Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade - Results of an explorative CGH meta-analysis

British Journal of Cancer

Volumn 92, Issue 5, 2005, Pages 935-941

  Moinzadeh, P ^a   Breuhahn, K ^a,b   Stutzer H ^a   Schirmacher, P ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Comparative genomic hybridisation; Hepatitis B virus; Hepatitis C virus; Hepatocarcinogenesis; Hepatocellular carcinoma; Meta analysis

Indexed keywords

AFLATOXIN B1; AXIN2 PROTEIN; BRCA3 PROTEIN; CYCLIN A2; CYCLIN DEPENDENT KINASE INHIBITOR 1; FAS LIGAND; FZD3 PROTEIN; GENE PRODUCT; LYMPHOID ENHANCER FACTOR 1; MYC PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; SIAH 1 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; UVOMORULIN; WISP1 PROTEIN; WNT14 PROTEIN;

ALCOHOL LIVER DISEASE; APOPTOSIS; ARTICLE; CANCER GRADING; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOME 13Q; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 1Q; CHROMOSOME 4Q; CHROMOSOME 6P; CHROMOSOME 6Q; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME ABERRATION; CHROMOSOME DELETION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE FUNCTION; HEMOCHROMATOSIS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER NODULE; MAJOR CLINICAL STUDY; META ANALYSIS; PRECANCER; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ALLELIC IMBALANCE; CARCINOMA, HEPATOCELLULAR; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; GENETIC MARKERS; HUMANS; LIVER NEOPLASMS; NUCLEIC ACID HYBRIDIZATION;

EID: 16244373665     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602448     Document Type: Article

References (28)

1. Blanquet V, Garreau F, Chenivesse X, Brechot C, Turleau C (1988) Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer. Hum Genet 80: 274-276
2. Breuhahn K, Vreden S, Haddad R, Beckebaum S, Stippel D, Flemming P, Nussbaum T, Caselmann WH, Haab BB, Schirmacher P (2004) Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression. Cancer Res 64: 6058-6064
3. Buetow KH, Murray JC, Israel JL, London WT, Smith M, Kew M, Blanquet V, Brechot C, Redeker A, Govindarajah S (1989) Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. Proc Natl Acad Sci USA 86: 8852-8856
4. Caselmann WH, Meyer M, Kekule AS, Lauer U, Hofschneider PH, Koshy R (1990) A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 87: 2970-2974
5. Cui J, Zhou X, Liu Y, Tang Z, Romeih M (2003) Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. J Gastroenterol Hepatol 18: 280-287
6. Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 7: 462-503
7. El-Serag HB (2002) Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 35: S72-S78
8. Feitelson MA (1998) Hepatitis B x antigen and p53 in the development of hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 5: 367-374
9. Kato N, Lan KH, Ono-Nita SK, Shiratori Y, Omata M (1997) Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. J Virol 71: 8856-8859
10. Kekule AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R (1990) The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 343: 457-461
11. Kern MA, Breuhahn K, Schirmacher P (2002a) Molecular pathogenesis of human hepatocellular carcinoma. Adv Cancer Res 86: 67-112
12. Kern MA, Schubert D, Sahi D, Schoneweiss MM, Moll I, Haugg AM, Dienes HP, Breuhahn K, Schirmacher P (2002b) Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells. Hepatology 36: 885-894
13. Koike K (1995) Hepatitis B virus HBx gene and hepatocarcinogenesis. Intervirology 38: 134-142
14. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
15. Luber B, Arnold N, Sturzl M, Hohne M, Schirmacher P, Lauer U, Wienberg J, Hofschneider PH, Kekule AS (1996) Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro. Oncogene 12: 1597-1608
16. Matsumura T, Makino R, Mitamura K (2001) Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 7: 594-599
17. Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, Matsuura Y, Kimura S, Miyamura T, Koike K (1998) The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4: 1065-1067
18. Nagaya T, Nakamura T, Tokino T, Tsurimoto T, Imai M, Mayumi T, Kamino K, Yamamura K, Matsubara K (1987) The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes Dev 1: 773-782
19. Ozturk M (1999) Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 19: 235-242
20. Pasquinelli C, Garreau F, Bougueleret L, Cariani E, Grzeschik KH, Thiers V, Croissant O, Hadchouel M, Tiollais P, Brechot C (1988) Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors. J Virol 62: 629-632
21. Paterlini P, Brechot C (1991) The detection of hepatitis B virus (HBV) in HBsAG negative individuals with primary liver cancer. Dig Dis Sci 36: 1122-1129
22. Pestova E, Wilber K, King W (2004) Microarray-based CGH in cancer. Methods Mol Med 97: 355-375
23. Prange W, Breuhahn K, Fischer F, Zilkens C, Pietsch T, Petmecky K, Eilers R, Dienes HP, Schirmacher P (2003) Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 201: 250-259
24. Qin LF, Ng IO, Fan ST, Ng M (1998) p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. Int J Cancer 79: 424-428
25. Weiss MM, Hermsen MA, Meijer GA, van Diest PJ (2002) Comparative genomic hybridization in cancer investigations. Methods Mol Biol 204: 369-378
26. Wessendorf S, Fritz B, Wrobel G, Nessling M, Lampel S, Goettel D, Kuepper M, Joos S, Hopman T, Kokocinski F, Dohner H, Bentz M, Schwaenen C, Lichter P (2002) Automated screening for genomic imbalances using matrix-based comparative genomic hybridization. Lab Invest 82: 47-60
27. Wollersheim M, Debelka U, Hofschneider PH (1988) A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 3: 545-552
28. Zhang X, Xu HJ, Murakami Y, Sachse R, Yashima K, Hirohashi S, Hu SX, Benedict WF, Sekiya T (1994) Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. Cancer Res 54: 4177-4182