Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts

Journal of Bone and Mineral Research

Volumn 18, Issue 9, 2003, Pages 1695-1705

  Saito, Mitsuru ^a   Soshi, Shigeru ^a   Fujii, Katsuyuki ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Collagen; Cross links; Hypergravity; Lysine hydroxylation; Microgravity

Indexed keywords

COLLAGEN; DEOXYPYRIDINOLINE; DIHYDROXYLYSINONORLEUCINE; ENZYME; HELICAL LYSYL HYDROXYLASE; HYDROXYLYSINONORLEUCINE; ISOENZYME; LYSINE; LYSINONORLEUCINE; MESSENGER RNA; NORLEUCINE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE 2; PROTEIN LYSINE 6 OXIDASE; PYRIDINOLINE; TELOPEPTIDYL LYSYL HYDROXYLASE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL STRAIN MC3T3 E1; CENTRIFUGATION; COLLAGEN METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION; GRAVITY; HYDROXYLATION; ISOTOPE LABELING; MICROGRAVITY; NONHUMAN; OSTEOBLAST; OSTEOPENIA; POLYMERASE CHAIN REACTION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PROCESSING; SPACE FLIGHT;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; COLLAGEN; COLLAGEN TYPE I; CROSS-LINKING REAGENTS; DNA; GRAVITATION; MICE; OSTEOBLASTS; PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-LYSINE 6-OXIDASE; WEIGHTLESSNESS SIMULATION;

EID: 0041475921     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.9.1695     Document Type: Article

References (60)

