Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: The role of apoptosis mediated by caspase-dependent and caspase-independent pathways

Integrative Cancer Therapies

Volumn 11, Issue 2, 2012, Pages 129-140

  Lu, Kung Wen ^a   Chen, Jung Chou ^a   Lai, Tung Yuan ^a,b   Yang, Jai Sing ^b   Weng, Shu Wen ^a   Ma, Yi Shih ^a   Lin, Hui Yi ^a   Wu, Rick Sai Chuan ^b   Wu, King Chuen ^b   Wood, W Gibson ^c   Chung, Jing Gung ^a,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c UNIVERSITY OF MINNESOTA   (United States)

^d ASIA UNIVERSITY   (Taiwan)

Author keywords

caspase cascade; caspase independent; gypenosides; human oral cancer SAS cells; murine xenograft model; traditional Chinese medicine

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DOXORUBICIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GYPENOSIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CANCER MODEL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRUCTURE; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MOUTH CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CALCIUM; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; G0 PHASE; G1 PHASE; GYNOSTEMMA; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MOUTH NEOPLASMS; PLANT EXTRACTS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84862023146     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735411403306     Document Type: Article

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