Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation

Biochemical and Biophysical Research Communications

Volumn 459, Issue 1, 2015, Pages 118-123

  Brady, Robert T ^a,b,c   O'Brien, Fergal J ^a,b   Hoey, David A ^b,c  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Differentiation; Fluid flow; Mesenchymal stem cell; Migration; Osteocyte; Paracrine signalling

Indexed keywords

ANIMAL CELL; ARTICLE; BONE CELL; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCYTE; OSTEOPROGENITOR CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; BONE; CELL LINE; CHEMOTAXIS; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; PHARMACOLOGY; PHYSIOLOGY; STIMULATION;

CULTURE MEDIUM;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMOTAXIS; CULTURE MEDIA, CONDITIONED; MESENCHYMAL STROMAL CELLS; MICE; OSTEOBLASTS; OSTEOCYTES; OSTEOGENESIS; PHYSICAL STIMULATION;

EID: 84930179413     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.080     Document Type: Article

References (32)

1. A. Modi, S. Sajjan, and S. Gandhi Challenges in implementing and maintaining osteoporosis therapy Int. J. Womens Health. 6 2014 759 769 10.2147/IJWH.S53489 eCollection 2014
2. S. Aggarwal, and Nityanand Calcium and vitamin D in post menopausal women Indian J. Endocrinol. Metab. 17 Suppl 3 2013 S618 S620 10.4103/2230-8210.123549
3. R. Baron, and E. Hesse Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives J. Clin. Endocrinol. Metab. 97 2 2012 311 325
4. S. Nakamura, and S. Tanaka Biological therapy for osteoporosis Clin. Calcium. 24 6 2014 919 925 doi CliCa1406919925
5. D. Park Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration Cell. Stem Cell. 10 3 2012 259 272 10.1016/j.stem.2012.02.003
6. B. Zhou Leptin-receptor-expressing mesenchymal stromal cells Represent the Main Source of bone Formed by Adult bone marrow Cell. Stem Cell. 18 14 2014 00256 00262
7. D. Corral Dissociation between bone resorption and bone formation in osteopenic transgenic mice Proc. Natl. Acad. Sci. U. S. A. 95 23 1998 13835 13840
8. D.L. Worthley Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential Cell 160 1-2 2015 269 284
9. E. Burger, and J. Klein-Nulend Mechanotransduction in bone-role of the lacuno-canalicular network Faseb J. 13 Suppl 1999 S101 S112
10. C.H. Turner Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine Bone 22 5 1998 463 469
11. M. Schaffler Osteocytes: master orchestrators of bone Calcif. Tissue Int. 94 1 2014 5 24 10.1007/s00223-013-9790-y Epub 2013 Sep. 17
12. S. Tatsumi Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction Cell. Metab. 5 6 2007 464 475
13. L. Bonewald The amazing osteocyte J. Bone Min. Res. 26 2 2011 229 238 10.1002/jbmr.320
14. S. Dallas, M. Prideaux, and L. Bonewald The osteocyte: an Endocrine cell and More Endocr. Rev. 26 2013 26
15. P. Govey, A. Loiselle, and H. Donahue Biophysical regulation of stem cell differentiation Curr. Osteoporos. Rep. 11 2 2013 83 91 10.1007/s11914-013-0138-3
16. A. Taylor Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions Am. J. Physiol. Cell. Physiol. 292 1 2007 C545 C552 Epub 2006 Aug 2
17. L. You Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading Bone 42 1 2008 172 179 Epub 2007 Sep. 26
18. S.D. Tan Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption Bone 41 5 2007 745 751
19. E. Birmingham Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche Eur. Cell. Mater. 23 2012 13 27
20. D. Hoey, D. Kelly, and C. Jacobs A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells Biochem. Biophys. Res. Commun. 412 1 2011 182 187 10.1016/j.bbrc.2011.07.072 Epub 2011 Jul 23
21. R.Y. Kwon Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation PLoS One 7 3 2012 e33336
22. M. Jaasma, and F. O'Brien Mechanical stimulation of osteoblasts using steady and dynamic fluid flow Tissue Eng. Part a. 14 7 2008 1213 1223 10.1089/tea.2007.0321
23. K. Matsuo, and N. Irie Osteoclast-osteoblast communication Arch. Biochem. Biophys. 473 2 2008 201 209
24. G. Galea, and J. Price Four-point bending protocols to study the effects of dynamic strain in osteoblastic cells in vitro Methods Mol. Biol. 1226 2015 117 130 10.1007/978-1-4939-1619-1-10
25. X. Zhou Quantifying fluid shear stress in a rocking culture dish J. Biomech. 43 8 2010 1598 1602 10.1016/j.jbiomech.2009.12.028 Epub 2010 Feb 24
26. D. Hoey Primary cilia-mediated mechanotransduction in human mesenchymal stem cells Stem Cells. 30 11 2012 2561 2570 10.1002/stem.1235
27. C. Turner Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine Bone 22 5 1998 463 469
28. T. Heino, T. Hentunen, and H. Vaananen Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts Exp. Cell. Res. 294 2 2004 458 468
29. M. Schaffler, and O. Kennedy Osteocyte signaling in bone Curr. Osteoporos. Rep. 10 2 2012 118 125 10.1007/s11914-012-0105-4
30. S. Woo Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo J. Bone Min. Res. 26 11 2011 2634 2646 10.1002/jbmr.465
31. S. Mohan, and D. Baylink Bone growth factors Clin. Orthop. Relat. Res. 263 1991 30 48
32. B. MacDonald, and M. Gowen The cell biology of bone Baillieres Clin. Rheumatol. 7 3 1993 421 443