Genes related to fatty acid β-oxidation play a role in the functional decline of the drosophila brain with age

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Laranjeira, António ^a   Schulz, Joachim ^a   Dotti, Carlos G ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BMM GENE; BRAIN DYSFUNCTION; BRAIN METABOLISM; CG10814 GENE; CONTROLLED STUDY; DAKH GENE; DHNF4 GENE; DOWN REGULATION; DROSOPHILA MELANOGASTER; FATTY ACID OXIDATION; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; LIPID TRANSPORT; MALE; MOLECULAR GENETICS; NERVOUS TISSUE; NONHUMAN; RNA INTERFERENCE; TISSUE SPECIFICITY; UPREGULATION; WILD TYPE; ANIMAL; BRAIN; CHEMISTRY; CIRCADIAN RHYTHM; GENETIC SCREENING; GENETICS; GROWTH, DEVELOPMENT AND AGING; LIPOLYSIS; LONGEVITY; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOLOGY;

DROSOPHILA PROTEIN; FATTY ACID;

AGING; ANIMALS; BRAIN; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FATTY ACIDS; FEMALE; GENETIC TESTING; LIPOLYSIS; LONGEVITY; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 84983514610     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0161143     Document Type: Article

References (50)

1. Murphy MP, Partridge L (2008) Towards a control theory analysis of aging. Annu.Rev. Biochem. 77, 777-798. doi: 10.1146/annurev.biochem.77.070606.101605 PMID: 18318658
2. Lopez-Otin C, Blasco MA, Partridge L, Serrano M and Kroemer G. (2013) The hallmarks of aging. Cell 153:1194-1217. doi: 10.1016/j.cell.2013.05.039 PMID: 23746838
3. Moskalev AA, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Yanai H, et al. (2013) The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev. 12(2):661-84. doi: 10.1016/j.arr.2012.02.001 PMID: 22353384
4. Navarro A, López-Cepero JM, Bández MJ, Sánchez-Pino MJ, Gómez C, Cadenas E, et al. (2008) Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol. 294(2): R501-9. PMID: 18077512
5. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, et al. (2012) Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 4(8):691-704. doi: 10.1002/emmm.201200245 PMID: 22585399
6. Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE (2009) Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem. 78:959-91. doi: 10.1146/annurev.biochem. 052308.114844 PMID: 19298183
7. Vijg J and Suh Y (2005) Genetics of longevity and aging. Annu. Rev. Med. 56:193-212. PMID: 15660509
8. Gems D, Partridge L (2013) Genetics of longevity in model Organisms: Debates and Paradigm Shifts. Annu Rev. Physiol. 75:621-44. doi: 10.1146/annurev-physiol-030212-183712 PMID: 23190075
9. Bishop N, Lu T, Yanker B (2010) Neural mechanisms of ageing and cognitive decline. Nature. 464,529-535. doi: 10.1038/nature08983 PMID: 20336135
10. Grotewiel MS, Martin I, Bhandari P, Cook-Wiens E (2005) Functional senescence in Drosophila melanogaster. Ageing research reviews. 4, 372-397. PMID: 16024299
11. Vijg J, Campisi J (2008) Puzzles, promises and a cure for ageing. Nature 454,1065-1071. doi: 10. 1038/nature07216 PMID: 18756247
12. Klass M.R. (1983) A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev. 22, 279-286. PMID: 6632998
13. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, et al. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106. PMID: 11292874
14. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, et al. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187. PMID: 12483226
15. Broughton S, Partridge L (2009) Insulin/IGF-like signalling, the central nervous system and aging. Biochem. J. 418(1):1-12. doi: 10.1042/BJ20082102 PMID: 19159343
16. Libert S, Chao Y, Zwiener J, Pletcher SD (2008) Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Mol. Immunol. 45, 810-817. PMID: 17681604
17. Taguchi A, Wartschow LM, White MF (2007) Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372. PMID: 17641201
18. Hwangbo DS, Gersham B, Tu MP, Palmer M, Tatar M (2004) Drosophila dFOXO controls lifespan and regulates insulin signaling in brain and fat body. Nature 429: 562-566. PMID: 15175753
19. Giannakou M, Goss M, Junger M, Hafen E, Leevers S, Partridge L (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305: 361. PMID: 15192154
20. Demontis F, Perrimon N (2010) FOXO/4E-BP signalling in Drosophila muscles regulates organismwide proteostasis during aging. Cell. 143, 813-825. doi: 10.1016/j.cell.2010.10.007 PMID: 21111239
21. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118(2): 401-15. PMID: 8223268
