메뉴 건너뛰기




Volumn 4, Issue 1, 2016, Pages

Blood brain barrier: An overview on strategies in drug delivery, realistic in vitro modeling and in vivo live tracking

Author keywords

blood brain barrier (BBB); brain on a chip; central nervous system; nanocarrier; strategies; tight junction

Indexed keywords

ANGIOPOIETIN; BONE MORPHOGENETIC PROTEIN; CELL PENETRATING PEPTIDE; CLAUDIN 5; CONANTOKIN G; DENDROTOXIN; G PROTEIN COUPLED RECEPTOR; INSULIN; LECTIN; LIPOPROTEIN; LYSOPHOSPHATIDIC ACID; NEUROPILIN 1; RETINAL DEHYDROGENASE; SEMAPHORIN; SONIC HEDGEHOG PROTEIN; SUPEROXIDE DISMUTASE; TAMOXIFEN; TETANUS TOXIN; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; DRUG CARRIER;

EID: 84981273787     PISSN: 21688362     EISSN: 21688370     Source Type: Journal    
DOI: 10.1080/21688370.2015.1129476     Document Type: Review
Times cited : (92)

References (148)
  • 1
    • 0025218499 scopus 로고
    • Development of blood–brain barrier
    • 1693235
    • W.Risau, H.Wolburg,. Development of blood–brain barrier. Trends Neurosci 1990; 13:174-78; PMID:1693235; http://dx.doi.org/10.1016/0166-2236(90)90043-A
    • (1990) Trends Neurosci , vol.13 , pp. 174-178
    • Risau, W.1    Wolburg, H.2
  • 2
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood–brain barrier
    • N.J.Abbott, I.A.Romero. Transporting therapeutics across the blood–brain barrier. Mol Med Today 1996; 2:106-13
    • (1996) Mol Med Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 3
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte–endothelial interactions and blood–brain barrier permeability
    • 12162730
    • N.J.Abbott. Astrocyte–endothelial interactions and blood–brain barrier permeability. J Anat 2002; 200:629-638; PMID:12162730; http://dx.doi.org/10.1046/j.1469-7580.2002.00064.x
    • (2002) J Anat , vol.200 , pp. 629-638
    • Abbott, N.J.1
  • 4
    • 0141620181 scopus 로고    scopus 로고
    • Structural and functional aspects of the blood–brain barrier
    • D.J.Begley, M.W.Brightman. Structural and functional aspects of the blood–brain barrier. Prog Drug Res 2003; 61:40-78
    • (2003) Prog Drug Res , vol.61 , pp. 40-78
    • Begley, D.J.1    Brightman, M.W.2
  • 5
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood–brain barrier: development, composition and regulation
    • H.Wolburg, A.Lippoldt. Tight junctions of the blood–brain barrier: development, composition and regulation. Vasc Pharmacol 2002; 38:323-37; http://dx.doi.org/10.1016/S1537-1891(02)00200-8
    • (2002) Vasc Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 6
    • 22944483792 scopus 로고    scopus 로고
    • The blood–brain barrier/ neurovascular unit in health and disease
    • 15914466
    • B.T.Hawkins, T.P.Davis. The blood–brain barrier/ neurovascular unit in health and disease. Pharmacol Rev 2005; 57:173-85; PMID:15914466; http://dx.doi.org/10.1124/pr.57.2.4
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 7
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specific assemblyand differentiation of CNS vasculature
    • 19023080
    • J.M.Stenman, J.Rajagopal, T.J.Carroll, M.Ishibashi, J.McMahon, A.P.McMa-hon. Canonical Wnt signaling regulates organ-specific assemblyand differentiation of CNS vasculature. Science 2008; 322:1247-50; PMID:19023080; http://dx.doi.org/10.1126/science.1164594
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3    Ishibashi, M.4    McMahon, J.5    McMa-hon, A.P.6
  • 9
    • 58849119932 scopus 로고    scopus 로고
    • Wnt/b-cateninsignaling is required for CNS, but not non-CNS, angiogenesis
    • R.Daneman, D.Agalliu, L.Zhou, F.Kuhnert, C.J.Kuo, B.A.Barres. Wnt/b-cateninsignaling is required for CNS, but not non-CNS, angiogenesis. Proc Nat Acad Sci USA 2009; 106:641-6; http://dx.doi.org/10.1073/pnas.0805165106
    • (2009) Proc Nat Acad Sci USA , vol.106 , pp. 641-646
    • Daneman, R.1    Agalliu, D.2    Zhou, L.3    Kuhnert, F.4    Kuo, C.J.5    Barres, B.A.6
  • 11
    • 84870897220 scopus 로고    scopus 로고
    • Norrin/Frizzled4 signaling in retinal vascular development and bloodbrain barrier plasticity
    • 23217714
    • Y.Wang, A.Rattner, Y.Zhou, J.Williams, P.M.Smallwood, J.Nathans. Norrin/Frizzled4 signaling in retinal vascular development and bloodbrain barrier plasticity. Cell 2012; 151:1332-44; PMID:23217714; http://dx.doi.org/10.1016/j.cell.2012.10.042
    • (2012) Cell , vol.151 , pp. 1332-1344
    • Wang, Y.1    Rattner, A.2    Zhou, Y.3    Williams, J.4    Smallwood, P.M.5    Nathans, J.6
  • 12
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood–brain barrier
    • A.Ben-Zvi, B.Lacoste, E.Kur, B.J.Andreone, Y.Mayshar, H.Yan, C.Gu. Mfsd2a is critical for the formation and function of the blood–brain barrier. Nature 2014; 22:507-11; http://dx.doi.org/10.1038/nature13324
    • (2014) Nature , vol.22 , pp. 507-511
    • Ben-Zvi, A.1    Lacoste, B.2    Kur, E.3    Andreone, B.J.4    Mayshar, Y.5    Yan, H.6    Gu, C.7
  • 13
    • 84940758944 scopus 로고    scopus 로고
    • Neurosurgical techniques for disruption of the blood–brain barrier for glioblastoma treatment
    • 26247958
    • A.Rodriguez, S.B.Tatter, W.Debinski. Neurosurgical techniques for disruption of the blood–brain barrier for glioblastoma treatment. Pharmaceutics 2015; 7:175-87; PMID:26247958; http://dx.doi.org/10.3390/pharmaceutics7030175
    • (2015) Pharmaceutics , vol.7 , pp. 175-187
    • Rodriguez, A.1    Tatter, S.B.2    Debinski, W.3
  • 14
  • 15
    • 84894433066 scopus 로고    scopus 로고
    • AngII-mediated BBB disruption in hypertension
    • 24343120
    • V.C.Biancardi, S.J.Son, S.Ahmadi, J.A.Filosa, J.E.Stern. AngII-mediated BBB disruption in hypertension. Hypertension 2014; 63:572-79; PMID:24343120; http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01743
    • (2014) Hypertension , vol.63 , pp. 572-579
    • Biancardi, V.C.1    Son, S.J.2    Ahmadi, S.3    Filosa, J.A.4    Stern, J.E.5
  • 16
    • 84946179288 scopus 로고    scopus 로고
    • Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via Vitamin D receptor-mediated NF-kB signaling pathways
    • S.Won, I.Sayeed, B.L.Peterson, B.Wali, J.S.Kahn, D.G.Stein. Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via Vitamin D receptor-mediated NF-kB signaling pathways. Plos One 2015; 10:1-17
    • (2015) Plos One , vol.10 , pp. 1-17
    • Won, S.1    Sayeed, I.2    Peterson, B.L.3    Wali, B.4    Kahn, J.S.5    Stein, D.G.6
  • 17
    • 84895190755 scopus 로고    scopus 로고
    • Cell-specific blood–brain barrier regulation in health and disease: a focus on hypoxia
    • S.Engelhardt, S.Patkar, O.O.Ogunshola. Cell-specific blood–brain barrier regulation in health and disease: a focus on hypoxia. Br J Pharmaco 2014; 171:1210-30; http://dx.doi.org/10.1111/bph.12489
    • (2014) Br J Pharmaco , vol.171 , pp. 1210-1230
    • Engelhardt, S.1    Patkar, S.2    Ogunshola, O.O.3
