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Volumn 7, Issue 26, 2016, Pages 40846-40859

The emerging roles and therapeutic potential of cyclindependent kinase 11 (CDK11) in human cancer

Author keywords

Cancer therapy; CDK11; CDKs inhibitor; Cell cycle; Therapeutic target

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 11; UNCLASSIFIED DRUG; CDK19 PROTEIN, HUMAN; PALBOCICLIB; PIPERAZINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE;

EID: 84982950022     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8519     Document Type: Article
Times cited : (56)

References (103)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D and Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144:646-674.
    • (2011) Cell. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 84942134683 scopus 로고    scopus 로고
    • Intraoperative Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer
    • Oseledchyk A and Zivanovic O. Intraoperative Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer. Oncology (Williston Park). 2015; 29.
    • (2015) Oncology (Williston Park) , pp. 29
    • Oseledchyk, A.1    Zivanovic, O.2
  • 4
    • 84955624400 scopus 로고    scopus 로고
    • Cancer-treatment-induced neurotoxicity-focus on newer treatments
    • Stone JB and DeAngelis LM. Cancer-treatment-induced neurotoxicity-focus on newer treatments. Nature reviews Clinical oncology. 2016; 13:92-105. doi: 10.1038/ nrclinonc.2015.152.
    • (2016) Nature reviews Clinical oncology. , vol.13 , pp. 92-105
    • Stone, J.B.1    DeAngelis, L.M.2
  • 5
    • 34247470836 scopus 로고    scopus 로고
    • Second generation inhibitors of BCRABL for the treatment of imatinib-resistant chronic myeloid leukaemia
    • Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A and Griffin JD. Second generation inhibitors of BCRABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nature reviews Cancer. 2007; 7:345-356.
    • (2007) Nature reviews Cancer. , vol.7 , pp. 345-356
    • Weisberg, E.1    Manley, P.W.2    Cowan-Jacob, S.W.3    Hochhaus, A.4    Griffin, J.D.5
  • 6
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman MM, Fojo T and Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature reviews Cancer. 2002; 2:48-58.
    • (2002) Nature reviews Cancer. , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 7
    • 84884139024 scopus 로고    scopus 로고
    • Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design
    • Rath SL and Senapati S. Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design. PloS one. 2013; 8: e73836.
    • (2013) PloS one. , vol.8
    • Rath, S.L.1    Senapati, S.2
  • 8
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • Lapenna S and Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009; 8:547-566.
    • (2009) Nat Rev Drug Discov. , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 9
    • 84899434901 scopus 로고    scopus 로고
    • Signaling through cyclin D-dependent kinases
    • Choi YJ and Anders L. Signaling through cyclin D-dependent kinases. Oncogene. 2014; 33:1890-1903.
    • (2014) Oncogene. , vol.33 , pp. 1890-1903
    • Choi, Y.J.1    Anders, L.2
  • 11
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol. 2006; 24:1770-1783.
    • (2006) J Clin Oncol. , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 12
    • 84940024653 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009-2014)
    • Malinkova V, Vylicil J and Krystof V. Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009-2014). Expert opinion on therapeutic patents. 2015; 25:953-970.
    • (2015) Expert opinion on therapeutic patents. , vol.25 , pp. 953-970
    • Malinkova, V.1    Vylicil, J.2    Krystof, V.3
  • 16
    • 84961684491 scopus 로고    scopus 로고
    • Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer
    • Mangini NS, Wesolowski R, Ramaswamy B, Lustberg MB and Berger MJ. Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer. The Annals of pharmacotherapy. 2015; 49:1252-60. doi: 10.1177/1060028015602273.
    • (2015) The Annals of pharmacotherapy. , vol.49 , pp. 1252-1260
    • Mangini, N.S.1    Wesolowski, R.2    Ramaswamy, B.3    Lustberg, M.B.4    Berger, M.J.5
  • 17
    • 84939181197 scopus 로고    scopus 로고
    • Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer
    • Lu J. Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer. Journal of hematology & oncology. 2015; 8:98.
    • (2015) Journal of hematology & oncology. , vol.8 , pp. 98
    • Lu, J.1
  • 19
    • 84865794821 scopus 로고    scopus 로고
    • Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation
    • Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS and Hornicek FJ. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clinical cancer research. 2012; 18:4580-4588.
    • (2012) Clinical cancer research. , vol.18 , pp. 4580-4588
    • Duan, Z.1    Zhang, J.2    Choy, E.3    Harmon, D.4    Liu, X.5    Nielsen, P.6    Mankin, H.7    Gray, N.S.8    Hornicek, F.J.9
  • 21
    • 84930224975 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth
    • Zhou Y, Han C, Li D, Yu Z, Li F, An Q, Bai H, Zhang X, Duan Z and Kan Q. Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth. Scientific reports. 2015; 5:10433.
    • (2015) Scientific reports. , vol.5 , pp. 10433
    • Zhou, Y.1    Han, C.2    Li, D.3    Yu, Z.4    Li, F.5    An, Q.6    Bai, H.7    Zhang, X.8    Duan, Z.9    Kan, Q.10
  • 24
    • 84880264045 scopus 로고    scopus 로고
    • Cdks, cyclins and CKIs: roles beyond cell cycle regulation
    • Lim S and Kaldis P. Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development. 2013; 140:3079-3093.
    • (2013) Development. , vol.140 , pp. 3079-3093
    • Lim, S.1    Kaldis, P.2
  • 26
    • 84908473540 scopus 로고    scopus 로고
    • Cyclin-dependent kinases
    • Malumbres M. Cyclin-dependent kinases. Genome biology. 2014; 15:122.
    • (2014) Genome biology. , vol.15 , pp. 122
    • Malumbres, M.1
  • 27
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. Journal of clinical oncology. 2006; 24:1770-1783.
    • (2006) Journal of clinical oncology. , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 29
    • 84905699926 scopus 로고    scopus 로고
    • Palbociclib: an evidence-based review of its potential in the treatment of breast cancer
    • Cadoo KA, Gucalp A and Traina TA. Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. Breast Cancer (Dove Med Press). 2014; 6:123-133.
    • (2014) Breast Cancer (Dove Med Press). , vol.6 , pp. 123-133
    • Cadoo, K.A.1    Gucalp, A.2    Traina, T.A.3
  • 30
    • 77956314453 scopus 로고    scopus 로고
    • CDK5 serves as a major control point in neurotransmitter release
    • Kim SH and Ryan TA. CDK5 serves as a major control point in neurotransmitter release. Neuron. 2010; 67:797-809.
    • (2010) Neuron. , vol.67 , pp. 797-809
    • Kim, S.H.1    Ryan, T.A.2
  • 31
    • 84943338852 scopus 로고    scopus 로고
    • Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease
    • Song WJ, Son MY, Lee HW, Seo H, Kim JH and Chung SH. Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease. PloS one. 2015; 10: e0136950.
    • (2015) PloS one. , vol.10
    • Song, W.J.1    Son, M.Y.2    Lee, H.W.3    Seo, H.4    Kim, J.H.5    Chung, S.H.6
  • 37
  • 38
    • 80655133995 scopus 로고    scopus 로고
    • Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells
    • Ohno S, Shibayama M, Sato M, Tokunaga A and Yoshida N. Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells. Cell Cycle. 2011; 10:3706-3713.
    • (2011) Cell Cycle. , vol.10 , pp. 3706-3713
    • Ohno, S.1    Shibayama, M.2    Sato, M.3    Tokunaga, A.4    Yoshida, N.5
  • 43
  • 47
    • 84881091080 scopus 로고    scopus 로고
    • LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway
    • Liu X, Cheng C, Shao B, Wu X, Ji Y, Lu X and Shen A. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cellular and molecular neurobiology. 2013; 33:779-787.
    • (2013) Cellular and molecular neurobiology. , vol.33 , pp. 779-787
    • Liu, X.1    Cheng, C.2    Shao, B.3    Wu, X.4    Ji, Y.5    Lu, X.6    Shen, A.7
  • 50
    • 84861111271 scopus 로고    scopus 로고
    • Cyclin dependent kinases in cancer: potential for therapeutic intervention
    • Canavese M, Santo L and Raje N. Cyclin dependent kinases in cancer: potential for therapeutic intervention. Cancer biology & therapy. 2012; 13:451-457.
    • (2012) Cancer biology & therapy. , vol.13 , pp. 451-457
    • Canavese, M.1    Santo, L.2    Raje, N.3
  • 51
    • 84905049014 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma
    • Chen TJ, Lee SW, Lin LC, Lin CY, Chang KY and Li CF. Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma. Tumour biology. 2014; 35:7209-7216.
    • (2014) Tumour biology. , vol.35 , pp. 7209-7216
    • Chen, T.J.1    Lee, S.W.2    Lin, L.C.3    Lin, C.Y.4    Chang, K.Y.5    Li, C.F.6
  • 54
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • Lapenna S and Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nature reviews Drug discovery. 2009; 8:547-566.
    • (2009) Nature reviews Drug discovery. , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 55
