The wrong white crystals: Not salt but sugar as aetiological in hypertension and cardiometabolic disease

Open Heart

Volumn 1, Issue 1, 2014, Pages

  DiNicolantonio, James J ^a   Lucan, Sean C ^b  

^a SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; SUCROSE; SWEETENING AGENT;

CALORIC INTAKE; CARBONATED BEVERAGE; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; FOOD INTAKE; FOOD PROCESSING; HUMAN; HYPERTENSION; INSULIN RESISTANCE; METABOLIC DISORDER; NUTRITIONAL VALUE; PATHOPHYSIOLOGY; POPULATION RESEARCH; PRACTICE GUIDELINE; REVIEW; RISK FACTOR; SODIUM INTAKE; SUGAR INTAKE;

EID: 84984598060     PISSN: None     EISSN: 20533624     Source Type: Journal    
DOI: 10.1136/openhrt-2014-000167     Document Type: Review

References (99)

1. Mokdad AH, Marks JS, Stroup DF, et al. Correction: actual causes of death in the United States, 2000. JAMA 2005;293:293-4.
2. Michaud CM, Murray CJ, Bloom BR. Burden of disease - implications for future research. JAMA 2001;285:535-9.
3. Minino AM. Death in the United States, 2009. NCHS Data Brief 2011:1-8.
4. Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224-60.
5. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 2012;125:e2-220.
6. Heidenreich PA, Trogdon JG, Khavjou OA, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 2011;123:933-44.
7. DiNicolantonio JJ, Niazi AK, Lavie CJ, et al. Problems with the American Heart Association Presidential Advisory advocating sodium restriction. Am J Hypertens 2013;26:1201-4.
8. DiNicolantonio JJ, Niazi AK, Sadaf R, et al. Dietary sodium restriction: take it with a grain of salt. Am J Med 2013;126:951-5.
9. DiNicolantonio JJ, O'Keefe JH, Lucan SC. Population-wide sodium reduction: reasons to resist. Mayo Clin Proc 2014;89:426-7.
10. Graudal NA, Galloe AM, Garred P. Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride: a meta-analysis. JAMA 1998;279:1383-91.
11. Ekinci EI, Clarke S, Thomas MC, et al. Dietary salt intake and mortality in patients with type 2 diabetes. Diabetes Care 2011;34:703-9.
12. Paterna S, Fasullo S, Parrinello G, et al. Short-term effects of hypertonic saline solution in acute heart failure and long-term effects of a moderate sodium restriction in patients with compensated heart failure with New York Heart Association class III (Class C) (SMAC-HF Study). Am J Med Sci 2011;342:27-37.
13. Paterna S, Di Pasquale P, Parrinello G, et al. Changes in brain natriuretic peptide levels and bioelectrical impedance measurements after treatment with high-dose furosemide and hypertonic saline solution versus high-dose furosemide alone in refractory congestive heart failure: a double-blind study. J Am Coll Cardiol 2005;45:1997-2003.
14. Licata G, Di Pasquale P, Parrinello G, et al. Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: long-term effects. Am Heart J 2003;145:459-66.
15. Paterna S, Gaspare P, Fasullo S, et al. Normal-sodium diet compared with low-sodium diet in compensated congestive heart failure: is sodium an old enemy or a new friend? Clin Sci (Lond) 2008;114:221-30.
16. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med 2014;371:612-23.
17. O'Donnell MJ, Yusuf S, Mente A, et al. Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA 2011;306:2229-38.
18. Centers for Disease Control and Prevention (CDC). Vital signs: food categories contributing the most to sodium consumption - United States, 2007-2008. MMWR Morb Mortal Wkly Rep 2012;61:92-8.
19. Jalonick M. USA Today 17, June 2014. http://www.usatoday.com/story/news/nation/2014/06/17/fda-reducing-salt/10686357/
20. Mente A, O'Donnell MJ, Yusuf S. The population risks of dietary salt excess are exaggerated. Can J Cardiol 2014;30:507-12.
21. McCarron DA, Geerling JC, Kazaks AG, et al. Can dietary sodium intake be modified by public policy? Clin J Am Soc Nephrol 2009;4:1878-82.
22. Bernstein AM, Willett WC. Trends in 24-h urinary sodium excretion in the United States, 1957-2003: a systematic review. Am J Clin Nutr 2010;92:1172-80.
23. DiNicolantonio JJ, Lucan SC, O'Keefe JH. An unsavory truth: sugar, more than salt, predisposes to hypertension and chronic disease. Am J Cardiol 2014;114:1126-8:In press.
24. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004;79:537-43.
25. Young JB, Landsberg L. Stimulation of the sympathetic nervous system during sucrose feeding. Nature 1977;269:615-17.
26. Bunag RD, Tomita T, Sasaki S. Chronic sucrose ingestion induces mild hypertension and tachycardia in rats. Hypertension 1983;5:218-25.
