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Volumn 9, Issue JUL, 2016, Pages

Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of alzheimer’s disease

Author keywords

Acetoacetate; Aging; Alzheimer s disease; Beta hydroxybutyrate; Glucose; Ketone; Medium chain fatty acid; Mild cognitive impairment

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; APOLIPOPROTEIN E4; KETONE; PRESENILIN 1;

EID: 84984623335     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2016.00053     Document Type: Article
Times cited : (159)

References (140)
  • 2
    • 0016431489 scopus 로고
    • Oxidation of glucose and D-B-OH-butyrate by the early human fetal brain
    • Adam, P. A., Raiha, N., Rahiala, E. L., and Kekomaki, M. (1975). Oxidation of glucose and D-B-OH-butyrate by the early human fetal brain. Acta Paediatr. Scand. 64, 17-24. doi: 10.1111/j.1651-2227.1975.tb04375.x
    • (1975) Acta Paediatr. Scand. , vol.64 , pp. 17-24
    • Adam, P.A.1    Raiha, N.2    Rahiala, E.L.3    Kekomaki, M.4
  • 3
    • 33745258377 scopus 로고    scopus 로고
    • Incidence and predictors of seizures in patients with Alzheimer’s disease
    • Amatniek, J. C., Hauser, W. A., DelCastillo-Castaneda, C., Jacobs, D. M., Marder, K., Bell, K., et al. (2006). Incidence and predictors of seizures in patients with Alzheimer’s disease. Epilepsia 47, 867-872. doi: 10.1111/j.1528-1167.2006.00554.x
    • (2006) Epilepsia , vol.47 , pp. 867-872
    • Amatniek, J.C.1    Hauser, W.A.2    DelCastillo-Castaneda, C.3    Jacobs, D.M.4    Marder, K.5    Bell, K.6
  • 4
    • 0025816090 scopus 로고
    • Ketone infusion lowers hormonal responses to hypoglycaemia: Evidence for acute cerebral utilization of a non-glucose fuel
    • Amiel, S. A., Archibald, H. R., Chusney, G., Williams, A. J., and Gale, E. A. (1991). Ketone infusion lowers hormonal responses to hypoglycaemia: Evidence for acute cerebral utilization of a non-glucose fuel. Clin. Sci. (Lond). 81, 189-194. doi: 10.1042/cs0810189
    • (1991) Clin. Sci. (Lond). , vol.81 , pp. 189-194
    • Amiel, S.A.1    Archibald, H.R.2    Chusney, G.3    Williams, A.J.4    Gale, E.A.5
  • 5
    • 0026020414 scopus 로고
    • Fatty acid oxidation and ketogenesis by astrocytes in primary culture
    • Auestad, N., Korsak, R. A., Morrow, J. W., and Edmond, J. (1991). Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J. Neurochem. 56, 1376-1386. doi: 10.1111/j.1471-4159.1991.tb11435.x
    • (1991) J. Neurochem. , vol.56 , pp. 1376-1386
    • Auestad, N.1    Korsak, R.A.2    Morrow, J.W.3    Edmond, J.4
  • 6
    • 0025322353 scopus 로고
    • Ketone body kinetics in vivo using simultaneous administration of acetoacetate and 3-hydroxybutyrate labelled with stable isotopes
    • Avogaro, A., Nosadini, R., Bier, D. M., Cobelli, C., Toffolo, G., Doria, A., et al. (1990). Ketone body kinetics in vivo using simultaneous administration of acetoacetate and 3-hydroxybutyrate labelled with stable isotopes. Acta Diabetol Lat. 27, 41-51. doi: 10.1007/BF02624721
    • (1990) Acta Diabetol Lat. , vol.27 , pp. 41-51
    • Avogaro, A.1    Nosadini, R.2    Bier, D.M.3    Cobelli, C.4    Toffolo, G.5    Doria, A.6
  • 7
    • 0020420292 scopus 로고
    • Medium-chain triglycerides: An update
    • Bach, A. C., and Babayan, V. K. (1982). Medium-chain triglycerides: An update. Am. J. Clin. Nutr. 36, 950-962.
    • (1982) Am. J. Clin. Nutr. , vol.36 , pp. 950-962
    • Bach, A.C.1    Babayan, V.K.2
  • 8
    • 78651274000 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    • Baker, L. D., Cross, D. J., Minoshima, S., Belongia, D., Watson, G. S., and Craft, S. (2011). Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68, 51-57. doi: 10.1001/archneurol.2010.225
    • (2011) Arch. Neurol. , vol.68 , pp. 51-57
    • Baker, L.D.1    Cross, D.J.2    Minoshima, S.3    Belongia, D.4    Watson, G.S.5    Craft, S.6
  • 9
    • 0024549618 scopus 로고
    • Ketone body production and disposal: Effects of fasting, diabetes, and exercise
    • Balasse, E. O., and Fery, F. (1989). Ketone body production and disposal: Effects of fasting, diabetes, and exercise. Diabetes Metab. Rev. 5, 247-270. doi: 10.1002/dmr.5610050304
    • (1989) Diabetes Metab. Rev. , vol.5 , pp. 247-270
    • Balasse, E.O.1    Fery, F.2
  • 10
    • 0018236730 scopus 로고
    • Changes induced by exercise in rates of turnover and oxidation of ketone bodies in fasting man
    • Balasse, E. O., Fery, F., and Neef, M. A. (1978). Changes induced by exercise in rates of turnover and oxidation of ketone bodies in fasting man. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 44, 5-11.
    • (1978) J. Appl. Physiol. Respir. Environ. Exerc. Physiol. , vol.44 , pp. 5-11
    • Balasse, E.O.1    Fery, F.2    Neef, M.A.3
  • 11
    • 0025145801 scopus 로고
    • An explanation for ketogenesis by the intestine of the suckling rat: The presence of an active hydroxymethylglutarylcoenzyme A pathway
    • Bekesi, A., and Williamson, D. H. (1990). An explanation for ketogenesis by the intestine of the suckling rat: The presence of an active hydroxymethylglutarylcoenzyme A pathway. Biol. Neonate 58, 160-165. doi: 10.1159/000243256
    • (1990) Biol. Neonate , vol.58 , pp. 160-165
    • Bekesi, A.1    Williamson, D.H.2
  • 12
    • 0020974955 scopus 로고
    • The fluorodeoxyglucose 18F scan in Alzheimer’s disease and multi-infarct dementia
    • Benson, D. F., Kuhl, D. E., Hawkins, R. A., Phelps, M. E., Cummings, J. L., and Tsai, S. Y. (1983). The fluorodeoxyglucose 18F scan in Alzheimer’s disease and multi-infarct dementia. Arch. Neurol. 40, 711-714. doi: 10.1001/archneur.1983.04050110029003
    • (1983) Arch. Neurol. , vol.40 , pp. 711-714
    • Benson, D.F.1    Kuhl, D.E.2    Hawkins, R.A.3    Phelps, M.E.4    Cummings, J.L.5    Tsai, S.Y.6
  • 14
    • 57749107571 scopus 로고    scopus 로고
    • A new approach to treating Alzheimer’s disease
    • Blass, J. P. (2008). A new approach to treating Alzheimer’s disease. Ann. N. Y. Acad. Sci. 1147, 122-128. doi: 10.1196/annals.1427.022
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 122-128
    • Blass, J.P.1
  • 15
    • 0036293650 scopus 로고    scopus 로고
    • Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients
    • Blomqvist, G., Alvarsson, M., Grill, V., Von Heijne, G., Ingvar, M., Thorell, J. O., et al. (2002). Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients Am. J. Physiol. Endocrinol. Metab. 283, E20-E28. doi: 10.1152/ajpendo.00294.2001
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283 , pp. E20-E28
    • Blomqvist, G.1    Alvarsson, M.2    Grill, V.3    Von Heijne, G.4    Ingvar, M.5    Thorell, J.O.6
  • 16
    • 0028789091 scopus 로고
    • Use of R-beta-[1-11C]hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans
    • Blomqvist, G., Thorell, J. O., Ingvar, M., Grill, V.,Widen, L., and Stone-Elander, S. (1995). Use of R-beta-[1-11C]hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans. Am. J. Physiol. 269(5 Pt 1), E948-E959.