    • 57349170148 scopus 로고    scopus 로고
    • Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
    • Romano G and Giordano A. Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. Cell Cycle. 2008; 7:3664-3668.
    • (2008) Cell Cycle. , vol.7 , pp. 3664-3668
    • Romano, G.1    Giordano, A.2
  • 59
    • 0031763924 scopus 로고    scopus 로고
    • Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2
    • Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF and Kidd VJ. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. Genome research. 1998; 8:929-939.
    • (1998) Genome research. , vol.8 , pp. 929-939
    • Gururajan, R.1    Lahti, J.M.2    Grenet, J.3    Easton, J.4    Gruber, I.5    Ambros, P.F.6    Kidd, V.J.7
  • 64
    • 0033215243 scopus 로고    scopus 로고
    • Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases
    • Ariza ME, Broome-Powell M, Lahti JM, Kidd VJ and Nelson MA. Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases. The Journal of biological chemistry. 1999; 274:28505-28513.
    • (1999) The Journal of biological chemistry. , vol.274 , pp. 28505-28513
    • Ariza, M.E.1    Broome-Powell, M.2    Lahti, J.M.3    Kidd, V.J.4    Nelson, M.A.5
  • 65
    • 0031809282 scopus 로고    scopus 로고
    • The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo
    • Loyer P, Trembley JH, Lahti JM and Kidd VJ. The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo. Journal of cell science. 1998; 111:1495-1506.
    • (1998) Journal of cell science. , vol.111 , pp. 1495-1506
    • Loyer, P.1    Trembley, J.H.2    Lahti, J.M.3    Kidd, V.J.4
  • 66
  • 68
    • 78650940473 scopus 로고    scopus 로고
    • The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2alpha complex on splicing
    • Loyer P, Busson A, Trembley JH, Hyle J, Grenet J, Zhao W, Ribault C, Montier T, Kidd VJ and Lahti JM. The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2alpha complex on splicing. The Journal of biological chemistry. 2011; 286:147-159.
    • (2011) The Journal of biological chemistry. , vol.286 , pp. 147-159
    • Loyer, P.1    Busson, A.2    Trembley, J.H.3    Hyle, J.4    Grenet, J.5    Zhao, W.6    Ribault, C.7    Montier, T.8    Kidd, V.J.9    Lahti, J.M.10
  • 70
    • 79551619340 scopus 로고    scopus 로고
    • CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes
    • Franck N, Montembault E, Rome P, Pascal A, Cremet JY and Giet R. CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. PloS one. 2011; 6: e14600.
    • (2011) PloS one. , vol.6
    • Franck, N.1    Montembault, E.2    Rome, P.3    Pascal, A.4    Cremet, J.Y.5    Giet, R.6
  • 71
    • 33645525342 scopus 로고    scopus 로고
    • The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation
    • Petretti C, Savoian M, Montembault E, Glover DM, Prigent C and Giet R. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO reports. 2006; 7:418-424.
    • (2006) EMBO reports. , vol.7 , pp. 418-424
    • Petretti, C.1    Savoian, M.2    Montembault, E.3    Glover, D.M.4    Prigent, C.5    Giet, R.6
  • 72
    • 34547767152 scopus 로고    scopus 로고
    • CDK11(p58) is required for the maintenance of sister chromatid cohesion
    • Hu D, Valentine M, Kidd VJ and Lahti JM. CDK11(p58) is required for the maintenance of sister chromatid cohesion. Journal of cell science. 2007; 120:2424-2434.
    • (2007) Journal of cell science. , vol.120 , pp. 2424-2434
    • Hu, D.1    Valentine, M.2    Kidd, V.J.3    Lahti, J.M.4
  • 73
    • 1842609933 scopus 로고    scopus 로고
    • Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development
    • Li T, Inoue A, Lahti JM and Kidd VJ. Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Molecular and cellular biology. 2004; 24:3188-3197.
    • (2004) Molecular and cellular biology. , vol.24 , pp. 3188-3197
    • Li, T.1    Inoue, A.2    Lahti, J.M.3    Kidd, V.J.4
  • 77
    • 84906050451 scopus 로고    scopus 로고
    • CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis
    • Rakkaa T, Escude C, Giet R, Magnaghi-Jaulin L and Jaulin C. CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis. Chromosome research. 2014; 22:267-276.
    • (2014) Chromosome research. , vol.22 , pp. 267-276
    • Rakkaa, T.1    Escude, C.2    Giet, R.3    Magnaghi-Jaulin, L.4    Jaulin, C.5
  • 81
    • 0037462817 scopus 로고    scopus 로고
    • Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro
    • Trembley JH, Hu D, Slaughter CA, Lahti JM and Kidd VJ. Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro. The Journal of biological chemistry. 2003; 278:2265-2270.
