Association of a high mobility group gene (HMGA2) variant with bone mineral density

Bone

Volumn 45, Issue 2, 2009, Pages 295-300

  Kuipers, Allison ^a   Zhang, Yingze ^b   Cauley, Jane A ^a   Nestlerode, Cara S ^a   Chu, Yanxia ^b   Bunker, Clareann H ^a   Patrick, Alan L ^c   Wheeler, Victor W ^c   Hoffman, Andrew R ^d   Orwoll, Eric S ^e   Zmuda, Joseph M ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Tobago Health Studies Office   (Trinidad and Tobago)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

BMD; Genetics; HMGA2; Men; Osteoporosis; Race

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; MESSENGER RNA;

ADULT; AFRICAN CARIBBEAN; AGED; ARTICLE; BODY HEIGHT; BONE DENSITY; BONE METABOLISM; COHORT ANALYSIS; CONTROLLED STUDY; EUROPEAN AMERICAN; FETUS; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MALE; METABOLIC REGULATION; NORMAL HUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RACE DIFFERENCE; TRABECULAR BONE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; ANTHROPOMETRY; BONE AND BONES; BONE DENSITY; CARIBBEAN REGION; CELL LINE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE EXPRESSION REGULATION; HMGA2 PROTEIN; HUMANS; MALE; MIDDLE AGED; OSTEOBLASTS; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 67649652034     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.04.197     Document Type: Article

References (24)

1. Zhou X., and Chada K. HMGI family protein: architectural transcription factors in mammalian development and cancer. Keio J. Med. 47 (1998) 73-77
2. Reeves R. Structure and function of the HMGI(Y) family of architectural transcription factors. Environ. Health Perspect. 108 (2000) 803-809
3. Noro B., Licheri B., Sgarra R., Rustighi A., Tessari M.A., Chau K.Y., et al. Molecular dissection of the architectural transcription factor HMGA2. Biochemistry 42 (2003) 4569-4577
4. Goodwin G. Molecules in focus: the high mobility group protein, HMGI-C. Int. J. Biochem. Cell Biol. 30 (1998) 761-766
5. Berg J.P. Pygmy mouse gene mutation protects against obesity. Euro. J. Endocrinol. 143 (2000) 317-318
6. Ruyter-Spira C.P., de Groof A.C., van der Poel J.J., Herbergs J., Masabanda J., Fries R., and Groenen M.M. The HMGI-C gene is a likely candidate for the autosomal dwarf locus in the chicken. J. Hered. 89 (1998) 295-300
7. Ligon A.H., Moore S.D.P., Parisi M.A., Mealiffe M.E., Harris D.J., Ferguson H.L., et al. Constitutional Rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am. J. Hum. Genet. 76 (2005) 340-348
8. Weedon M., Lettre G., Freathy R., Lindgren C., Voight B., Perry J., et al., The Diabetes Genetics Initiative, The Wellcome Trust Case Control Consortium. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat. Genet. 39 (2007) 1245-1250
9. Sanna S., Jackson A.U., Nagaraja R., Willer C.J., Chen W.M., Bonnycastle L., et al. Common variants in the GDF-UQCC region are associated with variation in human height. Nat. Genet. 40 (2008) 198-203
10. Johnson T., Bergmann S., Beckmann J.S., Vollenweider P., Waterworth D.M., Mooser V., et al., Cambridge GEM Cosortium, Diabetes Genetics Initiative, The Wellcome Trust Case Control Consortium. Genome-wide association analysis identifies 20 loci that influence adult height. Nat. Genet. 40 (2008) 575-583
11. Hill D.D., Cauley J.A., Sheu Y., Bunker C.H., Patrick A.L., Baker C.E., et al. Correlates of bone mineral density in men of African ancestry: the Tobago bone health study. Osteoporos. Int. 19 (2008) 227-234
12. Orwoll E., Blank J.B., Barrett-Connor E., Cauley J., Cummings S., Ensrud K., et al. Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study - A large observational study of the determinants of fracture in older men. Contemp. Clin. Trials 26 (2005) 569-585
13. Blank J.B., Cawthon P.M., Carrion-Petersen M.L., Harper L., Johnson J.P., Mitson E., et al. Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp. Clin. Trials 26 (2005) 557-568
14. Pollitzer W.S., and Anderson J.J.B. Ethnic and genetic differences in bone mass: a review with a hereditary vs environmental perspective. Am. J. Clin. Nutr. 50 (1989) 1244-1259
15. Battista S., Fidanza V., Fedele M., Klein-Szanto A.J.P., Outwater E., Brunner H., et al. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 59 (1999) 4793-4797
16. Gattas G.J., Quade B.J., Nowak R.A., and Morton C.C. HMGIC expression in human adult and fetal tissues and in uterine leiomyomata. Genes Chromosomes Cancer 25 (1999) 316-320
17. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277 (2001) 63-81
18. Narita M., Narita M., Krizhanovsky V., Nuñez S., Chicas A., Hearn S.A., et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126 (2006) 503-514
19. Thuault S., Valcourt U., Petersen M., Manfioletti G., Heldin C.H., and Moustakas A. Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J. Cell Biol. 174 (2006) 175-183
20. Kubo T., Matsui Y., Goto T., Yukata K., and Yasui N. Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. Biochem. Biophys. Res. Commun. 340 (2006) 476-481
21. Richter A, Hauschild G, Escobar HM, Nolte I, Bullerdiek J. Application of High-Mobility- Group-A proteins increases the proliferative activity of chondrocytes in vitro Tissue Eng Part A. Published online August 23, 2008; doi:10.1089/ten.tea.2007.0308.
22. Borrmann L., Wilkening S., and Bullerdiek J. The expression of HMGA genes is regulated by their 3′ UTR. Oncogene 20 (2001) 4537-4541
23. Lee Y.S., and Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 Oncogene. Genes Dev. 21 (2007) 1025-1030
24. Chen J.M., Férec C., and Cooper D.N. A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants. Hum. Genet. 120 (2006) 301-333