Stabilization of the third fibronectin type III domain of human tenascin-C through minimal mutation and rational design

Protein Engineering, Design and Selection

Volumn 27, Issue 10, 2014, Pages 411-418

  Gilbreth, R N ^a   Chacko, B M ^a   Grinberg, L ^a   Swers, J S ^a   Baca, M ^a   Makhatadze, George ^b  

^a MEDIMMUNE   (United States)

^b NONE

Author keywords

Alternative scaffold; Disulfide engineering; Fibronectin type III; Protein stability engineering; Structure guided design

Indexed keywords

BINDING SITES; COVALENT BONDS; PROTEINS; STABILITY; SULFUR COMPOUNDS;

BINDING PROTEINS; FIBRONECTIN TYPE III; MARGINAL STABILITY; PARALLEL STRATEGIES; PROTEIN STABILITY; RATIONAL DESIGN; THERAPEUTIC APPLICATION; THERAPEUTIC MOLECULES;

SCAFFOLDS (BIOLOGY);

FIBRONECTIN; FIBRONECTIN TYPE III; TENASCIN; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DISULFIDE BOND; HUMAN; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STABILITY; STRUCTURE ANALYSIS; TEMPERATURE; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; MOLECULAR GENETICS; PROCEDURES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; FIBRONECTINS; HUMANS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TENASCIN;

EID: 84924548215     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu024     Document Type: Conference Paper

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