miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Wang, Han ^a   Sun, Zhongyang ^a,b   Wang, Yixuan ^a   Hu, Zebing ^a   Zhou, Hua ^a   Zhang, Lianchang ^a   Hong, Bo ^a   Zhang, Shu ^a   Cao, Xinsheng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b No 454 Hospital of PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; HIGH MOBILITY GROUP A2 PROTEIN; MICRORNA; MIRN33 MICRORNA, MOUSE;

3' UNTRANSLATED REGION; ANIMAL; BINDING SITE; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; GENETICS; MECHANOTRANSDUCTION; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PHYSIOLOGY; RNA INTERFERENCE; WEIGHTLESSNESS;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; HMGA2 PROTEIN; MECHANOTRANSDUCTION, CELLULAR; MICE; MICRORNAS; OSTEOBLASTS; RNA INTERFERENCE; WEIGHTLESSNESS SIMULATION;

EID: 84982091074     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23170     Document Type: Article

References (69)

1. Kim, D. S., Jung, S. M., Yoon, G. H., Lee, H. C., & Shin, H. S. Development of a complex bone tissue culture system based on cellulose nanowhisker mechanical strain. Colloid Surface B. 123, 838-844 (2014
2. Yang M., et al. The role of integrin-beta/FAK in cyclic mechanical stimulation in MG-63 cells. Int J Clin Exp Pathol. 7, 7451-7459 (2014
3. Saito, M., Soshi, S., & Fujii, K. Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts. J Bone Miner Res. 18, 1695-1705 (2003
4. Aisha, M. D., Nor-Ashikin, M. N., Sharaniza, A. B., Nawawi, H., & Froemming, G. R. Orbital fluid shear stress promotes osteoblast metabolism, proliferation and alkaline phosphates activity in vitro. Exp Cell Res. 1, 87-93 (2015
5. Fushiki R., et al. High-magnitude mechanical strain inhibits the differentiation of bone-forming rat calvarial progenitor cells. Connect Tissue Res. 56, 336-341 (2015
6. Li P., et al. Fluid flow-induced calcium response in osteoclasts: signaling pathways. Ann Biomed Eng. 42, 1250-1260 (2014
7. Kido S., et al. Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone. 45, 1125-1132 (2009
8. Mousavi, S. J., & Doweidar, M. H. Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model. PLoS One. 10, e124529 (2015
9. Zeng, Q., et al. Integrin-beta1, not integrin-beta5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain. Biol Res. 48, 25 (2015
10. Basso, N., & Heersche, J. N. Characteristics of in Vitro Osteoblastic Cell Loading Models. Bone. 2, 347-51 (2002
11. Mehrotra, M., Saegusa, M., Voznesensky, O., & Pilbeam, C. Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts. Biochem Biophys Res Commun. 341, 1225-1230 (2006
12. Kido S., et al. Mechanical stress activates Smad pathway through PKCdelta to enhance interleukin-11 gene transcription in osteoblasts. PLoS One. 5, e13090 (2010
13. Landis, W. J., Hodgens, K. J., Block, D., Toma, C. D., & Gerstenfeld, L. C. Spaceflight effects on cultured embryonic chick bone cells. J Bone Miner Res. 15, 1099-1112 (2000
14. Ontiveros, C., & McCabe, L. R. Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation. J Cell Biochem. 88, 427-437 (2003
15. Uddin, S. M., & Qin, Y. X. Enhancement of osteogenic differentiation and proliferation in human mesenchymal stem cells by a modified low intensity ultrasound stimulation under simulated microgravity. PLoS One. 8, e73914 (2013
16. Boehrs, J., Zaharias, R. S., Laffoon, J., Ko, Y. J., & Schneider, G. B. Three-dimensional culture environments enhance osteoblast differentiation. J Prosthodont. 17, 517-521 (2008
17. Fernandez-Hernando, C., Suarez, Y., Rayner, K. J., & Moore, K. J. MicroRNAs in lipid metabolism. Curr Opin Lipidol. 22, 86-92 (2011
18. Najafi-Shoushtari, S. H. MicroRNAs in cardiometabolic disease. Curr Atheroscler Rep. 13, 202-207 (2011
19. Zhang Y., et al. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 287, 21926-21935 (2012
20. Hassan M. Q., et al. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 287, 42084-42092 (2012
21. Liu, X. D., Cai, F., Liu, L., Zhang, Y., & Yang, A. L. MicroRNA-210 is involved in the regulation of postmenopausal osteoporosis through promotion of VEGF expression and osteoblast differentiation. Biol Chem. 396, 339-347 (2015
22. Mai Z. H., et al. miRNA expression profile during fluid shear stress-induced osteogenic differentiation in MC3T3-E1 cells. Chin Med J (Engl). 126, 1544-1550 (2013
23. Zuo B., et al. microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2. J Bone Miner Res. 30, 330-345 (2015
24. Cao, Y., Lv, Q., & Lv, C. MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II. Int J Mol Med. 3, 760-766 (2015
25. Sun Z., et al. Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1osteoblasts. Sci. Rep. 5, 8077 (2015
26. Sun Z., et al. MiR-103 inhibits osteoblast proliferation mainly through suppressing Cav1.2 expression in simulated microgravity. Bone. 76, 121-128 (2015
27. Wu, J., & Wei, J. J. HMGA2 and high-grade serous ovarian carcinoma. J Mol Med (Berl). 91, 1155-1165 (2013
28. Brady, R. T., O'Brien, F. J., & Hoey, D. A. Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation. Biochem Biophys Res Commun. 459, 118-123 (2015
