Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

Protein Engineering, Design and Selection

Volumn 28, Issue 3, 2015, Pages 67-78

  Porebski, Benjamin T ^a   Nickson, Adrian A ^b   Hoke, David E ^a   Hunter, Morag R ^c   Zhu, Liguang ^a   McGowan, Sheena ^a   Webb, Geoffrey I ^a   Buckle, Ashley M ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Consensus design; Fibronectin type III; FN3; Molecular dynamics; Stability

Indexed keywords

AVAILABILITY; CONVERGENCE OF NUMERICAL METHODS; CRYSTAL STRUCTURE; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEINS;

CONSENSUS METHODS; FIBRONECTIN TYPE III; HOMOLOGOUS PROTEINS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MECHANISM; PROTEIN STABILITY; STRUCTURAL AND DYNAMIC PROPERTIES; X RAY CRYSTAL STRUCTURES;

STABILITY;

FIBRONECTIN; FIBRONECTIN TYPE III; SODIUM CHLORIDE; UNCLASSIFIED DRUG; FIBRONECTIN TYPE III LIKE PEPTIDE, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROPHOBICITY; MELTING POINT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN UNFOLDING; STATIC ELECTRICITY; WILD TYPE; X RAY CRYSTALLOGRAPHY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; PROCEDURES; PROTEIN DENATURATION; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; THERMODYNAMICS;

CRYSTALLOGRAPHY, X-RAY; FIBRONECTINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN DENATURATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY; TEMPERATURE; THERMODYNAMICS;

EID: 84983126623     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzv002     Document Type: Article

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