  • 18
    • 84874596863 scopus 로고    scopus 로고
    • Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1
    • M.P.H.Schreurs, C.A.Hubel, I.M.Bernstein, A.Jeyabalan, M.J.Cipolla. Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1. FASEB J 2012; 27:1254-63; http://dx.doi.org/10.1096/fj.12-222216
    • (2012) FASEB J , vol.27 , pp. 1254-1263
    • Schreurs, M.P.H.1    Hubel, C.A.2    Bernstein, I.M.3    Jeyabalan, A.4    Cipolla, M.J.5
  • 19
    • 84893771234 scopus 로고    scopus 로고
    • J. Nanoparticles and blood-brain barrier: the key to central nervous system diseases
    • A.Domínguez, B.Suárez-Merino, F.G.de-Cerio. J. Nanoparticles and blood-brain barrier: the key to central nervous system diseases. Nanosci Nanotechnol 2014; 14: 766-79; http://dx.doi.org/10.1166/jnn.2014.9119
    • (2014) Nanosci Nanotechnol , vol.14 , pp. 766-779
    • Domínguez, A.1    Suárez-Merino, B.2    de-Cerio, F.G.3
  • 20
    • 84959463237 scopus 로고    scopus 로고
    • Intranasal gene delivery for treating Parkinson's disease: overcoming the blood–brain barrier
    • 26289676
    • A.E.-E.Aly, B.L.Waszczak. Intranasal gene delivery for treating Parkinson's disease: overcoming the blood–brain barrier. Expert Opin Drug Deliv 2015; 12:1-19; PMID:26289676; http://dx.doi.org/10.1517/17425247.2015.1069815
    • (2015) Expert Opin Drug Deliv , vol.12 , pp. 1-19
    • Aly, A.E.-E.1    Waszczak, B.L.2
  • 21
    • 84897451667 scopus 로고    scopus 로고
    • Transporters at CNS barrier sites: obstacles or opportunities for drug delivery
    • 23789948
    • L.S.Covarrubias, L.M.Slosky, B.J.Thompson, T.P.Davis, P.T.Ronaldson. Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des 2014; 20:1422-49; PMID:23789948; http://dx.doi.org/10.2174/13816128113199990463
    • (2014) Curr Pharm Des , vol.20 , pp. 1422-1449
    • Covarrubias, L.S.1    Slosky, L.M.2    Thompson, B.J.3    Davis, T.P.4    Ronaldson, P.T.5
  • 23
    • 84900023528 scopus 로고    scopus 로고
    • In vitro models of the blood−brain barrier for the study of drug delivery to the brain
    • I.Wilhelm, I.A.Krizbai. In vitro models of the blood−brain barrier for the study of drug delivery to the brain. Mol Pharm 2014; 11:1949-63; http://dx.doi.org/10.1021/mp500046f
    • (2014) Mol Pharm , vol.11 , pp. 1949-1963
    • Wilhelm, I.1    Krizbai, I.A.2
  • 24
    • 77954921880 scopus 로고    scopus 로고
    • A model for transport studies of the blood–brain barrier
    • 20419434
    • D.J.Bobilya. A model for transport studies of the blood–brain barrier. Methods Mol Biol 2010; 637:149-63; PMID:20419434; http://dx.doi.org/10.1007/978-1-60761-700-6_8
    • (2010) Methods Mol Biol , vol.637 , pp. 149-163
    • Bobilya, D.J.1
  • 26
    • 84876536636 scopus 로고    scopus 로고
    • Noninvasive and targeted drug delivery to the brain using focused ultrasound
    • 23379618
    • A.Burgess, K.Hynynen. Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS Chem Neurosci 2013; 4:519−26; PMID:23379618; http://dx.doi.org/10.1021/cn300191b
    • (2013) ACS Chem Neurosci , vol.4 , pp. 519−26
    • Burgess, A.1    Hynynen, K.2
  • 27
    • 84925440506 scopus 로고    scopus 로고
    • Reelin expression in brain endothelial cells: an electron microscopy study
    • 25655275
    • E.P.Costas, E.Y.Fenton, H.J.Caruncho. Reelin expression in brain endothelial cells: an electron microscopy study. BMC Neurosci 2015; 16:1-8; PMID:25655275; http://dx.doi.org/10.1186/s12868-015-0140-z
    • (2015) BMC Neurosci , vol.16 , pp. 1-8
    • Costas, E.P.1    Fenton, E.Y.2    Caruncho, H.J.3
  • 29
    • 84886505477 scopus 로고    scopus 로고
    • Multimodality molecular imaging of stem cells therapy for stroke
    • F.Chao, Y.Shen, H.Zhang, M.Tian. Multimodality molecular imaging of stem cells therapy for stroke. Bio Med Res Int 2013; 2013:1-16
    • (2013) Bio Med Res Int , vol.2013 , pp. 1-16
    • Chao, F.1    Shen, Y.2    Zhang, H.3    Tian, M.4
  • 30
    • 84856164075 scopus 로고    scopus 로고
    • Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier
    • 22148835
    • H.Yan, L.Wang, J.Wang, X.Weng, H.Lei, X.Wang, L.Jiang, J.Zhu, W.Lu, X.Wei, C.Li. Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier. ACS Nano 2012; 6:410-420; PMID:22148835; http://dx.doi.org/10.1021/nn203749v
    • (2012) ACS Nano , vol.6 , pp. 410-420
    • Yan, H.1    Wang, L.2    Wang, J.3    Weng, X.4    Lei, H.5    Wang, X.6    Jiang, L.7    Zhu, J.8    Lu, W.9    Wei, X.10    Li, C.11
  • 31
    • 84925959180 scopus 로고    scopus 로고
    • Triheptanoin improves brain energy metabolism in patients with Huntington disease
    • 25568297
    • I.M.Adanyeguh, D.Rinaldi, P.G.Henry, S.Caillet, R.Valabregue, A.Durr, F.Mochel. Triheptanoin improves brain energy metabolism in patients with Huntington disease. Neurology 2015; 84:490-5; PMID:25568297; http://dx.doi.org/10.1212/WNL.0000000000001214
    • (2015) Neurology , vol.84 , pp. 490-495
    • Adanyeguh, I.M.1    Rinaldi, D.2    Henry, P.G.3    Caillet, S.4    Valabregue, R.5    Durr, A.6    Mochel, F.7
  • 32
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood–brain barrier characteristics in invading endothelial cells: a study using quail–chick transplantation chimeras
    • P.A.Stewart, M.J.Wiley. Developing nervous tissue induces formation of blood–brain barrier characteristics in invading endothelial cells: a study using quail–chick transplantation chimeras. Dev Bio 1981; 84:183-92; http://dx.doi.org/10.1016/0012-1606(81)90382-1
    • (1981) Dev Bio , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 33
    • 0014402361 scopus 로고
    • Blood–brain barrier to albumin in embryonic new born and adult rats
    • 5707962
    • Y.Olsson, I.Klatzo, P.Sourander, O.Steinwall. Blood–brain barrier to albumin in embryonic new born and adult rats. Acta Neuropathol 1968; 10:117-22; PMID:5707962; http://dx.doi.org/10.1007/BF00691305
    • (1968) Acta Neuropathol , vol.10 , pp. 117-122
    • Olsson, Y.1    Klatzo, I.2    Sourander, P.3    Steinwall, O.4
  • 34
    • 0021360279 scopus 로고
    • Evidence for the effectiveness of the blood–CSFbarrier in the fetal rat choroid plexus. A freeze-fracture and peroxidase diffusion study
    • 6701893
    • M.Tauc, X.Vignon, C.Bouchaud. Evidence for the effectiveness of the blood–CSFbarrier in the fetal rat choroid plexus. A freeze-fracture and peroxidase diffusion study. Tissue Cell 1984; 16:65-74; PMID:6701893; http://dx.doi.org/10.1016/0040-8166(84)90019-3
    • (1984) Tissue Cell , vol.16 , pp. 65-74
    • Tauc, M.1    Vignon, X.2    Bouchaud, C.3
  • 35
    • 8244225207 scopus 로고
    • Development of the blood–brain barrier to macromolecules
    • London: Macmillan Press
    • N.R.Saunders. Development of the blood–brain barrier to macromolecules. In: M.B.Segal, ed. Barriers fluids eye brain. London: Macmillan Press; 1992.
