Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 35, 2016, Pages E5212-E5221

  Fernandez Funez, Pedro ^a,b   Sanchez Garcia, Jonatan ^a   De Mena, Lorena ^a   Zhang, Yan ^a   Levites, Yona ^b   Khare, Swati ^a   Golde, Todd E ^a,b   Rincon Limas, Diego E ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyloid ; Drosophila; Engineered chaperones; Hsp70; Neuroprotections

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMYLOID BETA PROTEIN[1-42]; CHAPERONE; HEAT SHOCK PROTEIN 70; HOLDASE; PROTEIN AGGREGATE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; PROTEIN BINDING;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EXTRACELLULAR SPACE; FEMALE; LIFESPAN; LOCOMOTION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; EYE; GENETIC ENGINEERING; GENETICS; HEK293 CELL LINE; HUMAN; LONGEVITY; MALE; METABOLISM; MOTOR DYSFUNCTION; NERVE CELL; PROCEDURES; TRANSGENIC ANIMAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; EYE; FEMALE; GENETIC ENGINEERING; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LONGEVITY; MALE; MOTOR DISORDERS; NEURONS; NEUROPROTECTION; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 84984674677     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1608045113     Document Type: Article

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