Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Jham, Bruno C ^a   Ma, Tao ^a   Hu, Jiadi ^a   Chaisuparat, Risa ^a   Friedman, Eitan R ^a   Pandolfi, Pier Paolo ^d   Schneider, Abraham ^a,c   Sodhi, Akrit ^e   Montaner, Silvia ^a,b,c  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; G PROTEIN COUPLED RECEPTOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; I KAPPA B KINASE BETA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; RAPAMYCIN; CALCIUM BINDING PROTEIN; CYTOKINE; HIF1A PROTEIN, MOUSE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TSC PROTEIN, HUMAN; VASCULOTROPIN A;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; MOUSE; NONHUMAN; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CANCER TRANSPLANTATION; CYTOLOGY; ENDOTHELIUM CELL; GENETICS; HUMAN HERPESVIRUS 8; INFLAMMATION; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; TRANSGENIC MOUSE;

HUMAN HERPESVIRUS 8;

ANIMALS; CALCIUM-BINDING PROTEINS; CYTOKINES; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; MICE; MICE, NUDE; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, G-PROTEIN-COUPLED; SARCOMA, KAPOSI; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955733739     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019103     Document Type: Article

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