Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis

Molecular Cell

Volumn 61, Issue 3, 2016, Pages 329-340

  Cho, Sangwoo ^a   Dickey, Seth W ^a   Urban, Siniša ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; RHOMBOID PROTEASE; SERINE; UNCLASSIFIED DRUG; ALDEHYDE; ANTIINFECTIVE AGENT; DNA BINDING PROTEIN; ESCHERICHIA COLI PROTEIN; GLPG PROTEIN, E COLI; MEMBRANE PROTEIN; PEPTIDE; PROTEIN BINDING; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; INHIBITION KINETICS; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME SPECIFICITY; ENZYME STABILITY; GENETICS; KINETICS; METABOLISM; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ALDEHYDES; ANTI-BACTERIAL AGENTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; DRUG DESIGN; ENDOPEPTIDASES; ENZYME STABILITY; ESCHERICHIA COLI PROTEINS; KINETICS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; PEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84957437306     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.12.022     Document Type: Article

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