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Volumn 13, Issue 1, 2016, Pages

Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: A mechanistic study

Author keywords

Apoptosis; Ashwagandha; Inflammatory cytokines; Microglia; Neuroinflammation; Pro inflammatory mediators

Indexed keywords

ALPHA TUBULIN; AMYLOID BETA PROTEIN; CYCLIN D1; CYCLINE; FLUORESCEIN ISOTHIOCYANATE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MATRIX METALLOPROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; WITHANIA SOMNIFERA EXTRACT; ANTIINFLAMMATORY AGENT; CYTOKINE; HEAT SHOCK PROTEIN 72; LIPOCORTIN 5; NERVE PROTEIN; PLANT EXTRACT;

EID: 84983049664     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0650-3     Document Type: Article
Times cited : (69)

References (63)
  • 1
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76:77-98.
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 2
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11:775-87.
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 3
    • 33747494572 scopus 로고    scopus 로고
    • Microglia as a pharmacological target in infectious and inflammatory diseases of the brain
    • Rock RB, Peterson PK. Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. J Neuroimmune Pharmacol. 2006;1:117-26.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 117-126
    • Rock, R.B.1    Peterson, P.K.2
  • 4
    • 34547127632 scopus 로고    scopus 로고
    • Neuroprotective role of the innate immune system by microglia
    • Glezer I, Simard AR, Rivest S. Neuroprotective role of the innate immune system by microglia. Neuroscience. 2007;147:867-83.
    • (2007) Neuroscience , vol.147 , pp. 867-883
    • Glezer, I.1    Simard, A.R.2    Rivest, S.3
  • 5
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B, Hong JS. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharm Exp Ther. 2003;304:1-7.
    • (2003) J Pharm Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 6
    • 77954888689 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and brain inflammation: effects on microglial functions
    • Ajmone-Cat MA, Bernardo A, Greco A, Minghetti L. Non-steroidal anti-inflammatory drugs and brain inflammation: effects on microglial functions. Pharmaceuticals. 2010;3:1949-65.
    • (2010) Pharmaceuticals , vol.3 , pp. 1949-1965
    • Ajmone-Cat, M.A.1    Bernardo, A.2    Greco, A.3    Minghetti, L.4
  • 7
    • 0035107442 scopus 로고    scopus 로고
    • Neuroprotective effects of non steroidal anti inflammatory drugs by direct scavenging of nitric oxide radicals
    • Asanuma M, Nishibayashi Asanuma S, Miyazaki I, Kohno M, Ogawa N. Neuroprotective effects of non steroidal anti inflammatory drugs by direct scavenging of nitric oxide radicals. J Neurochem. 2001;76:1895-904.
    • (2001) J Neurochem , vol.76 , pp. 1895-1904
    • Asanuma, M.1    Nishibayashi Asanuma, S.2    Miyazaki, I.3    Kohno, M.4    Ogawa, N.5
  • 8
    • 79952167196 scopus 로고    scopus 로고
    • Inhibitors of microglial neurotoxicity: focus on natural products
    • Choi DK, Koppula S, Suk K. Inhibitors of microglial neurotoxicity: focus on natural products. Molecules. 2011;16:1021-43.
    • (2011) Molecules , vol.16 , pp. 1021-1043
    • Choi, D.K.1    Koppula, S.2    Suk, K.3
  • 9
    • 10644230076 scopus 로고    scopus 로고
    • (-) Epigallocatechin gallate inhibits lipopolysaccharide induced microglial activation and protects against inflammation mediated dopaminergic neuronal injury
    • Li R, Huang YG, Fang D, Le WD. (-) Epigallocatechin gallate inhibits lipopolysaccharide induced microglial activation and protects against inflammation mediated dopaminergic neuronal injury. J Neurosci Res. 2004;78:723-31.
    • (2004) J Neurosci Res , vol.78 , pp. 723-731
    • Li, R.1    Huang, Y.G.2    Fang, D.3    Le, W.D.4
  • 10
    • 84907349588 scopus 로고    scopus 로고
    • Resveratrol as a protective molecule for neuroinflammation: a review of mechanisms
    • Renaud J, Martinoli MG. Resveratrol as a protective molecule for neuroinflammation: a review of mechanisms. Curr Pharm Biotechnol. 2014;15:318-29.
