Active barnase variants with completely random hydrophobic cores

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 11, 1996, Pages 5590-5594

  Axe, Douglas D ^a   Foster, Nicholas W ^a   Fersht, Alan R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

combinatorial mutagenesis; molecular evolution; protein design; protein evolution

Indexed keywords

RIBONUCLEASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVITY; EVOLUTION; HYDROPHOBICITY; MOLECULAR BIOLOGY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN STRUCTURE; RANDOMIZATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CODON; ESCHERICHIA COLI; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RANDOM ALLOCATION; RECOMBINANT PROTEINS; RIBONUCLEASES; VARIATION (GENETICS);

EID: 0029980972     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.11.5590     Document Type: Article

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