Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

Autophagy

Volumn 11, Issue 10, 2015, Pages 1849-1863

  Zhao, Xuejiao ^a   Fang, Yong ^a   Yang, Yang ^a   Qin, Yu ^a   Wu, Peng ^a   Wang, Ting ^a   Lai, Huiling ^a   Meng, Li ^a   Wang, Daowen ^a   Zheng, Zhihui ^b   Lu, Xinhua ^b   Zhang, Hua ^c   Gao, Qinglei ^a   Zhou, Jianfeng ^a   Ma, Ding ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b North China Pharmaceutical Corporation   (China)

^c Shanghai Pharmaceutical Holding Co Ltd   (China)

Author keywords

Antitumor; Autophagy; Cell death; Elaiophylin; Natural compound; Ovarian cancer

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 9; CATHEPSIN B; CATHEPSIN D; CHLOROQUINE; CISPLATIN; CYTOTOXIC AGENT; DIMETHYL SULFOXIDE; ELAIOPHYLIN; RAPAMYCIN; SURVIVIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MACROLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CONTROL; CANCER INHIBITION; CANCER SIZE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MEGADOSE; DRUG POTENTIATION; EMBRYO; ENDOSOME; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; LYSOSOME MEMBRANE; MOUSE; NONHUMAN; OVARY CANCER; PANETH CELL; PHENOTYPE; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; THERAPEUTIC INDEX; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; METABOLISM; OVARIAN NEOPLASMS; PATHOLOGY; PHAGOSOME; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; LYSOSOMES; MACROLIDES; MICE; OVARIAN NEOPLASMS; PHAGOSOMES;

EID: 84953860064     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1017185     Document Type: Article

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