    • (2014) Curr Pharm Biotechnol , vol.15 , pp. 318-329
    • Renaud, J.1    Martinoli, M.G.2
  • 11
    • 84857395835 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells
    • Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y, et al. Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PloS One. 2012. doi: 10.1371/journal.pone.0032195.
    • (2012) PloS One.
    • Zhong, L.M.1    Zong, Y.2    Sun, L.3    Guo, J.Z.4    Zhang, W.5    He, Y.6
  • 12
    • 0033845752 scopus 로고    scopus 로고
    • Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review
    • Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000;5:334-46.
    • (2000) Altern Med Rev , vol.5 , pp. 334-346
    • Mishra, L.C.1    Singh, B.B.2    Dagenais, S.3
  • 13
    • 84875888319 scopus 로고    scopus 로고
    • Phytochemical and pharmacological profile of Withania somnifera Dunal: a review
    • Uddin Q, Samiulla L, Singh VK, Jamil SS. Phytochemical and pharmacological profile of Withania somnifera Dunal: a review. J Appl Pharm Sci. 2012;2:170-5.
    • (2012) J Appl Pharm Sci , vol.2 , pp. 170-175
    • Uddin, Q.1    Samiulla, L.2    Singh, V.K.3    Jamil, S.S.4
  • 14
    • 84855707051 scopus 로고    scopus 로고
    • An aqueous extract of Withania somnifera root inhibits amyloid β fibril formation in vitro
    • Kumar S, Harris RJ, Seal CJ, Okello EJ. An aqueous extract of Withania somnifera root inhibits amyloid β fibril formation in vitro. Phytother Res. 2012;26:113-7.
    • (2012) Phytother Res , vol.26 , pp. 113-117
    • Kumar, S.1    Harris, R.J.2    Seal, C.J.3    Okello, E.J.4
  • 15
    • 0034941412 scopus 로고    scopus 로고
    • Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum
    • Matsuda H, Murakami T, Kishi A, Yoshikawa M. Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg Med Chem. 2001;9:1499-507.
    • (2001) Bioorg Med Chem , vol.9 , pp. 1499-1507
    • Matsuda, H.1    Murakami, T.2    Kishi, A.3    Yoshikawa, M.4
  • 16
    • 78649785240 scopus 로고    scopus 로고
    • Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-kB activation suppression by Withania somnifera's key metabolite withaferin A
    • Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D. Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-kB activation suppression by Withania somnifera's key metabolite withaferin A. BMC Genomics. 2010;11 Suppl 4:S25.
    • (2010) BMC Genomics , vol.11 , pp. S25
    • Grover, A.1    Shandilya, A.2    Punetha, A.3    Bisaria, V.S.4    Sundar, D.5
  • 17
    • 33947530134 scopus 로고    scopus 로고
    • Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity
    • Kaileh M, Berghe WV, Heyerick A, Horion J, Piette J, Libert C, et al. Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Bio Chem. 2007;282:4253-64.
    • (2007) J Bio Chem , vol.282 , pp. 4253-4264
    • Kaileh, M.1    Berghe, W.V.2    Heyerick, A.3    Horion, J.4    Piette, J.5    Libert, C.6
  • 18
    • 84860389531 scopus 로고    scopus 로고
    • Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells
    • Min KJ, Choi K, Kwon TK. Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells. Int Immunopharmacol. 2011;11:1137-42.
    • (2011) Int Immunopharmacol , vol.11 , pp. 1137-1142
    • Min, K.J.1    Choi, K.2    Kwon, T.K.3
  • 19
    • 79953290426 scopus 로고    scopus 로고
    • Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells
    • Kataria H, Shah N, Kaul SC, Wadhwa R, Kaur G. Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells. Evid Based Complement Alternat Med. 2011. doi: 10.1093/ecam/nep188.
    • (2011) Evid Based Complement Alternat Med
    • Kataria, H.1    Shah, N.2    Kaul, S.C.3    Wadhwa, R.4    Kaur, G.5
  • 20
    • 84873142408 scopus 로고    scopus 로고
    • Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas
    • Kataria H, Wadhwa R, Kaul SC, Kaur G. Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas. PLoS One. 2013;2013:8.
