Bcl-xl-specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states

Journal of Neuroscience Research

Volumn 47, Issue 1, 1997, Pages 98-108

  Drache, B ^a   Diehl, G E ^a   Beyreuther, K ^b   Perlmutter, L S ^a   Konig G ^a  

^a BAYER CORPORATION   (United States)

^b Zentrum F Molec Biol Heidelberg   (Germany)

Author keywords

amyloid plaque; apoptosis; astrogliosis; glia

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; HUMAN; HUMAN CELL; MICROGLIA; NERVE DEGENERATION; PRIORITY JOURNAL;

AGING; ALZHEIMER DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; GLIOSIS; HUMANS; HYBRIDOMAS; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; MICROGLIA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECOMBINANT FUSION PROTEINS;

EID: 0031035608     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19970101)47:1<98::AID-JNR11>3.0.CO;2-6     Document Type: Article

References (49)

1. Abbas AK, Lichtman AH, Pober JS (1991): "Cellular and Molecular Immunology." Philadelphia: W.B. Saunders.
2. Ames BN, Shigenaga MK, Hagen TM (1993): Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922.
3. Anderson AJ, Su JH, Cotman CW (1996): DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to the brain area, and effect of post-mortem delay. J Neurosci 16:170-1719.
4. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Núñez G, Thompson CB (1993): Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608.
5. Clarke MR, Apel IJ, Benedict MA, Eipers PG, Sumantran V, González-García M, Doedens M, Fukunaga N, Davidson B, Dick JE, Minn AJ, Boise LH, Thompson CB, Wicha M, Núñez G (1995): A recombinant bcl-xs adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc Natl Acad Sci USA 92:11024-11028.
6. Cornell-Bell AH, Finkbeiner SM, Cooper MS, Smith SJ (1990): Glutamate induces waves in cultured astrocytes: Long-range glial signaling. Science 247:470-473.
7. Davis JN, Hunnicutt EJ, Chisholm JC (1995): A mitochondrial bottleneck hypothesis of Alzheimer's disease. Mol Med Today 1:240-247.
8. Dole MG, Jasty R, Cooper MJ, Thompson CB, Núñez G, Castle VP (1995): Bcl-xl is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. Cancer Res 55:2576-2582.
9. Eng LF (1985): The glial fibrillary acidic protein (GFAP): The major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol 8:203-214.
10. Fang W, Rivard JJ, Ganser JA, LeBien TW, Nath KA, Mueller DL, Behrens TW (1995): Bcl-xl rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol 155:66-75.
11. Forloni G, Chisa R, Smiroldo S, Verga L, Salmona M, Tagliavini F, Angeretti N (1993): Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35. NeuroReport 4:523-526.
12. Frankowski H, Missotten M, Fernandez P-A, Martinou I, Michel P, Sadoul R, Martinou J-C (1995): Function and expression of the Bcl-x gene in the developing and adult nervous system. NeuroReport 6:1917-1921.
13. Garcia I, Matinou I, Tsujimoto Y, Martinou J-C (1992): Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 258:302-304.
14. Gehrmann J, Matsumoto Y, Kreutzberg GW (1995): Microglia: Intrinsic immunoeffector cell of the brain. Brain Res 20:269-287.
15. González-García M, Pérez-Ballestero R, Ding L, Duan L, Boise LH, Thompson CB, Núñez G (1994): Bcl-xl is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120:3033-3042.
16. González-García M, García I, King L, O'Shea S, Boise LH, Thompson CB, Núñez G (1995): Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci USA 92:4304-4308.
17. Gottschalk AR, Boise LH, Thompson CB, Quintáns J (1994): Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci USA 91:7350-7354.
18. Hockenbery DM, Núñez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990): Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336.
19. Hockenbery DM, Oltvai YN, Yin X-M, Milliman CL, Korsmeyer SJ (1993): Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
20. Itagaki S, McGeer PI, Akiyama H, Zhu S, Selkoe D (1989): Relationship of microglia and astrocytes to amyloid deposits of Alzheimer's disease. J Neuroimmunol 24:173-182.
21. Krajewski S, Krajewska M, Shabaik A, Wang H-G, Irie S, Fong L, Reed JC (1994): Immunohistochemical analysis of in vivo patterns of bcl-x expression. Cancer Res 54:5501-5507.
