메뉴 건너뛰기




Volumn 8, Issue 4, 2014, Pages 3678-3689

Overcoming the blood-brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonist

Author keywords

adenosine receptor; blood brain barrier; brain drug delivery; multimodal imaging; nanoagonist

Indexed keywords

BLOOD; DISEASES; ENDOTHELIAL CELLS; LIGANDS; MACROMOLECULES;

EID: 84899443991     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn5003375     Document Type: Article
Times cited : (150)

References (54)
  • 1
    • 38149090292 scopus 로고    scopus 로고
    • The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
    • Zlokovic, B. V. The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders Neuron 2008, 57, 178-201
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 2
    • 0032600640 scopus 로고    scopus 로고
    • A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
    • Ghose, A. K.; Viswanadhan, V. N.; Wendoloski, J. J. A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases J. Comb. Chem. 1999, 1, 55-68
    • (1999) J. Comb. Chem. , vol.1 , pp. 55-68
    • Ghose, A.K.1    Viswanadhan, V.N.2    Wendoloski, J.J.3
  • 3
    • 84870408539 scopus 로고    scopus 로고
    • The Blood-Brain Barrier in Health and Disease
    • Daneman, R. The Blood-Brain Barrier in Health and Disease Ann. Neurol. 2012, 72, 648-672
    • (2012) Ann. Neurol. , vol.72 , pp. 648-672
    • Daneman, R.1
  • 5
    • 0035576934 scopus 로고    scopus 로고
    • Molecular Physiology and Pathophysiology of Tight Junctions in the Blood-Brain Barrier
    • Huber, J. D.; Egleton, R. D.; Davis, T. P. Molecular Physiology and Pathophysiology of Tight Junctions in the Blood-Brain Barrier Trends Neurosci. 2001, 24, 719-725
    • (2001) Trends Neurosci. , vol.24 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 6
    • 12344273726 scopus 로고    scopus 로고
    • The Blood-Brain Barrier: Bottleneck in Brain Drug Development
    • Pardridge, W. M. The Blood-Brain Barrier: Bottleneck in Brain Drug Development Neurorx 2005, 2, 3-14
    • (2005) Neurorx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 7
    • 0034461768 scopus 로고    scopus 로고
    • Drug-Like Properties and the Causes of Poor Solubility and Poor Permeability
    • Lipinski, C. A. Drug-Like Properties and the Causes of Poor Solubility and Poor Permeability J. Pharmacol. Toxicol. Methods 2000, 44, 235-249
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 9
    • 84893470061 scopus 로고    scopus 로고
    • Nanoprobes Visualizing Gliomas by Crossing the Blood Brain Tumor Barrier.
    • DOI: 10.1002/smll.201301673
    • Gao, X.; Li, C. Nanoprobes Visualizing Gliomas by Crossing the Blood Brain Tumor Barrier. Small 2013, DOI: 10.1002/smll.201301673.
