The metabolic topography of normal aging

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 3, 1996, Pages 385-398

  Moeller, J R ^a   Ishikawa, T ^b   Dhawan, V ^b   Spetsieris, P ^b   Mandel, F ^c   Alexander, G E ^d   Grady, C ^d   Pietrini, P ^d   Eidelberg, D ^a,c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging, normal; FDG; Metabolic topography; PET; Scaled Subprofile Model

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE;

ADULT; AGED; AGING; ARTICLE; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC RATE; NORMAL HUMAN; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STATISTICAL MODEL; TOPOGRAPHY;

EID: 0029865102     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199605000-00005     Document Type: Article

References (57)

1. Agid Y, Blin J, Bonnet AM, et al. (1989) Does aging contribute to aggravation of Parkinson's disease? In: Parkinsonism and Aging (Calne DB, ed), New York, Raven Press, pp 115-123
2. Alexander GE, Moeller JR (1994) Application of the scaled subprofile model to functional imaging in neuropsychiatrie disorders: A principal component approach to modeling brain function in disease. Hum Brain Mapping 2:1-6
3. Barrett G, Neshige R, Shibasaki H (1985) Cortical potentials preceding voluntary self paced movement in young, old and parkinsonian subjects. J Physiol (Lond) 372:48P
4. Bartus RT, Dean RL III, Beer B, Lippa AS (1982) The cholin- ergic hypothesis of geriatric memory dysfunction. Science 217:408-417
5. Calne DB, Peppard RF (1987) Aging of the nigrostriatal pathway in humans. Can J Neurol Sci 14:424-427
6. Corso JF (1975) Sensory processes in man during motility and senescence. In: Neurobiology of Aging (Ordy JM, Brizzee KR, eds), pp 119-143
7. Creasey H, Rapoport SI (1985) The aging human brain. Ann Neurol 17:2-10
8. Crossman AR, Mitchell IJ, Sambrook MA (1985) Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. Neuropharmacology 24:587-591
9. Daube-Witherspoon ME, Green MV, Holte S (1987) Performance of Scanditronix PC1024-7B PET scanner. J Nucl Med 28:607-608
10. deLeon MJ, George AE, Ferria SH, et al. (1984) Positron emission tomography and computed tomography assessments of the aging human brain. J Comput Assist Tomogr 9:88-94
11. 11CDG. Neurobiol Aging 8:319-323
12. Duara R, Margolin RA, Robertson-Tchabo EA, et al. (1983) Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain 106:761-775
13. Eidelberg D, Galaburda A (1984) Inferior parietal lobe: divergent architectonic asymmetries in the human brain. Arch Neurol 4:843-852
14. 18F-fluorodopa positron emission tomographic studies. Mov Disord 5:203-213
15. Eidelberg D, Moeller JR, Dhawan V, et al. (1994) The metabolic topography of parkinsonism. J Cereb Blood Flow Metab 14: 783-801
16. 18F-fluorodeoxyglucose and positron emission tomography. J Nucl Med 36:378-383
17. Evarts EV, Teravainen H, Calne DB (1981) Reaction time in Parkinson's disease. Brain 104:167-186
18. Fearnley JM, Lees AJ (1991) Aging and Parkinson's disease: substantia nigra regional selectivity. Brain 114:2283-2301
19. Flury B (1988) Common Principal Components and Related Multivariate Models. New York: John Wiley & Sons, pp 51-66
20. Grady CL, Horwitz B, Schapiro MB, Rapoport SI (1990) Changes in the integrated activity of the brain with healthy aging and dementia of the Alzheimer type. In: Aging Brain and Dementia: New Trends in Diagnosis and Therapy (Rapoport SI, Petit H, Leys D, Christen Y, eds), pp 355-369
21. Grady C (1991) Quantitative comparison of measurements of cerebral glucose rate made with two positron cameras. J Cereb Blood Flow Metab 11:A57-A63
22. Hochanadel G, Kaplan E. (1984) Neuropsychology of normal aging. In: Clinical Neurology of Aging (Albert ML, ed), Oxford University Press, New York, pp 231-244
23. Horwitz B, Duara R, Rapoport SI (1986) Age differences in intercorrelations between regional cerebral metabolic rates for glucose. Ann Neurol 19:60-67
24. Horwitz B, Grady CL, Schlageter NL, et al. (1987) Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease. Brain Res 407:294-306
25. Kemper T (1984) Neuroanatomical and neuropathological changes in normal aging and in dementia. In: Clinical Neurology of Aging (Albert ML, ed), Oxford University Press, New York, pp 9-52
26. Kornhuber HH, Deecke L (1978) An electrical sign of participation of the mesial supplementary motor cortex in human voluntary finger movement. Brain Res 159:473-476
27. Kuhl DE, Metter JE, Riege WH, Hawkins RA (1984) The effect of normal aging on patterns of local cerebral glucose utilization. Ann Neurol 15 (suppl):S133-S137