    • (1995) Am. J. Physiol. , vol.269 , Issue.5 , pp. E948-E959
    • Blomqvist, G.1    Thorell, J.O.2    Ingvar, M.3    Grill, V.4    Widen, L.5    Stone-Elander, S.6
  • 17
    • 33746848935 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    • Bough, K. J., Wetherington, J., Hassel, B., Pare, J. F., Gawryluk, J. W., Greene, J. G., et al. (2006). Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann. Neurol. 60, 223-235. doi: 10.1002/ana.20899
    • (2006) Ann. Neurol. , vol.60 , pp. 223-235
    • Bough, K.J.1    Wetherington, J.2    Hassel, B.3    Pare, J.F.4    Gawryluk, J.W.5    Greene, J.G.6
  • 18
    • 0022587135 scopus 로고
    • Ketone body transport in the human neonate and infant
    • Bougneres, P. F., Lemmel, C., Ferre, P., and Bier, D. M. (1986). Ketone body transport in the human neonate and infant. J. Clin. Invest. 77, 42-48. doi: 10.1172/JCI112299
    • (1986) J. Clin. Invest. , vol.77 , pp. 42-48
    • Bougneres, P.F.1    Lemmel, C.2    Ferre, P.3    Bier, D.M.4
  • 19
    • 0018410202 scopus 로고
    • Accelerated ageing or selective neuronal loss as an important cause of dementia?
    • Bowen, D. M., White, P., Spillane, J. A., Goodhardt,M. J., Curzon, G., Iwangoff, P., et al. (1979). Accelerated ageing or selective neuronal loss as an important cause of dementia?. Lancet 1, 11-14.
    • (1979) Lancet , vol.1 , pp. 11-14
    • Bowen, D.M.1    White, P.2    Spillane, J.A.3    Goodhardt, M.J.4    Curzon, G.5    Iwangoff, P.6
  • 20
    • 0014127854 scopus 로고
    • Molecular weight distributions of milk fat triglycerides from seven species
    • Breckenridge,W. C., and Kuksis, A. (1967). Molecular weight distributions of milk fat triglycerides from seven species. J. Lipid Res. 8, 473-478.
    • (1967) J. Lipid Res. , vol.8 , pp. 473-478
    • Breckenridge, W.C.1    Kuksis, A.2
  • 21
    • 33745105118 scopus 로고    scopus 로고
    • Anaplerotic molecules: Current and future
    • Brunengraber, H., and Roe, C. R. (2006). Anaplerotic molecules: Current and future. J. Inherit. Metab. Dis. 29, 327-331. doi: 10.1007/s10545-006-0320-1
    • (2006) J. Inherit. Metab. Dis. , vol.29 , pp. 327-331
    • Brunengraber, H.1    Roe, C.R.2
  • 22
    • 84878918038 scopus 로고    scopus 로고
    • Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions
    • Burns, C. M., Chen, K., Kaszniak, A. W., Lee, W., Alexander, G. E., Bandy, D., et al. (2013). Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions. Neurology 80, 1557-1564. doi: 10.1212/WNL.0b013e31828f17
    • (2013) Neurology , vol.80 , pp. 1557-1564
    • Burns, C.M.1    Chen, K.2    Kaszniak, A.W.3    Lee, W.4    Alexander, G.E.5    Bandy, D.6
  • 23
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • de Cahill, G. F. Jr. (2006). Fuel metabolism in starvation. Annu. Rev. Nutr. 26, 1-22. doi: 10.1146/annurev.nutr.26.061505.111258
    • (2006) Annu. Rev. Nutr. , vol.26 , pp. 1-22
    • de Cahill, G.F.1
  • 24
    • 84955465001 scopus 로고    scopus 로고
    • Regional brain glucose hypometabolism in young women with polycystic ovary syndrom: Possible link to mild insulin resistance
    • Castellano, C. A., Baillargeon, J. P., Nugent, S., Tremblay, S., Fortier, M., Imbeault, H., et al. (2015a). Regional brain glucose hypometabolism in young women with polycystic ovary syndrom: Possible link to mild insulin resistance. PLoS ONE 10: e0144116. doi: 10.1371/journal.pone.0144116
    • (2015) PLoS ONE , vol.10 , pp. 144116
    • Castellano, C.A.1    Baillargeon, J.P.2    Nugent, S.3    Tremblay, S.4    Fortier, M.5    Imbeault, H.6
  • 25
    • 84919917084 scopus 로고    scopus 로고
    • Lower brain 18F-Fluorodeoxyglucose uptake but normal 11CAcetoacetate metabolism in mild Alzheimer’s Disease dementia
    • Castellano, C. A., Nugent, S., Paquet, N., Tremblay, S., Bocti, C., Lacombe, G., et al. (2015b). Lower brain 18F-Fluorodeoxyglucose uptake but normal 11CAcetoacetate metabolism in mild Alzheimer’s Disease dementia. J. Alzheimers Dis. 43, 1343-1353. doi: 10.3233/JAD-141074
    • (2015) J. Alzheimers Dis. , vol.43 , pp. 1343-1353
    • Castellano, C.A.1    Nugent, S.2    Paquet, N.3    Tremblay, S.4    Bocti, C.5    Lacombe, G.6
  • 26
    • 84862236426 scopus 로고    scopus 로고
    • Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects
    • Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Todd King, M., Musa-Veloso, K., et al. (2012). Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol. 63, 401-408. doi: 10.1016/j.yrtph.2012.04.008
    • (2012) Regul. Toxicol. Pharmacol. , vol.63 , pp. 401-408
    • Clarke, K.1    Tchabanenko, K.2    Pawlosky, R.3    Carter, E.4    Todd King, M.5    Musa-Veloso, K.6
  • 27
    • 84875368921 scopus 로고    scopus 로고
    • Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism
    • Courchesne-Loyer, A., Fortier, M., Tremblay-Mercier, J., Chouinard-Watkins, R., Roy, M., Nugent, S., et al. (2013). Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism. Nutrition 29, 635-640. doi: 10.1016/j.nut.2012.09.009
    • (2013) Nutrition , vol.29 , pp. 635-640
    • Courchesne-Loyer, A.1    Fortier, M.2    Tremblay-Mercier, J.3    Chouinard-Watkins, R.4    Roy, M.5    Nugent, S.6
  • 28
    • 84942241274 scopus 로고    scopus 로고
    • Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans
    • Courchesne-Loyer, A., St-Pierre, V., Hennebelle, M., Castellano, C. A., Fortier, M., Tessier, D., et al. (2015). Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans. Nutrition 31, 1255-1259. doi: 10.1016/j.nut.2015.05.015
    • (2015) Nutrition , vol.31 , pp. 1255-1259
    • Courchesne-Loyer, A.1    St-Pierre, V.2    Hennebelle, M.3    Castellano, C.A.4    Fortier, M.5    Tessier, D.6
  • 29
    • 62449142597 scopus 로고    scopus 로고
    • The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged
    • Craft, S. (2009). The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged. Arch. Neurol. 66, 300-305. doi: 10.1001/archneurol.2009.27
    • (2009) Arch. Neurol. , vol.66 , pp. 300-305
    • Craft, S.1
  • 30
    • 84863724280 scopus 로고    scopus 로고
    • Alzheimer disease: Insulin resistance and AD-extending the translational path
    • Craft, S. (2012). Alzheimer disease: Insulin resistance and AD-extending the translational path. Nat. Rev. Neurol. 8, 360-362. doi: 10.1038/nrneurol.2012.112
    • (2012) Nat. Rev. Neurol. , vol.8 , pp. 360-362
    • Craft, S.1
  • 32
    • 84954271182 scopus 로고    scopus 로고
    • Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease
    • Cunnane, S. C., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Pierotti, T., Fortier, M., et al. (2016). Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Ann. N. Y. Acad. Sci. 1367, 12-20. doi: 10.1111/nyas.12999
    • (2016) Ann. N. Y. Acad. Sci. , vol.1367 , pp. 12-20
    • Cunnane, S.C.1    Courchesne-Loyer, A.2    St-Pierre, V.3    Vandenberghe, C.4    Pierotti, T.5    Fortier, M.6
  • 33
    • 84920590033 scopus 로고    scopus 로고
    • Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution
    • Cunnane, S. C., and Crawford, M. A. (2014). Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution. J. Hum. Evol. 77, 88-98. doi: 10.1016/j.jhevol.2014.05.001
    • (2014) J. Hum. Evol. , vol.77 , pp. 88-98
    • Cunnane, S.C.1    Crawford, M.A.2
  • 34
    • 0038647593 scopus 로고    scopus 로고
    • Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?
