The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

Autophagy

Volumn 10, Issue 5, 2014, Pages 736-749

  Lao, Yuanzhi ^a   Wan, Gang ^b   Liu, Zhenyan ^a   Wang, Xiaoyu ^a   Ruan, Ping ^c   Xu, Wei ^b   Xu, Danqing ^a,d   Xie, Weidong ^b   Zhang, Yaou ^b   Xu, Hongxi ^a   Xu, Naihan ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b TSINGHUA UNIVERSITY   (China)

^c GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^d Roche R and D Center China Ltd   (China)

Author keywords

Apoptosis; Autophagy; Cancer; Lysosome; Natural product; Oblongifolin C

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; CASPASE 3; CATHEPSIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ENZYME; OBLONGIFOLIN C; PLANT EXTRACT; SEQUESTOSOME 1; UNCLASSIFIED DRUG; TERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CALORIC RESTRICTION; CANCER CELL; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CELL CULTURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; DRUG SCREENING; ENERGY METABOLISM; ENZYME INHIBITION; FEMALE; FLUORESCENCE MICROSCOPY; GARCINIA; GARCINIA YUNNANENSIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METABOLIC STRESS; MOUSE; NONHUMAN; NUTRIENT; PH; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STARVATION; TUMOR XENOGRAFT; UTERINE CERVIX CANCER; ANIMAL; DRUG EFFECTS; FOOD; FOOD DEPRIVATION; HCT116 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; MCF 7 CELL LINE; PHYSIOLOGY; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; FOOD; FOOD DEPRIVATION; HCT116 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MICE; TERPENES; TREATMENT OUTCOME;

EID: 84899741515     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.28034     Document Type: Article

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