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Volumn 39, Issue 8, 2016, Pages 1114-1128

DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control

Author keywords

Diabetic complications; DPP 4 inhibitors; GLP 1; Type 2 diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; INCRETIN; INSULIN; ANTIDIABETIC AGENT; DPP4 PROTEIN, HUMAN; GLUCOSE BLOOD LEVEL;

EID: 84981267513     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-016-0813-x     Document Type: Review
Times cited : (48)

References (142)
  • 1
    • 84869873926 scopus 로고    scopus 로고
    • Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis
    • COI: 1:CAS:528:DC%2BC38XhsF2ms7vI, PID: 23122333
    • Aghili N, Devaney JM, Alderman LO, Zukowska Z, Epstein SE, Burnett MS (2012) Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis. Neuropeptides 46:367–371
    • (2012) Neuropeptides , vol.46 , pp. 367-371
    • Aghili, N.1    Devaney, J.M.2    Alderman, L.O.3    Zukowska, Z.4    Epstein, S.E.5    Burnett, M.S.6
  • 2
    • 83955161115 scopus 로고    scopus 로고
    • A novel long acting DPP-IV inhibitor PKF-275-055 stimulates beta-cell proliferation resulting in improved glucose homeostasis in diabetic rats
    • COI: 1:CAS:528:DC%2BC3MXhs1Gjs77F, PID: 22015634
    • Akarte AS, Srinivasan BP, Gandhi S (2012) A novel long acting DPP-IV inhibitor PKF-275-055 stimulates beta-cell proliferation resulting in improved glucose homeostasis in diabetic rats. Biochem Pharmacol 83:241–252
    • (2012) Biochem Pharmacol , vol.83 , pp. 241-252
    • Akarte, A.S.1    Srinivasan, B.P.2    Gandhi, S.3
  • 4
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • COI: 1:CAS:528:DC%2BC3cXltFSmtL0%3D, PID: 20068138
    • Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H (2010) Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59:1030–1037
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3    Ebato, C.4    Goto, H.5    Nomiyama, T.6    Fujitani, Y.7    Hirose, T.8    Kawamori, R.9    Watada, H.10
  • 7
    • 70450235041 scopus 로고    scopus 로고
    • Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process
    • COI: 1:CAS:528:DC%2BD1MXhsVCjtbzK, PID: 19755420
    • Aviv V, Meivar-Levy I, Rachmut IH, Rubinek T, Mor E, Ferber S (2009) Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process. J Biol Chem 284:33509–33520
    • (2009) J Biol Chem , vol.284 , pp. 33509-33520
    • Aviv, V.1    Meivar-Levy, I.2    Rachmut, I.H.3    Rubinek, T.4    Mor, E.5    Ferber, S.6
  • 11
    • 79956114434 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase
    • COI: 1:CAS:528:DC%2BC3MXmsVygsbo%3D, PID: 21145820
    • Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, Barzilai N, Oren R, Fishman S (2011) Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. J Hepatol 54:1214–1223
    • (2011) J Hepatol , vol.54 , pp. 1214-1223
    • Ben-Shlomo, S.1    Zvibel, I.2    Shnell, M.3    Shlomai, A.4    Chepurko, E.5    Halpern, Z.6    Barzilai, N.7    Oren, R.8    Fishman, S.9
  • 12
    • 83955163338 scopus 로고    scopus 로고
    • Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
    • COI: 1:CAS:528:DC%2BC38XjtVSlsbg%3D, PID: 21984837
    • Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, Ghezzi P, Cavaletti G, Lauria G (2012) Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy. J Pharmacol Exp Ther 340:64–72
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 64-72
    • Bianchi, R.1    Cervellini, I.2    Porretta-Serapiglia, C.3    Oggioni, N.4    Burkey, B.5    Ghezzi, P.6    Cavaletti, G.7    Lauria, G.8
  • 14
    • 84898964381 scopus 로고    scopus 로고
    • GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other?