    • Cunnane, S. C., Ryan, M. A., Nadeau, C. R., Bazinet, R. P., Musa-Veloso, K., and McCloy, U. (2003). Why is carbon from some polyunsaturates extensively recycled into lipid synthesis? Lipids 38, 477-484. doi: 10.1007/s11745-003-1087-8
    • (2003) Lipids , vol.38 , pp. 477-484
    • Cunnane, S.C.1    Ryan, M.A.2    Nadeau, C.R.3    Bazinet, R.P.4    Musa-Veloso, K.5    McCloy, U.6
  • 36
    • 0021925133 scopus 로고
    • Cerebral blood flow and metabolism in normal human aging, pathological aging, and senile dementia
    • Dastur, D. K. (1985). Cerebral blood flow and metabolism in normal human aging, pathological aging, and senile dementia. J. Cereb. Blood Flow Metab. 5, 1-9. doi: 10.1038/jcbfm.1985.1
    • (1985) J. Cereb. Blood Flow Metab. , vol.5 , pp. 1-9
    • Dastur, D.K.1
  • 37
    • 0028345792 scopus 로고
    • Kinetics of medium-chain triglycerides and free fatty acids in healthy volunteers and surgically stressed patients
    • De Gaetano, A., Castagneto, M., Mingrone, G., Gangeri, G., Sganga, G., Tataranni, P. A., et al. (1994). Kinetics of medium-chain triglycerides and free fatty acids in healthy volunteers and surgically stressed patients. JPEN J. Parenter. Enteral. Nutr. 18, 134-140. doi: 10.1177/0148607194018002134
    • (1994) JPEN J. Parenter. Enteral. Nutr. , vol.18 , pp. 134-140
    • De Gaetano, A.1    Castagneto, M.2    Mingrone, G.3    Gangeri, G.4    Sganga, G.5    Tataranni, P.A.6
  • 38
    • 0029444246 scopus 로고
    • Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects
    • De Santi, S., de Leon, M. J., Convit, A., Tarshish, C., Rusinek, H., Tsui, W. H., et al. (1995). Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects. Psychiatr. Q.Winter 66, 357-370. doi: 10.1007/BF02238755
    • (1995) Psychiatr. Q.Winter , vol.66 , pp. 357-370
    • De Santi, S.1    de Leon, M.J.2    Convit, A.3    Tarshish, C.4    Rusinek, H.5    Tsui, W.H.6
  • 40
    • 0015413298 scopus 로고
    • Resistance to symptomatic insulin reactions after fasting
    • Drenick, E. J., Alvarez, L. C., Tamasi, G. C., and Brickman, A. S. (1972). Resistance to symptomatic insulin reactions after fasting. J. Clin. Invest. 51, 2757-2762. doi: 10.1172/JCI107095
    • (1972) J. Clin. Invest. , vol.51 , pp. 2757-2762
    • Drenick, E.J.1    Alvarez, L.C.2    Tamasi, G.C.3    Brickman, A.S.4
  • 41
    • 0037707488 scopus 로고    scopus 로고
    • Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy
    • Ebert, D., Haller, R. G., and Walton, M. E. (2003). Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J. Neurosci. 23, 5928-5935.
    • (2003) J. Neurosci. , vol.23 , pp. 5928-5935
    • Ebert, D.1    Haller, R.G.2    Walton, M.E.3
  • 42
    • 18144449193 scopus 로고
    • Ketone body turnover during and after exercise in overnight-fasted and starved humans
    • Fery, F., and Balasse, E. O. (1983). Ketone body turnover during and after exercise in overnight-fasted and starved humans. Am. J. Physiol. 245, E318-E325.
    • (1983) Am. J. Physiol. , vol.245 , pp. E318-E325
    • Fery, F.1    Balasse, E.O.2
  • 43
    • 0022549399 scopus 로고
    • Response of ketone body metabolism to exercise during transition from postabsorptive to fasted state
    • Fery, F., and Balasse, E. O. (1986). Response of ketone body metabolism to exercise during transition from postabsorptive to fasted state. Am. J. Physiol. 250(5 Pt 1), E495-E501.
    • (1986) Am. J. Physiol. , vol.250 , Issue.5 , pp. E495-E501
    • Fery, F.1    Balasse, E.O.2
  • 44
    • 0015254098 scopus 로고
    • On the maximal possible rate of ketogenesis
    • Flatt, J. P. (1972). On the maximal possible rate of ketogenesis. Diabetes Metab. Res. Rev. 21, 50-53. doi: 10.2337/diab.21.1.50
    • (1972) Diabetes Metab. Res. Rev. , vol.21 , pp. 50-53
    • Flatt, J.P.1
  • 46
    • 0013973701 scopus 로고
    • Standardized ketosis in man following medium chain triglyceride ingestion
    • Freund, G., and Weinsier, R. L. (1966). Standardized ketosis in man following medium chain triglyceride ingestion. Metabolism 15, 980-991. doi: 10.1016/0026-0495(66)90046-1
    • (1966) Metabolism , vol.15 , pp. 980-991
    • Freund, G.1    Weinsier, R.L.2
  • 47
    • 1042276529 scopus 로고    scopus 로고
    • Pathways and control of ketone body metabolism: On the fringe of lipid biochemistry
    • Fukao, T., Lopaschuk, G. D., and Mitchell, G. A. (2004). Pathways and control of ketone body metabolism: On the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids 70, 243-251. doi: 10.1016/j.plefa.2003.11.001
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 243-251
    • Fukao, T.1    Lopaschuk, G.D.2    Mitchell, G.A.3
  • 48
    • 84955409052 scopus 로고    scopus 로고
    • From inflamm-aging to immune-paralysis: A slippery slope during aging for immune-adaptation
    • Fulop, T., Dupuis, G., Baehl, S., Le Page, A., Bourgade, K., Frost, E., et al. (2015). From inflamm-aging to immune-paralysis: A slippery slope during aging for immune-adaptation. Biogerontology 17, 147-157. doi: 10.1007/s10522-015-9615-7
    • (2015) Biogerontology , vol.17 , pp. 147-157
    • Fulop, T.1    Dupuis, G.2    Baehl, S.3    Le Page, A.4    Bourgade, K.5    Frost, E.6
  • 49
    • 84881281872 scopus 로고    scopus 로고
    • Elusive Alzheimer’s disease: Can immune signatures help our understanding of this challenging disease? Part 2: New immune paradigm
    • Fulop, T., Lacombe, G., Cunnane, S., Le Page, A., Dupuis, G., Frost, E. H., et al. (2013). Elusive Alzheimer’s disease: Can immune signatures help our understanding of this challenging disease? Part 2: New immune paradigm. Discov. Med. 15, 33-42.
    • (2013) Discov. Med. , vol.15 , pp. 33-42
    • Fulop, T.1    Lacombe, G.2    Cunnane, S.3    Le Page, A.4    Dupuis, G.5    Frost, E.H.6
  • 50
    • 0016274287 scopus 로고
    • Hepatic ketogenesis and gluconeogenesis in humans
    • Garber, A. J., Menzel, P. H., Boden, G., and Owen, O. E. (1974). Hepatic ketogenesis and gluconeogenesis in humans. J. Clin. Invest. 54, 981-989. doi: 10.1172/JCI107839
    • (1974) J. Clin. Invest. , vol.54 , pp. 981-989
    • Garber, A.J.1    Menzel, P.H.2    Boden, G.3    Owen, O.E.4
  • 51
    • 0033179191 scopus 로고    scopus 로고
    • Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcortico-frontal dementia, and cortical frontal dementia
    • Garraux, G., Salmon, E., Degueldre, C., Lemaire, C., Laureys, S., and Franck, G. (1999). Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcortico-frontal dementia, and cortical frontal dementia. Neuroimage 10, 149-162. doi: 10.1006/nimg.1999.0463
    • (1999) Neuroimage , vol.10 , pp. 149-162
    • Garraux, G.1    Salmon, E.2    Degueldre, C.3    Lemaire, C.4    Laureys, S.5    Franck, G.6
  • 52
  • 53
    • 0027531803 scopus 로고
    • Intestinal absorption and liver uptake of medium-chain fatty acids in non-anaesthetized pigs
    • Guillot, E., Vaugelade, P., Lemarchal, P., and Rerat, A. (1993). Intestinal absorption and liver uptake of medium-chain fatty acids in non-anaesthetized pigs. Br. J. Nutr. 69, 431-442. doi: 10.1079/BJN19930045
    • (1993) Br. J. Nutr. , vol.69 , pp. 431-442
    • Guillot, E.1    Vaugelade, P.2    Lemarchal, P.3    Rerat, A.4
  • 54
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap, A. P., and Price, N. T. (1999). The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation. Biochem. J. 343(Pt 2), 281-299. doi: 10.1042/0264-6021: 3430281
    • (1999) Biochem. J. , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 55
    • 0021686934 scopus 로고
    • Ketone body kinetics in humans: The effects of insulin-dependent diabetes, obesity, and starvation
    • Hall, S. E., Wastney, M. E., Bolton, T. M., Braaten, J. T., and Berman, M. (1984). Ketone body kinetics in humans: The effects of insulin-dependent diabetes, obesity, and starvation. J. Lipid Res. 25, 1184-1194.
