Functional senescence in Drosophila melanogaster

Ageing Research Reviews

Volumn 4, Issue 3, 2005, Pages 372-397

  Grotewiel, Michael S ^a   Martin, Ian ^a   Bhandari, Poonam ^a   Cook Wiens, Eric ^b,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Aging; Behavior; Biochemistry; Fruit flies; Heart; Immunity; Learning; Locomotion; Memory; Metabolism; Negative geotaxis; Olfaction; Reproduction; Review; Stress resistance

Indexed keywords

ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHATE; SOMATOMEDIN RECEPTOR; SUPEROXIDE DISMUTASE;

AGING; ANIMAL BEHAVIOR; BACTERIAL INFECTION; BASAL METABOLIC RATE; CIRCADIAN RHYTHM; CORRELATION ANALYSIS; DROSOPHILA MELANOGASTER; ELECTRIC SHOCK; FERTILITY; GENOME; HEART FUNCTION; HEART RATE; LEARNING; LIFESPAN; MEMORY; MOLECULAR GENETICS; MOTOR ACTIVITY; NONHUMAN; ODOR; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN METABOLISM; REPRODUCTION; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; SMELLING; SPERM; STARVATION; STRESS;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 23744502192     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2005.04.001     Document Type: Short Survey

References (153)

1. M.D. Adams, S.E. Celniker, R.A. Holt, C.A. Evans, J.D. Gocayne, P.G. Amanatides, S.E. Scherer, P.W. Li, R.A. Hoskins, R.F. Galle, R.A. George, S.E. Lewis, S. Richards, M. Ashburner, S.N. Henderson, G.G. Sutton, J.R. Wortman, M.D. Yandell, Q. Zhang, L.X. Chen, R.C. Brandon, Y.H. Rogers, R.G. Blazej, M. Champe, B.D. Pfeiffer, K.H. Wan, C. Doyle, E.G. Baxter, G. Helt, C.R. Nelson, G.L. Gabor Miklos, J.F. Abril, A. Agbayani, H.J. An, C. Andrews-Pfannkoch, D. Baldwin, R.M. Ballew, A. Basu, J. Baxendale, L. Bayraktaroglu, E.M. Beasley, K.Y. Beeson, P.V. Benos, B.P. Berman, D. Bhandari, S. Bolshakov, D. Borkova, M.R. Botchan, J. Bouck, P. Brokstein, P. Brottier, K.C. Burtis, D.A. Busam, H. Butler, E. Cadieu, A. Center, I. Chandra, J.M. Cherry, S. Cawley, C. Dahlke, L.B. Davenport, P. Davies, B. de Pablos, A. Delcher, Z. Deng, A.D. Mays, I. Dew, S.M. Dietz, K. Dodson, L.E. Doup, M. Downes, S. Dugan-Rocha, B.C. Dunkov, P. Dunn, K.J. Durbin, C.C. Evangelista, C. Ferraz, S. Ferriera, W. Fleischmann, C. Fosler, A.E. Gabrielian, N.S. Garg, W.M. Gelbart, K. Glasser, A. Glodek, F. Gong, J.H. Gorrell, Z. Gu, P. Guan, M. Harris, N.L. Harris, D. Harvey, T.J. Heiman, J.R. Hernandez, J. Houck, D. Hostin, K.A. Houston, T.J. Howland, M.H. Wei, C. Ibegwam, M. Jalali, F. Kalush, G.H. Karpen, Z. Ke, J.A. Kennison, K.A. Ketchum, B.E. Kimmel, C.D. Kodira, C. Kraft, S. Kravitz, D. Kulp, Z. Lai, P. Lasko, Y. Lei, A.A. Levitsky, J. Li, Z. Li, Y. Liang, X. Lin, X. Liu, B. Mattei, T.C. McIntosh, M.P. McLeod, D. McPherson, G. Merkulov, N.V. Milshina, C. Mobarry, J. Morris, A. Moshrefi, S.M. Mount, M. Moy, B. Murphy, L. Murphy, D.M. Muzny, D.L. Nelson, D.R. Nelson, K.A. Nelson, K. Nixon, D.R. Nusskern, J.M. Pacleb, M. Palazzolo, G.S. Pittman, S. Pan, J. Pollard, V. Puri, M.G. Reese, K. Reinert, K. Remington, R.D. Saunders, F. Scheeler, H. Shen, B.C. Shue, I. Siden-Kiamos, M. Simpson, M.P. Skupski, T. Smith, E. Spier, A.C. Spradling, M. Stapleton, R. Strong, E. Sun, R. Svirskas, C. Tector, R. Turner, E. Venter, A.H. Wang, X. Wang, Z.Y. Wang, D.A. Wassarman, G.M. Weinstock, J. Weissenbach, S.M. Williams, T. Woodage, K.C. Worley, D. Wu, S. Yang, Q.A. Yao, J. Ye, R.F. Yeh, J.S. Zaveri, M. Zhan, G. Zhang, Q. Zhao, L. Zheng, X.H. Zheng, F.N. Zhong, W. Zhong, X. Zhou, S. Zhu, X. Zhu, H.O. Smith, R.A. Gibbs, E.W. Myers, G.M. Rubin, and J.C. Venter The genome sequence of Drosophila melanogaster Science 287 5461 2000 2185 2195