22. 4. Nature 227:680-685.
23. Li Y-P, Bushnell AF, Lee C-M, Perlmutter LS, Wong SK-F (1996): β-Amyloid induces apoptosis in human-derived neurotypic SHSY5Y cells. Brain Res (in press).
24. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993): Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90:7951-7955.
25. Martinou J-C, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot SC, Pietra C, Huarte J (1994): Overexpression of Bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030.
26. Migheli A, Cavalla P, Piva R, Giordana MT, Schiffer D (1994): Bcl-2 protein expression in aged brain and neurodegenerative diseases. NeuroReport 5:1906-1908.
27. Minn AJ, Boise LH, Thompson CB (1996): Bcl-xs antagonizes the protective effects of Bcl-xl. J Biol Chem 271:6306-6312.
28. Mirra SS, McKeel DW, Crain BJ, Hughes JP, van Belle G, Heyman A (1990): Quality assurance in the neuropathology assessment of Alzheimer's disease: A multi-center study of the consortium to establish a registry for Alzheimer's disease (CERAD). J Neuropathol Exp Neurol 49:336.
29. Mizuguchi M, Sohma O, Takashima S, Ideda K, Yamada M, Shiraiwa N, Ohta S (1996): Immunochemical and immunohistochemical localization of Bcl-x protein in the rat central nervous system. Brain Res 712:281-286.
30. Motoyama M, Wang F, Roth KA, Sawa H, Nakayama K, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY (1995): Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice. Science 267:1506-1510.
31. Müller-Hill B, Beyreuther KT (1989). Molecular biology of Alzheimer's disease. Annu Rev Biochem 58:287-307.
32. Nixon RA, Cataldo AM (1994): Free radicals, proteolysis, and the degeneration of neurons in Alzheimer's disease: How essential is the β-amyloid link? Neurobiol Aging 15:463-469.
33. O'Barr S, Schultz J, Rogers J (1996): Expression of the protooncogene bcl-2 in Alzheimer's disease brain. Neurobiol Aging 17: 131-136.
34. Oppenheim RW (1991): Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
35. Perlmutter LS, Scott SA, Chang Chui H (1991): The role of microglia in the cortical neuropathology of Alzheimer's disease. Bull Clin Neurosci 56:120-130.
36. Perlmutter LS, Bushnell AF, Li Y-P, Webster S, Wong S (1995): Evidence for DNA damage, but no apoptosis, in Alzheimer's disease. Soc Neurosci Abst 21:672.11.
37. Prehn JHM, Bindokas VP, Jordan J, Glindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ (1996): Protective effect of transforming growth-factor-beta-1 on beta-amyloid neurotoxicity in rat hippocampal-neurons. Mol Pharmacol 49:319-328.
38. Rogers J, Luber-Narod J, Styren SD, Civin WH (1988): Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9:339-349.
39. Ross RA, Spengler BA, Biedler JL (1983): Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J Natl Cancer Inst 71:741-745.
40. Sato T, Hanada M, Bodrug S, Irie S, Iwama N, Boise LH, Thompson CB, Golemis E, Jong L, Wang H-G, Reed JC (1994). Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91:9238-9242.
41. Sohma O, Mizuguchi M, Takashima S, Yamada M, Ikeda K, Ohta S (1996): High expression of bcl-x protein in the developing human cerebellar cortex. J Neurosci Res 43:175-182.
42. Su JH, Anderson AJ, Cummings BJ, Cotman CW (1994): Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 5:2529-2533.
43. Tsujimoto Y, Croce CM (1986): Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83:5214-5218.
44. Van Hoesen GW, Hyman BT, Damasio AR (1991): Entorhinal cortex pathology in Alzheimer's disease. Hippocampus 1:1-8.
45. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ (1993): Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240.
46. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271:521-525.
47. Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee M-Y (1993): Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β-amyloid or A4 peptides. Proc Natl Acad Sci USA 90:9513-9517.
48. Wunderlich D, Lee A, Fracasso R, Mierz DV, Bayney RM, Ramab-hadran TV (1992): Use of recombinant fusion proteins for generation and rapid characterization of monoclonal antibodies. J Immunol Methods 147:1-11.
49. Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, Nishimoto I (1996): Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J 15:498-509.