    • (1984) J. Lipid Res. , vol.25 , pp. 1184-1194
    • Hall, S.E.1    Wastney, M.E.2    Bolton, T.M.3    Braaten, J.T.4    Berman, M.5
  • 56
    • 0028813537 scopus 로고
    • Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans
    • Hasselbalch, S. G., Knudsen, G. M., Jakobsen, J., Hageman, L. P., Holm, S., and Paulson, O. B. (1995). Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am. J. Physiol. 268(6 Pt 1), E1161-E1166.
    • (1995) Am. J. Physiol. , vol.268 , Issue.6 , pp. E1161-E1166
    • Hasselbalch, S.G.1    Knudsen, G.M.2    Jakobsen, J.3    Hageman, L.P.4    Holm, S.5    Paulson, O.B.6
  • 57
    • 0029894079 scopus 로고    scopus 로고
    • Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia
    • Hasselbalch, S. G., Madsen, P. L., Hageman, L. P., Olsen, K. S., Justesen, N., Holm, S., et al. (1996). Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am. J. Physiol. 270(5 Pt 1), E746-E751.
    • (1996) Am. J. Physiol. , vol.270 , Issue.5 , pp. E746-E751
    • Hasselbalch, S.G.1    Madsen, P.L.2    Hageman, L.P.3    Olsen, K.S.4    Justesen, N.5    Holm, S.6
  • 58
    • 0742323532 scopus 로고    scopus 로고
    • Insights into the ageing mind: A view from cognitive neuroscience
    • Hedden, T., and Gabrieli, J. D. (2004). Insights into the ageing mind: A view from cognitive neuroscience. Nat. Rev. Neurosci. 5, 87-96. doi: 10.1038/nrn1323
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 87-96
    • Hedden, T.1    Gabrieli, J.D.2
  • 59
    • 46749091229 scopus 로고    scopus 로고
    • Ketone bodies as a therapeutic for Alzheimer’s disease
    • Henderson, S. T. (2008). Ketone bodies as a therapeutic for Alzheimer’s disease. Neurotherapeutics 5, 470-480. doi: 10.1016/j.nurt.2008.05.004
    • (2008) Neurotherapeutics , vol.5 , pp. 470-480
    • Henderson, S.T.1
  • 60
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: A randomized, double-blind, placebo-controlled, multicenter trial
    • Henderson, S. T., Vogel, J. L., Barr, L. J., Garvin, F., Jones, J. J., and Costantini, L. C. (2009). Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: A randomized, double-blind, placebo-controlled, multicenter trial. Nutr. Metab. (Lond.) 6: 31. doi: 10.1186/1743-7075-6-31
    • (2009) Nutr. Metab. (Lond.) , vol.6 , pp. 31
    • Henderson, S.T.1    Vogel, J.L.2    Barr, L.J.3    Garvin, F.4    Jones, J.J.5    Costantini, L.C.6
  • 61
    • 84973863161 scopus 로고    scopus 로고
    • Preliminary evaluation of a differential effect of an alpha-linolenate-rich supplement on ketogenesis and plasma omega-3 fatty acids in young compared to older adults
    • Hennebelle, M., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Castellano, C. A., Fortier, M., et al. (2016). Preliminary evaluation of a differential effect of an alpha-linolenate-rich supplement on ketogenesis and plasma omega-3 fatty acids in young compared to older adults. Nutrition 16, 30040-30045. doi: 10.1016/j.nut.2016.03.025
    • (2016) Nutrition , vol.16 , pp. 30040-30045
    • Hennebelle, M.1    Courchesne-Loyer, A.2    St-Pierre, V.3    Vandenberghe, C.4    Castellano, C.A.5    Fortier, M.6
  • 62
    • 0036743220 scopus 로고    scopus 로고
    • Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET
    • Herholz, K., Salmon, E., Perani, D., Baron, J. C., Holthoff, V., Frolich, L., et al. (2002). Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 17, 302-316. doi: 10.1006/nimg.2002.1208
    • (2002) Neuroimage , vol.17 , pp. 302-316
    • Herholz, K.1    Salmon, E.2    Perani, D.3    Baron, J.C.4    Holthoff, V.5    Frolich, L.6
  • 63
    • 84935885840 scopus 로고    scopus 로고
    • Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, beta-amyloid toxicity, and astrocyte function
    • Hertz, L., Chen, Y., and Waagepetersen, H. S. (2015). Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, beta-amyloid toxicity, and astrocyte function. J. Neurochem. 134, 7-20. doi: 10.1111/jnc.13107
    • (2015) J. Neurochem. , vol.134 , pp. 7-20
    • Hertz, L.1    Chen, Y.2    Waagepetersen, H.S.3
  • 64
    • 84932015775 scopus 로고
    • Human-milk fat: 1. Component fatty acids
    • Hilditch, T. P., and Meara, M. L. (1944). Human-milk fat: 1. Component fatty acids. Biochem. J. 38, 29-34.
    • (1944) Biochem. J. , vol.38 , pp. 29-34
    • Hilditch, T.P.1    Meara, M.L.2
  • 65
    • 0026781603 scopus 로고
    • Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases
    • Hoyer, S. (1992). Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases. Mol. Chem. Neuropathol. 16, 207-224. doi: 10.1007/BF03159971
    • (1992) Mol. Chem. Neuropathol. , vol.16 , pp. 207-224
    • Hoyer, S.1
  • 66
    • 0023737618 scopus 로고
    • Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?
    • Hoyer, S., Oesterreich, K., and Wagner,O. (1988). Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type? J. Neurol. 235, 143-148. doi: 10.1007/BF00314304
    • (1988) J. Neurol. , vol.235 , pp. 143-148
    • Hoyer, S.1    Oesterreich, K.2    Wagner, O.3
  • 67
    • 0017143254 scopus 로고
    • Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy
    • Huttenlocher, P. R. (1976). Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr. Res. 10, 536-540. doi: 10.1203/00006450-197605000-00006
    • (1976) Pediatr. Res. , vol.10 , pp. 536-540
    • Huttenlocher, P.R.1
  • 68
    • 0011991041 scopus 로고
    • The fatty acids of human milk from mothers on diets taken ad libitum
    • Insull, W. Jr., and Ahrens, E. H. Jr. (1959). The fatty acids of human milk from mothers on diets taken ad libitum. Biochem. J. 72, 27-33. doi: 10.1042/bj0720027
    • (1959) Biochem. J. , vol.72 , pp. 27-33
    • Insull, W.1    Ahrens, E.H.2
  • 69
    • 84922008094 scopus 로고    scopus 로고
    • Relationship between Alzheimer disease-like pattern of 18F-FDG and fasting plasma glucose levels in cognitively normal volunteers
    • Ishibashi, K., Onishi, A., Fujiwara, Y., Ishiwata, K., and Ishii, K. (2015). Relationship between Alzheimer disease-like pattern of 18F-FDG and fasting plasma glucose levels in cognitively normal volunteers. J. Nucl. Med. 56, 229-233. doi: 10.2967/jnumed.114.150045
    • (2015) J. Nucl. Med. , vol.56 , pp. 229-233
    • Ishibashi, K.1    Onishi, A.2    Fujiwara, Y.3    Ishiwata, K.4    Ishii, K.5
  • 70
    • 0019142890 scopus 로고
    • Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases
    • Iwangoff, P., Armbruster, R., Enz, A., and Meier-Ruge, W. (1980). Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases. Mech. Ageing Dev. 14, 203-209. doi: 10.1016/0047-6374(80)90120-7
    • (1980) Mech. Ageing Dev. , vol.14 , pp. 203-209
    • Iwangoff, P.1    Armbruster, R.2    Enz, A.3    Meier-Ruge, W.4
  • 71
    • 56249093471 scopus 로고    scopus 로고
    • Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
    • Kalpouzos, G., Chetelat, G., Baron, J. C., Landeau, B., Mevel, K., Godeau, C., et al. (2009). Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiol. Aging 30, 112-124. doi: 10.1016/j.neurobiolaging.2007.05.019
    • (2009) Neurobiol. Aging , vol.30 , pp. 112-124