2. AHA, 2005. American Heart Association: Heart Disease and Stroke Statistics-2005 Update.
3. A.B. Araujo, B.A. Mohr, and J.B. McKinlay Changes in sexual function in middle-aged and older men: longitudinal data from the Massachusetts Male Aging Study J. Am. Geriatr. Soc. 52 9 2004 1502 1509
4. R. Arking Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity Exp. Gerontol. 22 3 1987 199 220
5. R. Arking The Biology of Aging: Observations and Principles 1998 Sinauer Associates
6. R. Arking, S. Buck, A. Berrios, S Dwyer, and G.T.d. Baker Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain of Drosophila Dev. Genet. 12 5 1991 362 370
7. R. Arking, V. Burde, K. Graves, R. Hari, E. Feldman, A. Zeevi, S. Soliman, A. Saraiya, S. Buck, J. Vettraino, K. Sathrasala, N. Wehr, and R.L. Levine Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns Exp. Gerontol. 35 2 2000 167 185
8. R. Arking, and R.A. Wells Genetic alteration of normal aging processes is responsible for extended longevity in Drosophila Dev. Genet. 11 2 1990 141 148
9. R.K. Ayer Jr., and J. Carlson Olfactory physiology in the Drosophila antenna and maxillary palp: acj6 distinguishes two classes of odorant pathways J. Neurobiol. 23 8 1992 965 982
10. G.T. Baker 3rd Insect flight muscle: maturation and senescence Gerontology 22 4 1976 334 361
11. G.T. Baker 3rd Age-dependent alpha-glycerophosphate dehydrogenase activity changes in mutant and wild type Drosophila melanogaster Mech. Ageing Dev. 7 5 1978 367 373
12. J.L. Barger, R.L. Walford, and R. Weindruch The retardation of aging by caloric restriction: its significance in the transgenic era Exp. Gerontol. 38 11-12 2003 1343 1451
13. E. Bonilla, S. Medina-Leendertz, and S. Diaz Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin Exp. Gerontol. 37 5 2002 629 638
14. G.L. Boulianne Neuronal regulation of lifespan: clues from flies and worms Mech. Ageing Dev. 122 9 2001 883 894
15. A.N. Bozcuk DNA synthesis in the absence of somatic cell division associated with ageing in Drosophila subobscura Exp. Gerontol. 7 3 1972 147 156
16. N. Brigui, E. Le Bourg, and J. Medioni Conditioned suppression of the proboscis-extension response in young, middle-aged, and old Drosophila melanogaster flies: acquisition and extinction J. Comp. Psychol. 104 3 1990 289 296
17. E.A. Burns Effects of aging on immune function J. Nutr. Health Aging 8 1 2004 9 18
18. D.A. Chavous, F.R. Jackson, and C.M. O'Connor Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase Proc. Natl. Acad. Sci. U.S.A. 98 26 2001 14814 14818
19. D.J. Clancy, D. Gems, L.G. Harshman, S. Oldham, H. Stocker, E. Hafen, S.J. Leevers, and L. Partridge Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein Science 292 5514 2001 104 106
20. Connolly, J.B., Tully, T., 1998. Behaviour, learning and memory. In: Roberts, D.B., (Ed.), Drosophila, A Practical Approach. IRL Press at Oxford University Press, Oxford, 1998, pp. 265-317.
