Oligomers of amyloid prevent physiological activation of the cellular prion protein-metabotropic glutamate receptor 5 complex by glutamate in Alzheimer disease

Journal of Biological Chemistry

Volumn 291, Issue 33, 2016, Pages 17112-17121

  Haas, Laura T ^a   Strittmatter, Stephen M ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; CHEMICAL ACTIVATION; ENZYME ACTIVITY; ENZYMES; NEURODEGENERATIVE DISEASES; OLIGOMERS; PHYSIOLOGY; PLANTS (BOTANY);

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II; CELLULAR PRION PROTEINS; INTRACELLULAR PROTEINS; INTRACELLULAR STORES; METABOTROPIC GLUTAMATE RECEPTORS; PROTEIN TYROSINE KINASE; PROTEIN-PROTEIN INTERACTIONS; SYNAPTIC RECEPTORS;

PROTEINS;

AMYLOID BETA PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; FOCAL ADHESION KINASE 2; GLUTAMIC ACID; METABOTROPIC RECEPTOR 5; PRION PROTEIN; PROTEIN KINASE FYN; AMYLOID BETA-PROTEIN (1-42); GRM5 PROTEIN, MOUSE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; PROTEINOSIS; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GLUTAMIC ACID; MALE; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PROTEIN AGGREGATION, PATHOLOGICAL; PRPC PROTEINS; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84981322942     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.720664     Document Type: Article

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