    • Kalpouzos, G.1    Chetelat, G.2    Baron, J.C.3    Landeau, B.4    Mevel, K.5    Godeau, C.6
  • 72
    • 0034624968 scopus 로고    scopus 로고
    • D-beta-hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease
    • Kashiwaya, Y., Takeshima, T., Mori, N., Nakashima, K., Clarke, K., and Veech, R. L. (2000). D-beta-hydroxybutyrate protects neurons in models of Alzheimer’s and Parkinson’s disease. Proc. Natl. Acad. Sci. U.S.A. 97, 5440-5444. doi: 10.1073/pnas.97.10.5440
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 5440-5444
    • Kashiwaya, Y.1    Takeshima, T.2    Mori, N.3    Nakashima, K.4    Clarke, K.5    Veech, R.L.6
  • 73
    • 82755194976 scopus 로고    scopus 로고
    • Dietary ketosis enhances memory in mild cognitive impairment
    • Krikorian, R., Shidler, M. D., Dangelo, K., Couch, S. C., Benoit, S. C., and Clegg, D. J. (2012). Dietary ketosis enhances memory in mild cognitive impairment Neurobiol. Aging 33, 425.e19-425.e27. doi: 10.1016/j.neurobiolaging.2010.10.006
    • (2012) Neurobiol. Aging , vol.33 , pp. 425.e19-425.e27
    • Krikorian, R.1    Shidler, M.D.2    Dangelo, K.3    Couch, S.C.4    Benoit, S.C.5    Clegg, D.J.6
  • 74
    • 0029165323 scopus 로고
    • Brain uptake and metabolism of [1-11C]octanoate in rats: Pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism
    • Kuge, Y., Yajima, K., Kawashima, H., Yamazaki, H., Hashimoto, N., and Miyake, Y. (1995). Brain uptake and metabolism of [1-11C]octanoate in rats: Pharmacokinetic basis for its application as a radiopharmaceutical for studying brain fatty acid metabolism. Ann. Nucl. Med. 9, 137-142. doi: 10.1007/BF03165040
    • (1995) Ann. Nucl. Med. , vol.9 , pp. 137-142
    • Kuge, Y.1    Yajima, K.2    Kawashima, H.3    Yamazaki, H.4    Hashimoto, N.5    Miyake, Y.6
  • 76
    • 0022896375 scopus 로고
    • Effects of fasting on ketone body concentrations in healthy men of different ages
    • Margolin, R. A., Duara, R., Holloway, H. W., Robertson-Tchabo, E. A., Cutler, N. R., et al. (1986). Effects of fasting on ketone body concentrations in healthy men of different ages. J. Gerontol. 41, 599-604. doi: 10.1093/geronj/41.5.599
    • (1986) J. Gerontol. , vol.41 , pp. 599-604
    • Margolin, R.A.1    Duara, R.2    Holloway, H.W.3    Robertson-Tchabo, E.A.4    Cutler, N.R.5
  • 77
    • 0019521834 scopus 로고
    • Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids
    • Lying-Tunell, U., Lindblad, B. S., Malmlund, H. O., and Persson, B. (1981). Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids. Acta Neurol. Scand. 63, 337-350. doi: 10.1111/j.1600-0404.1981.tb00788.x
    • (1981) Acta Neurol. Scand. , vol.63 , pp. 337-350
    • Lying-Tunell, U.1    Lindblad, B.S.2    Malmlund, H.O.3    Persson, B.4
  • 78
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf, M., Rho, J. M., andMattson, M. P. (2009). The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res. Rev. 59, 293-315. doi: 10.1016/j.brainresrev.2008.09.002
    • (2009) Brain Res. Rev. , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 79
    • 84865613285 scopus 로고    scopus 로고
    • Sporadic Alzheimer’s disease: The starving brain
    • Mamelak, M. (2012). Sporadic Alzheimer’s disease: The starving brain. J. Alzheimers Dis. 31, 459-474. doi: 10.3233/JAD-2012-120370
    • (2012) J. Alzheimers Dis. , vol.31 , pp. 459-474
    • Mamelak, M.1
  • 80
    • 77956364857 scopus 로고    scopus 로고
    • Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama study
    • Matsuzaki, T., Sasaki, K., Tanizaki, Y., Hata, J., Fujimi, K., Matsui, Y., et al. (2010). Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama study. Neurology 75, 764-770. doi: 10.1212/WNL.0b013e3181eee25f
    • (2010) Neurology , vol.75 , pp. 764-770
    • Matsuzaki, T.1    Sasaki, K.2    Tanizaki, Y.3    Hata, J.4    Fujimi, K.5    Matsui, Y.6
  • 81
    • 0028309490 scopus 로고
    • What is primary and what secondary for amyloid deposition in Alzheimer’s disease
    • Meier-Ruge, W., Iwangoff, P., and Bertoni-Freddari, C. (1994). What is primary and what secondary for amyloid deposition in Alzheimer’s disease. Ann. N. Y. Acad. Sci. 719, 230-237. doi: 10.1111/j.1749-6632.1994.tb56831.x
    • (1994) Ann. N. Y. Acad. Sci. , vol.719 , pp. 230-237
    • Meier-Ruge, W.1    Iwangoff, P.2    Bertoni-Freddari, C.3
  • 82
    • 0030708717 scopus 로고    scopus 로고
    • Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and traumainduced dementia of the Alzheimer type
    • Meier-Ruge, W. A., and Bertoni-Freddari, C. (1997). Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and traumainduced dementia of the Alzheimer type. Ann. N. Y. Acad. Sci. 826, 229-241. doi: 10.1111/j.1749-6632.1997.tb48474.x
    • (1997) Ann. N. Y. Acad. Sci. , vol.826 , pp. 229-241
    • Meier-Ruge, W.A.1    Bertoni-Freddari, C.2
  • 84
    • 15344348978 scopus 로고    scopus 로고
    • Pyruvate carboxylase deficiency: Clinical and biochemical response to anaplerotic diet therapy
    • Mochel, F., DeLonlay, P., Touati, G., Brunengraber, H., Kinman, R. P., Rabier, D., et al. (2005). Pyruvate carboxylase deficiency: Clinical and biochemical response to anaplerotic diet therapy. Mol. Genet. Metab. 84, 305-312. doi: 10.1016/j.ymgme.2004.09.007
    • (2005) Mol. Genet. Metab. , vol.84 , pp. 305-312
    • Mochel, F.1    DeLonlay, P.2    Touati, G.3    Brunengraber, H.4    Kinman, R.P.5    Rabier, D.6
  • 85
    • 77955984220 scopus 로고    scopus 로고
    • Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington’s disease
    • Mochel, F., Duteil, S., Marelli, C., Jauffret, C., Barles, A., Holm, J., et al. (2010). Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington’s disease. Eur. J. Hum. Genet. 18, 1057-1060. doi: 10.1038/ejhg.2010.72
    • (2010) Eur. J. Hum. Genet. , vol.18 , pp. 1057-1060
    • Mochel, F.1    Duteil, S.2    Marelli, C.3    Jauffret, C.4    Barles, A.5    Holm, J.6
  • 87
    • 33947261376 scopus 로고    scopus 로고
    • Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer’s disease
    • Mosconi, L., Sorbi, S., de Leon, M. J., Li, Y., Nacmias, B., Myoung, P. S., et al. (2006). Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer’s disease. J. Nucl. Med. 47, 1778-1786.
    • (2006) J. Nucl. Med. , vol.47 , pp. 1778-1786
    • Mosconi, L.1    Sorbi, S.2    de Leon, M.J.3    Li, Y.4    Nacmias, B.5    Myoung, P.S.6
  • 88
    • 84922709891 scopus 로고    scopus 로고
    • A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer’s disease
    • Newport, M. T., VanItallie, T. B., Kashiwaya, Y., King, M. T., and Veech, R. L. (2015). A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer’s disease. Alzheimers Dement. 11, 99-103. doi: 10.1016/j.jalz.2014.01.006
    • (2015) Alzheimers Dement. , vol.11 , pp. 99-103
    • Newport, M.T.1    VanItallie, T.B.2    Kashiwaya, Y.3    King, M.T.4    Veech, R.L.5
  • 89
    • 84955416036 scopus 로고    scopus 로고
    • Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: Do cognitively-normal older adults have a particular metabolic phenotype?