    • (2013) Small
    • Gao, X.1    Li, C.2
  • 10
    • 84857645929 scopus 로고    scopus 로고
    • MRI of Blood-Brain Barrier Permeability in Cerebral Ischemia
    • Jiang, Q.; Ewing, J. R.; Chopp, M. MRI of Blood-Brain Barrier Permeability in Cerebral Ischemia Transl. Stroke Res. 2012, 3, 56-64
    • (2012) Transl. Stroke Res. , vol.3 , pp. 56-64
    • Jiang, Q.1    Ewing, J.R.2    Chopp, M.3
  • 11
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative Evaluation of Blood-Brain Barrier Permeability Following Middle Cerebral Artery Occlusion in Rats
    • Belayev, L.; Busto, R.; Zhao, W.; Ginsberg, M. D. Quantitative Evaluation of Blood-Brain Barrier Permeability Following Middle Cerebral Artery Occlusion in Rats Brain Res. 1996, 739, 88-96
    • (1996) Brain Res. , vol.739 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 12
    • 34249040510 scopus 로고    scopus 로고
    • Blood-Brain Barrier Impairment in Alzheimer Disease: Stability and Functional Significance
    • Bowman, G. L.; Kaye, J. A.; Moore, M.; Waichunas, D.; Carlson, N. E.; Quinn, J. F. Blood-Brain Barrier Impairment in Alzheimer Disease: Stability and Functional Significance Neurology 2007, 68, 1809-1814
    • (2007) Neurology , vol.68 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 13
    • 63249115678 scopus 로고    scopus 로고
    • The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
    • Weiss, N.; Miller, F.; Cazaubon, S.; Couraud, P. O. The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases Biochim. Biophys. Acta 2009, 1788, 842-857
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 14
    • 0035212257 scopus 로고    scopus 로고
    • Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations
    • Lee, G.; Dallas, S.; Hong, M.; Bendayan, R. Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations Pharmacol. Rev. 2001, 53, 569-596
    • (2001) Pharmacol. Rev. , vol.53 , pp. 569-596
    • Lee, G.1    Dallas, S.2    Hong, M.3    Bendayan, R.4
  • 15
    • 77951477367 scopus 로고    scopus 로고
    • Blood-Brain Barrier Disruption with Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment
    • Liu, H. L.; Hua, M. Y.; Chen, P. Y.; Chu, P. C.; Pan, C. H.; Yang, H. W.; Huang, C. Y.; Wang, J. J.; Yen, T. C.; Wei, K. C. Blood-Brain Barrier Disruption with Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment Radiology 2010, 255, 415-425
    • (2010) Radiology , vol.255 , pp. 415-425
    • Liu, H.L.1    Hua, M.Y.2    Chen, P.Y.3    Chu, P.C.4    Pan, C.H.5    Yang, H.W.6    Huang, C.Y.7    Wang, J.J.8    Yen, T.C.9    Wei, K.C.10
  • 17
    • 60849128839 scopus 로고    scopus 로고
    • Convection-Enhanced Delivery of Nanocarriers for the Treatment of Brain Tumors
    • Allard, E.; Passirani, C.; Benoit, J. P. Convection-Enhanced Delivery of Nanocarriers for the Treatment of Brain Tumors Biomaterials 2009, 30, 2302-2318
    • (2009) Biomaterials , vol.30 , pp. 2302-2318
    • Allard, E.1    Passirani, C.2    Benoit, J.P.3
  • 18
    • 0033974507 scopus 로고    scopus 로고
    • Osmotic Opening of the Blood-Brain Barrier: Principles, Mechanism, and Therapeutic Applications
    • Rapoport, S. I. Osmotic Opening of the Blood-Brain Barrier: Principles, Mechanism, and Therapeutic Applications Cell. Mol. Neurobiol. 2000, 20, 217-230
    • (2000) Cell. Mol. Neurobiol. , vol.20 , pp. 217-230
    • Rapoport, S.I.1
  • 19
    • 0021082395 scopus 로고
    • Pharmacology and Neurotoxicity of Cis-Diamminedichloroplatinum, Bleomycin, 5-Fluorouracil, and Cyclophosphamide Administration Following Osmotic Blood-Brain Barrier Modification
