TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice

Journal of Autoimmunity

Volumn 60, Issue , 2015, Pages 40-50

  Wen, Jing ^a   Doerner, Jessica ^a   Weidenheim, Karen ^a   Xia, Yumin ^a   Stock, Ariel ^a   Michaelson, Jennifer S ^b   Baruch, Kuti ^c   Deczkowska, Aleksandra ^c   Gulinello, Maria ^a   Schwartz, Michal ^c   Burkly, Linda C ^d   Putterman, Chaim ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Jounce Therapeutics   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d BIOGEN   (United States)

Author keywords

Fn14; Neuropsychiatric lupus (NPSLE); Systemic lupus erythematous (SLE); TWEAK

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C6; DEXTRAN; FIBRONECTIN; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN G; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR LIKE WEAK INDUCER OF APOPTOSIS; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; PROTEIN ZO1; TJP1 PROTEIN, MOUSE; TNFSF12 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR; TWEAK RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HISTOLOGY; BRAIN TISSUE; CELL INFILTRATION; CHOROID PLEXUS; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FEMALE; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LUPUS VULGARIS; MEMBRANE PERMEABILITY; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPSYCHIATRIC LUPUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BIOSYNTHESIS; COGNITION; DEPRESSION; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; CHOROID PLEXUS; COGNITION; COMPLEMENT C3; COMPLEMENT C4A; COMPLEMENT C6; DEPRESSION; DISEASE MODELS, ANIMAL; GLIOSIS; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE-1; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; NERVE DEGENERATION; NEURONS; PERMEABILITY; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS; VASCULAR CELL ADHESION MOLECULE-1; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84931010152     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.03.005     Document Type: Article

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