    • (2013) PLoS One , vol.2013 , pp. 8
    • Kataria, H.1    Wadhwa, R.2    Kaul, S.C.3    Kaur, G.4
  • 21
    • 84937964399 scopus 로고    scopus 로고
    • Withania somnifera suppresses tumor growth of intracranial allograft of glioma cells
    • Kataria H, Kumar S, Chaudhary H, Kaur G. Withania somnifera suppresses tumor growth of intracranial allograft of glioma cells. Mol Neurobiol. 2015. doi: 10.1007/s12035-015-9320-1.
    • (2015) Mol Neurobiol
    • Kataria, H.1    Kumar, S.2    Chaudhary, H.3    Kaur, G.4
  • 22
    • 84860995536 scopus 로고    scopus 로고
    • Water extract from the leaves of Withania somnifera protects RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity
    • Kataria H, Wadhwa R, Kaul SC, Kaur G. Water extract from the leaves of Withania somnifera protects RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PloS One. 2012. doi: 10.1371/journal.pone.0037080.
    • (2012) PloS One.
    • Kataria, H.1    Wadhwa, R.2    Kaul, S.C.3    Kaur, G.4
  • 23
    • 0032167508 scopus 로고    scopus 로고
    • Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS-binding proteins
    • Amura CR, Kamei T, Ito N, Soares MJ, Morrison DC. Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS-binding proteins. J Immunol. 1998;161:2552-60.
    • (1998) J Immunol , vol.161 , pp. 2552-2560
    • Amura, C.R.1    Kamei, T.2    Ito, N.3    Soares, M.J.4    Morrison, D.C.5
  • 24
    • 84897977837 scopus 로고    scopus 로고
    • Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
    • Cai Z, Hussain MD, Yan LJ. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease. Int J Neurosci. 2014;124:307-21.
    • (2014) Int J Neurosci , vol.124 , pp. 307-321
    • Cai, Z.1    Hussain, M.D.2    Yan, L.J.3
  • 25
    • 0344013138 scopus 로고    scopus 로고
    • High yield isolation of murine microglia by mild trypsinization
    • Saura J, Tusell JM, Serratosa J. High yield isolation of murine microglia by mild trypsinization. Glia. 2003;44:183-9.
    • (2003) Glia , vol.44 , pp. 183-189
    • Saura, J.1    Tusell, J.M.2    Serratosa, J.3
  • 26
    • 0024595042 scopus 로고
    • Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
    • Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods. 1989;119:203-10.
    • (1989) J Immunol Methods , vol.119 , pp. 203-210
    • Hansen, M.B.1    Nielsen, S.E.2    Berg, K.3
  • 27
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: a confocal time lapse analysis in hippocampal slices
    • Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time lapse analysis in hippocampal slices. Glia. 2001;33:256-66.
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 28
    • 84906934110 scopus 로고    scopus 로고
    • Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
    • Gonzalez H, Elgueta D, Montoya A, Pacheco R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol. 2014;274:1-13.
    • (2014) J Neuroimmunol , vol.274 , pp. 1-13
    • Gonzalez, H.1    Elgueta, D.2    Montoya, A.3    Pacheco, R.4
  • 29
    • 0033824729 scopus 로고    scopus 로고
    • Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
    • Ohsawa K, Imai Y, Kanazawa H, Sasaki Y, Kohsaka S. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci. 2000;113:3073-84.
    • (2000) J Cell Sci , vol.113 , pp. 3073-3084
    • Ohsawa, K.1    Imai, Y.2    Kanazawa, H.3    Sasaki, Y.4    Kohsaka, S.5
  • 30
    • 80053004011 scopus 로고    scopus 로고
    • Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities
    • Chiurchiu V, Maccarrone M. Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011;15:2605-41.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2605-2641
    • Chiurchiu, V.1    Maccarrone, M.2
  • 31
    • 34548806001 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity
    • Qian L, Tan KS, Wei SJ, Wu HM, Xu Z, Wilson B, et al. Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity. J Immunol. 2007;179:1198-209.