    • Neuwelt, E. A.; Barnett, P. A.; Glasberg, M.; Frenkel, E. P. Pharmacology and Neurotoxicity of Cis-Diamminedichloroplatinum, Bleomycin, 5-Fluorouracil, and Cyclophosphamide Administration Following Osmotic Blood-Brain Barrier Modification Cancer Res. 1983, 43, 5278-5285
    • (1983) Cancer Res. , vol.43 , pp. 5278-5285
    • Neuwelt, E.A.1    Barnett, P.A.2    Glasberg, M.3    Frenkel, E.P.4
  • 21
    • 44149099480 scopus 로고    scopus 로고
    • Ultrasound for Drug and Gene Delivery to the Brain
    • Hynynen, K. Ultrasound for Drug and Gene Delivery to the Brain Adv. Drug Delivery Rev. 2008, 60, 1209-1217
    • (2008) Adv. Drug Delivery Rev. , vol.60 , pp. 1209-1217
    • Hynynen, K.1
  • 22
    • 33746851261 scopus 로고    scopus 로고
    • Noninvasive Localized Delivery of Herceptin to the Mouse Brain by Mri-Guided Focused Ultrasound-Induced Blood-Brain Barrier Disruption
    • Kinoshita, M.; McDannold, N.; Jolesz, F. A.; Hynynen, K. Noninvasive Localized Delivery of Herceptin to the Mouse Brain by Mri-Guided Focused Ultrasound-Induced Blood-Brain Barrier Disruption Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 11719-11723
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 11719-11723
    • Kinoshita, M.1    McDannold, N.2    Jolesz, F.A.3    Hynynen, K.4
  • 23
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: Crossing Cellular Barriers
    • Tuma, P.; Hubbard, A. L. Transcytosis: Crossing Cellular Barriers Physiol. Rev. 2003, 83, 871-932
    • (2003) Physiol. Rev. , vol.83 , pp. 871-932
    • Tuma, P.1    Hubbard, A.L.2
  • 24
    • 57149110011 scopus 로고    scopus 로고
    • CNS Delivery via Adsorptive Transcytosis
    • Herve, F.; Ghinea, N.; Scherrmann, J. M. CNS Delivery via Adsorptive Transcytosis AAPS J. 2008, 10, 455-472
    • (2008) AAPS J. , vol.10 , pp. 455-472
    • Herve, F.1    Ghinea, N.2    Scherrmann, J.M.3
  • 26
    • 79959903861 scopus 로고    scopus 로고
    • Imaging Brain Tumor by Dendrimer-Based Optical/Paramagnetic Nanoprobe et al.across the Blood-Brain Barrier
    • Yan, H.; Wang, J.; Yi, P.; Lei, H.; Zhan, C.; Xie, C.; Feng, L.; Qian, J.; Zhu, J.; Lu, W. et al. Imaging Brain Tumor by Dendrimer-Based Optical/Paramagnetic Nanoprobe across the Blood-Brain Barrier Chem. Commun. 2011, 47, 8130-8132
    • (2011) Chem. Commun. , vol.47 , pp. 8130-8132
    • Yan, H.1    Wang, J.2    Yi, P.3    Lei, H.4    Zhan, C.5    Xie, C.6    Feng, L.7    Qian, J.8    Zhu, J.9    Lu, W.10
  • 27
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine Receptors as Therapeutic Targets
    • Jacobson, K. A.; Gao, Z. G. Adenosine Receptors as Therapeutic Targets Nat. Rev. Drug Discovery 2006, 5, 247-264
    • (2006) Nat. Rev. Drug Discovery , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 28
    • 80052932416 scopus 로고    scopus 로고
    • Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier
    • Carman, A. J.; Mills, J. H.; Krenz, A.; Kim, D. G.; Bynoe, M. S. Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier J. Neurosci. 2011, 31, 13272-13280
    • (2011) J. Neurosci. , vol.31 , pp. 13272-13280
    • Carman, A.J.1    Mills, J.H.2    Krenz, A.3    Kim, D.G.4    Bynoe, M.S.5
  • 30
    • 84893316235 scopus 로고    scopus 로고
    • Adenosine A2a Receptor as a Drug Discovery Target
    • 10.1021/jm4011669
    • de Lera Ruiz, M.; Lim, Y.-H.; Zheng, J. Adenosine A2a Receptor as a Drug Discovery Target J. Med. Chem. 2013, 10.1021/jm4011669
    • (2013) J. Med. Chem.