27. Facchini FS, Stoohs RA, Reaven GM. Enhanced sympathetic nervous system activity. The linchpin between insulin resistance, hyperinsulinemia, and heart rate. Am J Hypertens 1996;9:1013-17.
28. Hwang IS, Ho H, Hoffman BB, et al. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987;10:512-16.
29. Preuss HG, Fournier RD. Effects of sucrose ingestion on blood pressure. Life Sci 1982;30:879-86.
30. Young JB, Landsberg L. Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat. Metabolism 1981;30:421-4.
31. Preuss MB, Preuss HG. The effects of sucrose and sodium on blood pressures in various substrains of Wistar rats. Lab Invest 1980;43:101-7.
32. Vasdev S, Prabhakaran VM, Whelan M, et al. Fructose-induced hypertension, hypertriglyceridemia and elevated cytosolic calcium in rats: prevention by deuterium oxide. Artery 1994;21:124-47.
33. Bhanot S, McNeill JH, Bryer-Ash M. Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats. Hypertension 1994;23:308-12.
34. Farah V, Elased KM, Chen Y, et al. Nocturnal hypertension in mice consuming a high fructose diet. Auton Neurosci 2006;130:41-50.
35. Sanchez-Lozada LG, Tapia E, Bautista-Garcia P, et al. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2008;294:F710-18.
36. Jalal DI, Smits G, Johnson RJ, et al. Increased fructose associates with elevated blood pressure. J Am Soc Nephrol 2010;21:1543-9.
37. Nguyen S, Choi HK, Lustig RH, et al. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009;154:807-13.
38. Kell KP, Cardel MI, Bohan Brown MM, et al. Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children. Am J Clin Nutr 2014;100:46-52.
39. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996;334:374-81.
40. Szanto S, Yudkin J. Dietary sucrose and the behaviour of blood platelets. Proc Nutr Soc 1970;29:Suppl:3A.
41. Reiser S, Bohn E, Hallfrisch J, et al. Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am J Clin Nutr 1981;34:2348-58.
42. Szanto S, Yudkin J. Insulin and atheroma. Lancet 1969;1:1211-12.
43. Daly ME, Vale C, Walker M, et al. Dietary carbohydrates and insulin sensitivity: a review of the evidence and clinical implications. Am J Clin Nutr 1997;66:1072-85.
44. Reaven GM. Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology and clinical course of hypertension. Am J Med 1991;90:7s-12s.
45. Reiser S, Handler HB, Gardner LB, et al. Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blood insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load. Am J Clin Nutr 1979;32:2206-16.
46. Hallfrisch J, Ellwood KC, Michaelis OE 4th, et al. Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr 1983;113:1819-26.
47. Bruckdorfer KR, Kang SS, Yudkin J. Insulin sensitivity of adipose tissue of rats fed with various carbohydrates. Proc Nutr Soc 1974;33:4a-5a.
48. Landsberg L. Insulin and the sympathetic nervous system in the pathophysiology of hypertension. Blood Press Suppl 1996;1:25-9.
49. Landsberg L. Pathophysiology of obesity-related hypertension: role of insulin and the sympathetic nervous system. J Cardiovasc Pharmacol 1994;23(Suppl 1):S1-8.
50. Canale MP, Manca di Villahermosa S, Martino G, et al. Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity. Int J Endocrinol 2013;2013:865965.
51. Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N Engl J Med 1987;317:350-7.
52. Shen DC, Shieh SM, Fuh MM, et al. Resistance to insulin-stimulated-glucose uptake in patients with hypertension. J Clin Endocrinol Metab 1988;66:580-3.
53. Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009;119:1322-34.
54. Vasdev S, Stuckless J. Role of methylglyoxal in essential hypertension. Int J Angiol 2010;19:e58-65.
55. Pell S, D'Alonzo CA. Some aspects of hypertension in diabetes mellitus. JAMA 1967;202:104-10.
56. Christlieb AR. Diabetes and hypertensive vascular disease. Mechanisms and treatment. Am J Cardiol 1973;32:592-606.
57. Zavaroni I, Mazza S, Dall'Aglio E, et al. Prevalence of hyperinsulinaemia in patients with high blood pressure. J Intern Med 1992;231:235-40.
58. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990;39:167-74.
59. Cohen AM, Teitelbaum A, Balogh M, et al. Effect of interchanging bread and sucrose as main source of carbohydrate in a low fat diet on the glucose tolerance curve of healthy volunteer subjects. Am J Clin Nutr 1966;19:59-62.
60. Yudkin J. Sugar and disease. Nature 1972;239:197-9.
61. Basu S, Yoffe P, Hills N, et al. The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS ONE 2013;8:e57873.
62. Yang Q, Zhang Z, Gregg EW, et al. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med 2014;174:516-24.
63. Marriott BP, Olsho L, Hadden L, et al. Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003-2006. Crit Rev Food Sci Nutr 2010;50:228-58.