    • COI: 1:CAS:528:DC%2BC2cXmslyjt74%3D, PID: 24499291
    • Brunton S (2014) GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other? Int J Clin Pract 68:557–567
    • (2014) Int J Clin Pract , vol.68 , pp. 557-567
    • Brunton, S.1
  • 15
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • COI: 1:CAS:528:DyaK28XjvVWjtLo%3D, PID: 8770921
    • Bullock BP, Heller RS, Habener JF (1996) Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968–2978
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 18
    • 84964725797 scopus 로고    scopus 로고
    • An update on the effect of incretin-based therapies on beta-cell function and mass
    • PID: 27126881
    • Chon S, Gautier JF (2016) An update on the effect of incretin-based therapies on beta-cell function and mass. Diabetes Metab J 40:99–114
    • (2016) Diabetes Metab J , vol.40 , pp. 99-114
    • Chon, S.1    Gautier, J.F.2
  • 20
    • 70349774693 scopus 로고    scopus 로고
    • On the origin of serum CD26 and its altered concentration in cancer patients
    • COI: 1:CAS:528:DC%2BD1MXhtVWisbvM, PID: 19557413
    • Cordero OJ, Salgado FJ, Nogueira M (2009) On the origin of serum CD26 and its altered concentration in cancer patients. Cancer Immunol Immunother 58:1723–1747
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1723-1747
    • Cordero, O.J.1    Salgado, F.J.2    Nogueira, M.3
  • 21
    • 84859341109 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: 3 years of experience
    • COI: 1:CAS:528:DC%2BC38XkvFSnsrk%3D, PID: 22324384
    • Derosa G, Maffioli P (2012) Dipeptidyl peptidase-4 inhibitors: 3 years of experience. Diabetes Technol Ther 14:350–364
    • (2012) Diabetes Technol Ther , vol.14 , pp. 350-364
    • Derosa, G.1    Maffioli, P.2
  • 22
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • COI: 1:CAS:528:DC%2BD28Xpt1Snsw%3D%3D, PID: 16374859
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA (2006) Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43:173–181
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 25
    • 77957881269 scopus 로고    scopus 로고
    • Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease: a novel liver disease biomarker
    • PID: 20805868
    • Firneisz G, Varga T, Lengyel G, Feher J, Ghyczy D, Wichmann B, Selmeci L, Tulassay Z, Racz K, Somogyi A (2010) Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease: a novel liver disease biomarker. PLoS One 5:e12226
    • (2010) PLoS One , vol.5
    • Firneisz, G.1    Varga, T.2    Lengyel, G.3    Feher, J.4    Ghyczy, D.5    Wichmann, B.6    Selmeci, L.7    Tulassay, Z.8    Racz, K.9    Somogyi, A.10
  • 26
    • 36849040001 scopus 로고    scopus 로고
    • Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice
    • COI: 1:CAS:528:DC%2BD2sXhsValurvI, PID: 17717280
    • Flock G, Baggio LL, Longuet C, Drucker DJ (2007) Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 56:3006–3013
    • (2007) Diabetes , vol.56 , pp. 3006-3013
    • Flock, G.1    Baggio, L.L.2    Longuet, C.3    Drucker, D.J.4
  • 27
    • 48649107640 scopus 로고    scopus 로고
    • Conditioning response to granulocyte colony-stimulating factor via the dipeptidyl peptidase IV-adenosine deaminase complex
    • COI: 1:CAS:528:DC%2BD1cXptF2htr8%3D, PID: 18511574
    • Focosi D, Kast RE, Galimberti S, Petrini M (2008) Conditioning response to granulocyte colony-stimulating factor via the dipeptidyl peptidase IV-adenosine deaminase complex. J Leukoc Biol 84:331–337
    • (2008) J Leukoc Biol , vol.84 , pp. 331-337
    • Focosi, D.1    Kast, R.E.2    Galimberti, S.3    Petrini, M.4
  • 28
    • 84877618486 scopus 로고    scopus 로고