    • Nugent, S., Castellano, C. A., Bocti, C., Dionne, I., Fulop, T., and Cunnane, S. C. (2016). Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: Do cognitively-normal older adults have a particular metabolic phenotype? Biogerontology 17, 241-255. doi: 10.1007/s10522-015-9595-7
    • (2016) Biogerontology , vol.17 , pp. 241-255
    • Nugent, S.1    Castellano, C.A.2    Bocti, C.3    Dionne, I.4    Fulop, T.5    Cunnane, S.C.6
  • 90
    • 84901725111 scopus 로고    scopus 로고
    • Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults
    • Nugent, S., Castellano, C. A., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., et al. (2014a). Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults Am. J. Physiol. Endocrinol. Metab. 306, E1315-E1321. doi: 10.1152/ajpendo.00067.2014
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E1315-E1321
    • Nugent, S.1    Castellano, C.A.2    Goffaux, P.3    Whittingstall, K.4    Lepage, M.5    Paquet, N.6
  • 91
    • 84903362456 scopus 로고    scopus 로고
    • Brain glucose and acetoacetate metabolism: A comparison of young and older adults
    • Nugent, S., Tremblay, S., Chen, K. W., Ayutyanont, N., Roontiva, A., Castellano, C. A., et al. (2014b). Brain glucose and acetoacetate metabolism: A comparison of young and older adults. Neurobiol. Aging 35, 1386-1395. doi: 10.1016/j.neurobiolaging.2013.11.027
    • (2014) Neurobiol. Aging , vol.35 , pp. 1386-1395
    • Nugent, S.1    Tremblay, S.2    Chen, K.W.3    Ayutyanont, N.4    Roontiva, A.5    Castellano, C.A.6
  • 92
    • 0030200659 scopus 로고    scopus 로고
    • Altered energy metabolism in Alzheimer’s disease
    • Ogawa, M., Fukuyama, H., Ouchi, Y., Yamauchi, H., and Kimura, J. (1996). Altered energy metabolism in Alzheimer’s disease. J. Neurol. Sci. 139, 78-82. doi: 10.1016/0022-510X(96)00033-0
    • (1996) J. Neurol. Sci. , vol.139 , pp. 78-82
    • Ogawa, M.1    Fukuyama, H.2    Ouchi, Y.3    Yamauchi, H.4    Kimura, J.5
  • 93
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • Owen, O. E., Kalhan, S. C., and Hanson, R. W. (2002). The key role of anaplerosis and cataplerosis for citric acid cycle function. J. Biol. Chem. 277, 30409-30412. doi: 10.1074/jbc.R200006200
    • (2002) J. Biol. Chem. , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 95
    • 0015089157 scopus 로고
    • Human forearm metabolism during progressive starvation
    • Owen, O. E., and Reichard, G. A. Jr. (1971). Human forearm metabolism during progressive starvation. J. Clin. Invest. 50, 1536-1545. doi: 10.1172/JCI106639
    • (1971) J. Clin. Invest. , vol.50 , pp. 1536-1545
    • Owen, O.E.1    Reichard, G.A.2
  • 96
    • 0015864398 scopus 로고
    • Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses
    • Owen, O. E., Reichard, G. A. Jr., Markus, H., Boden, G., Mozzoli, M. A., and Shuman, C. R. (1973). Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses. J. Clin. Invest. 52, 2606-2616. doi: 10.1172/JCI107453
    • (1973) J. Clin. Invest. , vol.52 , pp. 2606-2616
    • Owen, O.E.1    Reichard, G.A.2    Markus, H.3    Boden, G.4    Mozzoli, M.A.5    Shuman, C.R.6
  • 97
    • 65549125306 scopus 로고    scopus 로고
    • Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia
    • Page, K. A., Williamson, A., Yu, N., McNay, E. C., Dzuira, J., McCrimmon, R. J., et al. (2009). Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58, 1237-1244. doi: 10.2337/db08-1557
    • (2009) Diabetes , vol.58 , pp. 1237-1244
    • Page, K.A.1    Williamson, A.2    Yu, N.3    McNay, E.C.4    Dzuira, J.5    McCrimmon, R.J.6
  • 98
    • 0034858370 scopus 로고    scopus 로고
    • Cytokinemediated inhibition of ketogenesis is unrelated to nitric oxide or protein synthesis
    • Pailla, K., El-Mir, M. Y., Cynober, L., and Blonde-Cynober, F. (2001). Cytokinemediated inhibition of ketogenesis is unrelated to nitric oxide or protein synthesis. Clin. Nutr. 20, 313-317. doi: 10.1054/clnu.2001.0421
    • (2001) Clin. Nutr. , vol.20 , pp. 313-317
    • Pailla, K.1    El-Mir, M.Y.2    Cynober, L.3    Blonde-Cynober, F.4
  • 99
    • 0034753639 scopus 로고    scopus 로고
    • Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain
    • Pan, J. W., Telang, F. W., Lee, J. H., de Graaf, R. A., Rothman, D. L., Stein, D. T., et al. (2001). Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J. Neurochem. 79, 539-544. doi: 10.1046/j.1471-4159.2001.00575.x
    • (2001) J. Neurochem. , vol.79 , pp. 539-544
    • Pan, J.W.1    Telang, F.W.2    Lee, J.H.3    de Graaf, R.A.4    Rothman, D.L.5    Stein, D.T.6
  • 100
    • 84908007846 scopus 로고    scopus 로고
    • Triheptanoin for glucose transporter type I deficiency (G1D): Modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement
    • Pascual, J. M., Liu, P., Mao, D., Kelly, D. I., Hernandez, A., Sheng, M., et al. (2014). Triheptanoin for glucose transporter type I deficiency (G1D): Modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement. JAMA Neurol. 71, 1255-1265. doi: 10.1001/jamaneurol.2014.1584
    • (2014) JAMA Neurol. , vol.71 , pp. 1255-1265
    • Pascual, J.M.1    Liu, P.2    Mao, D.3    Kelly, D.I.4    Hernandez, A.5    Sheng, M.6
  • 101
    • 0018826694 scopus 로고
    • Coenzyme A-acetylating enzymes in Alzheimer’s disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase
    • Perry, E. K., Perry, R. H., Tomlinson, B. E., Blessed, G., and Gibson, P. H. (1980). Coenzyme A-acetylating enzymes in Alzheimer’s disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase. Neurosci. Lett. 18, 105-110. doi: 10.1016/0304-3940(80)90220-7
    • (1980) Neurosci. Lett. , vol.18 , pp. 105-110
    • Perry, E.K.1    Perry, R.H.2    Tomlinson, B.E.3    Blessed, G.4    Gibson, P.H.5
  • 102
    • 0031824258 scopus 로고    scopus 로고
    • Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping
    • Petit-Taboue, M. C., Landeau, B., Desson, J. F., Desgranges, B., and Baron, J. C. (1998). Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage 7, 176-184. doi: 10.1006/nimg.1997.0318
    • (1998) Neuroimage , vol.7 , pp. 176-184
    • Petit-Taboue, M.C.1    Landeau, B.2    Desson, J.F.3    Desgranges, B.4    Baron, J.C.5
  • 103
    • 79957963820 scopus 로고    scopus 로고
    • Mild experimental ketosis increases brain uptake of (11)Cacetoacetate and (18)F-fluorodeoxyglucose: A dual-tracer PET imaging study in rats
    • Pifferi, F., Tremblay, S., Croteau, E., Fortier, M., Tremblay-Mercier, J., Lecomte, R., et al. (2011). Mild experimental ketosis increases brain uptake of (11)Cacetoacetate and (18)F-fluorodeoxyglucose: A dual-tracer PET imaging study in rats. Nutr. Neurosci. 14, 51-58. doi: 10.1179/1476830510Y.0000000001
    • (2011) Nutr. Neurosci. , vol.14 , pp. 51-58
    • Pifferi, F.1    Tremblay, S.2    Croteau, E.3    Fortier, M.4    Tremblay-Mercier, J.5    Lecomte, R.6
  • 104
    • 0014470879 scopus 로고
    • Insulin and ketone responses to ingestion of medium and long-chain triglycerides in man
    • Pi-Sunyer, F. X., Hashim, S. A., and Van Itallie, T. B. (1969). Insulin and ketone responses to ingestion of medium and long-chain triglycerides in man. Diabetes Metab. Res. Rev. 18, 96-100.