21. E. Cook-Wiens, and M.S. Grotewiel Dissociation between functional senescence and oxidative stress resistance in Drosophila Exp. Gerontol. 37 12 2002 1347 1357
22. G. Copinschi, and E. Van Cauter Effects of ageing on modulation of hormonal secretions by sleep and circadian rhythmicity Horm. Res. 43 1-3 1995 20 24
23. N. Das, R.L. Levine, W.C. Orr, and R.S. Sohal Selectivity of protein oxidative damage during aging in Drosophila melanogaster Biochem. J. 360 Pt 1 2001 209 216
24. J. David, Y. Cohet, and P. Fouillet The variability between individuals as a measure of senescencce: a study of the number of eggs laid and the percentage of hatched eggs in the case of Drosophila melanogaster Exp. Gerontol. 1975 1017 1025
25. R.L. Davis Physiology and biochemistry of Drosophila learning mutants Physiol. Rev. 76 2 1996 299 317
26. R.L. Davis Olfactory learning Neuron 44 1 2004 31 48
27. D. DeJianne, T.R. McGuire, and A. Pruzan-Hotchkiss Conditioned suppression of proboscis extension in Drosophila melanogaster J. Comp. Psychol. 99 1 1985 74 80
28. B. DeVeale, T. Brummel, and L. Seroude Immunity and aging: the enemy within? Aging Cell 3 4 2004 195 208
29. C. Driver The circadian clock in old Drosophila melanogaster Biogerontology 1 2 2000 157 162
30. J.S. Duerr, and W.G. Quinn Three Drosophila mutations that block associative learning also affect habituation and sensitization Proc. Natl. Acad. Sci. U.S.A. 79 11 1982 3646 3650
31. M. Durusoy, N. Diril, and A.N. Bozcuk Age-related activity of catalase in different genotypes of Drosophila melanogaster Exp. Gerontol. 30 1 1995 77 86
32. A.C. Economos, J. Miquel, R. Binnard, and S. Kessler Quantitative analysis of mating behavior in aging male Drosophila melanogaster Mech. Ageing Dev. 10 3-4 1979 233 240
33. P. Enzlin, R. Mak, F. Kittel, and K. Demyttenaere Sexual functioning in a population-based study of men aged 40-69 years: the good news Int. J. Impot. Res. 16 6 2004 512 520
34. J.R. Fernandez, M.D. Grant, N.M. Tulli, L.M. Karkowski, and G.E. McClearn Differences in locomotor activity across the lifespan of Drosophila melanogaster Exp. Gerontol. 34 5 1999 621 631
35. J.L. Fleg, F. O'Connor, G. Gerstenblith, L.C. Becker, J. Clulow, S.P. Schulman, and E.G. Lakatta Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women J. Appl. Physiol. 78 3 1995 890 900
36. J.E. Fleming, P.S. Melnikoff, G.I. Latter, D. Chandra, and K.G. Bensch Age dependent changes in the expression of Drosophila mitochondrial proteins Mech. Ageing Dev. 34 1 1986 63 72
37. J.E. Fleming, I. Reveillaud, and A. Niedzwiecki Role of oxidative stress in Drosophila aging Mutat. Res. 275 3-6 1992 267 279
38. C. Fois, J. Medioni, and E. Le Bourg Habituation of the proboscis extension response as a function of age in Drosophila melanogaster Gerontology 37 4 1991 187 192
39. A.G. Force, T. Staples, S. Soliman, and R. Arking Comparative biochemical and stress analysis of genetically selected Drosophila strains with different longevities Dev. Genet. 17 4 1995 340 351
40. N. Fresquet, and J. Medioni Effects of ageing on visual discrimination learning in Drosophila melanogaster Q. J. Exp. Psychol. [B] 46 4 1993 399 412
41. B. Ganetzky, and J.R. Flanagan On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster Exp. Gerontol. 13 3-4 1978 189 196
42. J.W. Gargano, I. Martin, P. Bhandari, and M.S. Grotewiel Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila Exp. Gerontol. 40 5 2005 386 395