    • Effect of vildagliptin compared to glimepiride on postprandial proinsulin processing in the beta cell of patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC3sXntFyrsr4%3D, PID: 23384119
    • Forst T, Dworak M, Berndt-Zipfel C, Loffler A, Klamp I, Mitry M, Pfutzner A (2013) Effect of vildagliptin compared to glimepiride on postprandial proinsulin processing in the beta cell of patients with type 2 diabetes mellitus. Diabetes Obes Metab 15:576–579
    • (2013) Diabetes Obes Metab , vol.15 , pp. 576-579
    • Forst, T.1    Dworak, M.2    Berndt-Zipfel, C.3    Loffler, A.4    Klamp, I.5    Mitry, M.6    Pfutzner, A.7
  • 29
    • 84893771907 scopus 로고    scopus 로고
    • The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice
    • COI: 1:CAS:528:DC%2BC3sXhvFOgs7nL, PID: 24309217
    • Fukuda-Tsuru S, Kakimoto T, Utsumi H, Kiuchi S, Ishii S (2014) The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice. Eur J Pharmacol 723:207–215
    • (2014) Eur J Pharmacol , vol.723 , pp. 207-215
    • Fukuda-Tsuru, S.1    Kakimoto, T.2    Utsumi, H.3    Kiuchi, S.4    Ishii, S.5
  • 30
    • 0025284740 scopus 로고
    • Quantitative immunogold localization of dipeptidyl peptidase IV (DPP IV) in rat liver cells
    • COI: 1:CAS:528:DyaK3cXkslGgtrw%3D, PID: 1972662
    • Fukui Y, Yamamoto A, Kyoden T, Kato K, Tashiro Y (1990) Quantitative immunogold localization of dipeptidyl peptidase IV (DPP IV) in rat liver cells. Cell Struct Funct 15:117–125
    • (1990) Cell Struct Funct , vol.15 , pp. 117-125
    • Fukui, Y.1    Yamamoto, A.2    Kyoden, T.3    Kato, K.4    Tashiro, Y.5
  • 31
    • 0031925072 scopus 로고    scopus 로고
    • Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells
    • COI: 1:CAS:528:DyaK1cXisFCksbo%3D, PID: 9537431
    • Gaetaniello L, Fiore M, de Filippo S, Pozzi N, Tamasi S, Pignata C (1998) Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells. Hepatology 27:934–942
    • (1998) Hepatology , vol.27 , pp. 934-942
    • Gaetaniello, L.1    Fiore, M.2    de Filippo, S.3    Pozzi, N.4    Tamasi, S.5    Pignata, C.6
  • 32
    • 84884977867 scopus 로고    scopus 로고
    • Prognostic implications of DPP-4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting–results of the 1 year follow-up of the prospective DiaRegis registry
    • COI: 1:CAS:528:DC%2BC3sXhslGhsbvJ, PID: 23981060
    • Gitt AK, Bramlage P, Binz C, Krekler M, Deeg E, Tschope D (2013) Prognostic implications of DPP-4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting–results of the 1 year follow-up of the prospective DiaRegis registry. Int J Clin Pract 67:1005–1014
    • (2013) Int J Clin Pract , vol.67 , pp. 1005-1014
    • Gitt, A.K.1    Bramlage, P.2    Binz, C.3    Krekler, M.4    Deeg, E.5    Tschope, D.6
  • 33
    • 84860441011 scopus 로고    scopus 로고
    • Inflammation and lipid signaling in the etiology of insulin resistance
    • COI: 1:CAS:528:DC%2BC38XmsVCjtLc%3D, PID: 22560216
    • Glass CK, Olefsky JM (2012) Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 15:635–645
    • (2012) Cell Metab , vol.15 , pp. 635-645
    • Glass, C.K.1    Olefsky, J.M.2
  • 34
    • 17144404555 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
    • COI: 1:CAS:528:DC%2BD2MXisV2jtrY%3D
    • Gorrell MD (2005) Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin Sci (Lond) 108:277–292
    • (2005) Clin Sci (Lond) , vol.108 , pp. 277-292
    • Gorrell, M.D.1
  • 35
    • 0035723325 scopus 로고    scopus 로고
    • CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes
    • COI: 1:CAS:528:DC%2BD3MXnt1Sru7c%3D, PID: 11555388
    • Gorrell MD, Gysbers V, McCaughan GW (2001) CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol 54:249–264
