Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet radiation-treated normal human epidermal keratinocytes (NHEK)

Journal of Pineal Research

Volumn , Issue , 2016, Pages 187-197

  Kleszczyński, Konrad ^a   Zillikens, Detlef ^a   Fischer, Tobias W ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

melatonin; normal human epidermal keratinocytes; nuclear erythroid 2 related factor 2; phase 2 antioxidative enzymes; ultraviolet radiation

Indexed keywords

ADENOSINE TRIPHOSPHATE; FREE RADICAL; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MELATONIN; NADPH QUINONE DEHYDROGENASE 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRION; OXIDATIVE STRESS; PROTON TRANSPORT; ULTRAVIOLET RADIATION;

EID: 84982860365     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12338     Document Type: Article

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