22. Mackay T, Richards S, Stone E, Barbadilla A, Ayroles J, Zhu D, et al. (2012) The Drosophila melanogaster Genetic Reference Panel. Nature 482, 173-178. doi: 10.1038/nature10811 PMID: 22318601
23. Gargano J, Martin I, Bhandari P, Grotewiel M (2005) Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Exp. Geront. 40,386-395.
24. Koh K, Evans J, Hendricks J, Sehgal A (2006) A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci USA 103,13843-13847. PMID: 16938867
25. Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD (2008) Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4:2, 176-184. PMID: 18059160
26. Edgecomb RS, Harth CE, Schneiderman AM (1994) Regulation of feeding behaviour in adult Drosophila melanogaster varies with feeding regime and nutritional state. J. exp. Biol. 197, 215-235. PMID: 7852903
27. Wong R, Piper MD, Wertheim B, Partridge L. (2009) Quantification of food intake in Drosophila. PLOS one, Vol. 4, issue 6, e6063.
28. Palanker L, Tennesen J, Lam G and Thummel C (2009) Drosophila HNF4 regulates Lipid Mobilization and β-oxidation. Cell Metab. 9:228-239. doi: 10.1016/j.cmet.2009.01.009 PMID: 19254568
29. Girardot F, Lasbleiz C, Monnier V, Tricoire H (2006) Specific age related signatures in Drosophila body parts transcriptome. BMC Genomics 7:69. PMID: 16584578
30. Vaz FM, Wanders RJ (2002) Carnitine biosynthesis in mammals. Biochem. J. 361, 417-429. PMID: 11802770
31. Bross TG, Rogina B, Helfand SL (2005) Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. Aging Cell 4, pp309-317.
32. Pandi-Perumal SR, Seils LK, Kayumov L, Ralph MR, Lowe A, Moller H, et al. (2002) Senescence, sleep, and circadian rhythms. Ageing Res Rev 1(3):559-604. PMID: 12067601
33. Tsai L, Szweda PA, Vinogradova O, Szweda LI. (1998) Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine. Proc Natl Acad Sci USA. 95(14):7975-80. PMID: 9653125
34. Sun X, Wheeler CT, Yolitz J, Laslo M, Alberico T, Sun Y, et al. (2014) A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Cell Rep. 2; 8(6):1781-92.
35. Strijbis K, Vaz FM, Distel B (2010) Enzymology of the Carnitine Biosynthesis Pathway. IUBMB Life, 62 (5):357-362. doi: 10.1002/iub.323 PMID: 20306513
36. Gronke S, Muller G, Hirsch J, Fellert S, Andreou A, Haase T, et al. (2007) Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila. Plos Biol. 5:1248-1256.
37. Osterwalder T, Yoon KS, White BH, Keshishian H. (2001) A conditional tissue-specific transgene expression system using inducible GAL4. Proc. Natl. Acad. Sci. U.S.A. 98, 12596-12601 PMID: 11675495
38. Beal MT, Hyman BT, KoroshetzW(1993) Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci. 16:125-131. PMID: 7682343
39. Navarro A, Boveris A. (2007) The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol. 292(2):C670-86 PMID: 17020935
40. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-23. PMID: 15164064
41. Sohal RS (2002) Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med. 33(1):37-44. PMID: 12086680
42. Mannaerts GP, van Veldhoven P (1996) Functions and organization of peroxisomal beta-oxidation. Ann. NY Acad. Sci. 804:99-115. PMID: 8993539
43. Houten SM, Violante S, Ventura FV, Wanders RJ. (2015) The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. Annu Rev Physiol. Epub ahead of print.
44. Rigault C, Le Borgne F, Tazir B, Benani A, Demarquoy J (2013) A high-fat diet increases L-carnitine synthesis through a differential maturation of the Bbox1 mRNAs. Biochim Biophys Acta. 1831(2):370-7. doi: 10.1016/j.bbalip.2012.10.007 PMID: 23127966
45. Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, Spitzer T, et al. (2002) Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10:1225-1234. PMID: 12220494
46. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, et al. (2015) Glial lipid dropplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell 160,177-190. doi: 10.1016/j. cell.2014.12.019 PMID: 25594180
47. Bailey AP, Koster G, Guillermier C, Hirst EMA, MacRae JI, Lechene CP, et al. (2015) Antioxidant role for lipid droplets in a stem cell niche of Drosophila. Cell 163,340-353 doi: 10.1016/j.cell.2015.09.020 PMID: 26451484
48. Koubova J, Guarente L (2003) How does calorie restriction work? Genes Dev. 17(3):313-21. PMID: 12569120
49. Blüher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 299(5606):572-4. PMID: 12543978
50. Mourikis P, Hurlbut GD, Artavanis-Tsakonas S. (2006) Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. Proc Natl Acad Sci USA. 103(5):1307-12. PMID: 16434470