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Volumn 2, Issue 5, 2014, Pages 500-520

Cytochrome P450 induction properties of food and herbal-derived compounds using a novel multiplex RT-qPCR in vitro assay, a drug–food interaction prediction tool

Author keywords

CYP1A2; CYP2D6; CYP3A4; drug food interactions; multiplex RT qPCR

Indexed keywords


EID: 84983182618     PISSN: None     EISSN: 20487177     Source Type: Journal    
DOI: 10.1002/fsn3.122     Document Type: Article
Times cited : (25)

References (55)
  • 1
    • 33646110508 scopus 로고    scopus 로고
    • Resveratrol affects CYP1A expression in rainbow trout hepatocytes
    • Aluru, N., and M. M. Vijayan. 2006. Resveratrol affects CYP1A expression in rainbow trout hepatocytes. Aquat. Toxicol. 77:291–297.
    • (2006) Aquat. Toxicol. , vol.77 , pp. 291-297
    • Aluru, N.1    Vijayan, M.M.2
  • 2
    • 84879898204 scopus 로고    scopus 로고
    • Drug and nutrition interactions: not just food for thought
    • Boullata, J. I. 2013. Drug and nutrition interactions: not just food for thought. J. Clin. Pharm. Ther. 38:269–271.
    • (2013) J. Clin. Pharm. Ther. , vol.38 , pp. 269-271
    • Boullata, J.I.1
  • 3
    • 84859108573 scopus 로고    scopus 로고
    • Drug–nutrient interactions: a broad view with implications for practice
    • Boullata, J. I., and L. M. Hudson. 2012. Drug–nutrient interactions: a broad view with implications for practice. J. Acad. Nutr. Diet. 112:506–517.
    • (2012) J. Acad. Nutr. Diet. , vol.112 , pp. 506-517
    • Boullata, J.I.1    Hudson, L.M.2
  • 4
    • 0033927671 scopus 로고    scopus 로고
    • Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction
    • Bowen, W. P., J. E. Carey, A. Miah, H. F. McMurray, P. W. Munday, R. S. James, et al. 2000. Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Drug Metab. Dispos. 28:781–788.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 781-788
    • Bowen, W.P.1    Carey, J.E.2    Miah, A.3    McMurray, H.F.4    Munday, P.W.5    James, R.S.6
  • 5
    • 0033495930 scopus 로고    scopus 로고
    • Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol
    • Bramer, S. L., and A. Suri. 1999. Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol. Clin. Pharmacokinet. 37(Suppl. 2):41–51.
    • (1999) Clin. Pharmacokinet. , vol.37 , pp. 41-51
    • Bramer, S.L.1    Suri, A.2
  • 6
    • 77956412951 scopus 로고    scopus 로고
    • Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study
    • Chow, H. H., L. L. Garland, C. H. Hsu, D. R. Vining, W. M. Chew, J. A. Miller, et al. 2010. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev. Res. (Phila) 3:1168–1175.
    • (2010) Cancer Prev. Res. (Phila) , vol.3 , pp. 1168-1175
    • Chow, H.H.1    Garland, L.L.2    Hsu, C.H.3    Vining, D.R.4    Chew, W.M.5    Miller, J.A.6
  • 8
    • 0025368026 scopus 로고
    • Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450
    • Diaz, D., I. Fabre, M. Daujat, B. Saint Aubert, P. Bories, H. Michel, et al. 1990. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology 99:737–747.
    • (1990) Gastroenterology , vol.99 , pp. 737-747
    • Diaz, D.1    Fabre, I.2    Daujat, M.3    Saint Aubert, B.4    Bories, P.5    Michel, H.6
  • 9
    • 84867886267 scopus 로고    scopus 로고
    • Fruit juices as perpetrators of drug interactions: the role of organic anion-transporting polypeptides
    • Dolton, M. J., B. D. Roufogalis, and A. J. McLachlan. 2012. Fruit juices as perpetrators of drug interactions: the role of organic anion-transporting polypeptides. Clin. Pharmacol. Ther. 92:622–630.