43. M.M. Goddeeris, E. Cook-Wiens, W.J. Horton, H. Wolf, J.R. Stoltzfus, M. Borrusch, and M.S. Grotewiel Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants Aging Cell 2 5 2003 257 264
44. C.L. Grady, and F.I. Craik Changes in memory processing with age Curr. Opin. Neurobiol. 10 2 2000 224 231
45. R.J. Greenspan, G. Tononi, C. Cirelli, and P.J. Shaw Sleep and the fruit fly Trends Neurosci. 24 3 2001 142 145
46. M.S. Grotewiel, C.D. Beck, K.H. Wu, X.R. Zhu, and R.L. Davis Integrin-mediated short-term memory in Drosophila Nature 391 6666 1998 455 460
47. L. Guarente, and C. Kenyon Genetic pathways that regulate ageing in model organisms Nature 408 6809 2000 255 262
48. S.L. Helfand, and B. Rogina Regulation of gene expression during aging S. Hekimi The Molecular Genetics of Aging vol. 29 2000 Berlin Heidelberg Springer-Verlag 67 80
49. S.L. Helfand, and B. Rogina Genetics of aging in the fruit fly, Drosophila melanogaster Annu. Rev. Genet. 37 2003 329 348
50. S.L. Helfand, and B. Rogina Molecular genetics of aging in the fly: is this the end of the beginning? Bioessays 25 2 2003 134 141
51. B. Hood, D. Bruck, and G. Kennedy Determinants of sleep quality in the healthy aged: the role of physical, psychological, circadian and naturalistic light variables Age Ageing 33 2 2004 159 165
52. A.J. Hulbert, D.J. Clancy, W. Mair, B.P. Braeckman, D. Gems, and L. Partridge Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster Exp. Gerontol. 39 8 2004 1137 1143
53. D.S. Hwangbo, B. Gersham, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 6991 2004 562 566
54. K. Ito, and Y. Hotta Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogaster Dev. Biol. 149 1 1992 134 148
55. J.A. Joseph, B. Shukitt-Hale, N.A. Denisova, D. Bielinski, A. Martin, J.J. McEwen, and P.C. Bickford Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation J. Neurosci. 19 18 1999 8114 8121
56. D. Joshi, R. Barnabas, E.R. Martin, V. Parihar, and M. Kanojiya Aging alters properties of the circadian pacemaker controlling the locomotor activity rhythm in males of Drosophila nasuta Chronobiol. Int. 16 6 1999 751 758
57. A. Jung, and W.B. Schill Male sexuality with advancing age Eur. J. Obstet. Gynecol. Reprod. Biol. 113 2 2004 123 125
58. H.L. Kang, S. Benzer, and K.T. Min Life extension in Drosophila by feeding a drug Proc. Natl. Acad. Sci. U.S.A. 99 2 2002 838 843
59. C. Kenyon A conserved regulatory system for aging Cell 105 2 2001 165 168
60. Y.S. Kim, H.J. Nam, H.Y. Chung, N.D. Kim, J.H. Ryu, W.J. Lee, R. Arking, and M.A. Yoo Role of xanthine dehydrogenase and aging on the innate immune response of Drosophila J. Am. Aging Assoc. 24 2001 184 197
61. K. Kosuda The aging effect on male mating activity in Drosophila melanogaster Behav. Genet. 15 3 1985 297 303
62. M.A. Kotarski, S. Pickert, D.A. Leonard, G.J. LaRosa, and R.J. MacIntyre The characterization of alpha-glycerophosphate dehydrogenase mutants in Drosophila melanogaster Genetics 105 2 1983 387 407
63. T. Kovacs Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders Ageing Res. Rev. 3 2 2004 215 232
64. R. Kozakai, S. Tsuzuku, K. Yabe, F. Ando, N. Niino, and H. Shimokata Age-related changes in gait velocity and leg extension power in middle-aged and elderly people J. Epidemiol. 10 Suppl. 1 2000 S77 S81
65. E.G. Lakatta Cardiovascular regulatory mechanisms in advanced age Physiol. Rev. 73 2 1993 413 467
66. B.N. Landis, C.G. Konnerth, and T. Hummel A study on the frequency of olfactory dysfunction Laryngoscope 114 10 2004 1764 1769