1. Morey-Holton ER, Whalen RT, Arnaud SB, van der Meulen MC 1996 The skeleton and its adaptation to gravity. In: Fregly MJ, Blatteis CM (eds.) Handbook of Physiology: Environmental Physiology, vol. 1. Oxford University Press, New York, NY, USA, pp. 691-720.
2. Biewener AA, Bertran JEA 1993 Mechanical loading and bone growth in vivo. In: Hall BK (ed.) Bone Growth-B, vol. 7. CRC Press, Boca Raton, FL, USA, pp. 1-36.
3. Burger EH, Veldhuijzen JP 1993 Influence of mechanical factors on bone formation, resorption, and growth in vitro. In: Hall BK (ed.) Bone Growth-B, vol. 7. CRC Press, Boca Raton, FL, USA, pp. 37-56.
4. Jee WSS, Frost HM 1992 Skeletal adaptations during growth. Triangle 31:77-88.
5. Lanyon LE 1992 Control of architecture by functional load bearing. J Bone Miner Res 7:S369-S375.
6. Morey ER, Baylink DJ 1978 Inhibition of bone formation during space flight, Science 201:1138-1141.
7. Jee WSS, Wronski TJ, Morey ER, Kimmel DB 1983 Effects of spaceflight on trabecular bone in rats. Am J Physiol 244:R310-R314.
8. Vico L, Alexandre C 1992 Microgravity and bone adaptation at the tissue level. J Bone Miner Res 7:S445-S447.
9. Vico L, Chappard D, Alexandre C, Palle S, Minaire P, Riffat G, Novikov VE, Backulum AV 1987 Effects of weightlessness on bone mass and osteoclast number in pregnant rats after a five-day spaceflight (COSMOS 1514). Bone 8:95-103.
10. Sarkar D, Nagaya T, Koga K, Nomura Y, Gruener R, Seo H 2000 Culture in vector-averaged gravity under clinostat rotation results in apoptosis of osteoblastic ROS 17/2.8 cells. J Bone Miner Res 15:489-498.
11. Carmeliet G, Nys G, Bouillon R 1997 Microgravity reduces the differentiation of human osteoblastic MG-63 cells. J Bone Miner Res 12:786-793.
12. Westerlind KC, Turner RT 1995 The skeletal effects of spaceflight in growing rats: Tissue-specific alterations in mRNA levels for TGF-beta. J Bone Miner Res 10:843-848.
13. Carmeliet G, Nys G, Stockmans I, Bouillon R 1998 Gene expression related to differentiation of osteoblastic cells is altered by microgravity. Bone 22:139S-143S.
14. Misawa M, Kozawa O, Tokuda H, Kawakubo A, Yoneda M, Oiso Y, Takatsuki K 1991 Effects of hypergravity on proliferation and differentiation of osteoblast-like cells. Bone Miner 14:15-25.
15. Guignandon A, Usson Y, Laroche N, Lafage-Proust MH, Sabido O, Alexandre C, Vico L 1997 Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: Quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells. Exp Cell Res 236:66-75.
16. Fitzgerald J, Hughes-Fulford M 1996 Gravitational loading of a simulated launch alters mRNA expression in osteoblasts. Exp Cell Res 228:168-171.
17. Oxlund H, Brackman M, Ortoff G, Andreassen TT 1995 Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone 17(Suppl):365S-371S.
18. Saito M, Marumo K, Fujii K, Ishioka N 1997 Single-column high-performance liquid chromatographic-fluorescence detection of immature, mature, and senescent cross-links of collagen. Anal Biochem 253:26-32.
19. Bailey AJ, Wotton SF, Sims TJ, Thompson PW 1993 Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res 29:119-132.
20. Masse PG, Rimnac CM, Yamauchi M, Coburn SP, Rucker RB, Howell DS, Boskey AL 1996 Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone 18:567-574.
21. Mechanic GL, Katz EP, Henmi M, Noyes C, Yamauchi M 1987 Locus of a histidine-based, stable trifunctional, helix to helix collagen cross-link: Stereospecific collagen structure of type I skin fibrils. Biochemistry 26:3500-3509.
22. Yamauchi M, Chandler GS, Tanzawa H, Katz EP 1996 Cross-linking and the molecular packing of comeal collagen. Biochem Biophys Res Commun 219:311-315.
23. Brinckmann J, Acil Y, Tronnier M, Notbohm H, Batge B, Schmeller W, Koch MH, Muller PK, Wolff HH 1996 Altered x-ray diffraction pattern is accompanied by a change in the mode of cross-link formation in lipodermatosclerosis. J Invest Dermatol 107:589-592.
24. Yamauchi M, Katz EP 1993 The post-translational chemistry and molecular packing of mineralizing tendon collagens. Connect Tissue Res 29:81-98.
25. Eyre DR, Paz A, Gallop PM 1984 Cross-linking in collagen and elastin. Annu Rev Biochem 53:717-748.
26. Reiser K, McCrormick RJ, Rucker RB 1992 Enzymatic and non-enzymatic cross-linking of collagen and elastin. FASEB J 6:2439-2449.
27. Robins SP 1982 Analysis of the crosslinking components in collagen and elastin. Methods Biochem Anal 28:329-379.
28. Bank RA, Robins SP, Wijmenga C, Breslau-Siderius LJ, Bardoel AF, van der Sluijs HA, Pruijs HE, TeKoppele JM 1999 Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: Indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17. Proc Natl Acad Sci USA 96:1054-1058.
29. Knott L, Bailey AJ 1998 Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance. Bone 22:181-187.
30. Ichigi J, Asashima M 2001 Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity. In Vitro Cell Dev Biol Anim 37:31-44.