    • De Lera Ruiz, M.1    Lim, Y.-H.2    Zheng, J.3
  • 31
    • 84864258079 scopus 로고    scopus 로고
    • The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
    • Albanese, A.; Tang, P. S.; Chan, W. C. The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems Annu. Rev. Biomed. Eng. 2012, 14, 1-16
    • (2012) Annu. Rev. Biomed. Eng. , vol.14 , pp. 1-16
    • Albanese, A.1    Tang, P.S.2    Chan, W.C.3
  • 34
    • 71849102712 scopus 로고    scopus 로고
    • Molecules of Various Pharmacologically-Relevant Sizes Can Cross the Ultrasound-Induced Blood-Brain Barrier Opening in Vivo
    • Choi, J. J.; Wang, S.; Tung, Y. S.; Morrison, B., 3rd; Konofagou, E. E. Molecules of Various Pharmacologically-Relevant Sizes Can Cross the Ultrasound-Induced Blood-Brain Barrier Opening in Vivo Ultrasound Med. Biol. 2010, 36, 58-67
    • (2010) Ultrasound Med. Biol. , vol.36 , pp. 58-67
    • Choi, J.J.1    Wang, S.2    Tung, Y.S.3    Morrison III, B.4    Konofagou, E.E.5
  • 36
    • 37049081723 scopus 로고
    • Adenine Isosteres with Bridgehead Nitrogen. Part 1. Two Independent Syntheses of the [1,2,4]Triazolo[1,5-A][1,3,5]Triazine Ring System Leading to a Range of Substituents in the 2, 5 and 7 Positions
    • Caulkett, P. W. R.; Jones, G.; McPartlin, M.; Renshaw, N. D.; Stewart, S. K.; Wright, B. Adenine Isosteres with Bridgehead Nitrogen. Part 1. Two Independent Syntheses of the [1,2,4]Triazolo[1,5-a][1,3,5]Triazine Ring System Leading to a Range of Substituents in the 2, 5 and 7 Positions J. Chem. Soc., Perkins Trans. 1 1995, 801-808
    • (1995) J. Chem. Soc., Perkins Trans. 1 , pp. 801-808
    • Caulkett, P.W.R.1    Jones, G.2    McPartlin, M.3    Renshaw, N.D.4    Stewart, S.K.5    Wright, B.6
  • 37
    • 0021968534 scopus 로고
    • Growth of Human Lung Tumor in the Brain of the Nude Rat as a Model to Evaluate Antitumor Agent Delivery across the Blood-Brain Barrier
    • Neuwelt, E. A.; Frenkel, E. P.; D'Agostino, A. N.; Carney, D. N.; Minna, J. D.; Barnett, P. A.; McCormick, C. I. Growth of Human Lung Tumor in the Brain of the Nude Rat as a Model to Evaluate Antitumor Agent Delivery across the Blood-Brain Barrier Cancer Res. 1985, 45, 2827-2833
    • (1985) Cancer Res. , vol.45 , pp. 2827-2833
    • Neuwelt, E.A.1    Frenkel, E.P.2    D'Agostino, A.N.3    Carney, D.N.4    Minna, J.D.5    Barnett, P.A.6    McCormick, C.I.7
  • 38
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes Are Required for Blood-Brain Barrier Integrity during Embryogenesis
    • Daneman, R.; Zhou, L.; Kebede, A. A.; Barres, B. A. Pericytes Are Required for Blood-Brain Barrier Integrity during Embryogenesis Nature 2010, 468, 562-566
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 40
    • 84870905282 scopus 로고    scopus 로고
    • Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury
    • Thal, S. C.; Luh, C.; Schaible, E. V.; Timaru-Kast, R.; Hedrich, J.; Luhmann, H. J.; Engelhard, K.; Zehendner, C. M. Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury PLoS One 2012, 7, e50752
    • (2012) PLoS One , vol.7 , pp. 50752
    • Thal, S.C.1    Luh, C.2    Schaible, E.V.3    Timaru-Kast, R.4    Hedrich, J.5    Luhmann, H.J.6    Engelhard, K.7    Zehendner, C.M.8
  • 41
    • 0029053842 scopus 로고