29. Soves C. P., et al. Megakaryocytes are mechanically responsive and influence osteoblast proliferation and differentiation. Bone. 66, 111-120 (2014
30. Gong, X., Yang, W., Wang, L., Duncan, R. L., & Pan, J. Prostaglandin E2 modulates F-actin stress fiber in FSS-stimulated MC3T3-E1 cells in a PKA-dependent manner. Acta Biochim Biophys Sin (Shanghai). 46, 40-47 (2014
31. Qi, L., & Zhang, Y. The microRNA 132 regulates fluid shear stress-induced differentiation in periodontal ligament cells through mTOR signaling pathway. Cell Physiol Biochem. 33, 433-445 (2014
32. Norvell, S. M., Alvarez, M., Bidwell, J. P., & Pavalko, F. M. Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int. 75, 396-404 (2004
33. Broderick K. E., et al. Guanosine 3' ,5' -cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol. 21, 1148-1162 (2007
34. Wang X., et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 19, 93-100 (2013
35. Carmeliet, G., Nys, G., Stockmans, I., & Bouillon, R. Gene expression related to the differentiation of osteoblastic cells is altered by microgravity. Bone. 22, 139S-143S (1998
36. Hu, L. F., Li, J. B., Qian, A. R., Wang, F., & Shang, P. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biol Int. 39, 364-372 (2015
37. Sun L., et al. Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. J Spinal Cord Med. 36, 616-622 (2013
38. Zheng Q., et al. Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways? Biol Chem. 388, 755-763 (2007
39. Weber, M. J. New human and mouse microRNA genes found by homology search. FEBS J. 272, 59-73 (2005
40. Chiang H. R., et al. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 24, 992-1009 (2010
41. Bredenkamp, N., Seoighe, C., & Illing, N. Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. Dev Genes Evol. 217, 227-233 (2007
42. Najafi-Shoushtari S. H., et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 328, 1566-1569 (2010
43. Horie T., et al. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci USA. 107, 17321-17326 (2010
44. Rayner, K. J., et al. Fernandez-Hernando, C. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 328, 1570-1573 (2010
45. Marquart, T. J., Allen, R. M., Ory, D. S., & Baldan, A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA. 107, 12228-12232 (2010
46. Gerin I., et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem. 285, 33652-33661 (2010
47. Rayner K. J., et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 478, 404-407 (2011
48. Marquart T. J., et al. Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptordeficient mice. Arterioscler Thromb Vasc Biol. 33, 455-458 (2013
49. Rotllan N., et al. Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice-brief report. Arterioscler Thromb Vasc Biol. 33, 1973-1977 (2013
50. Goedeke L., et al. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 6, 1133-1141 (2014
51. Rayner K. J., et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 121, 2921-2931 (2011
52. Wald A., et al. Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. Head Neck. 33, 504-512 (2011
53. Perbellini R., et al. Dysregulation and cellular mislocalization of specific miRNAs in myotonic dystrophy type 1. Neuromuscul Disord. 21, 81-88 (2011
54. Zhou J., et al. miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1alpha. Cancer Biol Ther. 16, 846-855 (2015
55. Rottiers V., et al. MicroRNAs in metabolism and metabolic diseases. Cold Spring Harb Symp Quant Biol. 76, 225-233 (2011
56. Horie T., et al. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice. J Am Heart Assoc. 1, e3376 (2012
57. Herrera-Merchan A., et al. miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle. 9, 3277-3285 (2010
58. Ho P. C., et al. Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J. 25, 1758-1766 (2011
59. Rice S. J., et al. MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). J Biol Chem. 23, 16348-16360 (2013
60. Lin, Y., et al. MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Sci. Rep. 5, 9995 (2015
61. Fedele M., et al. HMGA2: A pituitary tumour subtype-specific oncogene? Mol Cell Endocrinol. 326, 19-24 (2010
62. Hammond S. M., et al.HMGA2, microRNAs, and stem cell aging. Cell. 135, 1013-1016 2008
63. Ashar H. R., et al. In vivo modulation of HMGA2 expression. Biochim Biophys Acta. 1799, 55-61 (2010
64. Ligon A., et al. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet. 76, 340-348 (2005
65. Sanna S., et al. Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet. 40, 198-203 (2008
66. Kuipers A., et al. Association of a high mobility group gene (HMGA2) variant with bone mineral density. Bone. 45, 295-300 (2009
67. Wei J., et al. let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2. Stem Cells Dev. 13, 1452-1463 (2014
68. Wang B., et al. Focal adhesion kinase signaling pathway is involved in mechanotransduction in MG-63 cells. Biochem Biophys Res Commun. 410, 671-676 (2011
69. Ban Y., et al. Response of osteoblasts to low fluid shear stress is time dependent. Tissue Cell. 43, 311-317 (2011