    • (1992) Barriers fluids eye brain
    • Saunders, N.R.1    Segal, M.B.2
  • 36
    • 0027222651 scopus 로고
    • Cerebrovascular permeability to azo dyes and plasma proteins in rodents of different ages
    • 8316332
    • T.Moos, K.Møllgård. Cerebrovascular permeability to azo dyes and plasma proteins in rodents of different ages. Neuropathol Appl Neurobiol 1993; 19:120-7; PMID:8316332; http://dx.doi.org/10.1111/j.1365-2990.1993.tb00416.x
    • (1993) Neuropathol Appl Neurobiol , vol.19 , pp. 120-127
    • Moos, T.1    Møllgård, K.2
  • 37
    • 0028846054 scopus 로고
    • Developmental changes in blood–brainbarrier potassium permeability in the rat: relation to brain growth
    • 8568682
    • R.F.Keep, S.R.Ennis, M.E.Beer, A.L.Betz. Developmental changes in blood–brainbarrier potassium permeability in the rat: relation to brain growth. J Physiol 1995; 488(Pt 2):439-48; PMID:8568682; http://dx.doi.org/10.1113/jphysiol.1995.sp020978
    • (1995) J Physiol , vol.488 , pp. 439-448
    • Keep, R.F.1    Ennis, S.R.2    Beer, M.E.3    Betz, A.L.4
  • 38
  • 39
    • 77953405595 scopus 로고    scopus 로고
    • Differentiation of the brain vasculature: the answer came blowing by the Wnt
    • S.Liebner, K.H.Plate. Differentiation of the brain vasculature: the answer came blowing by the Wnt. J Angiogenes Res 2010; 2:1
    • (2010) J Angiogenes Res , vol.2 , pp. 1
    • Liebner, S.1    Plate, K.H.2
  • 41
    • 0005817912 scopus 로고
    • Intracranial haemorrhage and blood–brain barrier problems in the new-born; a pathologico-anatomical and experimental investigation
    • O.Grontoft. Intracranial haemorrhage and blood–brain barrier problems in the new-born; a pathologico-anatomical and experimental investigation. Acta Pathol Microbiol Scand Suppl 1954; 8:100-9
    • (1954) Acta Pathol Microbiol Scand Suppl , vol.8 , pp. 100-109
    • Grontoft, O.1
  • 42
    • 33947723274 scopus 로고    scopus 로고
    • The impact of glia-derived extracellular matrices on the barrier function of cerebralendothelial cells: an in vitro study
    • 17346702
    • C.Hartmann, A.Zozulya, J.Wegener, H.J.Galla. The impact of glia-derived extracellular matrices on the barrier function of cerebralendothelial cells: an in vitro study. Exp Cell Res 2007; 313:1318-25; PMID:17346702; http://dx.doi.org/10.1016/j.yexcr.2007.01.024
    • (2007) Exp Cell Res , vol.313 , pp. 1318-1325
    • Hartmann, C.1    Zozulya, A.2    Wegener, J.3    Galla, H.J.4
  • 43
    • 84928204948 scopus 로고    scopus 로고
    • Anatomy and physiology of the blood–brain barrier
    • Y.Serlin, I.Shelef, B.Knyazer, A.Friedman. Anatomy and physiology of the blood–brain barrier. Semin Cell Dev Biol 2015; 38:2-6; http://dx.doi.org/10.1016/j.semcdb.2015.01.002
    • (2015) Semin Cell Dev Biol , vol.38 , pp. 2-6
    • Serlin, Y.1    Shelef, I.2    Knyazer, B.3    Friedman, A.4
  • 44
    • 1642418268 scopus 로고    scopus 로고
    • Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor
    • 14983237
    • S.Raab, H.Beck, A.Gaumann, A.Yuce, H.P.Gerber, K.Plate, H.P.Hammes, N.Ferrara, G.Breier. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost 2004; 91:595-605; PMID:14983237
    • (2004) Thromb Haemost , vol.91 , pp. 595-605
    • Raab, S.1    Beck, H.2    Gaumann, A.3    Yuce, A.4    Gerber, H.P.5    Plate, K.6    Hammes, H.P.7    Ferrara, N.8    Breier, G.9
  • 47
    • 84981243697 scopus 로고    scopus 로고
    • Morphogens and blood-brain barrier function in health and disease
    • R.Nienke. N.R.Wevers, H.E. de Vries. Morphogens and blood-brain barrier function in health and disease. Tissue Barriers 2015
    • (2015) Tissue Barriers
    • Nienke, R.1    Wevers, N.R.2    E. de Vries, H.3
  • 48
    • 0038686623 scopus 로고    scopus 로고
    • Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    • 12852851
    • C.Gu, E.R.Rodriguez, D.V.Reimert, T.Shu, B.Fritzsch, L.J.Richards, A.L.Kolodkin, D.D.Ginty. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell 2003; 5:45-57; PMID:12852851; http://dx.doi.org/10.1016/S1534-5807(03)00169-2
    • (2003) Dev Cell , vol.5 , pp. 45-57
    • Gu, C.1    Rodriguez, E.R.2    Reimert, D.V.3    Shu, T.4    Fritzsch, B.5    Richards, L.J.6    Kolodkin, A.L.7    Ginty, D.D.8
  • 50
    • 0022972629 scopus 로고
    • Differentiation dependent expression of proteins in brain endothelium during development of the blood brain barrier
    • 2875908
    • W.Risau, R.Hallmann, U.Albrecht. Differentiation dependent expression of proteins in brain endothelium during development of the blood brain barrier. Dev Biol 1986; 117:537-45; PMID:2875908; http://dx.doi.org/10.1016/0012-1606(86)90321-0
    • (1986) Dev Biol , vol.117 , pp. 537-545
    • Risau, W.1    Hallmann, R.2    Albrecht, U.3
  • 51
    • 84861184294 scopus 로고    scopus 로고
    • Barriers in the developing brain and Neurotoxicology
    • 22198708
    • C.J.Ek, K.M.Dziegielewska, M.D.Habgood, N.R.Saunders. Barriers in the developing brain and Neurotoxicology. Neurotoxicology 2012; 33:586-604; PMID:22198708; http://dx.doi.org/10.1016/j.neuro.2011.12.009
    • (2012) Neurotoxicology , vol.33 , pp. 586-604
    • Ek, C.J.1    Dziegielewska, K.M.2    Habgood, M.D.3    Saunders, N.R.4
  • 52
    • 84942420319 scopus 로고    scopus 로고
    • Foxf2 is required for brain pericyte differentiationand development and maintenance of the blood-brain barrier
    • A.Reyahi, A.M.Nik, M.Ghiami, A.G.Linde, F.Pontén, B.R.Johansson, P.Carlsson. Foxf2 is required for brain pericyte differentiationand development and maintenance of the blood-brain barrier. Dev Cell 2015; 6:19-32; http://dx.doi.org/10.1016/j.devcel.2015.05.008
    • (2015) Dev Cell , vol.6 , pp. 19-32
    • Reyahi, A.1    Nik, A.M.2    Ghiami, M.3    Linde, A.G.4    Pontén, F.5    Johansson, B.R.6    Carlsson, P.7
  • 53
    • 84908641037 scopus 로고    scopus 로고
    • Blood-brain barrier regulation
    • M.R.Mizee, H.E.de Vries. Blood-brain barrier regulation. Tissue Barriers 2015; 1:5, e26882; http://dx.doi.org/10.4161/tisb.26882
    • (2015) Tissue Barriers , vol.1 , Issue.5 , pp. e26882
    • Mizee, M.R.1    de Vries, H.E.2
  • 54
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
    • 15186921
    • N.J.Abbott. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 2004; 45:545-52; PMID:15186921; http://dx.doi.org/10.1016/j.neuint.2003.11.006
    • (2004) Neurochem Int , vol.45 , pp. 545-552
    • Abbott, N.J.1
  • 56
    • 1942438622 scopus 로고    scopus 로고
    • Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium
    • 15075203
    • R.C.Brown, K.S.Mark, R.D.Egleton, T.P.Davis. Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium. Am J Physiol Cell Physiol 2004; 286:C1045-C1052; PMID:15075203; http://dx.doi.org/10.1152/ajpcell.00360.2003
    • (2004) Am J Physiol Cell Physiol , vol.286 , pp. C1045-C1052
    • Brown, R.C.1    Mark, K.S.2    Egleton, R.D.3    Davis, T.P.4
  • 57
    • 0019556901 scopus 로고
    • Efflux of radiolabeled polyethylene glycol and albumin from rat brain
    • 7223889
