Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 13, 2016, Pages 3527-3532

  Gorelik, Maryna ^a,b   Orlicky, Stephen ^c   Sartori, Maria A ^a,b   Tang, Xiaojing ^c   Marcon, Edyta ^a,b   Kurinov, Igor ^d   Greenblatt, Jack F ^a,b   Tyers, Mike ^c,e   Moffat, Jason ^a,b   Sicheri, Frank ^b,c   Sidhu, Sachdev S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d Université de Montréal ^*  (United States)

^e INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Cul1 affinity; Fbxw11; Fbxw7; SCF inhibitors; Trcp

Indexed keywords

CUL1 PROTEIN; CYCLIN E; DIMER; F BOX PROTEIN; FBW11 PROTEIN; FBW7 PROTEIN; MONOMER; MULTIPROTEIN COMPLEX; MYC PROTEIN; PROTEIN INHIBITOR; PROTEIN VARIANT; SKP1 PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UBIQUITIN VARIANT INHIBITOR; UNCLASSIFIED DRUG; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CELL CYCLE PROTEIN; CULLIN; CULLIN 1; ENZYME INHIBITOR; F BOX/WD REPEAT CONTAINING PROTEIN 7; FBXW11 PROTEIN, HUMAN; FBXW7 PROTEIN, HUMAN; UBIQUITIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; EC50; ENZYME INHIBITION; IC50; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; UBIQUITINATION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; GENETIC VARIATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; PEPTIDE LIBRARY; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; BINDING SITES; CELL CYCLE PROTEINS; CULLIN PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; F-BOX PROTEINS; F-BOX-WD REPEAT-CONTAINING PROTEIN 7; GENETIC VARIATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE HOMOLOGY, AMINO ACID; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 84962110911     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519389113     Document Type: Article

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