67. G.N. Landis, D. Abdueva, D. Skvortsov, J. Yang, B.E. Rabin, J. Carrick, S. Tavare, and J. Tower Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster Proc. Natl. Acad. Sci. U.S.A. 101 20 2004 7663 7668
68. G.N. Landis, and J. Tower Superoxide dismutase evolution and life span regulation Mech. Ageing Dev. 126 3 2005 365 379
69. M. Larsson, D. Finkel, and N.L. Pedersen Odor identification: influences of age, gender, cognition, and personality J. Gerontol. B Psychol. Sci. Soc. Sci. 55 5 2000 P304 P310
70. E. Le Bourg Aging and habituation of the tarsal response in Drosophila melanogaster Gerontology 29 6 1983 388 393
71. E. Le Bourg Patterns of movement and ageing in Drosophila melanogaster Arch. Gerontol. Geriatr. 2 4 1983 299 306
72. E. Le Bourg The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster Exp. Gerontol. 22 5 1987 359 369
73. E. Le Bourg, and F.A. Lints A longitudinal study of the effects of age on spontaneous locomotor activity in Drosophila melanogaster Gerontology 30 2 1984 79 86
74. E. Le Bourg, and N. Minois A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster Exp. Gerontol. 34 2 1999 157 172
75. E. Le Bourg, P. Valenti, P. Lucchetta, and F. Payre Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster Biogerontology 2 3 2001 155 164
76. D. Leffelaar, and T. Grigliatti Age-dependent behavior loss in adult Drosophila melanogaster Dev. Genet. 4 1984 211 227
77. Y.J. Lin, L. Seroude, and S. Benzer Extended life-span and stress resistance in the Drosophila mutant methuselah Science 282 5390 1998 943 946
78. F.A. Lints, and C.V. Lints Respiration in Drosophila. II. Respiration in relation to age by wild, inbred and hybrid Drosophila melanogaster imagos Exp. Gerontol. 3 4 1968 341 349
79. F.A. Lints, and C.V. Lints Respiration in Drosophila. 3. Influence of preimaginal environment on respiration and aging in Drosophila melanogaster hybrids Exp. Gerontol. 4 2 1969 81 94
80. R. Liu, I.Y. Liu, X. Bi, R.F. Thompson, S.R. Doctrow, B. Malfroy, and M. Baudry Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics Proc. Natl. Acad. Sci. U.S.A. 100 14 2003 8526 8531
81. L.S. Luckinbill, and M.J. Clare Selection for life span in Drosophila melanogaster Heredity 55 Pt 1 1985 9 18
82. J.H. Marden, B. Rogina, K.L. Montooth, and S.L. Helfand Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies Proc. Natl. Acad. Sci. U.S.A. 100 6 2003 3369 3373
83. I. Martin, J.W. Gargano, and M.S. Grotewiel A proposed set of descriptors for functional senescence data Aging Cell 4 3 2005 161 164
84. J.R. Martin, R. Ernst, and M. Heisenberg Temporal pattern of locomotor activity in Drosophila melanogaster J. Comp. Physiol. [A] 184 1 1999 73 84
85. H.R. Massie, V.R. Aiello, and T.R. Williams Changes i superoxide dismutase activity and copper during development and ageing in the fruit fly Drosophila melanogaster Mech. Ageing Dev. 12 3 1980 279 286
86. C.A. McGibbon, and D.E. Krebs Age-related changes in lower trunk coordination and energy transfer during gait J. Neurophysiol. 85 5 2001 1923 1931
87. A. Miller The internal anatomy and histology of the imago of Drosophila melanogaster M. Demerec Biology of Drosophila 1994 Cold Spring Harbor Laboratory Press New York 420 534
88. N. Minois, A.A. Khazaeli, and J.W. Curtsinger Locomotor activity as a function of age and life span in Drosophila melanogaster overexpressing hsp70 Exp. Gerontol. 36 7 2001 1137 1153
89. N. Minois, and E. Le Bourg Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity Mech. Ageing Dev. 109 1 1999 53 64