    • Lung Macrophage Uptake of Unopsonized Environmental Particulates. Role of Scavenger-Type Receptors
    • Kobzik, L. Lung Macrophage Uptake of Unopsonized Environmental Particulates. Role of Scavenger-Type Receptors J. Immunol. 1995, 155, 367-376
    • (1995) J. Immunol. , vol.155 , pp. 367-376
    • Kobzik, L.1
  • 42
    • 79952670561 scopus 로고    scopus 로고
    • Detection of Amyloid Plaques Targeted by Uspio-Abeta1-42 in Alzheimer's Disease Transgenic Mice Using Magnetic Resonance Microimaging
    • Yang, J.; Wadghiri, Y. Z.; Hoang, D. M.; Tsui, W.; Sun, Y.; Chung, E.; Li, Y.; Wang, A.; de Leon, M.; Wisniewski, T. Detection of Amyloid Plaques Targeted by Uspio-Abeta1-42 in Alzheimer's Disease Transgenic Mice Using Magnetic Resonance Microimaging Neuroimage 2011, 55, 1600-1609
    • (2011) Neuroimage , vol.55 , pp. 1600-1609
    • Yang, J.1    Wadghiri, Y.Z.2    Hoang, D.M.3    Tsui, W.4    Sun, Y.5    Chung, E.6    Li, Y.7    Wang, A.8    De Leon, M.9    Wisniewski, T.10
  • 43
    • 34748867746 scopus 로고    scopus 로고
    • Enhanced Disruption of the Blood Brain Barrier by Intracarotid Mannitol Injection during Transient Cerebral Hypoperfusion in Rabbits
    • Wang, M.; Etu, J.; Joshi, S. Enhanced Disruption of the Blood Brain Barrier by Intracarotid Mannitol Injection during Transient Cerebral Hypoperfusion in Rabbits J. Neurosurg. Anesthesiol. 2007, 19, 249-256
    • (2007) J. Neurosurg. Anesthesiol. , vol.19 , pp. 249-256
    • Wang, M.1    Etu, J.2    Joshi, S.3
  • 45
    • 34250324684 scopus 로고    scopus 로고
    • a Calculations of Aliphatic Amines, Diamines, and Aminoamides via Density Functional Theory with a Poisson-Boltzmann Continuum Solvent Model
    • a Calculations of Aliphatic Amines, Diamines, and Aminoamides via Density Functional Theory with a Poisson-Boltzmann Continuum Solvent Model J. Phys. Chem. A 2007, 111, 4422-4430
    • (2007) J. Phys. Chem. A , vol.111 , pp. 4422-4430
    • Bryantsev, V.S.1    Diallo, M.S.2    Goddard III W., A.3
  • 46
    • 39749132227 scopus 로고    scopus 로고
    • Toward Multivalent Signaling across G Protein-Coupled Receptors from Poly(Amidoamine) Dendrimers
    • Kim, Y.; Hechler, B.; Klutz, A. M.; Gachet, C.; Jacobson, K. A. Toward Multivalent Signaling across G Protein-Coupled Receptors from Poly(Amidoamine) Dendrimers Bioconjugate Chem. 2008, 19, 406-411
    • (2008) Bioconjugate Chem. , vol.19 , pp. 406-411
    • Kim, Y.1    Hechler, B.2    Klutz, A.M.3    Gachet, C.4    Jacobson, K.A.5
  • 47
    • 77049109479 scopus 로고    scopus 로고
    • Polyamidoamine (PAMAM) Dendrimer Conjugates of "clickable" Agonists of the A3 Adenosine Receptor and Coactivation of the P2y14 Receptor by a Tethered Nucleotide
    • Tosh, D. K.; Yoo, L. S.; Chinn, M.; Hong, K.; Kilbey, S. M., 2nd; Barrett, M. O.; Fricks, I. P.; Harden, T. K.; Gao, Z. G.; Jacobson, K. A. Polyamidoamine (PAMAM) Dendrimer Conjugates of "Clickable" Agonists of the A3 Adenosine Receptor and Coactivation of the P2y14 Receptor by a Tethered Nucleotide Bioconjugate Chem. 2010, 21, 372-384
    • (2010) Bioconjugate Chem. , vol.21 , pp. 372-384
    • Tosh, D.K.1    Yoo, L.S.2    Chinn, M.3    Hong, K.4    Kilbey II, S.M.5    Barrett, M.O.6    Fricks, I.P.7    Harden, T.K.8    Gao, Z.G.9    Jacobson, K.A.10
  • 48
