Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability

Journal of Molecular Biology

Volumn 302, Issue 3, 2000, Pages 713-725

  Cota, Ernesto ^a   Hamill, Stefan J ^a   Fowler, Susan B ^a   Clarke, Jane ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Guanidine isothiocyanate; Hydrogen exchange; Immunoglobulin like domains; Protein folding; Protein stability

Indexed keywords

FIBRONECTIN; TENASCIN;

ARTICLE; ENERGY; HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

EID: 0034703474     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4053     Document Type: Article

References (30)

1. Primary structure effects on peptide group hydrogen exchange
2. The Pfam protein families database
3. Comparison of different modes of 2-dimensional reverse-correlation NMR for the study of proteins
4. Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin
5. The nature of the accessible and buried surfaces in proteins
6. Hydrogen exchange and protein folding
7. Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways
8. Folding and stability of a fibronectin type III domain of human tenascin
9. Folding studies of Ig-like beta-sandwich proteins suggest they share a common folding pathway
10. Folding of beta-sandwich proteins: Three state transition of a fibronectin type III module
11. Use of a glass electrode to measure acidities in deuterium oxide
12. The effect of boundary selection on the stability and folding of the third fibronectin type III domain from human tenascin
13. Conservation of folding and stability within a protein family: The tyrosine corner as an evolutionary cul-de-sac
14. Hydrogen exchange in proteins
15. Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2
16. Molscript - A program to produce both detailed and schematic plots of protein structures
17. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein
18. 2.0 Å Crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region
19. Deuterium exchange between peptides and water
20. The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions
21. Context-dependent nature of destabilizing mutations on the stability of FKBP12
22. The role of the ninth and tenth type III domains of human fibronectin in cell adhesion
23. The dependence of chemical exchange on boundary selection in a fibronectin type III domain from human tenascin
24. An integrated kinetic analysis of intermediates and transition states in protein folding reactions
25. The folding of an enzyme. II. Substructure of barnase and the contribution of different interactions to protein stability
26. The energetics and cooperativity of protein folding: A simple experimental analysis based upon the solvation of internal residues
27. WHATIF: A molecular modelling and drug design program
28. Hydrogen isotope exchange kinetics of single protons in BPTI
29. Hydrogen exchange rates and the dynamic structure of proteins