    • (2007) J Immunol , vol.179 , pp. 1198-1209
    • Qian, L.1    Tan, K.S.2    Wei, S.J.3    Wu, H.M.4    Xu, Z.5    Wilson, B.6
  • 32
    • 0027178135 scopus 로고
    • Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
    • Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci. 1993;13:2651-61.
    • (1993) J Neurosci , vol.13 , pp. 2651-2661
    • Dawson, V.L.1    Dawson, T.M.2    Bartley, D.A.3    Uhl, G.R.4    Snyder, S.H.5
  • 33
    • 62349087989 scopus 로고    scopus 로고
    • Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease
    • RajaSankar S, Manivasagam T, Surendran S. Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease. Neurosci Lett. 2009;454:11-5.
    • (2009) Neurosci Lett , vol.454 , pp. 11-15
    • RajaSankar, S.1    Manivasagam, T.2    Surendran, S.3
  • 34
    • 14244268253 scopus 로고    scopus 로고
    • Effect of GRP75/mthsp70/PBP74/mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells
    • Liu Y, Liu W, Song XD, Zuo J. Effect of GRP75/mthsp70/PBP74/mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells. Mol Cell Biochem. 2005;268:45-51.
    • (2005) Mol Cell Biochem , vol.268 , pp. 45-51
    • Liu, Y.1    Liu, W.2    Song, X.D.3    Zuo, J.4
  • 35
    • 59149091608 scopus 로고    scopus 로고
    • Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia
    • Xu L, Voloboueva LA, Ouyang Y, Emery JF, Giffard RG. Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia. J Cereb Blood Flow Metab. 2009;29:365-74.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 365-374
    • Xu, L.1    Voloboueva, L.A.2    Ouyang, Y.3    Emery, J.F.4    Giffard, R.G.5
  • 36
    • 77950358769 scopus 로고    scopus 로고
    • LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kB
    • Dokladny K, Lobb R, Wharton W, Ma TY, Moseley PL. LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kB. Cell Stress Chaperon. 2010;15:153-63.
    • (2010) Cell Stress Chaperon , vol.15 , pp. 153-163
    • Dokladny, K.1    Lobb, R.2    Wharton, W.3    Ma, T.Y.4    Moseley, P.L.5
  • 37
    • 50849096377 scopus 로고    scopus 로고
    • Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kB: neuroprotective implications
    • Nam KN, Son MS, Park JH, Lee EH. Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kB: neuroprotective implications. Neuropharmacology. 2008;55:819-25.
    • (2008) Neuropharmacology , vol.55 , pp. 819-825
    • Nam, K.N.1    Son, M.S.2    Park, J.H.3    Lee, E.H.4
  • 38
    • 33748702290 scopus 로고    scopus 로고
    • Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    • McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, et al. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci. 2006;26:9365-75.
    • (2006) J Neurosci , vol.26 , pp. 9365-9375
    • McCoy, M.K.1    Martinez, T.N.2    Ruhn, K.A.3    Szymkowski, D.E.4    Smith, C.G.5    Botterman, B.R.6
  • 39
    • 0035134830 scopus 로고    scopus 로고
    • Inhibition of the cyclooxygenase isoenzymes COX 1 and COX 2 provide neuroprotection in the MPTP mouse model of Parkinson's disease
    • Teismann P, Ferger B. Inhibition of the cyclooxygenase isoenzymes COX 1 and COX 2 provide neuroprotection in the MPTP mouse model of Parkinson's disease. Synapse. 2001;39:167-74.
    • (2001) Synapse , vol.39 , pp. 167-174
    • Teismann, P.1    Ferger, B.2
  • 40
    • 1042278014 scopus 로고    scopus 로고
    • Role of reactive oxygen species in LPS induced production of prostaglandin E2 in microglia
    • Wang T, Qin L, Liu B, Liu Y, Wilson B, Eling TE, et al. Role of reactive oxygen species in LPS induced production of prostaglandin E2 in microglia. J Neurochem. 2004;88:939-47.
    • (2004) J Neurochem , vol.88 , pp. 939-947
    • Wang, T.1    Qin, L.2    Liu, B.3    Liu, Y.4    Wilson, B.5    Eling, T.E.6
  • 41
    • 77957028140 scopus 로고    scopus 로고
    • Microglial activation and chronic neurodegeneration
    • Lull ME, Block ML. Microglial activation and chronic neurodegeneration. Neurotherapeutics. 2010;7:354-65.