    • H.Cserr, D.N.Cooper, P.K.Suri, C.S.Patlak. Efflux of radiolabeled polyethylene glycol and albumin from rat brain. Am J Physiol 1981; 240:F319-F328; PMID:7223889
    • (1981) Am J Physiol , vol.240 , pp. F319-F328
    • Cserr, H.1    Cooper, D.N.2    Suri, P.K.3    Patlak, C.S.4
  • 59
    • 18844451469 scopus 로고    scopus 로고
    • Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture
    • 15857386
    • D.Dolman, S.Drndarski, N.J.Abbott, M.Rattray. Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. J Neurochem 2005; 93:825-33; PMID:15857386; http://dx.doi.org/10.1111/j.1471-4159.2005.03111.x
    • (2005) J Neurochem , vol.93 , pp. 825-833
    • Dolman, D.1    Drndarski, S.2    Abbott, N.J.3    Rattray, M.4
  • 60
    • 0015237340 scopus 로고
    • Cerebrospinal fluid production by the choroid plexus and brain
    • 4997797
    • T.H.Milhorat, M.K.Hammock, J.D.Fenstermacher, V.A.Levin. Cerebrospinal fluid production by the choroid plexus and brain. Science 1971; 173:330-32; PMID:4997797; http://dx.doi.org/10.1126/science.173.3994.330
    • (1971) Science , vol.173 , pp. 330-332
    • Milhorat, T.H.1    Hammock, M.K.2    Fenstermacher, J.D.3    Levin, V.A.4
  • 62
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte–endothelial interactions at the blood-brain barrier
    • 16371949
    • N.J.Abbott, L.Rönnbäck, E.Hansson. Astrocyte–endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7:41-53; PMID:16371949; http://dx.doi.org/10.1038/nrn1824
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 64
    • 45949107902 scopus 로고    scopus 로고
    • On the rate and extent of drug delivery to the brain
    • 18058202
    • M.Hammarlund-Udenaes, M.Fridén, S.Syvanen, A.Gupta. On the rate and extent of drug delivery to the brain. Pharm Res 2008; 25:1737-50; PMID:18058202; http://dx.doi.org/10.1007/s11095-007-9502-2
    • (2008) Pharm Res , vol.25 , pp. 1737-1750
    • Hammarlund-Udenaes, M.1    Fridén, M.2    Syvanen, S.3    Gupta, A.4
  • 66
    • 84871745687 scopus 로고    scopus 로고
    • Brain extracellular space as a diffusion barrier
    • 23172993
    • C.Nicholson, P.K.Zare, L.Tao. Brain extracellular space as a diffusion barrier. Comput Vis Sci 2011; 14:309-25; PMID:23172993; http://dx.doi.org/10.1007/s00791-012-0185-9
    • (2011) Comput Vis Sci , vol.14 , pp. 309-325
    • Nicholson, C.1    Zare, P.K.2    Tao, L.3
  • 67
    • 84875485383 scopus 로고    scopus 로고
    • Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states
    • 23256608
    • A.K.Deo, F.P.Theil, J.M.Nicolas. Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states. Mol Pharm 2013; 10:1581-95; PMID:23256608; http://dx.doi.org/10.1021/mp300570z
    • (2013) Mol Pharm , vol.10 , pp. 1581-1595
    • Deo, A.K.1    Theil, F.P.2    Nicolas, J.M.3
  • 69
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • 20944625
    • R.Daneman, L.Zhou, A.A.Kebede, B.A.Barres. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010; 468:562-6; PMID:20944625; http://dx.doi.org/10.1038/nature09513
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 70
    • 84981282223 scopus 로고    scopus 로고
    • Dorovini-Zis K., ed. The blood-brain barrier in health and disease, volume 2: pathophysiology and pathology. Boca Raton: CRC press, 2015; 5-6
  • 72
    • 0142186830 scopus 로고    scopus 로고
    • Pain and the blood-brain barrier: obstacles to drug delivery
    • 12935941
    • A.M.Wolka, J.D.Huber, T.P.Davis. Pain and the blood-brain barrier: obstacles to drug delivery. Adv Drug Deliv Rev 2003; 55:987-1006; PMID:12935941; http://dx.doi.org/10.1016/S0169-409X(03)00100-5
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 987-1006
    • Wolka, A.M.1    Huber, J.D.2    Davis, T.P.3
  • 73
    • 79960927426 scopus 로고    scopus 로고
    • Potential role for S100A4 in the disruption of the blood-brain barrier in collagen-induced arthritic mice, an animal model of rheumatoid arthritis
    • 21627981
    • T.Nishioku, K.Furusho, A.Tomita, H.Ohishi, S.Dohgu, H.Shuto, A.Yamauchi, Y.Kataoka. Potential role for S100A4 in the disruption of the blood-brain barrier in collagen-induced arthritic mice, an animal model of rheumatoid arthritis. Neuroscience 2011; 189:286-92; PMID:21627981; http://dx.doi.org/10.1016/j.neuroscience.2011.05.044
    • (2011) Neuroscience , vol.189 , pp. 286-292
    • Nishioku, T.1    Furusho, K.2    Tomita, A.3    Ohishi, H.4    Dohgu, S.5    Shuto, H.6    Yamauchi, A.7    Kataoka, Y.8
  • 74
    • 0037228838 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging
    • 12486269
    • J.M.Starr, J.Wardlaw, K.Ferguson, A.MacLullich, I.J.Deary, I.Marshall. Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging. J Neurol, Neurosurg Psychiat 2003; 74:70-6; PMID:12486269; http://dx.doi.org/10.1136/jnnp.74.1.70
    • (2003) J Neurol, Neurosurg Psychiat , vol.74 , pp. 70-76
    • Starr, J.M.1    Wardlaw, J.2    Ferguson, K.3    MacLullich, A.4    Deary, I.J.5    Marshall, I.6
  • 75
    • 84861584116 scopus 로고    scopus 로고
    • Blood-brain barrier in acute liver failure
    • 22100566
    • J.H.Nguyen. Blood-brain barrier in acute liver failure. Neurochem Int 2012; 60:676-83; PMID:22100566; http://dx.doi.org/10.1016/j.neuint.2011.10.012
    • (2012) Neurochem Int , vol.60 , pp. 676-683
    • Nguyen, J.H.1
  • 76
    • 79851495688 scopus 로고    scopus 로고
    • Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia
    • 21071591
    • M.J.Cipolla, J.G.Sweet, S.L.Chan. Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia. J Appl Physiol 2011; 110:329-39; PMID:21071591; http://dx.doi.org/10.1152/japplphysiol.01159.2010
    • (2011) J Appl Physiol , vol.110 , pp. 329-339
    • Cipolla, M.J.1    Sweet, J.G.2    Chan, S.L.3
  • 77
    • 0026592535 scopus 로고
    • Effect of chronic hypertension on the blood-brain barrier permeability of libenzapril
    • 1553348
    • J.P.Tang, A.Rakhit, F.L.Douglas, S.Melethil. Effect of chronic hypertension on the blood-brain barrier permeability of libenzapril. Pharm Res 1992; 9:236-43; PMID:1553348; http://dx.doi.org/10.1023/A:1018945608888
    • (1992) Pharm Res , vol.9 , pp. 236-243
    • Tang, J.P.1    Rakhit, A.2    Douglas, F.L.3    Melethil, S.4
  • 78
    • 1842608817 scopus 로고    scopus 로고
    • Iron, atherosclerosis, and neurodegeneration: a key role for cholesterol in promoting iron-dependent oxidative damage
    • W.Y.Ong, B.Halliwell. Iron, atherosclerosis, and neurodegeneration: a key role for cholesterol in promoting iron-dependent oxidative damage? Ann NY Acad Sci 2004; 1012:51-64; http://dx.doi.org/10.1196/annals.1306.005
    • (2004) Ann NY Acad Sci , vol.1012 , pp. 51-64
    • Ong, W.Y.1    Halliwell, B.2
  • 79
    • 84930649436 scopus 로고    scopus 로고
    • Disruption in the blood-brain barrier: the missing link between brain and body inflammation in bipolar disorder
    • J.P.Patel and B.N.Frey. Disruption in the blood-brain barrier: the missing link between brain and body inflammation in bipolar disorder? Neural Plast 2015; 2015:1-12.
