Cytokine-mediated inhibition of ketogenesis is unrelated to nitric oxide or protein synthesis

Clinical Nutrition

Volumn 20, Issue 4, 2001, Pages 313-317

  Pailla, K ^a   El Mir, M Y ^b   Cynober, L ^c   Blonde Cynober, F ^d  

^a Hôpitaux Universitaires Henri Mondor   (France)

^b laboratoire de bioénergétique fondamentale et appliquée   (France)

^c HÔTEL DIEU   (France)

^d DUPUYTREN UNIVERSITY HOSPITAL   (France)

Author keywords

Cytokines; Free fatty acids; Hepatocytes; Ketogenesis; Rats; ketoisocaproate

Indexed keywords

2 OXOISOCAPROIC ACID; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; CYCLOHEXIMIDE; CYTOKINE; FATTY ACID; INTERLEUKIN 6; KETONE BODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OLEIC ACID; OXOACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; INCUBATION TIME; KETOGENESIS; LIPID METABOLISM; LIVER CELL CULTURE; MALE; METABOLIC REGULATION; MONOLAYER CULTURE; NONHUMAN; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; SEPSIS;

EID: 0034858370     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1054/clnu.2001.0421     Document Type: Article

References (39)

1. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
2. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6
3. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat: A synergistic effect with interleukin-1
4. Interaction between corticosterone and tumor necrosis factor stimulated protein breakdown in rat skeletal muscle, similar to sepsis
5. Branched-chain amino acid metabolism
6. Metabolic interaction between skeletal muscle and liver during bacteremia
7. Plasma branched-chain keto acids in burn patients
8. Lipopolysaccharide (LPS) increases the in vivo oxidation of branched-chain amino acids in the rat: A cytokine-mediated effect
9. Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain α-keto acid dehydrogenase
10. Leucine metabolism in TNF-alpha-and endotoxin-treated rats: Contribution of hepatic tissue
11. Leucine metabolism in fasted and tumor necrosis factor-treated rats
12. TNFα and IL-6 synergistically inhibit ketogenesis from fatty acids and α-ketoisocaproate in isolated rat hepatocytes
13. Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo
14. Tumor necrosis factor-increased hepatic very low density lipoprotein production and increased serum triglyceride levels in diabetic rats
15. Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo
16. The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis
17. Effect of different sepsis-related cytokines on lipid synthesis by isolated hepatocytes
18. Serum lipids in infection
19. Role of the liver in regulation of ketone body production during sepsis
20. Regulation of ketone body flux in septic patients
21. Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: Synergy among TNF, IL-6, and IL-1
22. Inhibition of hepatic ketogenesis by tumor necrosis factor-α in rats
23. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes
24. Nitric oxide donor NOR 3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism
25. Inhibition of hepatic gluconeogenesis by nitric oxide: A comparison with endotoxic shock
26. 15N] nitrate in biological fluids
27. The effects of recombinant tumor necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations
28. Search for mediators of the lipogenic effects of tumor necrosis factor: Potential role for interleukin 6
29. Mechanisms by which tumor necrosis factor stimulates hepatic fatty acid synthesis in vivo
30. Multiple cytokines stimulate hepatic lipid synthesis in vivo
31. Effects of tumor necrosis factor-α on glucose and albumin production in primary cultures of rat hepatocytes
32. Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes
33. Effect of multiple cytokines plus endotoxin on glucose and nitric oxide production by cultured hepatocytes
34. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non amino-acid isothioureas
35. International union of pharmacology nomenclature in nitric oxide research
36. Tumour necrosis factor α and interleukin 1 signalling: Do MAPKK kinases connect it all?
37. IL-6 cytokine family and signal transduction: A model of the cytokines system
38. In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines
39. Regulation of fatty acid utilization in isolated perfused livers from Streptococcus pneumoniae infected rats