    • (1969) Diabetes Metab. Res. Rev. , vol.18 , pp. 96-100
    • Pi-Sunyer, F.X.1    Hashim, S.A.2    Van Itallie, T.B.3
  • 105
    • 0035992255 scopus 로고    scopus 로고
    • Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: Monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy
    • Plecko, B., Stoeckler-Ipsiroglu, S., Schober, E., Harrer, G., Mlynarik, V., Gruber, S., et al. (2002). Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: Monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. Pediatr. Res. 52, 301-306. doi: 10.1203/00006450-200208000-00025
    • (2002) Pediatr. Res. , vol.52 , pp. 301-306
    • Plecko, B.1    Stoeckler-Ipsiroglu, S.2    Schober, E.3    Harrer, G.4    Mlynarik, V.5    Gruber, S.6
  • 106
    • 84901325457 scopus 로고    scopus 로고
    • The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
    • Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Muller-Fielitz, H., et al. (2014). The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat. Commun. 5: 3944. doi: 10.1038/ncomms4944
    • (2014) Nat. Commun. , vol.5 , pp. 3944
    • Rahman, M.1    Muhammad, S.2    Khan, M.A.3    Chen, H.4    Ridder, D.A.5    Muller-Fielitz, H.6
  • 107
    • 84921468542 scopus 로고    scopus 로고
    • Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial
    • Rebello, C. J., Keller, J. N., Liu, A. G., Johnson, W. D., and Greenway, F. L. (2015). Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial. BBA Clin. 3, 123-125. doi: 10.1016/j.bbacli.2015.01.001
    • (2015) BBA Clin. , vol.3 , pp. 123-125
    • Rebello, C.J.1    Keller, J.N.2    Liu, A.G.3    Johnson, W.D.4    Greenway, F.L.5
  • 108
    • 84954518314 scopus 로고    scopus 로고
    • White matter microstructure and cognitive function in young women with polycystic ovary syndrome
    • Rees, D. A., Udiawar, M., Berlot, R., Jones, D. K., and O’Sullivan, M. J. (2016). White matter microstructure and cognitive function in young women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 101, 314-323. doi: 10.1210/jc.2015-2318
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 314-323
    • Rees, D.A.1    Udiawar, M.2    Berlot, R.3    Jones, D.K.4    O’Sullivan, M.J.5
  • 109
    • 1242338801 scopus 로고    scopus 로고
    • Effects of beta-hydroxybutyrate on cognition in memory-impaired adults
    • Reger, M. A., Henderson, S. T., Hale, C., Cholerton, B., Baker, L. D., Watson, G. S., et al. (2004). Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol. Aging 25, 311-314. doi: 10.1016/S0197-4580(03)00087-3
    • (2004) Neurobiol. Aging , vol.25 , pp. 311-314
    • Reger, M.A.1    Henderson, S.T.2    Hale, C.3    Cholerton, B.4    Baker, L.D.5    Watson, G.S.6
  • 110
    • 0015965338 scopus 로고
    • Ketone-body production and oxidation in fasting obese humans
    • Reichard, G. A. Jr., Owen, O. E., Haff, A. C., Paul, P., and Bortz, W. M. (1974). Ketone-body production and oxidation in fasting obese humans. J. Clin. Invest. 53, 508-515. doi: 10.1172/JCI107584
    • (1974) J. Clin. Invest. , vol.53 , pp. 508-515
    • Reichard, G.A.1    Owen, O.E.2    Haff, A.C.3    Paul, P.4    Bortz, W.M.5
  • 111
    • 0347719366 scopus 로고    scopus 로고
    • Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia
    • Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., et al. (2004). Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc. Natl. Acad. Sci. U.S.A. 101, 284-289. doi: 10.1073/pnas.2635903100
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 284-289
    • Reiman, E.M.1    Chen, K.2    Alexander, G.E.3    Caselli, R.J.4    Bandy, D.5    Osborne, D.6
  • 112
    • 0018876377 scopus 로고
    • Physiological roles of ketone bodies as substrates and signals in mammalian tissues
    • Robinson, A. M., and Williamson, D. H. (1980). Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60, 143-187.
    • (1980) Physiol. Rev. , vol.60 , pp. 143-187
    • Robinson, A.M.1    Williamson, D.H.2
  • 113
    • 33745088995 scopus 로고    scopus 로고
    • Anaplerotic diet therapy in inherited metabolic disease: Therapeutic potential
    • Roe, C. R., and Mochel, F. (2006). Anaplerotic diet therapy in inherited metabolic disease: Therapeutic potential. J. Inherit. Metab. Dis. 29, 332-340. doi: 10.1007/s10545-006-0290-3
    • (2006) J. Inherit. Metab. Dis. , vol.29 , pp. 332-340
    • Roe, C.R.1    Mochel, F.2
  • 115
    • 84934444202 scopus 로고    scopus 로고
    • Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: An integrated study using (1)H-and (13)C-NMR spectroscopy
    • Roy, M., Beauvieux, M. C., Naulin, J., El Hamrani, D., Gallis, J. L., Cunnane, S. C., et al. (2015). Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: An integrated study using (1)H-and (13)C-NMR spectroscopy. J. Cereb. Blood Flow Metab. 35, 1154-1162. doi: 10.1038/jcbfm.2015.29
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 1154-1162
    • Roy, M.1    Beauvieux, M.C.2    Naulin, J.3    El Hamrani, D.4    Gallis, J.L.5    Cunnane, S.C.6
  • 116
    • 84869095794 scopus 로고    scopus 로고
    • The ketogenic diet increases brain glucose and ketone uptake in aged rats: A dual tracer PET and volumetric MRI study
    • Roy, M., Nugent, S., Tremblay-Mercier, J., Tremblay, S., Courchesne-Loyer, A., Beaudoin, J. F., et al. (2012). The ketogenic diet increases brain glucose and ketone uptake in aged rats: A dual tracer PET and volumetric MRI study. Brain Res. 1488, 14-23. doi: 10.1016/j.brainres.2012.10.008
    • (2012) Brain Res. , vol.1488 , pp. 14-23
    • Roy, M.1    Nugent, S.2    Tremblay-Mercier, J.3    Tremblay, S.4    Courchesne-Loyer, A.5    Beaudoin, J.F.6
  • 117
    • 0023129180 scopus 로고
    • Storage of mediumchain triglycerides in adipose tissue of orally fed infants
    • Sarda, P., Lepage, G., Roy, C. C., and Chessex, P. (1987). Storage of mediumchain triglycerides in adipose tissue of orally fed infants. Am. J. Clin. Nutr. 45, 399-405.
    • (1987) Am. J. Clin. Nutr. , vol.45 , pp. 399-405
    • Sarda, P.1    Lepage, G.2    Roy, C.C.3    Chessex, P.4
  • 118
    • 84868094595 scopus 로고    scopus 로고
    • Brain insulin signaling and Alzheimer’s disease: Current evidence and future directions
    • Schioth, H. B., Craft, S., Brooks, S. J., Frey, W. H. II, and Benedict, C. (2012). Brain insulin signaling and Alzheimer’s disease: Current evidence and future directions. Mol. Neurobiol. 46, 4-10. doi: 10.1007/s12035-011-8229-6
    • (2012) Mol. Neurobiol. , vol.46 , pp. 4-10
    • Schioth, H.B.1    Craft, S.2    Brooks, S.J.3    Frey, W.H.I.I.4    Benedict, C.5
  • 119
    • 79957877195 scopus 로고    scopus 로고
    • Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers
    • Scholl, M., Almkvist, O., Bogdanovic, N., Wall, A., Langstrom, B., Viitanen, M., et al. (2011). Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers. J. Alzheimers Dis. 24, 495-506. doi: 10.3233/JAD-2011-101563
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 495-506
    • Scholl, M.1    Almkvist, O.2    Bogdanovic, N.3    Wall, A.4    Langstrom, B.5    Viitanen, M.6
  • 120
  • 121
    • 0022973047 scopus 로고
    • Thermic effect of medium-chain and long-chain triglycerides in man
    • Seaton, T. B., Welle, S. L., Warenko, M. K., and Campbell, R. G. (1986). Thermic effect of medium-chain and long-chain triglycerides in man. Am. J. Clin. Nutr. 44, 630-634.
    • (1986) Am. J. Clin. Nutr. , vol.44 , pp. 630-634
    • Seaton, T.B.1    Welle, S.L.2    Warenko, M.K.3    Campbell, R.G.4
  • 122
    • 0017226826 scopus 로고
    • Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants
    • Settergren, G., Lindblad, B. S., and Persson, B. (1976). Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants. Acta Paediatr. Scand. 65, 343-353. doi: 10.1111/j.1651-2227.1976.tb04896.x
    • (1976) Acta Paediatr. Scand. , vol.65 , pp. 343-353
    • Settergren, G.1    Lindblad, B.S.2    Persson, B.3
  • 123
    • 34547624611 scopus 로고    scopus 로고
    • Supply and demand in cerebral energy metabolism: The role of nutrient transporters
    • Simpson, I. A., Carruthers, A., and Vannucci, S. J. (2007). Supply and demand in cerebral energy metabolism: The role of nutrient transporters. J. Cereb. Blood Flow Metab. 27, 1766-1791. doi: 10.1038/sj.jcbfm.9600521
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1766-1791
    • Simpson, I.A.1    Carruthers, A.2    Vannucci, S.J.3
  • 124
    • 0020685951 scopus 로고
    • Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
    • Sorbi, S., Bird, E. D., and Blass, J. P. (1983). Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann. Neurol. 13, 72-78. doi: 10.1002/ana.410130116
    • (1983) Ann. Neurol. , vol.13 , pp. 72-78
    • Sorbi, S.1    Bird, E.D.2    Blass, J.P.3
  • 125
    • 0036194092 scopus 로고    scopus 로고
    • Physiological effects of medium-chain triglycerides: Potential agents in the prevention of obesity
    • St-Onge, M. P., and Jones, P. J. (2002). Physiological effects of medium-chain triglycerides: Potential agents in the prevention of obesity. J. Nutr. 132, 329-332.