    • (2015) Neural Plast
    • Patel, J.P.1    Frey, B.N.2
  • 82
    • 84939582946 scopus 로고    scopus 로고
    • Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis
    • 25958228
    • J.A.Gorter, E.A.van Vliet, E.Aronica. Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis. Epilepsy Behav 2015; 49:13-6; PMID:25958228; http://dx.doi.org/10.1016/j.yebeh.2015.04.047
    • (2015) Epilepsy Behav , vol.49 , pp. 13-16
    • Gorter, J.A.1    van Vliet, E.A.2    Aronica, E.3
  • 83
    • 0031723106 scopus 로고    scopus 로고
    • Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
    • 9778257
    • R.Paul, S.Lorenzl, U.Koedel, B.Sporer, U.Vogel, M.Frosch, H.W.Pfister. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol 1998; 44:592-600; PMID:9778257; http://dx.doi.org/10.1002/ana.410440404
    • (1998) Ann Neurol , vol.44 , pp. 592-600
    • Paul, R.1    Lorenzl, S.2    Koedel, U.3    Sporer, B.4    Vogel, U.5    Frosch, M.6    Pfister, H.W.7
  • 85
    • 84889872057 scopus 로고    scopus 로고
    • Development, maintenance and disruption of the blood-brain barrier
    • 24309662
    • B.Obermeier, R.Daneman, R.M.Ransohoff. Development, maintenance and disruption of the blood-brain barrier. Nat Med 2013; 19: 1584-96; PMID:24309662; http://dx.doi.org/10.1038/nm.3407
    • (2013) Nat Med , vol.19 , pp. 1584-1596
    • Obermeier, B.1    Daneman, R.2    Ransohoff, R.M.3
  • 86
    • 39749086433 scopus 로고    scopus 로고
    • Polymeric nanoparticles for the drug delivery to the central nervous system
    • G.Tosi, L.Costantino, B.Ruozi, F.Forni, M.A.Vandelli. Polymeric nanoparticles for the drug delivery to the central nervous system. Exp OpinDrug Deliv 2008; 5:155-74; http://dx.doi.org/10.1517/17425247.5.2.155
    • (2008) Exp OpinDrug Deliv , vol.5 , pp. 155-174
    • Tosi, G.1    Costantino, L.2    Ruozi, B.3    Forni, F.4    Vandelli, M.A.5
  • 87
    • 84861142135 scopus 로고    scopus 로고
    • In vitro evaluation on a model of blood brain barrier of idebenone loaded solid lipid nanoparticles
    • 22523983
    • L.Montenegro, A.Trapani, A.Latrofa, G.Puglisi. In vitro evaluation on a model of blood brain barrier of idebenone loaded solid lipid nanoparticles. J Nanosci Nanotechnol 2012; 12:330-7; PMID:22523983; http://dx.doi.org/10.1166/jnn.2012.5174
    • (2012) J Nanosci Nanotechnol , vol.12 , pp. 330-337
    • Montenegro, L.1    Trapani, A.2    Latrofa, A.3    Puglisi, G.4
  • 88
    • 80053209371 scopus 로고    scopus 로고
    • Functionalization of liposomes with ApoEderived peptides at different density affects cellular uptake and drug transport across a blood–brain barrier model
    • 21658472
    • F.Re, I.Cambianica, C.Zona, S.Sesana, M.Gregori, R.Rigolio, B.L.Ferla, F.Nicotra, G.Forloni, A.Cagnotto. Functionalization of liposomes with ApoEderived peptides at different density affects cellular uptake and drug transport across a blood–brain barrier model. Nanomedicine 2011; 7:551-9; PMID:21658472; http://dx.doi.org/10.1016/j.nano.2011.05.004
    • (2011) Nanomedicine , vol.7 , pp. 551-559
    • Re, F.1    Cambianica, I.2    Zona, C.3    Sesana, S.4    Gregori, M.5    Rigolio, R.6    Ferla, B.L.7    Nicotra, F.8    Forloni, G.9    Cagnotto, A.10
  • 89
    • 84859050279 scopus 로고    scopus 로고
    • Transport of a caspase inhibitoracross the blood-brain barrier by chitosan nanoparticles
    • 22449930
    • M.Yemisci, Y.GürsoyÖzdemir, S.Caban, E.Bodur, Y.Capan, T.Dalkara. Transport of a caspase inhibitoracross the blood-brain barrier by chitosan nanoparticles. Methods Enzymol 2012; 508:253-69; PMID:22449930; http://dx.doi.org/10.1016/B978-0-12-391860-4.00013-6
    • (2012) Methods Enzymol , vol.508 , pp. 253-269
    • Yemisci, M.1    GürsoyÖzdemir, Y.2    Caban, S.3    Bodur, E.4    Capan, Y.5    Dalkara, T.6
  • 90
    • 79959976472 scopus 로고    scopus 로고
    • Dendrimers as novel systems for delivery of neuropharmaceuticals to the brain
    • 21631401
    • S.Beg, A.Samad, M.I.Alam, I.Nazish. Dendrimers as novel systems for delivery of neuropharmaceuticals to the brain. CNS Neurol Disord Drug Targets 2011; 10:576-88; PMID:21631401; http://dx.doi.org/10.2174/187152711796235023
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 576-588
    • Beg, S.1    Samad, A.2    Alam, M.I.3    Nazish, I.4
  • 91
    • 84862790727 scopus 로고    scopus 로고
    • dual targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferring and tamoxifen for treating brain gliomas
    • 22364698
    • Y.Li, H.He, X.Jia, W.L.Lu, J.Lou, Y.Wei.A dual targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferring and tamoxifen for treating brain gliomas. Biomaterials 2012; 33:3899-908; PMID:22364698; http://dx.doi.org/10.1016/j.biomaterials.2012.02.004
    • (2012) Biomaterials , vol.33 , pp. 3899-3908
    • Li, Y.1    He, H.2    Jia, X.3    Lu, W.L.4    Lou, J.5    Wei, Y.6
  • 92
    • 78751694921 scopus 로고    scopus 로고
    • NanoNRTIs: efficient inhibitors of HIV type1 in macrophages with a reduced mitochondrial toxicity
    • 21045256
    • S.V.Vinogradov, L.Y.Poluektova, E.Makarov, T.Gerson, M.T.Senanayake. NanoNRTIs: efficient inhibitors of HIV type1 in macrophages with a reduced mitochondrial toxicity. Antivir Chem Chemother 2010; 21:1-14; PMID:21045256; http://dx.doi.org/10.3851/IMP1680
    • (2010) Antivir Chem Chemother , vol.21 , pp. 1-14
    • Vinogradov, S.V.1    Poluektova, L.Y.2    Makarov, E.3    Gerson, T.4    Senanayake, M.T.5
  • 93
    • 84873690481 scopus 로고    scopus 로고
    • Effects of surface modification of PLGA–PEG–PLGA nanoparticles on loperamide delivery efficiency across the blood–brain barrier
    • 22207601
    • Y.C.Chen, W.Y.Hsieh, W.F.Lee, D.T.Zeng. Effects of surface modification of PLGA–PEG–PLGA nanoparticles on loperamide delivery efficiency across the blood–brain barrier. J Biomater Appl 2011; 27:909-22; PMID:22207601; http://dx.doi.org/10.1177/0885328211429495
    • (2011) J Biomater Appl , vol.27 , pp. 909-922
    • Chen, Y.C.1    Hsieh, W.Y.2    Lee, W.F.3    Zeng, D.T.4
  • 95
    • 84896709577 scopus 로고    scopus 로고
    • Antitumor effects of hightemperature hyperthermia on a glioma rat model
    • 24944659
    • H.Takagi, K.Azuma, T.Tsuka. Antitumor effects of hightemperature hyperthermia on a glioma rat model. Oncol Lett 2014; 7:1007-10; PMID:24944659
    • (2014) Oncol Lett , vol.7 , pp. 1007-1010
    • Takagi, H.1    Azuma, K.2    Tsuka, T.3
  • 96
    • 84897067703 scopus 로고    scopus 로고
    • Fighting fire with fire: the revival of thermotherapy for gliomas
    • 24510985
    • W.Titsworth, G.J.Murad, B.L.Hoh, M.Rahman. Fighting fire with fire: the revival of thermotherapy for gliomas. Anticancer Res 2014; 34:565-574; PMID:24510985
    • (2014) Anticancer Res , vol.34 , pp. 565-574
    • Titsworth, W.1    Murad, G.J.2    Hoh, B.L.3    Rahman, M.4
  • 97
    • 34547121440 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
    • 17437269
    • L.H.Treat, N.McDannold, N.Vykhodtseva, Y.Zhang, K.Tam, K.Hynynen. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 2007; 121:901-7; PMID:17437269; http://dx.doi.org/10.1002/ijc.22732