    • (2010) Neurotherapeutics , vol.7 , pp. 354-365
    • Lull, M.E.1    Block, M.L.2
  • 42
    • 0032077890 scopus 로고    scopus 로고
    • Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
    • Jeohn GH, Kong LY, Wilson B, Hudson P, Hong JS. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J Neuroimmunol. 1998;85:1-10.
    • (1998) J Neuroimmunol , vol.85 , pp. 1-10
    • Jeohn, G.H.1    Kong, L.Y.2    Wilson, B.3    Hudson, P.4    Hong, J.S.5
  • 43
    • 54949113573 scopus 로고    scopus 로고
    • Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kB in RAW 264.7 cells
    • Oh JH, Lee TJ, Park JW, Kwon TK. Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kB in RAW 264.7 cells. Eur J Pharmacol. 2008;599:11-7.
    • (2008) Eur J Pharmacol , vol.599 , pp. 11-17
    • Oh, J.H.1    Lee, T.J.2    Park, J.W.3    Kwon, T.K.4
  • 44
    • 2342515281 scopus 로고    scopus 로고
    • Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin
    • Leiro J, Arranz JA, Yanez M, Ubeira FM, Sanmartin ML, Orallo F. Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin. Int Immunopharmacol. 2004;4:763-78.
    • (2004) Int Immunopharmacol , vol.4 , pp. 763-778
    • Leiro, J.1    Arranz, J.A.2    Yanez, M.3    Ubeira, F.M.4    Sanmartin, M.L.5    Orallo, F.6
  • 45
    • 34250209146 scopus 로고    scopus 로고
    • Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV-2 microglia
    • Moon DO, Park SY, Lee KJ, Heo MS, Kim KC, Kim MO, et al. Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV-2 microglia. Int Immunopharmacol. 2007;7:1092-101.
    • (2007) Int Immunopharmacol , vol.7 , pp. 1092-1101
    • Moon, D.O.1    Park, S.Y.2    Lee, K.J.3    Heo, M.S.4    Kim, K.C.5    Kim, M.O.6
  • 46
    • 84969749893 scopus 로고    scopus 로고
    • Anti-inflammatory activity of Withania somnifera leaf extract in stainless steel implant induced inflammation in adult zebrafish
    • Sivamani S, Joseph B, Kar B. Anti-inflammatory activity of Withania somnifera leaf extract in stainless steel implant induced inflammation in adult zebrafish. J Genet Eng Biotechn. 2014;12:1-6.
    • (2014) J Genet Eng Biotechn , vol.12 , pp. 1-6
    • Sivamani, S.1    Joseph, B.2    Kar, B.3
  • 47
    • 67651171596 scopus 로고    scopus 로고
    • Inhibition of NFkappaB by the natural product Withaferin A in cellular models of cystic fibrosis inflammation
    • Maitra R, Porter MA, Huang S, Gilmour BP. Inhibition of NFkappaB by the natural product Withaferin A in cellular models of cystic fibrosis inflammation. Inflamm (Lond). 2009;6:15.
    • (2009) Inflamm (Lond) , vol.6 , pp. 15
    • Maitra, R.1    Porter, M.A.2    Huang, S.3    Gilmour, B.P.4
  • 48
    • 34347358646 scopus 로고    scopus 로고
    • JNK signalling: a possible target to prevent neurodegeneration
    • Borsello T, Forloni G. JNK signalling: a possible target to prevent neurodegeneration. Curr Pharm Des. 2007;13:1875-86.
    • (2007) Curr Pharm Des , vol.13 , pp. 1875-1886
    • Borsello, T.1    Forloni, G.2
  • 49
    • 44949125522 scopus 로고    scopus 로고
    • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
    • Jang S, Kelley KW, Johnson RW. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A. 2008;105:7534-9.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7534-7539
    • Jang, S.1    Kelley, K.W.2    Johnson, R.W.3
  • 50
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805-20.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 51
    • 4344660420 scopus 로고    scopus 로고
    • NF-kB and AP-1 connection: mechanism of NF-kB-dependent regulation of AP-1 activity
    • Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, Uwagawa T, et al. NF-kB and AP-1 connection: mechanism of NF-kB-dependent regulation of AP-1 activity. Mol Cell Biol. 2004;24:7806-19.