    • (2001) Scand J Immunol , vol.54 , pp. 249-264
    • Gorrell, M.D.1    Gysbers, V.2    McCaughan, G.W.3
  • 37
    • 84890476805 scopus 로고    scopus 로고
    • Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
    • COI: 1:CAS:528:DC%2BC3sXhsl2ht7vN, PID: 24026560
    • Groop PH, Cooper ME, Perkovic V, Emser A, Woerle HJ, von Eynatten M (2013) Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction. Diabetes Care 36:3460–3468
    • (2013) Diabetes Care , vol.36 , pp. 3460-3468
    • Groop, P.H.1    Cooper, M.E.2    Perkovic, V.3    Emser, A.4    Woerle, H.J.5    von Eynatten, M.6
  • 38
    • 84908077770 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
    • COI: 1:CAS:528:DC%2BC2MXisFWls78%3D, PID: 25336915
    • Gu N, Park MK, Kim TE, Bahng MY, Lim KS, Cho SH, Yoon SH, Cho JY, Jang IJ, Yu KS (2014) Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers. Drug Des Devel Ther 8:1709–1721
    • (2014) Drug Des Devel Ther , vol.8 , pp. 1709-1721
    • Gu, N.1    Park, M.K.2    Kim, T.E.3    Bahng, M.Y.4    Lim, K.S.5    Cho, S.H.6    Yoon, S.H.7    Cho, J.Y.8    Jang, I.J.9    Yu, K.S.10
  • 39
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • COI: 1:CAS:528:DC%2BC3cXntFCqtb0%3D, PID: 20225248
    • Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, Saxena NK, Anania FA (2010) Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 51:1584–1592
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6    Anania, F.A.7
  • 41
    • 79955821979 scopus 로고    scopus 로고
    • Effect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats
    • COI: 1:CAS:528:DC%2BC3MXmtFartLw%3D, PID: 21345512
    • Han SJ, Choi SE, Kang Y, Jung JG, Yi SA, Kim HJ, Lee KW, Kim DJ (2011) Effect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats. Diabetes Res Clin Pract 92:213–222
    • (2011) Diabetes Res Clin Pract , vol.92 , pp. 213-222
    • Han, S.J.1    Choi, S.E.2    Kang, Y.3    Jung, J.G.4    Yi, S.A.5    Kim, H.J.6    Lee, K.W.7    Kim, D.J.8
  • 43
    • 84931035973 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor vildagliptin has the capacity to repair beta-cell dysfunction and insulin resistance
    • COI: 1:CAS:528:DC%2BC2cXhvVekurvN, PID: 24977657
    • Horie A, Tokuyama Y, Ishizuka T, Suzuki Y, Marumo K, Oshikiri K, Ide K, Sunaga M, Kanatsuka A (2014) The dipeptidyl peptidase-4 inhibitor vildagliptin has the capacity to repair beta-cell dysfunction and insulin resistance. Horm Metab Res 46:814–818
    • (2014) Horm Metab Res , vol.46 , pp. 814-818
    • Horie, A.1    Tokuyama, Y.2    Ishizuka, T.3    Suzuki, Y.4    Marumo, K.5    Oshikiri, K.6    Ide, K.7    Sunaga, M.8    Kanatsuka, A.9
  • 44
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • COI: 1:CAS:528:DC%2BC3cXhsVygt74%3D, PID: 19957161
    • Hsieh J, Longuet C, Baker CL, Qin B, Federico LM, Drucker DJ, Adeli K (2010) The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 53:552–561
    • (2010) Diabetologia , vol.53 , pp. 552-561
    • Hsieh, J.1    Longuet, C.2    Baker, C.L.3    Qin, B.4    Federico, L.M.5    Drucker, D.J.6    Adeli, K.7
  • 45
    • 0041765665 scopus 로고    scopus 로고
    • Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia
    • COI: 1:CAS:528:DC%2BD3sXlvFCgtb0%3D, PID: 12882932
    • Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, Fernyhough P (2003) Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes 52:2129–2136
    • (2003) Diabetes , vol.52 , pp. 2129-2136
    • Huang, T.J.1    Price, S.A.2    Chilton, L.3    Calcutt, N.A.4    Tomlinson, D.R.5    Verkhratsky, A.6    Fernyhough, P.7
  • 46
    • 84949424443 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor teneligliptin attenuates hepatic lipogenesis via AMPK activation in non-alcoholic fatty liver disease model mice