    • (2003) The Journal of biological chemistry. , vol.278 , pp. 2265-2270
    • Trembley, J.H.1    Hu, D.2    Slaughter, C.A.3    Lahti, J.M.4    Kidd, V.J.5
  • 82
    • 28444451148 scopus 로고    scopus 로고
    • A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
    • Nybakken K, Vokes SA, Lin TY, McMahon AP and Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nature genetics. 2005; 37:1323-1332.
    • (2005) Nature genetics. , vol.37 , pp. 1323-1332
    • Nybakken, K.1    Vokes, S.A.2    Lin, T.Y.3    McMahon, A.P.4    Perrimon, N.5
  • 84
    • 73349124764 scopus 로고    scopus 로고
    • Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant beta-Catenin Activation in Colon Cancer
    • Naik S, Dothager RS, Marasa J, Lewis CL and Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant beta-Catenin Activation in Colon Cancer. Clinical cancer research. 2009; 15:7529-7537.
    • (2009) Clinical cancer research. , vol.15 , pp. 7529-7537
    • Naik, S.1    Dothager, R.S.2    Marasa, J.3    Lewis, C.L.4    Piwnica-Worms, D.5
  • 85
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J and Hui CC. Hedgehog signaling in development and cancer. Developmental cell. 2008; 15:801-812.
    • (2008) Developmental cell. , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 86
    • 84906875879 scopus 로고    scopus 로고
    • Roles for Hedgehog signaling in adult organ homeostasis and repair
    • Petrova R and Joyner AL. Roles for Hedgehog signaling in adult organ homeostasis and repair. Development. 2014; 141:3445-3457.
    • (2014) Development. , vol.141 , pp. 3445-3457
    • Petrova, R.1    Joyner, A.L.2
  • 87
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald BT, Tamai K and He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Developmental cell. 2009; 17:9-26.
    • (2009) Developmental cell. , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 88
    • 12344334604 scopus 로고    scopus 로고
    • Isolation and characterization of the human Cdc2L1 gene promoter
    • Kahle A, Feng Y and M AN. Isolation and characterization of the human Cdc2L1 gene promoter. Gene. 2005; 344:53-60.
    • (2005) Gene. , vol.344 , pp. 53-60
    • Kahle, A.1    Feng, Y.M.A.N.2
  • 89
    • 1842839994 scopus 로고    scopus 로고
    • Identification and characterization of the human Cdc212 gene promoter
    • Feng Y, Goulet AC and Nelson MA. Identification and characterization of the human Cdc212 gene promoter. Gene. 2004; 330:75-84.
    • (2004) Gene. , vol.330 , pp. 75-84
    • Feng, Y.1    Goulet, A.C.2    Nelson, M.A.3
  • 90
    • 0344827194 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 11(p110) activity in the absence of CK2
    • Sachs NA and Vaillancourt RR. Cyclin-dependent kinase 11(p110) activity in the absence of CK2. Biochimica et biophysica acta. 2003; 1624:98-108.
    • (2003) Biochimica et biophysica acta. , vol.1624 , pp. 98-108
    • Sachs, N.A.1    Vaillancourt, R.R.2
  • 92
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • Briscoe J and Therond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nature reviews Molecular cell biology. 2013; 14:416-429.
    • (2013) Nature reviews Molecular cell biology. , vol.14 , pp. 416-429
    • Briscoe, J.1    Therond, P.P.2
  • 93
    • 10944221728 scopus 로고    scopus 로고
    • Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90
    • Mikolajczyk M and Nelson MA. Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90. The Biochemical journal. 2004; 384:461-467.
    • (2004) The Biochemical journal. , vol.384 , pp. 461-467
    • Mikolajczyk, M.1    Nelson, M.A.2
  • 97
    • 84924243634 scopus 로고    scopus 로고
    • Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy
    • Kren BT, Unger GM, Abedin MJ, Vogel RI, Henzler CM, Ahmed K and Trembley JH. Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast cancer research. 2015; 17:19.
    • (2015) Breast cancer research. , vol.17 , pp. 19
    • Kren, B.T.1    Unger, G.M.2    Abedin, M.J.3    Vogel, R.I.4    Henzler, C.M.5    Ahmed, K.6    Trembley, J.H.7
  • 98
    • 84863012484 scopus 로고    scopus 로고
    • Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome
    • Tiedemann RE, Zhu YX, Schmidt J, Shi CX, Sereduk C, Yin H, Mousses S and Stewart AK. Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome. Cancer research. 2012; 72:757-768.
    • (2012) Cancer research. , vol.72 , pp. 757-768
    • Tiedemann, R.E.1    Zhu, Y.X.2    Schmidt, J.3    Shi, C.X.4    Sereduk, C.5    Yin, H.6    Mousses, S.7    Stewart, A.K.8
  • 100


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.