Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation

Bone

Volumn 45, Issue 6, 2009, Pages 1125-1132

  Kido, Shinsuke ^a   Kuriwaka Kido, Rika ^a   Imamura, Takeshi ^b   Ito, Yuji ^a   Inoue, Daisuke ^a   Matsumoto, Toshio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

Activator protein (AP) 1; Fluid shear stress (FSS); Interleukin (IL) 11; Mechanical stress; Osteoblast differentiation

Indexed keywords

CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DICKKOPF 2 PROTEIN; GLYCOPROTEIN; INTERLEUKIN 11; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN ANTIBODY; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR JUND; UNCLASSIFIED DRUG; WNT PROTEIN;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; IN VITRO STUDY; MECHANICAL STRESS; MOUSE; NONHUMAN; OSTEOBLAST; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WILD TYPE;

ADIPOGENESIS; ANIMALS; BETA CATENIN; CALCIUM; CELL DIFFERENTIATION; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-11; MAP KINASE SIGNALING SYSTEM; MICE; OSTEOBLASTS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; RHEOLOGY; STRESS, MECHANICAL; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; WEIGHT-BEARING; WNT PROTEINS;

EID: 70350215880     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.07.087     Document Type: Article

References (33)

1. Watanabe Y., Ohshima H., Mizuno K., Sekiguchi C., Fukunaga M., Kohri K., et al. Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed rest. J. Bone Miner. Res. 19 (2004) 1771-1778
2. Morey E.R., and Baylink D.J. Inhibition of bone formation during space flight. Science 201 (1978) 1138-1141
3. Inoue M., Tanaka H., Moriwake T., Oka M., Sekiguchi C., and Seino Y. Altered biochemical markers of bone turnover in humans during 120 days of bed rest. Bone 26 (2000) 281-286
4. Lean J.M., Mackay A.G., Chow J.W., and Chambers T.J. Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus. Am. J. Physiol. 270 (1996) E937-E945
5. Grigoriadis A.E., Schellander K., Wang Z.Q., and Wagner E.F. Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122 (1993) 685-701
6. Inoue D., Kido S., and Matsumoto T. Transcriptional induction of FosB/DFosB gene by mechanical stress in osteoblasts. J. Biol. Chem. 279 (2004) 49795-49803
7. Mumberg D., Lucibello F.C., Schuermann M., and Muller R. Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins. Genes Dev. 5 (1991) 1212-1223
8. Yen J., Wisdom R.M., Tratner I., and Verma I.M. An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 5077-5081
9. Nakabeppu Y., and Nathans D. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. Cell 64 (1991) 751-759
10. Sabatakos G., Sims N.A., Chen J., Aoki K., Kelz M.B., Amling M., et al. Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat. Med. 6 (2000) 985-990
11. Brown J.R., Ye H., Bronson R.T., Dikkes P., and Greenberg M.E. A defect in nurturing in mice lacking the immediate early gene fosB. Cell 86 (1996) 297-309
12. Gruda M.C., van Amsterdam J., Rizzo C.A., Durham S.K., Lira S., and Bravo R. Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene 12 (1996) 2177-2185
13. Keller D.C., Du X.X., Srour E.F., Hoffman R., and Williams D.A. Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures. Blood 82 (1993) 1428-1435
14. Du X., and Williams D.A. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 89 (1997) 3897-3908
15. Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., et al. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett. 283 (1991) 199-202
16. Kodama Y., Takeuchi Y., Suzawa M., Fukumoto S., Murayama H., Yamato H., et al. Reduced expression of interleukin-11 in bone marrow stromal cells of senescence-accelerated mice (SAMP6): relationship to osteopenia with enhanced adipogenesis. J. Bone Miner. Res. 13 (1998) 1370-1377
17. Tohjima E., Inoue D., Yamamoto N., Kido S., Ito Y., Kato S., et al. Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice. J. Bone Miner. Res. 18 (2003) 1461-1470
18. Takeuchi Y., Watanabe S., Ishii G., Takeda S., Nakayama K., Fukumoto S., et al. Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J. Biol. Chem. 277 (2002) 49011-49018
19. Moon R.T., Bowerman B., Boutros M., and Perrimon N. The promise and perils of Wnt signaling through β-catenin. Science 296 (2002) 1644-1646
20. Wehrli M., Dougan S.T., Caldwell K., O'Keefe L., Schwartz S., Vaizel-Ohayon D., et al. arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407 (2000) 527-530
21. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 (2001) 513-523
22. Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346 (2002) 1513-1521
23. Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osborne M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70 (2002) 11-19
24. Van Wesenbeeck L., Cleiren E., Gram J., Beals R.K., Benichou O., Scopelliti D., et al. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am. J. Hum. Genet. 72 (2003) 763-771
25. Babij P., Zhao W., Small C., Kharode Y., Yaworsky P.J., Bouxsein M.L., et al. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18 (2003) 960-974
26. Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass II D.A., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157 (2002) 303-314
27. Robinson J.A., Chatterjee-Kishore M., Yaworsky P.J., Cullen D.M., Zhao W., Li C., et al. Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone. J. Biol. Chem. 281 (2006) 31720-31728
28. Sakai K., Mohtai M., Shida J., Harimaya K., Benvenuti S., Brandi M.L., et al. Fluid shear stress increases interleukin-11 expression in human osteoblast-like cells: its role in osteoclast induction. J. Bone Miner. Res. 14 (1999) 2089-2098
29. Weinbaum S., Cowin S.C., and Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 27 (1994) 339-360
30. Ito Y., Inoue D., Kido S., and Matsumoto T. c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors. Bone 37 (2005) 842-849
31. Hens J.R., Wilson K.M., Dann P., Chen X., Horowitz M.C., and Wysolmerski J.J. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J. Bone Miner. Res. 20 (2005) 1103-1113
32. Suga K., Saitoh M., Fukushima S., Takahashi K., Nara H., Yasuda S., et al. Interleukin-11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein-2 in C3H10T1/2 cells. J. Interferon Cytokine Res. 21 (2001) 695-707
33. Robling A.G., Niziolek P.J., Baldridge L.A., Condon K.W., Allen M.R., Alam I., et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J. Biol. Chem. 283 (2008) 5866-5875