90. J. Miquel, P.R. Lundgren, K.G. Bensch, and H. Atlan Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster Mech. Ageing Dev. 5 5 1976 347 370
91. R.J. Mockett, W.C. Orr, J.J. Rahmandar, B.H. Sohal, and R.S. Sohal Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster Exp. Gerontol. 36 3 2001 441 463
92. K.K. Ng, R. Donat, L. Chan, A. Lalak, I. Di Pierro, and D.J. Handelsman Sperm output of older men Hum. Reprod. 19 8 2004 1811 1815
93. D. Nghiem, A.G. Gibbs, M.R. Rose, and T.J. Bradley Postponed aging and desiccation resistance in Drosophila melanogaster Exp. Gerontol. 35 8 2000 957 969
94. A. Niedzwiecki, I. Reveillaud, and J.E. Fleming Changes in superoxide dismutase and catalase in aging heat-shocked Drosophila Free Radic. Res. Commun. 17 6 1992 355 367
95. V.N. Novoseltsev, R. Arking, J.R. Carey, J.A. Novoseltseva, and A.I. Yashin How an individual fecundity pattern looks in Drosophila and medflies Ann. N. Y. Acad. Sci. 1019 2004 577 580
96. V.N. Novoseltsev, J.A. Novoseltseva, and A.I. Yashin What does a fly's individual fecundity pattern look like? The dynamics of resource allocation in reproduction and ageing Mech. Ageing Dev. 124 5 2003 605 617
97. S.J. O'Brien, and R.J. MacIntyre The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects Biochem. Genet. 7 2 1972 141 161
98. M.J. Palladino, T.J. Hadley, and B. Ganetzky Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila Genetics 161 3 2002 1197 1208
99. L. Partridge, N. Prowse, and P. Pignatelli Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster Proc. R. Soc. Lond. B Biol. Sci. 266 1416 1999 255 261
100. G. Paternostro, C. Vignola, D.U. Bartsch, J.H. Omens, A.D. McCulloch, and J.C. Reed Age-associated cardiac dysfunction in Drosophila melanogaster Circ. Res. 88 10 2001 1053 1058
101. M. Perlmutter, R. Metzger, T. Nezworski, and K. Miller Spatial and temporal memory in 20 to 60 year olds J. Gerontol. 36 1 1981 59 65
102. E.A. Phelan, L.A. Anderson, A.Z. LaCroix, and E.B. Larson Older adults' views of "successful aging" - how do they compare with researchers' definitions? J. Am. Geriatr. Soc. 52 2 2004 211 216
103. T.P. Plackett, E.D. Boehmer, D.E. Faunce, and E.J. Kovacs Aging and innate immune cells J. Leukoc. Biol. 76 2 2004 291 299
104. S.D. Pletcher, S.J. Macdonald, R. Marguerie, U. Certa, S.C. Stearns, D.B. Goldstein, and L. Partridge Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster Curr. Biol. 12 9 2002 712 723
105. T. Preat Decreased odor avoidance after electric shock in Drosophila mutants biases learning and memory tests J. Neurosci. 18 20 1998 8534 8538
106. D.E. Promislow, and T.S. Haselkorn Age-specific metabolic rates and mortality rates in the genus Drosophila Aging Cell 1 1 2002 66 74
107. N. Prowse, and L. Partridge The effects of reproduction on longevity and fertility in male Drosophila melanogaster J. Insect Physiol. 43 6 1997 501 512
108. I. Rebrin, A.C. Bayne, R.J. Mockett, W.C. Orr, and R.S. Sohal Free aminothiols, glutathione redox state and protein mixed disulphides in aging Drosophila melanogaster Biochem. J. 382 Pt 1 2004 131 136
109. J. Rittweger, H. Schiessl, D. Felsenberg, and M. Runge Reproducibility of the jumping mechanography as a test of mechanical power output in physically competent adult and elderly subjects J. Am. Geriatr. Soc. 52 1 2004 128 131
110. M. Rockstein, T. Lopez, J. Miquel, and A.N. Bozcuk Age-related activity changes in actomyosin ATPase and arginine phosphokinase in male Drosophila melanogaster Meig Gerontology 27 6 1981 301 305