31. Hosen T, Kamisaka S, Buchen B, Sievers A, Yamashita M, Masuda Y 1996 Possible use of a 3-D clinostat to analyze plant growth processes under microgravity conditions. Adv Space Res 17:47-53.
32. Labarca C, Paigen K 1980 A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352.
33. Kind PRN, King EJ 1954 Estimation of Plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol 7:322-326.
34. Matsumoto T, Kawakami M, Kuribayashi K, Takanaka T, Minamide A, Tamaki T 1999 Effects of sintered bovine bone on cell proliferation, collagen synthesis, and osteoblastic expression in MC3T3-E1 osteoblast-like cells. J Orthop Res 17:586-592.
35. Svinarich DM, Twomey TA, Macauley SP, Krebs CJ, Yang TP, Krawetz SA 1992 Characterization of the human lysyl oxidase gene locus. J Biol Chem 267:14382-14387.
36. Eyre DR, Koob TJ, Van Ness KP 1984 Quantification of hydroxypyridinium crosslinks in collagen by High-Performance Liquid Chromatography. Anal Biochem 137:380-388.
37. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG, Brenner DA, Yamauchi M 1999 Differential expression of human lysyl hydroxylase genes, lysyl hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J Bone Miner Res 14:1272-1280.
38. Rubin AL, Drake MP, Davison PE, Pfahl D, Speakman PT, Schmitt FO 1965 Effect of pepsin treatment on the interaction properties of tropocollagen macromolecules. Biochemistry 4:181-190.
39. Lehmann HW, Bado M, Frohn C, Nerlich A, Rimek D, Notbohm H, Muller PK 1992 Lysyl hydroxylation in collagens from hyperplastic callus and embryonic bones. Biochem J 282:313-318.
40. Siegel RC 1974 Biosynthesis of collagen cross-links: Increased activity of purified lysyl oxidase with reconstituted collagen fibrils. Proc Nat Acad Sci USA 71:4826-4830.
41. Uzel MI, Shih SD, Gross H, Kessler E, Gerstenfeld LC, Trackman PC 2000 Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones. J Bone Miner Res 15:1189-1197.
42. Miller RL 1972 Rapid assay for lysyl-protocollagen hydroxylase activity. Anal Biochem 45:202-210.
43. Robinson RJ, Doty SB, Cooper RR 1973 Electron microscopy of mammalian bone. In: Zipkin I (ed.) Biological Mineralization. Academic Press. New York, NY, USA, pp. 257-296.
44. Kawashima K, Shibata R, Negishi R, Endo H 1998 Stimulative effect of high-level hypergravity on differentiated functions of osteoblast-like cells. Cell Struct Function 23:221-229.
45. Turner RT, Bell NH, Duvall P, Bobyn JD, Spector M, Holton EM, Baylink DJ 1985 Spaceflight results in formation of defective bone. Proc Soc Exp Biol Med 180:544-549.
46. Vailas AC, Zernicke RF, Grindeland RE, Kaplansky A, Durnova GN, Li KC, Martinez DA 1990 Effect of spaceflight on rat humerus geometry, biomechanics, and biochemistry. FASEB J 4:47-54.
47. Wronski TJ, Morey ER 1983 Effect of spaceflight on periosteal bone formation in rats. Am J Physiol 244:R305-R309.
48. Vico L, Chappard D, Palle S, Bakulin AV, Novicov VE, Alexandre C 1988 Trabecular bone remodeling after seven days of weightlessness exposure (BIOCOSMOS 1667). Am J Physiol 255:R243-R247.
49. Nakajima T 1991 Effect of hypergravity on migration proliferation and function of mouse osteoblastic cell line MC3T3-E1. J Stomatology Soc Japan 58:529-544.
50. Hughes-Fulford M, Lewis ML 1996 Effect of microgravity on osteoblast growth activation. Exp Cell Res 224:103-109.
51. Gerstenfeld LC, Chipman SD, Kelly CM, Hodgens KJ, Lee DD, Landis WJ 1988 Collagen expression, ultrastructural assembly, and mineralization in cultures of chicken embryo osteoblasts. J Cell Biol 106:979-989.
52. Kuboki Y, Kudo A, Mizuno M, Kawamura M 1992 Time-dependent changes of collagen cross-links and their precursors in the culture of osteogenic cells. Calcif Tissue Int 50:473-480.
53. 2. Am J Respir Cell Mol Biol 11:751-755.
54. Feres-Filho EJ, Choi YJ, Han X, Takala TE, Trackman PC 1995 Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells. J Biol Chem 270:30797-30803.
55. Burger EH, Klein-Nulend J 1998 Microgravity and bone cell mechanosensitivity. Bone 22:127S-130S.
56. Eyre DR 1981 Cross-links maturation of bone collagen. Dev Biochem 22:51-55.
57. Eyre DR, Oguchi H 1980 Hydroxypyridinium cross-links of skeletal collagens: Their measurement, properties and proposed pathway of formation. Biochem Biophys Res Commun 92:403-410.
58. Robins SP, Duncan A 1983 Cross-linking of collagen. Location of pyridinoline in bovine articular cartilage at two sites of molecule. Biochem J 215:175-182.
59. Saito M 1999 Age-related changes in biochemical characteristics of collagen from human weight-bearing and non-weight-bearing bone. Tokyo Jikeikai Med J 114:327-337.
60. Royce PM, Barnes MJ 1985 Failure of highly purified lysyl hydroxylase to hydroxylate lysyl residues in the non-helical regions of collagen. Biochem J 230:475-480.