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 622-630
    • Dolton, M.J.1    Roufogalis, B.D.2    McLachlan, A.J.3
  • 10
    • 33745253791 scopus 로고    scopus 로고
    • Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor
    • Duret, C., M. Daujat-Chavanieu, J. M. Pascussi, L. Pichard-Garcia, P. Balaguer, J. M. Fabre, et al. 2006. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol. Pharmacol. 70:329–339.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 329-339
    • Duret, C.1    Daujat-Chavanieu, M.2    Pascussi, J.M.3    Pichard-Garcia, L.4    Balaguer, P.5    Fabre, J.M.6
  • 11
    • 33748802003 scopus 로고    scopus 로고
    • Structural basis for ligand promiscuity in cytochrome P450 3A4
    • Ekroos, M., and T. Sjogren. 2006. Structural basis for ligand promiscuity in cytochrome P450 3A4. Proc. Natl. Acad. Sci. USA 103:13682–13687.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 13682-13687
    • Ekroos, M.1    Sjogren, T.2
  • 12
    • 77955999532 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes
    • Fahmi, O. A., M. Kish, S. Boldt, and R. S. Obach. 2010. Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes. Drug Metab. Dispos. 38:1605–1611.
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1605-1611
    • Fahmi, O.A.1    Kish, M.2    Boldt, S.3    Obach, R.S.4
  • 15
    • 78349260498 scopus 로고    scopus 로고
    • Effects of Curcuma extracts and curcuminoids on expression of P-glycoprotein and cytochrome P450 3A4 in the intestinal cell culture model LS180
    • Graber-Maier, A., K. B. Buter, J. Aeschlimann, C. Bittel, M. Kreuter, J. Drewe, et al. 2010. Effects of Curcuma extracts and curcuminoids on expression of P-glycoprotein and cytochrome P450 3A4 in the intestinal cell culture model LS180. Planta Med. 76:1866–1870.
    • (2010) Planta Med. , vol.76 , pp. 1866-1870
    • Graber-Maier, A.1    Buter, K.B.2    Aeschlimann, J.3    Bittel, C.4    Kreuter, M.5    Drewe, J.6
  • 16
    • 53249123498 scopus 로고    scopus 로고
    • Clinical assessment of CYP2D6-mediated herb–drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea
    • Gurley, B. J., A. Swain, M. A. Hubbard, D. K. Williams, G. Barone, F. Hartsfield, et al. 2008. Clinical assessment of CYP2D6-mediated herb–drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. Mol. Nutr. Food Res. 52:755–763.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 755-763
    • Gurley, B.J.1    Swain, A.2    Hubbard, M.A.3    Williams, D.K.4    Barone, G.5    Hartsfield, F.6
  • 17
    • 33845996201 scopus 로고    scopus 로고
    • The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    • Hellum, B. H., Z. Hu, and O. G. Nilsen. 2006. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin. Pharmacol. Toxicol. 100:8.
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.100 , pp. 8
    • Hellum, B.H.1    Hu, Z.2    Nilsen, O.G.3
  • 18
    • 33846230463 scopus 로고    scopus 로고
    • Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
    • Huang, H., H. Wang, M. Sinz, M. Zoeckler, J. Staudinger, M. R. Redinbo, et al. 2007. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 26:258–268.
    • (2007) Oncogene , vol.26 , pp. 258-268
    • Huang, H.1    Wang, H.2    Sinz, M.3    Zoeckler, M.4    Staudinger, J.5    Redinbo, M.R.6
  • 19
    • 84868571010 scopus 로고    scopus 로고
    • Induction of cytochrome P450 enzymes: a view on human in vivo findings
    • Hukkanen, J. 2012. Induction of cytochrome P450 enzymes: a view on human in vivo findings. Expert Rev. Clin. Pharmacol. 5:569–585.