111. R.E. Ross Age-specific decrease in aerobic efficiency associated with increase in oxygen free radical production in Drosophila melanogaster J. Insect Physiol. 46 11 2000 1477 1480
112. H. Ruan, X.D. Tang, M.L. Chen, M.L. Joiner, G. Sun, N. Brot, H. Weissbach, S.H. Heinemann, L. Iverson, C.F. Wu, T. Hoshi, and M.A. Joiner High-quality life extension by the enzyme peptide methionine sulfoxide reductase Proc. Natl. Acad. Sci. U.S.A. 99 5 2002 2748 2753
113. E. Savvateeva, A. Popov, N. Kamyshev, J. Bragina, M. Heisenberg, D. Senitz, J. Kornhuber, and P. Riederer Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine J. Neural Transm. 107 5 2000 581 601
114. E.V. Savvateeva, A.V. Popov, N.G. Kamyshev, K.G. Iliadi, J.V. Bragina, M. Heisenberg, J. Kornhuber, and P. Riederer Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism Ross Fiziol Zh. Im. I. M. Sechenova. 85 1 1999 167 183
115. S.R. Schwarze, R. Weindruch, and J.M. Aiken Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila Free Radic. Biol. Med. 25 6 1998 740 747
116. L. Seroude, T. Brummel, P. Kapahi, and S. Benzer Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster Aging Cell 1 1 2002 47 56
117. P.M. Service, and A.J. Fales Evolution of delayed reproductive senescence in male fruit flies: sperm competition Genetica 91 1-3 1993 111 125
118. E.A. Sestini, J.C. Carlson, and R. Allsopp The effects of ambient temperature on life span, lipid peroxidation, superoxide dismutase, and phospholipase A2 activity in Drosophila melanogaster Exp. Gerontol. 26 4 1991 385 395
119. P.J. Shaw, C. Cirelli, R.J. Greenspan, and G. Tononi Correlates of sleep and waking in Drosophila melanogaster Science 287 5459 2000 1834 1837
120. J.C. Shepherd, U. Walldorf, P. Hug, and W.J. Gehring Fruit flies with additional expression of the elongation factor EF-1 alpha live longer Proc. Natl. Acad. Sci. U.S.A. 86 19 1989 7520 7521
121. N. Shikama, R. Ackermann, and C. Brack Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster Proc. Natl. Acad. Sci. U.S.A. 91 10 1994 4199 4203
122. N. Shikama, and C. Brack Changes in the expression of genes involved in protein synthesis during Drosophila aging Gerontology 42 3 1996 123 136
123. N. Shkuratova, M.E. Morris, and F. Huxham Effects of age on balance control during walking Arch. Phys. Med. Rehabil. 85 4 2004 582 588
124. A.F. Simon, C. Shih, A. Mack, and S. Benzer Steroid control of longevity in Drosophila melanogaster Science 299 5611 2003 1407 1410
125. R.S. Sohal Aging in insects Pharmacology G.A. in: L.I. Kerkut Gilbert Comprehensive Insect Physiology Biochemistry vol. 10 1985 Pergamon Press Oxford 595 631
126. R.S. Sohal, L. Arnold, and W.C. Orr Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster Mech. Ageing Dev. 56 3 1990 223 235
127. R.S. Sohal, R.J. Mockett, and W.C. Orr Mechanisms of aging: an appraisal of the oxidative stress hypothesis Free Radic. Biol. Med. 33 5 2002 575 586
128. E.R. Stadtman Role of oxidant species in aging Curr. Med. Chem. 11 9 2004 1105 1112
129. J.R. Stoltzfus, W.J. Horton, and M.S. Grotewiel Odor-guided behavior in Drosophila requires calreticulin J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 189 6 2003 471 483
130. Y. Takahashi, O.M. Kuro, and F. Ishikawa Aging mechanisms Proc. Natl. Acad. Sci. U.S.A. 97 23 2000 12407 12408
