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20 Gottlieb, G.J., Ragaz, A., Vogel, J.V., Friedman-Kien, A., Rywlin, A.M., Weiner, E.A., Ackerman, A.B., A preliminary communication on extensively disseminated Kaposi's sarcoma in young homosexual men. Am J Dermatopathol 3 (1981), 111–114.
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23 Pyakurel, P., Pak, F., Mwakigonja, A.R., Kaaya, E., Heiden, T., Biberfeld, P., Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development. Int J Cancer 119 (2006), 1262–1267.
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26 Kaaya, E.E., Parravicini, C., Ordonez, C., Gendelman, R., Berti, E., Gallo, R.C., Biberfeld, P., Heterogeneity of spindle cells in Kaposi's sarcoma: comparison of cells in lesions and in culture. J Acquir Immune Defic Syndr Hum Retrovirol 10 (1995), 295–305.
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28
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The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen
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First study to identify the viral gene encoding KSHV LANA.
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28•• Rainbow, L., Platt, G.M., Simpson, G.R., Sarid, R., Gao, S.J., Stoiber, H., Herrington, C.S., Moore, P.S., Schulz, T.F., The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 71 (1997), 5915–5921 First study to identify the viral gene encoding KSHV LANA.
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29
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Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
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One of the first studies to show the presence of KSHV in KS spindle cells and endothelial cells lining vascular spaces of KS lesions.
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29•• Boshoff, C., Schulz, T.F., Kennedy, M.M., Graham, A.K., Fisher, C., Thomas, A., McGee, J.O., Weiss, R.A., O'Leary, J.J., Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1 (1995), 1274–1278 One of the first studies to show the presence of KSHV in KS spindle cells and endothelial cells lining vascular spaces of KS lesions.
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30
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30 Dupin, N., Fisher, C., Kellam, P., Ariad, S., Tulliez, M., Franck, N., van Marck, E., Salmon, D., Gorin, I., Escande, J.P., et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci U S A 96 (1999), 4546–4551.
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Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells
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This study showed the presence of both latent and lytic KSHV transcripts in KS spindle cells.
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31•• Staskus, K.A., Zhong, W., Gebhard, K., Herndier, B., Wang, H., Renne, R., Beneke, J., Pudney, J., Anderson, D.J., Ganem, D., et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 71 (1997), 715–719 This study showed the presence of both latent and lytic KSHV transcripts in KS spindle cells.
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Clinical study that showed the possibility to prevent KS development using anti-herpesviral drugs.
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37 Orenstein, J.M., Alkan, S., Blauvelt, A., Jeang, K.T., Weinstein, M.D., Ganem, D., Herndier, B., Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. Aids 11 (1997), F35–F45.
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