    • (2012) Expert Rev. Clin. Pharmacol. , vol.5 , pp. 569-585
    • Hukkanen, J.1
  • 20
    • 0035805255 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
    • Ideker, T., V. Thorsson, J. A. Ranish, R. Christmas, J. Buhler, J. K. Eng, et al. 2001. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292:929–934.
    • (2001) Science , vol.292 , pp. 929-934
    • Ideker, T.1    Thorsson, V.2    Ranish, J.A.3    Christmas, R.4    Buhler, J.5    Eng, J.K.6
  • 21
    • 84867481588 scopus 로고    scopus 로고
    • Interactions between antiarrhythmic drugs and food
    • Jauregui-Garrido, B., and I. Jauregui-Lobera. 2012. Interactions between antiarrhythmic drugs and food. Nutr. Hosp. 27:1399–1407.
    • (2012) Nutr. Hosp. , vol.27 , pp. 1399-1407
    • Jauregui-Garrido, B.1    Jauregui-Lobera, I.2
  • 22
    • 0033822059 scopus 로고    scopus 로고
    • A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition
    • Kelly, J. H., and N. L. Sussman. 2000. A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition. J. Biomol. Screen. 5:249–254.
    • (2000) J. Biomol. Screen. , vol.5 , pp. 249-254
    • Kelly, J.H.1    Sussman, N.L.2
  • 23
    • 11144355476 scopus 로고    scopus 로고
    • Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
    • Komoroski, B. J., S. Zhang, H. Cai, J. M. Hutzler, R. Frye, T. S. Tracy, et al. 2004. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab. Dispos. 32:512–518.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 512-518
    • Komoroski, B.J.1    Zhang, S.2    Cai, H.3    Hutzler, J.M.4    Frye, R.5    Tracy, T.S.6
  • 24
    • 33745395225 scopus 로고    scopus 로고
    • CYP induction-mediated drug interactions: in vitro assessment and clinical implications
    • Lin, J. H. 2006. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm. Res. 23:1089–1116.
    • (2006) Pharm. Res. , vol.23 , pp. 1089-1116
    • Lin, J.H.1
  • 25
    • 84859915424 scopus 로고    scopus 로고
    • Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect
    • Lin, H. L., C. Kenaan, and P. F. Hollenberg. 2012. Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect. Drug Metab. Dispos. 40:998–1006.
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 998-1006
    • Lin, H.L.1    Kenaan, C.2    Hollenberg, P.F.3
  • 26
    • 0030982634 scopus 로고    scopus 로고
    • Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
    • Lown, K. S., D. G. Bailey, R. J. Fontana, S. K. Janardan, C. H. Adair, L. A. Fortlage, et al. 1997. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J. Clin. Investig. 99:2545–2553.
    • (1997) J. Clin. Investig. , vol.99 , pp. 2545-2553
    • Lown, K.S.1    Bailey, D.G.2    Fontana, R.J.3    Janardan, S.K.4    Adair, C.H.5    Fortlage, L.A.6
  • 27
    • 34547663626 scopus 로고    scopus 로고
    • The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects
    • Lynch, T., and A. Price. 2007. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am. Fam. Physician 76:391–396.
    • (2007) Am. Fam. Physician , vol.76 , pp. 391-396
    • Lynch, T.1    Price, A.2
  • 28
    • 0037379409 scopus 로고    scopus 로고
    • Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    • Madan, A., R. A. Graham, K. M. Carroll, D. R. Mudra, L. A. Burton, L. A. Krueger, et al. 2003. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab. Dispos. 31:421–431.
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 421-431
    • Madan, A.1    Graham, R.A.2    Carroll, K.M.3    Mudra, D.R.4    Burton, L.A.5    Krueger, L.A.6
  • 29
    • 71149108056 scopus 로고    scopus 로고
    • Correlation of mRNA and protein in complex iological samples
    • Maier, T., M. Guell, and L. Serrano. 2009. Correlation of mRNA and protein in complex iological samples. FEBS Lett. 583:3966–3973.