28. Kumar A, Schapiro MB, Grady C, et al. (1991) High-resolution PET studies in Alzheimer's disease. Neuropsychopharmacology 4:35-46
29. Leenders KL, Perani D, Lammertsma AA, et al. (1990) Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age. Brain 113:27-47
30. Marchal G, Rioux P, Petit-Taboue MC, et al. (1992) Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. Arch Neurol 49:1013-1020
31. Martin AJ, Friston KJ, Colebatch JG, Frackowiak RSJ (1991) Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab 11:684-689
32. Martin WRW, Palmer MR, Patlak CS, Calne DB (1989) Nigrostriatal function in humans studied with positron emission tomography. Ann Neurol 26:535-542
33. Matsuda H, Maeda T, Yamada M, et al. (1984) Age-matched normal values and topographic maps for regional cerebral blood flow measurements by Xe-133 inhalation. Stroke 15: 336-342
34. McFarland RA, Warren B, Kavis C (1958) Alterations in critical flicker frequency as a function of age and light: dark ratio. J Exp Psychol 56:529-538
35. McGeer PL, McGeer EG, Suzuki JS (1977) Aging and extrapyramidal function. Arch Neurol 34:33-36
36. McGeer PL, Itagaski S, Akiyama H, McGeer EG (1989) Comparison of neuronal loss in Parkinson's disease and aging. In: Parkinsonism and Aging (Calne DB, et al., eds), New York, Raven Press, pp 25-34
37. Mesulam M (1981) A cortical network for directed attention and unilateral neglect. Ann Neurol 10:309-325
38. Metter EJ, Riege WH, Kuhl DE, Phelps ME (1984) Cerebral metabolic relationships for selected brain regions in healthy adults. J Cereb Blood Flow Metab 4:1-7
39. Moeller JR, Strother SC, Sidtis JJ, et al. (1987) The scaled subprofile model: a statistical approach to the analysis of functional patterns in positron emission tomographic data. J Cereb Blood Flow Metab 7:649-658
40. Moeller JR, Strother SC (1991) A regional covariance approach to the analysis of functional patterns in positron emission tomographic data. J Cereb Blood Flow Metab 11:A121-A135
41. Mortimer JA, Webster DD (1982) Comparison of extrapyramidal motor function in normal aging and Parkinson's disease. In: The Aging Motor System (Mortimer JA, Pirozzolo FJ, Maletta GJ, eds) Praeger, New York, pp 217-241
42. Murphy DGM, DeCarli C, Schapiro MB, et al. (1992) Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neural 49:839-845
43. Palombo E, Porrino LJ, Bankiewicz KS, et al. (1990) Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP. J Neurosci 10:860-869
44. Posner MI, Petersen SE (1990) The attention system of the human brain. Annu Rev Neurosci 13:25-32
45. Robeson W, Dhawan V, Takikawa S, et al. (1993) SuperPETT 3000 time-of-flight PET tomograph: optimization of factors affecting quantitation. IEEE/Trans Nucl Sci 40:135-142
46. Sackeim HA, Prohovnik I, Moeller JR, et al. (1990) Regional cerebral blood flow in mood disorders: I. Comparison of major depressives and normal controls at rest. Arch Gen Psychiatry 47:60-70
47. Sackeim HA, Prohovnik I. Moeller JR, et al. (1993) Regional cerebral blood flow in mood disorders. 11. Comparison of major depression and Alzheimer's disease. J Nucl Med 34:1,090-1,101
48. Scherman D, Desnos C, Darchen F, et al. (1989) Striatal dopamine deficiency in Parkinson's disease: role of aging. Ann Neurol 26:551-557
49. Schlageter NL, Horwitz B, Creasey H, et al. (1987) Relation of measured brain glucose utilization and cerebral atrophy in man. J Neurol Neurosurg Psychiatry 50:779-785
50. Simpson JA, Khuraibet AJ (1987) Readiness potential of cortical area 6 preceding self paced movements in Parkinson's disease. J Neurol Neurosurg Psychiatry 50:1,184-1,191
51. Spetsieris P, Dhawan V, Takikawa S, et al. (1993) Imaging cerebral function. lEEE/Comput Graphics 13:15-26
52. Teravainen H, Calne DB (1983) Motor system in normal aging and Parkinson's disease. In: The Neurology of Aging (Katzman R, Terry R, eds), Philadelphia, FA Davis, pp 85-109
53. Tomlinson BE, Blessed G, Roth M (1968) Observations on the brains of nondemented old people. J Neurol Sci 7:331-356
54. Videen TO, Perlmutter JS, Mintun MA, Raichle ME (1988) Regional correction of positron emission tomography data for the effects of cerebral atrophy. J Cereb Blood Flow Metab 8:662-670
55. Welford AT (1977) Motor performance. In: Handbook of the Psychology of Aging (Birren JE, Schaie KW, eds), pp 450-496
56. Wolters EC, Calne DB (1989) Is Parkinson's disease related to aging? In: Parkinsonism and Aging (Calne DB, et al., eds), New York, Raven Press, pp 125-132
57. Yoshii F, Barker WW, Chang JY, et al. (1988) Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy, and cerebrovascular risk factors. J Cereb Blood Flow Metab 8:654-661