131. T. Tamura, A.S. Chiang, N. Ito, H.P. Liu, J. Horiuchi, T. Tully, and M. Saitoe Aging specifically impairs amnesiac-dependent memory in Drosophila Neuron 40 5 2003 1003 1011
132. M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 5611 2003 1346 1351
133. M. Tatar, A. Kopelman, D. Epstein, M.P. Tu, C.M. Yin, and R.S. Garofalo A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 5514 2001 107 110
134. J. Tower Transgenic methods for increasing Drosophila life span Mech. Ageing Dev. 118 1-2 2000 1 14
135. M.P. Tu, D. Epstein, and M. Tatar The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico Aging Cell 1 1 2002 75 80
136. P. Tzou, J.M. Reichhart, and B. Lemaitre Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants Proc. Natl. Acad. Sci. U.S.A. 99 4 2002 2152 2157
137. B. Uttl, and P. Graf Episodic spatial memory in adulthood Psychol. Aging 8 2 1993 257 273
138. W.A. van Voorhies, A.A. Khazaeli, and J.W. Curtsinger Selected contribution: long-lived Drosophila melanogaster lines exhibit normal metabolic rates J. Appl. Physiol. 95 6 2003 2605 2613 (discussion 2604)
139. W.A. Van Voorhies, A.A. Khazaeli, and J.W. Curtsinger Testing the "rate of living" model: further evidence that longevity and metabolic rate are not inversely correlated in Drosophila melanogaster J. Appl. Physiol. 97 5 2004 1915 1922
140. A.C. Vann, and G.C. Webster Age-related changes in mitochondrial function in Drosophila melanogaster Exp. Gerontol. 12 1-2 1977 1 5
141. H.D. Wang, P. Kazemi-Esfarjani, and S. Benzer Multiple-stress analysis for isolation of Drosophila longevity genes Proc. Natl. Acad. Sci. U.S.A. 101 34 2004 12610 12615
142. Y. Wang, A.S. Chiang, S. Xia, T. Kitamoto, T. Tully, and Y. Zhong Blockade of neurotransmission in Drosophila mushroom bodies impairs odor attraction, but not repulsion Curr. Biol. 13 21 2003 1900 1904
143. S. Webb, and M.A. Tribe Are there major degenerative changes in the flight muscle of ageing diptera? Exp. Gerontol. 9 1 1974 43 49
144. G.C. Webster, V.T. Beachell, and S.L. Webster Differential decrease in protein synthesis by microsomes from aging Drosophila melanogaster Exp. Gerontol. 15 5 1980 495 497
145. G.C. Webster, and S.L. Webster Decreased protein synthesis by microsomes from aging Drosophila melanogaster Exp. Gerontol. 14 6 1979 343 348
146. G.C. Webster, and S.L. Webster Effects of age on the post-initiation stages of protein synthesis Mech. Ageing Dev. 18 4 1982 369 378
147. R.J. Wessells, and R. Bodmer Screening assays for heart function mutants in Drosophila Biotechniques 37 1 2004 58 66
148. R.J. Wessells, E. Fitzgerald, J.R. Cypser, M. Tatar, and R. Bodmer Insulin regulation of heart function in aging fruit flies Nat. Genet. 36 12 2004 1275 1281
149. C. Wicker, J.M. Reichhart, D. Hoffmann, D. Hultmark, C. Samakovlis, and J.A. Hoffmann Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides J. Biol. Chem. 265 36 1990 22493 22498
150. D.A. Winter, A.E. Patla, J.S. Frank, and S.E. Walt Biomechanical walking pattern changes in the fit and healthy elderly Phys. Ther. 70 6 1990 340 347
151. J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, M. Tatar, and D. Sinclair Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 7000 2004 686 689
152. I.Y. Yoon, D.F. Kripke, J.A. Elliott, S.D. Youngstedt, K.M. Rex, and R.L. Hauger Age-related changes of circadian rhythms and sleep-wake cycles J. Am. Geriatr. Soc. 51 8 2003 1085 1091
153. M. Zerofsky, E. Harel, N. Silverman, and M. Tatar Aging of the innate immune response in Drosophila melanogaster Aging Cell 4 2 2005 103