    • (2009) FEBS Lett. , vol.583 , pp. 3966-3973
    • Maier, T.1    Guell, M.2    Serrano, L.3
  • 31
    • 34547211016 scopus 로고    scopus 로고
    • Drug interactions due to cytochrome P450
    • Ogu, C. C., and J. L. Maxa. 2000. Drug interactions due to cytochrome P450. Proc. (Bayl. Univ. Med. Cent.) 13:421–423.
    • (2000) Proc. (Bayl. Univ. Med. Cent.) , vol.13 , pp. 421-423
    • Ogu, C.C.1    Maxa, J.L.2
  • 32
    • 37449013831 scopus 로고    scopus 로고
    • Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide
    • Pekthong, D., H. Martin, C. Abadie, A. Bonet, B. Heyd, G. Mantion, et al. 2008. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J. Ethnopharmacol. 115:432–440.
    • (2008) J. Ethnopharmacol. , vol.115 , pp. 432-440
    • Pekthong, D.1    Martin, H.2    Abadie, C.3    Bonet, A.4    Heyd, B.5    Mantion, G.6
  • 33
    • 62749197576 scopus 로고    scopus 로고
    • Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures
    • Pekthong, D., N. Blanchard, C. Abadie, A. Bonet, B. Heyd, G. Mantion, et al. 2009. Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chem. Biol. Interact. 179:247–255.
    • (2009) Chem. Biol. Interact. , vol.179 , pp. 247-255
    • Pekthong, D.1    Blanchard, N.2    Abadie, C.3    Bonet, A.4    Heyd, B.5    Mantion, G.6
  • 35
    • 84872334653 scopus 로고    scopus 로고
    • Drug-grapefruit juice interactions
    • Pirmohamed, M. 2013. Drug-grapefruit juice interactions. BMJ 346:f1.
    • (2013) BMJ , vol.346 , pp. f1
    • Pirmohamed, M.1
  • 36
    • 4544292829 scopus 로고    scopus 로고
    • Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4
    • Regev-Shoshani, G., O. Shoseyov, and Z. Kerem. 2004. Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P450 3A4. Biochem. Biophys. Res. Commun. 323:668–673.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 668-673
    • Regev-Shoshani, G.1    Shoseyov, O.2    Kerem, Z.3
  • 39
    • 11244283586 scopus 로고    scopus 로고
    • Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor
    • Ruhl, R., R. Sczech, N. Landes, P. Pfluger, D. Kluth, and F. J. Schweigert. 2004. Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor. Eur. J. Nutr. 43:336–343.
    • (2004) Eur. J. Nutr. , vol.43 , pp. 336-343
    • Ruhl, R.1    Sczech, R.2    Landes, N.3    Pfluger, P.4    Kluth, D.5    Schweigert, F.J.6
  • 41
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T., H. Yamazaki, M. Mimura, Y. Inui, and F. P. Guengerich. 1994. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270:414–423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 42
    • 0032870729 scopus 로고    scopus 로고
    • Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6
    • Shin, J. G., N. Soukhova, and D. A. Flockhart. 1999. Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab. Dispos. 27:1078–1084.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1078-1084
    • Shin, J.G.1    Soukhova, N.2    Flockhart, D.A.3
  • 43
    • 84879068823 scopus 로고    scopus 로고
    • Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug–drug interactions
    • Shirasaka, Y., J. E. Sager, J. D. Lutz, C. Davis, and N. Isoherranen. 2013. Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug–drug interactions. Drug Metab. Dispos. 41:1414–1424.
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 1414-1424
    • Shirasaka, Y.1    Sager, J.E.2    Lutz, J.D.3    Davis, C.4    Isoherranen, N.5
  • 44
    • 84857842546 scopus 로고    scopus 로고
    • Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract
    • Sunaga, K., K. Ohkawa, K. Nakamura, A. Ohkubo, S. Harada, and T. Tsuda. 2012. Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol. Pharm. Bull. 35:329–334.