64. Brown IJ, Stamler J, Van Horn L, et al. Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure. Hypertension 2011;57:695-701.
65. Malik AH, Akram Y, Shetty S, et al. Impact of sugar-sweetened beverages on blood pressure. Am J Cardiol 2014;113:1574-80.
66. Walker RW, Dumke KA, Goran MI. Fructose content in popular beverages made with and without high fructose corn syrup. Nutrition 2014;30:928-35.
67. Ventura EE, Davis JN, Goran MI. Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content. Obesity (Silver Spring, Md) 2011;19:868-74.
68. Malik VS, Popkin BM, Bray GA, et al. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 2010;33:2477-83.
69. Schulze MB, Manson JE, Ludwig DS, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA 2004;292:927-34.
70. Fung TT, Malik V, Rexrode KM, et al. Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr 2009;89:1037-42.
71. Larsson SC, Akesson A, Wolk A. Sweetened beverage consumption is associated with increased risk of stroke in women and men. J Nutr 2014;144:856-60.
72. Choi HK, Willett W, Curhan G. Fructose-rich beverages and risk of gout in women. JAMA 2010;304:2270-8.
73. Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 2006;84:274-88.
74. Ferraro PM, Taylor EN, Gambaro G, et al. Soda and other beverages and the risk of kidney stones. Clin J Am Soc Nephrol 2013;8:1389-95.
75. Singh GM, Micha R, Katibzadeh S, et al. Mortality due to sugar sweetened beverage consumption: a global, regional, and national comparative risk assessment. Circulation 2013;127:AMP22.
76. Israel KD, Michaelis OE 4th, Reiser S, et al. Serum uric acid, inorganic phosphorus, and glutamic-oxalacetic transaminase and blood pressure in carbohydrate-sensitive adults consuming three different levels of sucrose. Ann Nutr Metab 1983;27:425-35.
77. Te Morenga LA, Howatson AJ, Jones RM, et al. Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Am J Clin Nutr 2014;100:65-79.
78. Raben A, Vasilaras TH, Moller AC, et al. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 2002;76:721-9.
79. Rebello T, Hodges RE, Smith JL. Short-term effects of various sugars on antinatriuresis and blood pressure changes in normotensive young men. Am J Clin Nutr 1983;38:84-94.
80. Rumessen JJ, Gudmand-Hoyer E. Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut 1986;27:1161-8.
81. Le MT, Frye RF, Rivard CJ, et al. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism 2012;61:641-51.
82. Brown CM, Dulloo AG, Yepuri G, et al. Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol 2008;294:R730-7.
83. Hata J, Arima H, Rothwell PM, et al. Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial. Circulation 2013;128:1325-34.
84. Webb AJ, Rothwell PM. Physiological correlates of beat-to-beat, ambulatory, and day-to-day home blood pressure variability after transient ischemic attack or minor stroke. Stroke 2014;45:533-8.
85. Parati G, Pomidossi G, Albini F, et al. Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension. J Hypertens 1987;5:93-8.
86. Perez-Pozo SE, Schold J, Nakagawa T, et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond) 2010;34:454-61.
87. Brymora A, Flisinski M, Johnson RJ, et al. Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease. Nephrol Dial Transplant 2012;27:608-12.
88. Meyer BJ, de Bruin EJ, Du Plessis DG, et al. Some biochemical effects of a mainly fruit diet in man. S Afr Med J 1971;45:253-61.
89. Madero M, Arriaga JC, Jalal D, et al. The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial. Metabolism 2011;60:1551-9.
90. Yudkin J. Pure, white and deadly. Penguin Books, 2012.
91. Strom S. U.S. Cuts Estimate of Sugar Intake. The New York Times 26 October 2012.
92. Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: more than just Syndrome X. Comp Biochem Physiol A Mol Integr Physiol 2003;136:95-112.
93. http://www.sugarstacks.com (accessed 27 Aug 2014).
94. Westman EC. Is dietary carbohydrate essential for human nutrition? Am J Clin Nutr 2002;75:951-3; author reply 3-4.
95. Johnson RK, Appel LJ, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 2009;120:1011-20.
96. Malnik E. World Health Organisation advises halving sugar intake. The Telegraph March 2014.
97. Trumbo P, Schlicker S, Yates AA, et al. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc 2002;102:1621-30.
98. Eckel RH, Jakicic JM, Ard JD, et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;63(25 Pt B):2960-84.
99. Lucan SC. Attempting to reduce sodium intake might do harm and distract from a greater enemy. Am J Public Health 2013;103:e3.