Ketones block amyloid entry and improve cognition in an Alzheimer's model

Neurobiology of Aging

Volumn 39, Issue , 2016, Pages 25-37

  Yin, Jun Xiang ^a   Maalouf, Marwan ^a   Han, Pengcheng ^a   Zhao, Minglei ^b   Gao, Ming ^a   Dharshaun, Turner ^a   Ryan, Christopher ^c   Whitelegge, Julian ^c   Wu, Jie ^a   Eisenberg, David ^b   Reiman, Eric M ^d   Schweizer, Felix E ^b   Shi, Jiong ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BANNER ALZHEIMER S INSTITUTE   (United States)

Author keywords

Acetoacetate; Alzheimer's disease; Ketones; Mitochondria; hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; AMYLOID BETA PROTEIN[1-42]; KETONE BODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ACETOACETIC ACID DERIVATIVE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; ENZYME ACTIVITY; LEARNING; MEMORY; MOUSE; MOUSE MODEL; NERVE CELL PLASTICITY; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TRANSPORT; ANIMAL; CHEMICAL PHENOMENA; CHEMICAL STIMULATION; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; PSYCHOLOGY; TRANSGENIC MOUSE;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION; DEPRESSION, CHEMICAL; DISEASE MODELS, ANIMAL; KETONE BODIES; LEARNING; MEMORY; MICE, TRANSGENIC; NADH DEHYDROGENASE; NEURONAL PLASTICITY; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; STIMULATION, CHEMICAL;

EID: 84959499873     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.11.018     Document Type: Article

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