    • (2012) Biol. Pharm. Bull. , vol.35 , pp. 329-334
    • Sunaga, K.1    Ohkawa, K.2    Nakamura, K.3    Ohkubo, A.4    Harada, S.5    Tsuda, T.6
  • 46
    • 0034770465 scopus 로고    scopus 로고
    • Human drug metabolism and the cytochromes P450: application and relevance of in vitro models
    • Venkatakrishnan, K., L. L. Von Moltke, and D. J. Greenblatt. 2001. Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J. Clin. Pharmacol. 41:1149–1179.
    • (2001) J. Clin. Pharmacol. , vol.41 , pp. 1149-1179
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 47
    • 84872225618 scopus 로고    scopus 로고
    • Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
    • Volak, L. P., M. J. Hanley, G. Masse, S. Hazarika, J. S. Harmatz, V. Badmaev, et al. 2013. Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Br. J. Clin. Pharmacol. 75:450–462.
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 450-462
    • Volak, L.P.1    Hanley, M.J.2    Masse, G.3    Hazarika, S.4    Harmatz, J.S.5    Badmaev, V.6
  • 48
    • 60749119589 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition and induction
    • Walsky, R. L., and S. E. Boldt. 2008. In vitro cytochrome P450 inhibition and induction. Curr. Drug Metab. 9:928–939.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 928-939
    • Walsky, R.L.1    Boldt, S.E.2
  • 49
    • 0036707618 scopus 로고    scopus 로고
    • Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes
    • Wen, Y. H., J. Sahi, E. Urda, S. Kulkarni, K. Rose, X. Zheng, et al. 2002. Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes. Drug Metab. Dispos. 30:977–984.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 977-984
    • Wen, Y.H.1    Sahi, J.2    Urda, E.3    Kulkarni, S.4    Rose, K.5    Zheng, X.6
  • 50
    • 36148955117 scopus 로고    scopus 로고
    • Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
    • Westerink, W. M., and W. G. Schoonen. 2007. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro 21:1581–1591.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1581-1591
    • Westerink, W.M.1    Schoonen, W.G.2
  • 52
    • 0035523337 scopus 로고    scopus 로고
    • Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery
    • Yan, Z., and G. W. Caldwell. 2001. Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Curr. Top. Med. Chem. 1:403–425.
    • (2001) Curr. Top. Med. Chem. , vol.1 , pp. 403-425
    • Yan, Z.1    Caldwell, G.W.2
  • 53
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
    • Zanger, U., S. Raimundo, and M. Eichelbaum. 2004. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch. Pharmacol. 369:23–37.
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol. , vol.369 , pp. 23-37
    • Zanger, U.1    Raimundo, S.2    Eichelbaum, M.3
  • 54
    • 34547733497 scopus 로고    scopus 로고
    • Identification of drugs that interact with herbs in drug development
    • Zhou, S. F., Z. W. Zhou, C. G. Li, X. Chen, X. Yu, C. C. Xue, et al. 2007. Identification of drugs that interact with herbs in drug development. Drug Discov. Today 12:664–673.
    • (2007) Drug Discov. Today , vol.12 , pp. 664-673
    • Zhou, S.F.1    Zhou, Z.W.2    Li, C.G.3    Chen, X.4    Yu, X.5    Xue, C.C.6
  • 55
    • 26944495704 scopus 로고    scopus 로고
    • High throughput P450 inhibition screens in early drug discovery
    • Zlokarnik, G., P. D. Grootenhuis, and J. B. Watson. 2005. High throughput P450 inhibition screens in early drug discovery. Drug Discov. Today 10:1443–1450.
    • (2005) Drug Discov. Today , vol.10 , pp. 1443-1450
    • Zlokarnik, G.1    Grootenhuis, P.D.2    Watson, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.