan J and Abal M 2012 Tumor invasion and oxidative stress: biomarkers and therapeutic strategies Curr. Mol. Med. 12 746-62
61. Härmä V et al 2010 A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses PLoS One 5 e10431
62. Won C H et al 2012 Comparative secretome analysis of human follicular dermal papilla cells and fibroblasts using shotgun proteomics BMB Rep. 45 253-8
63. Apte R N et al 2006 The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions Cancer Metastasis Rev. 25 387-408
64. Bonavita E et al 2015 PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer Cell 160 700-14
65. Gonda T A, Tu S and Wang T C 2009 Chronic inflammation, the tumor microenvironment and carcinogenesis Cell Cycle 8 2005-13
66. Pio R, Ajona D and Lambris J D 2013 Complement inhibition in cancer therapy Semin. Immunol. 25 54-64
67. Rutkowski M J, Sughrue M E, Kane A J, Mills S A and Parsa A T 2010 Cancer and the complement cascade Mol. Cancer Res. 8 1453-65
68. Dowling P et al 2012 Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer Int. J. Cancer 131 911-23
69. Lin K et al 2014 Complement component 3 is a prognostic factor of non-small cell lung cancer Mol. Med. Rep. 10 811-7
70. Yamaguchi K, Sakiyama H, Matsumoto M, Moriya H and Sakiyama S 1990 Degradation of type I and II collagen by human activated C1-s FEBS Lett. 268 206-8
71. Joyce J A et al 2004 Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis Cancer Cell 5 443-53
72. Tessitore A et al 2013 Serum biomarkers identification by mass spectrometry in high-mortality tumors Int. J. Proteomics 2013 125858
73. Benien P and Swami A 2014 3D tumor models: history, advances and future perspectives Future Oncol. 10 1311-27
74. Devaud C, John L B, Westwood J A, Darcy P K and Kershaw M H 2013 Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy Oncoimmunology 2 e25961
75. Tehranirokh M, Kouzani A Z, Francis P S and Kanwar J R 2013 Microfluidic devices for cell cultivation and proliferation Biomicrofluidics 7 51502
76. Mantovani A, Allavena P, Sica A and Balkwill F 2008 Cancer-related inflammation Nature 454 436-44