    • 33746296180 scopus 로고    scopus 로고
    • Synthetic Multivalent Ligands as Probes of Signal Transduction
    • Kiessling, L. L.; Gestwicki, J. E.; Strong, L. E. Synthetic Multivalent Ligands as Probes of Signal Transduction Angew. Chem., Int. Ed. 2006, 45, 2348-2368
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 2348-2368
    • Kiessling, L.L.1    Gestwicki, J.E.2    Strong, L.E.3
  • 49
    • 34447632041 scopus 로고    scopus 로고
    • Allosteric GPCR Modulators: Taking Advantage of Permissive Receptor Pharmacology
    • Leach, K.; Sexton, P. M.; Christopoulos, A. Allosteric GPCR Modulators: Taking Advantage of Permissive Receptor Pharmacology Trends Pharmacol. Sci. 2007, 28, 382-389
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 382-389
    • Leach, K.1    Sexton, P.M.2    Christopoulos, A.3
  • 50
    • 70349157276 scopus 로고    scopus 로고
    • Enhanced Potency of Nucleotide-Dendrimer Conjugates as Agonists of the P2y14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition
    • Das, A.; Zhou, Y.; Ivanov, A. A.; Carter, R. L.; Harden, T. K.; Jacobson, K. A. Enhanced Potency of Nucleotide-Dendrimer Conjugates as Agonists of the P2y14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition Bioconjugate Chem. 2009, 20, 1650-1659
    • (2009) Bioconjugate Chem. , vol.20 , pp. 1650-1659
    • Das, A.1    Zhou, Y.2    Ivanov, A.A.3    Carter, R.L.4    Harden, T.K.5    Jacobson, K.A.6
  • 51
    • 0036973951 scopus 로고    scopus 로고
    • Adenosine Receptors in the Nervous System: Pathophysiological Implications
    • Ribeiro, J. A.; Sebastiao, A. M.; de Mendonca, A. Adenosine Receptors in the Nervous System: Pathophysiological Implications Prog. Neurobiol. 2002, 68, 377-392
    • (2002) Prog. Neurobiol. , vol.68 , pp. 377-392
    • Ribeiro, J.A.1    Sebastiao, A.M.2    De Mendonca, A.3
  • 52
    • 84856164075 scopus 로고    scopus 로고
    • Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier
    • Yan, H.; Wang, L.; Wang, J.; Weng, X.; Lei, H.; Wang, X.; Jiang, L.; Zhu, J.; Lu, W.; Wei, X. et al. Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier ACS Nano 2012, 6, 410-420
    • (2012) ACS Nano , vol.6 , pp. 410-420
    • Yan, H.1    Wang, L.2    Wang, J.3    Weng, X.4    Lei, H.5    Wang, X.6    Jiang, L.7    Zhu, J.8    Lu, W.9    Wei, X.10
  • 53
    • 65249102263 scopus 로고    scopus 로고
    • Facile Synthesis of 1-(Acetic Acid)-4,7,10-Tris(tert- Butoxycarbonylmethyl)-1,4,7,10-Tetraaza-Cyclododecane: A Reactive Precursor Chelating Agent
    • Li, C.; Winnard, P., Jr.; Bhujwalla, Z. M. Facile Synthesis of 1-(Acetic Acid)-4,7,10-Tris(tert-Butoxycarbonylmethyl)-1,4,7,10-Tetraaza-Cyclododecane: A Reactive Precursor Chelating Agent Tetrahedron Lett. 2009, 50, 2929-2931
    • (2009) Tetrahedron Lett. , vol.50 , pp. 2929-2931
    • Li, C.1    Winnard Jr., P.2    Bhujwalla, Z.M.3
  • 54
    • 0035847134 scopus 로고    scopus 로고
    • 3)H]Zm241385-an Antagonist Radioligand for Adenosine a(2a) Receptors in Rat Brain
    • Alexander, S. P.; Millns, P. J. [(3)H]Zm241385-an Antagonist Radioligand for Adenosine a(2a) Receptors in Rat Brain Eur. J. Pharmacol. 2001, 411, 205-210
    • (2001) Eur. J. Pharmacol. , vol.411 , pp. 205-210
    • Alexander, S.P.1    Millns, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.