    • (2007) Int J Cancer , vol.121 , pp. 901-907
    • Treat, L.H.1    McDannold, N.2    Vykhodtseva, N.3    Zhang, Y.4    Tam, K.5    Hynynen, K.6
  • 99
    • 0025204352 scopus 로고
    • Cerebrovascular and metabolic effects on the rat brain of focal Nd:YAG laser irradiation
    • 2230973
    • M.Kiessling, E.Herchenhan, H.R.Eggert. Cerebrovascular and metabolic effects on the rat brain of focal Nd:YAG laser irradiation. J Neurosurg 1990; 73:909-17; PMID:2230973; http://dx.doi.org/10.3171/jns.1990.73.6.0909
    • (1990) J Neurosurg , vol.73 , pp. 909-917
    • Kiessling, M.1    Herchenhan, E.2    Eggert, H.R.3
  • 100
    • 79959349811 scopus 로고    scopus 로고
    • Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability
    • M.Choi, T.Ku, K.Chong, J.Yoon, C.Choi. Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability. Proc Natl Acad Sci USA 2011; 108: 9256-61; http://dx.doi.org/10.1073/pnas.1018790108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9256-9261
    • Choi, M.1    Ku, T.2    Chong, K.3    Yoon, J.4    Choi, C.5
  • 101
    • 84925014789 scopus 로고    scopus 로고
    • Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery
    • 25724273
    • S.N.Tabatabaei, H.Girouard, A.S.Carret, S.Martel. Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery. J Control Rel 2015; 206: 49-57; PMID:25724273; http://dx.doi.org/10.1016/j.jconrel.2015.02.027
    • (2015) J Control Rel , vol.206 , pp. 49-57
    • Tabatabaei, S.N.1    Girouard, H.2    Carret, A.S.3    Martel, S.4
  • 102
    • 0029867619 scopus 로고    scopus 로고
    • Receptor-mediated transcytosis of transferring through blood-brain barrier endothelial cells
    • L.Descamps, M.P.Dehouck, G.Torpier, R.Cecchelli. Receptor-mediated transcytosis of transferring through blood-brain barrier endothelial cells. Am J Physiol 1996; 270:1149-58;
    • (1996) Am J Physiol , vol.270 , pp. 1149-1158
    • Descamps, L.1    Dehouck, M.P.2    Torpier, G.3    Cecchelli, R.4
  • 103
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier
    • 9265653
    • B.Dehouck, L.Fenart, M.P.Dehouck, A.Pierce, G.Torpier, R.Cecchelli. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J Cell Biol 1997; 138:877-89; PMID:9265653; http://dx.doi.org/10.1083/jcb.138.4.877
    • (1997) J Cell Biol , vol.138 , pp. 877-889
    • Dehouck, B.1    Fenart, L.2    Dehouck, M.P.3    Pierce, A.4    Torpier, G.5    Cecchelli, R.6
  • 104
    • 60549085837 scopus 로고    scopus 로고
    • Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro
    • 19065317
    • P.Candela, F.Gosselet, F.Miller, V.B.Scherrer, G.Torpier, R.Cecchelli, L.Fenart. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium 2008; 15:254-64; PMID:19065317; http://dx.doi.org/10.1080/10623320802487759
    • (2008) Endothelium , vol.15 , pp. 254-264
    • Candela, P.1    Gosselet, F.2    Miller, F.3    Scherrer, V.B.4    Torpier, G.5    Cecchelli, R.6    Fenart, L.7
  • 105
    • 1942453793 scopus 로고    scopus 로고
    • Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake
    • 15109771
    • N.S.Chung, K.M.Wasan. Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake. Adv Drug Deliv Rev 2004; 56:1315-34; PMID:15109771; http://dx.doi.org/10.1016/j.addr.2003.12.003
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1315-1334
    • Chung, N.S.1    Wasan, K.M.2
  • 106
    • 84899443991 scopus 로고    scopus 로고
    • Overcoming the blood brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonist
    • 24673594
    • X.Gao, J.Qian, S.Zheng, Y.Changyi, J.Zhang, S.Ju, J.Zhu, C.Li. Overcoming the blood brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonist. ACS Nano 2014; 8:3678-89; PMID:24673594; http://dx.doi.org/10.1021/nn5003375
    • (2014) ACS Nano , vol.8 , pp. 3678-3689
    • Gao, X.1    Qian, J.2    Zheng, S.3    Changyi, Y.4    Zhang, J.5    Ju, S.6    Zhu, J.7    Li, C.8
  • 107
    • 77952231544 scopus 로고    scopus 로고
    • Cell-penetrating peptides and their therapeutic applications
    • V.Sebbage. Cell-penetrating peptides and their therapeutic applications. Biosci Horizons 2009; 2:64-72; http://dx.doi.org/10.1093/biohorizons/hzp001
    • (2009) Biosci Horizons , vol.2 , pp. 64-72
    • Sebbage, V.1
  • 108
    • 84876728629 scopus 로고    scopus 로고
    • Cell-penetrating peptide-mediated therapeutic molecule delivery into the central nervous system
    • 23997754
    • L.L.Zou, J.L.Ma, T.Wang, T.B.Yang, C.B.Liu. Cell-penetrating peptide-mediated therapeutic molecule delivery into the central nervous system. Curr Neuropharmacol 2013; 11:197-208; PMID:23997754; http://dx.doi.org/10.2174/1570159X11311020006
    • (2013) Curr Neuropharmacol , vol.11 , pp. 197-208
    • Zou, L.L.1    Ma, J.L.2    Wang, T.3    Yang, T.B.4    Liu, C.B.5
  • 109
    • 77956182174 scopus 로고    scopus 로고
    • Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors
    • 20688391
    • M.Roger, A.Clavreul, M.C.V.Julienne, C.Passirani, L.Sindji, P.Schiller, C.M.Menei, P.Menei. Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. Biomaterials 2010; 31:8393-401; PMID:20688391; http://dx.doi.org/10.1016/j.biomaterials.2010.07.048
    • (2010) Biomaterials , vol.31 , pp. 8393-8401
    • Roger, M.1    Clavreul, A.2    Julienne, M.C.V.3    Passirani, C.4    Sindji, L.5    Schiller, P.6    Menei, C.M.7    Menei, P.8
  • 110
    • 84886692414 scopus 로고    scopus 로고
    • Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo
    • 25206518
    • C.Fan, D.Wang, Q.Zhang, J.Zhou. Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo. Neural Regen Res 2013; 8:2093-102; PMID:25206518
    • (2013) Neural Regen Res , vol.8 , pp. 2093-2102
    • Fan, C.1    Wang, D.2    Zhang, Q.3    Zhou, J.4
  • 111
    • 84892933877 scopus 로고    scopus 로고
    • Drug delivery using genetically modified mesenchymal stem cells: a promising targeted-delivery method
    • A.Ebrahimi, N.Lalvand. Drug delivery using genetically modified mesenchymal stem cells: a promising targeted-delivery method. Hyg J Drugs Med 2013; 5:90-104
    • (2013) Hyg J Drugs Med , vol.5 , pp. 90-104
    • Ebrahimi, A.1    Lalvand, N.2
  • 112
    • 33645471469 scopus 로고    scopus 로고
    • Systemic delivery of drugs to humans via inhalation
    • 16551214
    • I.Gonda Systemic delivery of drugs to humans via inhalation. J Aerosol Med 2006, 19:47-53; PMID:16551214; http://dx.doi.org/10.1089/jam.2006.19.47
    • (2006) J Aerosol Med , vol.19 , pp. 47-53
    • Gonda, I.1
  • 113
    • 84939980324 scopus 로고
    • The use of creosoted oil for the expulsion of tracheal false membranes after tracheotomy; and of intranasal injections of oil in various affection
    • 20757845
    • W.Ewart. The use of creosoted oil for the expulsion of tracheal false membranes after tracheotomy; and of intranasal injections of oil in various affection. Br Med J 1898; 1:1381-83; PMID:20757845; http://dx.doi.org/10.1136/bmj.1.1952.1381
    • (1898) Br Med J , vol.1 , pp. 1381-1383
    • Ewart, W.1
  • 114
    • 84905512946 scopus 로고    scopus 로고
    • Intranasal delivery of neural stem cells: a CNS specific, non-invasive cell-based therapy for experimental autoimmune encephalomyelitis