    • (2002) J. Nutr. , vol.132 , pp. 329-332
    • St-Onge, M.P.1    Jones, P.J.2
  • 126
    • 84903304968 scopus 로고    scopus 로고
    • The Alzheimer’s disease mitochondrial cascade hypothesis: Progress and perspectives
    • Swerdlow, R. H., Burns, J. M., and Khan, S. M. (2014). The Alzheimer’s disease mitochondrial cascade hypothesis: Progress and perspectives. Biochim. Biophys. Acta 1842, 1219-1231. doi: 10.1016/j.bbadis.2013.09.010
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 1219-1231
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 127
    • 3042806534 scopus 로고    scopus 로고
    • A "mitochondrial cascade hypothesis" for sporadic Alzheimer’s disease
    • Swerdlow, R. H., and Khan, S. M. (2004). A "mitochondrial cascade hypothesis" for sporadic Alzheimer’s disease. Med. Hypotheses 63, 8-20. doi: 10.1016/j.mehy.2003.12.045
    • (2004) Med. Hypotheses , vol.63 , pp. 8-20
    • Swerdlow, R.H.1    Khan, S.M.2
  • 128
    • 0033983014 scopus 로고    scopus 로고
    • Review of the toxicologic properties of medium-chain triglycerides
    • Traul, K. A., Driedger, A., Ingle, D. L., and Nakhasi, D. (2000). Review of the toxicologic properties of medium-chain triglycerides. Food Chem. Toxicol. 38, 79-98. doi: 10.1016/S0278-6915(99)00106-4
    • (2000) Food Chem. Toxicol. , vol.38 , pp. 79-98
    • Traul, K.A.1    Driedger, A.2    Ingle, D.L.3    Nakhasi, D.4
  • 129
    • 34547583836 scopus 로고    scopus 로고
    • Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose
    • Tremblay, S., Ouellet, R., Rodrigue, S., Langlois, R., Benard, F., and Cunnane, S. C. (2007). Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose. Appl. Radiat. Isot. 65, 934-940. doi: 10.1016/j.apradiso.2007.03.015
    • (2007) Appl. Radiat. Isot. , vol.65 , pp. 934-940
    • Tremblay, S.1    Ouellet, R.2    Rodrigue, S.3    Langlois, R.4    Benard, F.5    Cunnane, S.C.6
  • 130
    • 77953730768 scopus 로고    scopus 로고
    • Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects
    • Tremblay-Mercier, J., Tessier, D., Plourde, M., Fortier, M., Lorrain, D., and Cunnane, S. C. (2010). Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. J. Pharmacol. Exp. Ther. 334, 341-346. doi: 10.1124/jpet.110.166504
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 341-346
    • Tremblay-Mercier, J.1    Tessier, D.2    Plourde, M.3    Fortier, M.4    Lorrain, D.5    Cunnane, S.C.6
  • 131
    • 0034844219 scopus 로고    scopus 로고
    • Ketone bodies, potential therapeutic uses
    • Veech, R. L., Chance, B., Kashiwaya, Y., Lardy, H. A., and Cahill, G. F. Jr. (2001). Ketone bodies, potential therapeutic uses. IUBMB Life 51, 241-247. doi: 10.1080/152165401753311780
    • (2001) IUBMB Life , vol.51 , pp. 241-247
    • Veech, R.L.1    Chance, B.2    Kashiwaya, Y.3    Lardy, H.A.4    Cahill, G.F.5
  • 132
    • 28044458281 scopus 로고    scopus 로고
    • Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer’s disease pathogenesis
    • Velliquette, R. A., O’Connor, T., and Vassar, R. (2005). Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer’s disease pathogenesis. J. Neurosci. 25, 10874-10883. doi: 10.1523/JNEUROSCI.2350-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 10874-10883
    • Velliquette, R.A.1    O’Connor, T.2    Vassar, R.3
  • 133
    • 0028566199 scopus 로고
    • Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans
    • Veneman, T., Mitrakou, A., Mokan, M., Cryer, P., and Gerich, J. (1994). Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes Metab. Res. Rev. 43, 1311-1317.
    • (1994) Diabetes Metab. Res. Rev. , vol.43 , pp. 1311-1317
    • Veneman, T.1    Mitrakou, A.2    Mokan, M.3    Cryer, P.4    Gerich, J.5
  • 134
    • 84938099390 scopus 로고    scopus 로고
    • Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure
    • Viggiano, A., Pilla, R., Arnold, P., Monda, M., D’Agostino, D., and Coppola, G. (2015). Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. Brain Res. 1618, 50-54. doi: 10.1016/j.brainres.2015.05.023
    • (2015) Brain Res. , vol.1618 , pp. 50-54
    • Viggiano, A.1    Pilla, R.2    Arnold, P.3    Monda, M.4    D’Agostino, D.5    Coppola, G.6
  • 135
    • 84883759456 scopus 로고    scopus 로고
    • Seizures and epileptiform activity in the early stages of Alzheimer disease
    • Vossel, K. A., Beagle, A. J., Rabinovici, G. D., Shu, H., Lee, S. E., Naasan, G., et al. (2013). Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 70, 1158-1166. doi: 10.1001/jamaneurol.2013.136
    • (2013) JAMA Neurol. , vol.70 , pp. 1158-1166
    • Vossel, K.A.1    Beagle, A.J.2    Rabinovici, G.D.3    Shu, H.4    Lee, S.E.5    Naasan, G.6
  • 136
    • 84960158846 scopus 로고    scopus 로고
    • Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure
    • Wilkins, H. M., Koppel, S., Carl, S. M., Ramanujan, S., Weidling, I., Michaelis, M. L., et al. (2016). Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure. J. Neurochem. 137, 76-87. doi: 10.1111/jnc.13545
    • (2016) J. Neurochem. , vol.137 , pp. 76-87
    • Wilkins, H.M.1    Koppel, S.2    Carl, S.M.3    Ramanujan, S.4    Weidling, I.5    Michaelis, M.L.6
  • 137
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer’s pathology in female mouse model of Alzheimer’s disease
    • Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., and Brinton, R. D. (2009). Mitochondrial bioenergetic deficit precedes Alzheimer’s pathology in female mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U.S.A. 106, 14670-14675. doi: 10.1073/pnas.0903563106
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 138
    • 84959499873 scopus 로고    scopus 로고
    • Ketones block amyloid entry and improve cognition in an Alzheimer’s model
    • Yin, J. X., Maalouf, M., Han, P., Zhao, M., Gao, M., Dharshaun, T., et al. (2016). Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiol. Aging 39, 25-37. doi: 10.1016/j.neurobiolaging.2015.11.018
    • (2016) Neurobiol. Aging , vol.39 , pp. 25-37
    • Yin, J.X.1    Maalouf, M.2    Han, P.3    Zhao, M.4    Gao, M.5    Dharshaun, T.6
  • 139
    • 84875235160 scopus 로고    scopus 로고
    • Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer’s disease
    • Zilberter, M., Ivanov, A., Ziyatdinova, S., Mukhtarov, M., Malkov, A., Alpar, A., et al. (2013). Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer’s disease. J. Neurochem. 125, 157-171. doi: 10.1111/jnc.12127
    • (2013) J. Neurochem. , vol.125 , pp. 157-171
    • Zilberter, M.1    Ivanov, A.2    Ziyatdinova, S.3    Mukhtarov, M.4    Malkov, A.5    Alpar, A.6
  • 140
    • 0037213433 scopus 로고    scopus 로고
    • Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging
    • Zuendorf, G., Kerrouche, N., Herholz, K., and Baron, J. C. (2003). Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging. Hum. Brain Mapp. 18, 13-21. doi: 10.1002/hbm.10069
    • (2003) Hum. Brain Mapp. , vol.18 , pp. 13-21
    • Zuendorf, G.1    Kerrouche, N.2    Herholz, K.3    Baron, J.C.4


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