Retrospective analysis of the effect of interferon therapy on the clinical outcome of patients with viral cirrhosis

Cancer

Volumn 83, Issue 5, 1998, Pages 901-909

  Benvegnù, Luisa ^a   Chemello, Liliana ^a   Noventa, Franco ^a   Fattovich, Giovanna ^b   Pontisso, Patrizia ^a   Alberti, Alfredo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Cirrhosis; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Interferon

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; INTERFERON; PROTHROMBIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LEUKOCYTE COUNT; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS C; HUMANS; INTERFERONS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0032169816     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19980901)83:5<901::AID-CNCR15>3.0.CO;2-Z     Document Type: Article

References (35)

1. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22.707 men in Taiwan. Lancet 1981;2:1129-32.
2. Colombo M, Kuo G, Choo QI, Donato MF Del Ninno E, Tommasini MA, et al. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet 1989;2:1006-8.
3. Kiyosawa K, Sodeyama T, Tananka E, Gibo Y, Yoshizawa K, Nakano Y, et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 1990;12:671-5.
4. Tremolada F, Benvegnù L, Casarin C, Pontisso P, Tagger A, Alberti A. Antibody to hepatitis C virus in hepatocellular carcinoma. Lancet 1990;335:300-1.
5. Simonetti RG, Gammà C, Fiorello F, Cottone M, Rapicetta M, Marino L, et al. Hepatitis C virus infection as risk factor for hepatocellular carcinoma in patients with cirrhosis: a case-control study. Ann Intern Med 1992;116:97-102.
6. Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993;328:1797-801.
7. Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, et al. A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology 1993;18:47-53.
8. Takano S, Yokosuka O, Imazeki F, Tagawa M, Omata M. Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology 1995;21:650-5.
9. Benvegnù L, Alberti A. Risk factors and prevention of hepatocellular carcinoma in HCV infection. Dig Dis Sci 1996; 41(Suppl):49S-55S.
10. Ruiz J, Sangro B, Cuende JI, Beloqui O, Riezu-Boj JI, Herrero JI, et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992;16:637-41.
11. Tarao K, Ohkawa S, Shimizu A, Harada M, Nakamura Y, Ito Y, et al. Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C virus-positive cirrhotic patients. Cancer 1994; 73:1149-54.
12. Benvegnù L, Fattovich G, Noventa F, Tremolada F, Chemello L, Cecchetto A, et al. Concurrent hepatitis B and C virus infection and risk of hepatocellular carcinoma in cirrhosis. A prospective study. Cancer 1994;74:2442-8.
13. Ballardini G, Groff P, Zoli M, Bianchi GP, Giostra F, Francesconi R, et al. Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation. J Hepatol 1994;20;218-22.
14. Hoofnagle JH, Peters MG, Mullen KD, Jones DB, Rustgi V, Di Bisceglie AM, et al. Randomized, controlled trial of recombinant human α-interferon in patients with chronic hepatitis B. Gastroenterology 1988;95:1318-25.
15. Perrillo RP, Schiff ER, Davis GL, Bodenheimer HC, Lindsay K, Payne J, et al. A randomized, controlled trial of interferon a-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323:295-301.
16. Lok ASF, Chung HT, Liu VWS, Ma OCK. Long-term follow-up of chronic hepatitis B patients treated with interferon alpha. Gastroenterology 1993;105:1833-8.
17. Tinè F, Liberati A, Craxì A, Almasio P, Pagliaro L. Interferon treatment in patients with chronic hepatitis B: a meta-analysis of the published literature. J Hepatol 1993;18:154-62.
18. Wong DKH, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. Ann Intern Med 1993;119:312-23.
19. Hoofnagle JH, Mullen KD, Jones DB, Rustgi V, Di Bisceglie AM, Peters M, et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon: a preliminary report. N Engl J Med 1986;315:1575-8.
20. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC Jr., Perrillo RP, et al. Treatment of chronic hepatitis G with recombinant interferon alpha: a multicenter randomized, controlled trial. N Engl J Med 1989;321:1501-6.
21. Di Bisceglie AM, Martiin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, et al. Recombinant interferon alpha therapy for chronic hepatitis C; a randomized, double-blind, placebo-controlled trial. N Engl J Med 1989;321: 1506-10.
22. Shindo M, Di Bisceglie AM, Hoofnagle JH. Long-term follow-up of patients with chronic hepatitis C treated with α-inteferon. Hepatology 1992;15:1013-6.
23. Alberti A, Chemello L, Bonetti P, Casarin C, Diodati G, Cavalletto L, et al. Treatment with interferon(s) of community-acquired chronic hepatitis and cirrhosis type C. J Hepatol 1992;17(Suppl 3):S123-6.
24. Saracco G, Rosina F, Abate ML, Chiandussi L, Gallo V, Cerutti E, et al. Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon-α2b. Hepatology 1993;18:1300-5.
25. Chemello L, Bonetti P, Cavalletto L, Talato F, Donadon V, Casarin P, et al. Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. Hepatology 1995;22:700-6.
26. Hoofnagle Jh, Di Bisceglie AM. The treatment of chronic viral hepatitis. N Engl J Med 1997;336:347-56.
27. Hoofnagle JH, Di Bisceglie AM, Waggoner JG, Park Y. Interferon alpha for patients with clinically apparent cirrhosis due to chronic hepatitis B. Gastroenterology 1993;104:1116-21.
28. Jouet P, Roudot-Thoraval F, Dhumeaux D, Métreau JM, le Groupe Francais puor l'Etude du Traitement es Hépatites Chroniques NANB/C. Comparative efficacy of intreferon alpha in cirrhotic and noncirrhotic patoients with non-A, non-B, C hepatitis. Gastroentrology 1994;106:686-90.
29. Mazzella G, Accogli E, Sottili S, Festi D, Orsini M, Salzetta A, et al. Alpha interferon treatment may prevent hepato-cellular carcinoma in HCV-related cirrhosis. J Hepatol 1996;24:141-7.
30. Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, et al. Randomised trial of effects of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 1995;346:1051-5.
31. Fattovich G, Giustina G, Degos F, Tremolada F, Diodati G, Almasio P, et al. Morbidity and mortality in compensated cirrhosis C: a retrospective follow-up study of 384 patients. Gastroenterology 1997;112:463-72.
32. Tisminetzky G, Gerotto M, Pontisso P, Chemello L, Ruvoletto MG, Baralle F, et al. Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C. Int Hepatol Commun 1994;2:105-12.
33. Brown MB, Engleman L, Jennrich HI. BMDP statistical software manual. Dixon WJ, editor. Berkeley: University of California Press, 1990.
34. Fattovich G, Giustina G, Schalm SW, Hadziayannis S, Sanchez-Tapias J, Almasio P, et al. Occurrence of hepato-cellular carcinoma and decompensation in western European patients with cirrhosis type B. Hepatology 1995;21:77-82.
35. Tong MJ, El-Farra NS, Reikes AR, Co RL. Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995;332:1463-6.