    • 24244890
    • S.Wu Intranasal delivery of neural stem cells: a CNS specific, non-invasive cell-based therapy for experimental autoimmune encephalomyelitis. J Clin Cell Immunol 2013; 1:4; PMID:24244890
    • (2013) J Clin Cell Immunol , vol.1 , pp. 4
    • Wu, S.1
  • 115
    • 84903525487 scopus 로고    scopus 로고
    • Exploratory trial of intranasal administration of glucagon-like Peptide-1 in Japanese patients with type 2 diabetes
    • 24667460
    • H.Ueno, M.Mizuta, T.Shiiya, W.Tsuchimochi, K.Noma, N.Nakashima, M.Fujihara, M.Nakazato. Exploratory trial of intranasal administration of glucagon-like Peptide-1 in Japanese patients with type 2 diabetes. Diabetes Care 2014; 37:2024-27; PMID:24667460; http://dx.doi.org/10.2337/dc13-0690
    • (2014) Diabetes Care , vol.37 , pp. 2024-2027
    • Ueno, H.1    Mizuta, M.2    Shiiya, T.3    Tsuchimochi, W.4    Noma, K.5    Nakashima, N.6    Fujihara, M.7    Nakazato, M.8
  • 116
    • 0033974507 scopus 로고    scopus 로고
    • Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications
    • S.I.Rapoport. Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell. Mol. Neurol. 2000; 20:217-30; http://dx.doi.org/10.1023/A:1007049806660
    • (2000) Cell. Mol. Neurol. , vol.20 , pp. 217-230
    • Rapoport, S.I.1
  • 117
    • 84981181902 scopus 로고    scopus 로고
    • Bypassing the blood–brian barrier using established skull base reconstruction techniques
    • M.M.Miyake, B.S.Bleier. Bypassing the blood–brian barrier using established skull base reconstruction techniques. WJO 2015; 1:11-16
    • (2015) WJO , vol.1 , pp. 11-16
    • Miyake, M.M.1    Bleier, B.S.2
  • 119
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood brain barrier (mBBB)
    • 22422217
    • R.Booth, H.Kim. Characterization of a microfluidic in vitro model of the blood brain barrier (mBBB). Lab Chip 2012; 12:1784-92; PMID:22422217; http://dx.doi.org/10.1039/c2lc40094d
    • (2012) Lab Chip , vol.12 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 120
    • 78650678061 scopus 로고    scopus 로고
    • Murine in vitro model of the blood-brain barrier for evaluating drug transport
    • 21078386
    • G.Shayan, Y.S.Choi, E.V.Shusta, M.L.Shuler, K.H.Lee. Murine in vitro model of the blood-brain barrier for evaluating drug transport. Eur J Pharm Sci 2011; 42:148-55; PMID:21078386; http://dx.doi.org/10.1016/j.ejps.2010.11.005
    • (2011) Eur J Pharm Sci , vol.42 , pp. 148-155
    • Shayan, G.1    Choi, Y.S.2    Shusta, E.V.3    Shuler, M.L.4    Lee, K.H.5
  • 121
    • 79961022877 scopus 로고    scopus 로고
    • The effect of astrocytes on the induction of barrier properties in aortic endothelial cells
    • 21626719
    • G.Shayan, M.L.Shuler, K.H.Lee. The effect of astrocytes on the induction of barrier properties in aortic endothelial cells. Biotechnol Prog 2011; 27:1137-45; PMID:21626719; http://dx.doi.org/10.1002/btpr.620
    • (2011) Biotechnol Prog , vol.27 , pp. 1137-1145
    • Shayan, G.1    Shuler, M.L.2    Lee, K.H.3
  • 122
    • 84921949599 scopus 로고    scopus 로고
    • Setting-up an in vitro model of rat blood-brain barrier (BBB): afocus on BBB impermeability and receptor-mediated transport
    • Y.Molino, F.Jabès, E.Lacassagne, N.Gaudin, M.Khrestchatisky. Setting-up an in vitro model of rat blood-brain barrier (BBB): afocus on BBB impermeability and receptor-mediated transport. J Vis Exp 2014; 88:512-78
    • (2014) J Vis Exp , vol.88 , pp. 512-578
    • Molino, Y.1    Jabès, F.2    Lacassagne, E.3    Gaudin, N.4    Khrestchatisky, M.5
  • 124
    • 84879892445 scopus 로고    scopus 로고
    • Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts
    • 23736663
    • M.Shi, D.Majumdar, Y.Gao B.M.Brewer, C.R.Goodwin, J.A.McLean, D.Li, D.J.Webb. Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. Lab Chip 2013; 13:3008-21; PMID:23736663; http://dx.doi.org/10.1039/c3lc50249j
    • (2013) Lab Chip , vol.13 , pp. 3008-3021
    • Shi, M.1    Majumdar, D.2    Gao, Y.3    Brewer, B.M.4    Goodwin, C.R.5    McLean, J.A.6    Li, D.7    Webb, D.J.8
  • 126
    • 79954998485 scopus 로고    scopus 로고
    • Efficient generation of schwann cells from human embryonic stem cell-derived neurospheres
    • 21052870
    • L.Ziegler, S.Grigoryan, I.H.Yang, N.V.Thakor,, R.S.Goldstein. Efficient generation of schwann cells from human embryonic stem cell-derived neurospheres. Stem Cell Rev 2011; 7:394-403; PMID:21052870; http://dx.doi.org/10.1007/s12015-010-9198-2
    • (2011) Stem Cell Rev , vol.7 , pp. 394-403
    • Ziegler, L.1    Grigoryan, S.2    Yang, I.H.3    Thakor, N.V.4    Goldstein, R.S.5
  • 127
    • 84879986080 scopus 로고    scopus 로고
    • Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS
    • 23695230
    • A.Kunze, S.Lengacher, E.Dirren, P.Aebischer, P.J.Magistrettic, P.Renaud. Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS. Integr Biol (Camb) 2013; 5:964-75; PMID:23695230; http://dx.doi.org/10.1039/c3ib40022k
    • (2013) Integr Biol (Camb) , vol.5 , pp. 964-975
    • Kunze, A.1    Lengacher, S.2    Dirren, E.3    Aebischer, P.4    Magistrettic, P.J.5    Renaud, P.6
  • 128
    • 84904507155 scopus 로고    scopus 로고
    • West nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model
    • K.Roe, B.Orillo, S.Verma. West nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model. Plos One 2014; 9:1-12; http://dx.doi.org/10.1371/journal.pone.0102598
    • (2014) Plos One , vol.9 , pp. 1-12
    • Roe, K.1    Orillo, B.2    Verma, S.3
  • 129
    • 84940978184 scopus 로고    scopus 로고
    • Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier
    • 26334482
    • X.Xiong, Y.Sun, A.Sattiraju, Y.Jung, A.Mintz, S.Hayasaka, K.C.P.Li. Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier. J Control Release 2015; 217:113-20; PMID:26334482
    • (2015) J Control Release , vol.217 , pp. 113-120
    • Xiong, X.1    Sun, Y.2    Sattiraju, A.3    Jung, Y.4    Mintz, A.5    Hayasaka, S.6    Li, K.C.P.7
  • 130
    • 79551646674 scopus 로고    scopus 로고
    • A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system
    • 20842162
    • L.Cucullo, N.Marchi, M.Hossain, D.Janigro. A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system. J Cereb Blood Flow Metab 2011; 31:767-77; PMID:20842162
    • (2011) J Cereb Blood FlowMetab , vol.31 , pp. 767-777
    • Cucullo, L.1    Marchi, N.2    Hossain, M.3    Janigro, D.4
  • 131
    • 84927934861 scopus 로고    scopus 로고
    • In vitro models of the blood-brain barrier
    • 24510883
    • C.J.Czupalla, S.Liebner, K.Devraj. In vitro models of the blood-brain barrier. Methods Mol Biol 2014; 1135:415-37; PMID:24510883
    • (2014) Methods Mol Biol , vol.1135 , pp. 415-437
    • Czupalla, C.J.1    Liebner, S.2    Devraj, K.3
  • 132
    • 84939268433 scopus 로고    scopus 로고
    • In vitro blood–brain barrier models—An overview of established models and new microfluidic approaches
    • A.Wolff, M.Antfolk, B.Brodin, M.Tenje. In vitro blood–brain barrier models—An overview of established models and new microfluidic approaches. J Pharm Sci 2015; 104:2727-46.