    • (2004) Mol Cell Biol , vol.24 , pp. 7806-7819
    • Fujioka, S.1    Niu, J.2    Schmidt, C.3    Sclabas, G.M.4    Peng, B.5    Uwagawa, T.6
  • 52
    • 1842783105 scopus 로고    scopus 로고
    • Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor. kappa. b bindings in BV2 microglial cells
    • Kang G, Kong PJ, Yuh YJ, Lim SY, Yim SV, Chun W, et al. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor. kappa. b bindings in BV2 microglial cells. J Pharmacol Sci. 2004;94:325-8.
    • (2004) J Pharmacol Sci , vol.94 , pp. 325-328
    • Kang, G.1    Kong, P.J.2    Yuh, Y.J.3    Lim, S.Y.4    Yim, S.V.5    Chun, W.6
  • 53
    • 71749101420 scopus 로고    scopus 로고
    • Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kB
    • Yang X, Du L, Tang X, Jung SY, Zheng B, Soh BY, et al. Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kB. J Neuroimmunol. 2009;216:32-8.
    • (2009) J Neuroimmunol , vol.216 , pp. 32-38
    • Yang, X.1    Du, L.2    Tang, X.3    Jung, S.Y.4    Zheng, B.5    Soh, B.Y.6
  • 54
    • 84891534157 scopus 로고    scopus 로고
    • Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-kB signaling pathway in BV-2 microglia
    • Yuan L, Wu Y, Ren X, Liu Q, Wang J, Liu X. Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-kB signaling pathway in BV-2 microglia. Mol Cell Biochem. 2014;386:153-65.
    • (2014) Mol Cell Biochem , vol.386 , pp. 153-165
    • Yuan, L.1    Wu, Y.2    Ren, X.3    Liu, Q.4    Wang, J.5    Liu, X.6
  • 55
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296:1655-7.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 56
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003;24:358-63.
    • (2003) Trends Immunol , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 57
  • 58
    • 0346120435 scopus 로고    scopus 로고
    • Seizures preferentially stimulate proliferation of radial glia like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis
    • Huttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhauser C, et al. Seizures preferentially stimulate proliferation of radial glia like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci. 2003;18:2769-78.
    • (2003) Eur J Neurosci , vol.18 , pp. 2769-2778
    • Huttmann, K.1    Sadgrove, M.2    Wallraff, A.3    Hinterkeuser, S.4    Kirchhoff, F.5    Steinhauser, C.6
  • 60
    • 0031035608 scopus 로고    scopus 로고
    • Bcl xl Specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states
    • Drache B, Diehl GE, Beyreuther K, Perlmutter LS, Konig G. Bcl xl Specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states. J Neurosci Res. 1997;47:98-108.
    • (1997) J Neurosci Res , vol.47 , pp. 98-108
    • Drache, B.1    Diehl, G.E.2    Beyreuther, K.3    Perlmutter, L.S.4    Konig, G.5
  • 61
    • 12744250300 scopus 로고    scopus 로고
    • Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia
    • Elsisi NS, Darling-Reed S, Lee EY, Oriaku ET, Soliman KF. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neurosci Lett. 2005;375:91-6.
    • (2005) Neurosci Lett , vol.375 , pp. 91-96
    • Elsisi, N.S.1    Darling-Reed, S.2    Lee, E.Y.3    Oriaku, E.T.4    Soliman, K.F.5
  • 62
    • 0036737795 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation
    • Rosenberg GA. Matrix metalloproteinases in neuroinflammation. Glia. 2002;39:279-91.
    • (2002) Glia , vol.39 , pp. 279-291
    • Rosenberg, G.A.1
  • 63
    • 84879092634 scopus 로고    scopus 로고
    • The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion
    • Lively S, Schlichter LC. The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion. J Neuroinflammation. 2013;10:1186.
    • (2013) J Neuroinflammation , vol.10 , pp. 1186
    • Lively, S.1    Schlichter, L.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.