Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 31, 2016, Pages 8705-8710

  Leung, Isabel ^a   Dekel, Ayelet ^b   Shifman, Julia M ^b   Sidhu, Sachdev S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; UBIQUITIN; UBIQUITIN SPECIFIC PROTEASE 2; UBIQUITIN SPECIFIC PROTEASE 21; UNCLASSIFIED DRUG; PROTEIN BINDING; PROTEINASE; UBIQUITIN THIOLESTERASE; USP2 PROTEIN, HUMAN; USP21 PROTEIN, HUMAN;

BACTERIOPHAGE; BINDING SITE; COMBINATORIAL LIBRARY; CONFERENCE PAPER; ENZYME ACTIVE SITE; IC50; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; POSITION WEIGHT MATRIX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; ENDOPEPTIDASES; EPITOPES; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; PROTEIN DOMAINS; SEQUENCE HOMOLOGY, AMINO ACID; UBIQUITIN; UBIQUITIN THIOLESTERASE;

EID: 84982683735     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524648113     Document Type: Article

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