    • (2015) J Pharm Sci , vol.104 , pp. 2727-2746
    • Wolff, A.1    Antfolk, M.2    Brodin, B.3    Tenje, M.4
  • 133
    • 84860001254 scopus 로고    scopus 로고
    • Strategies to minimize CNS toxicity: in vitro high throughput assays and computational modeling
    • T.T.Wager, J.L.Liras, S.Mente, P.Trapa. Strategies to minimize CNS toxicity: in vitro high throughput assays and computational modeling. Expert Opin Drug Metab Toxicol 2012;8: 531-42.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 531-542
    • Wager, T.T.1    Liras, J.L.2    Mente, S.3    Trapa, P.4
  • 134
    • 84934760672 scopus 로고    scopus 로고
    • Blood brain barrier modeling: challenges and perspectives
    • T.Ruck, S.Bittner, S.G.Meuth. Blood brain barrier modeling: challenges and perspectives. Neural Regen Res 2015;10:889-91.
    • (2015) Neural Regen Res , vol.10 , pp. 889-891
    • Ruck, T.1    Bittner, S.2    Meuth, S.G.3
  • 135
    • 70349971923 scopus 로고    scopus 로고
    • Dynamic in vivo imaging of cerebral blood flow and blood–brain barrier permeability
    • O.Prager, Y.Chassidim, C.Klein, H.Levi, I.Shelef, A.Friedman. Dynamic in vivo imaging of cerebral blood flow and blood–brain barrier permeability. Neuroimage 2010; 49:337-44.
    • (2010) Neuroimage , vol.49 , pp. 337-344
    • Prager, O.1    Chassidim, Y.2    Klein, C.3    Levi, H.4    Shelef, I.5    Friedman, A.6
  • 136
    • 0025895384 scopus 로고
    • The effect of bile salts on the permeability and ultrastructure of the perfused, energy-depleted, rat blood–brain barrier
    • J.Greenwood, J.Adu, A.J.Davey, N.J.Abbott, M.W.Bradbury. The effect of bile salts on the permeability and ultrastructure of the perfused, energy-depleted, rat blood–brain barrier. Off J Int Soc Cereb Blood Flow Metabol 1991; 11:644-54.
    • (1991) Off J Int Soc Cereb Blood Flow Metabol , vol.11 , pp. 644-654
    • Greenwood, J.1    Adu, J.2    Davey, A.J.3    Abbott, N.J.4    Bradbury, M.W.5
  • 138
    • 84858800779 scopus 로고    scopus 로고
    • Laser speckle contrast imaging of cerebral blood flow
    • A.K.Dunn. Laser speckle contrast imaging of cerebral blood flow. Ann Biomed Eng 2012; 40:367-77.
    • (2012) Ann Biomed Eng , vol.40 , pp. 367-377
    • Dunn, A.K.1
  • 139
    • 59349100522 scopus 로고    scopus 로고
    • Non-invasive visualization of CNS inflammation with nuclear and optical imaging
    • A.Wunder, J.Klohs, U.Dirnagl. Non-invasive visualization of CNS inflammation with nuclear and optical imaging. Neuroscience 2009; 158:1161-73.
    • (2009) Neuroscience , vol.158 , pp. 1161-1173
    • Wunder, A.1    Klohs, J.2    Dirnagl, U.3
  • 140
    • 67849083569 scopus 로고    scopus 로고
    • PET radiotracers: crossing the blood-brain barrier and surviving metabolism
    • V.W.Pike. PET radiotracers: crossing the blood-brain barrier and surviving metabolism. Trends Pharmacol Sci 2009; 30:431-40.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 431-440
    • Pike, V.W.1
  • 141
    • 84911425316 scopus 로고    scopus 로고
    • Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging
    • D.J.Wolak, M.E.Pizzo, R.G.Thorne. Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging. J Control Release 2015; 197:78-86.
    • (2015) J Control Release , vol.197 , pp. 78-86
    • Wolak, D.J.1    Pizzo, M.E.2    Thorne, R.G.3
  • 142
    • 29244490903 scopus 로고    scopus 로고
    • Evaluation of drug penetration into the brain: a double study by in vivo imaging with positron emission tomography and using an in vitro model of the human blood-brain barrier
    • V.Josserand, H.Pélerin, B.de Bruin, B.Jego, B.Kuhnast, F.Hinnen, F.Ducongé, R.Boisgard, F.Beuvon, F.Chassoux, et al. Evaluation of drug penetration into the brain: a double study by in vivo imaging with positron emission tomography and using an in vitro model of the human blood-brain barrier. J Pharmacol Exp Ther 2006; 316:79-86.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 79-86
    • Josserand, V.1    Pélerin, H.2    de Bruin, B.3    Jego, B.4    Kuhnast, B.5    Hinnen, F.6    Ducongé, F.7    Boisgard, R.8    Beuvon, F.9    Chassoux, F.10
  • 143
    • 84877292573 scopus 로고    scopus 로고
    • Diffusion of macromolecules in the brain: implications for drug delivery
    • D.J.Wolak, R.G.Thorne. Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm 2013; 10:1492-1504.
    • (2013) Mol Pharm , vol.10 , pp. 1492-1504
    • Wolak, D.J.1    Thorne, R.G.2
  • 144
    • 55949130305 scopus 로고    scopus 로고
    • Diffusion in brain extracellular space
    • E.Sykova, C.Nicholson. Diffusion in brain extracellular space. Physiol Rev 2008; 88:1277-1340.; http://dx.doi.org/10.1152/physrev.00027.2007
    • (2008) Physiol Rev , vol.88 , pp. 1277-1340
    • Sykova, E.1    Nicholson, C.2
  • 145
    • 0027136083 scopus 로고
    • Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging
    • C.Nicholson, L.Tao. Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging. Biophys J 1993; 65:2277-90.
    • (1993) Biophys J , vol.65 , pp. 2277-2290
    • Nicholson, C.1    Tao, L.2
  • 146
    • 8644244647 scopus 로고    scopus 로고
    • Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
    • R.G.Thorne, S.Hrabetova, C.Nicholson. Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging. J Neurophysiol 2004; 92:3471-81; http://dx.doi.org/10.1152/jn.00352.2004
    • (2004) J Neurophysiol , vol.92 , pp. 3471-3481
    • Thorne, R.G.1    Hrabetova, S.2    Nicholson, C.3
  • 147
    • 84940536512 scopus 로고    scopus 로고
    • Novel bimodal iron oxide particles for efficient tracking of human neural stem cells in vivo
    • M.Aswendt, N.Henn, S.Michalk, G.Schneider, M.S.Steiner, U.Bissa, C.Dose, M.Hoehn. Novel bimodal iron oxide particles for efficient tracking of human neural stem cells in vivo. Nanomedicine 2015; 10; 16:2499-512.; http://dx.doi.org/10.2217/nnm.15.94
    • (2015) Nanomedicine , vol.10 , Issue.16 , pp. 2499-2512
    • Aswendt, M.1    Henn, N.2    Michalk, S.3    Schneider, G.4    Steiner, M.S.5    Bissa, U.6    Dose, C.7    Hoehn, M.8
  • 148
    • 84934759897 scopus 로고    scopus 로고
    • In vivo tracking of human adipose-derived stem cells labeled with ferumoxytol in rats with middle cerebral artery occlusion by magnetic resonance imaging
    • Y.Yin, X.Zhou, X.Guan, Y.Liu, C.Jiang, J.Liu. In vivo tracking of human adipose-derived stem cells labeled with ferumoxytol in rats with middle cerebral artery occlusion by magnetic resonance imaging. Neural Regener Res 2015; 10:909-15; http://dx.doi.org/10.4103/1673-5374.158355
    • (2015) Neural Regener Res , vol.10 , pp. 909-915
    • Yin, Y.1    Zhou, X.2    Guan, X.3    Liu, Y.4    Jiang, C.5    Liu, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.