    • PID: 26670228
    • Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, Shimizu M (2015) The dipeptidyl peptidase-4 inhibitor teneligliptin attenuates hepatic lipogenesis via AMPK activation in non-alcoholic fatty liver disease model mice. Int J Mol Sci 16:29207–29218
    • (2015) Int J Mol Sci , vol.16 , pp. 29207-29218
    • Ideta, T.1    Shirakami, Y.2    Miyazaki, T.3    Kochi, T.4    Sakai, H.5    Moriwaki, H.6    Shimizu, M.7
  • 47
    • 84866653492 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor improves insulin resistance and steatosis in a refractory nonalcoholic fatty liver disease patient: a case report
    • PID: 22949894
    • Itou M, Kawaguchi T, Taniguchi E, Oriishi T, Sata M (2012) Dipeptidyl peptidase IV inhibitor improves insulin resistance and steatosis in a refractory nonalcoholic fatty liver disease patient: a case report. Case Rep Gastroenterol 6:538–544
    • (2012) Case Rep Gastroenterol , vol.6 , pp. 538-544
    • Itou, M.1    Kawaguchi, T.2    Taniguchi, E.3    Oriishi, T.4    Sata, M.5
  • 49
    • 71649102751 scopus 로고    scopus 로고
    • Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BD1MXhsFyns77E, PID: 20082866
    • Jin HY, Liu WJ, Park JH, Baek HS, Park TS (2009) Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. Arch Med Res 40:536–544
    • (2009) Arch Med Res , vol.40 , pp. 536-544
    • Jin, H.Y.1    Liu, W.J.2    Park, J.H.3    Baek, H.S.4    Park, T.S.5
  • 50
    • 80053409431 scopus 로고    scopus 로고
    • GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice
    • COI: 1:CAS:528:DC%2BC3MXhsVOjsrbO, PID: 21635674
    • Jolivalt C, Fineman M, Deacon CF, Carr R, Calcutt N (2011) GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes Obes Metab 13:990–1000
    • (2011) Diabetes Obes Metab , vol.13 , pp. 990-1000
    • Jolivalt, C.1    Fineman, M.2    Deacon, C.F.3    Carr, R.4    Calcutt, N.5
  • 53
    • 84901309585 scopus 로고    scopus 로고
    • Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen
    • COI: 1:CAS:528:DC%2BC2cXhsV2ls73L, PID: 24574044
    • Kanasaki K, Shi S, Kanasaki M, He J, Nagai T, Nakamura Y, Ishigaki Y, Kitada M, Srivastava SP, Koya D (2014) Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen. Diabetes 63:2120–2131
    • (2014) Diabetes , vol.63 , pp. 2120-2131
    • Kanasaki, K.1    Shi, S.2    Kanasaki, M.3    He, J.4    Nagai, T.5    Nakamura, Y.6    Ishigaki, Y.7    Kitada, M.8    Srivastava, S.P.9    Koya, D.10
  • 54
    • 84859174317 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis
    • PID: 22411919
    • Karagiannis T, Paschos P, Paletas K, Matthews DR, Tsapas A (2012) Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ 344:e1369
    • (2012) BMJ , vol.344
    • Karagiannis, T.1    Paschos, P.2    Paletas, K.3    Matthews, D.R.4    Tsapas, A.5
  • 55
    • 80655146931 scopus 로고    scopus 로고
    • Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methyl pyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor
    • COI: 1:CAS:528:DC%2BC3MXhsVehsrzO, PID: 22019046
    • Kato N, Oka M, Murase T, Yoshida M, Sakairi M, Yamashita S, Yasuda Y, Yoshikawa A, Hayashi Y, Makino M, Takeda M, Mirensha Y, Kakigami T (2011) Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methyl pyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorg Med Chem 19:7221–7227
    • (2011) Bioorg Med Chem , vol.19 , pp. 7221-7227
    • Kato, N.1    Oka, M.2    Murase, T.3    Yoshida, M.4    Sakairi, M.5    Yamashita, S.6    Yasuda, Y.7    Yoshikawa, A.8    Hayashi, Y.9    Makino, M.10    Takeda, M.11    Mirensha, Y.12    Kakigami, T.13
  • 57
    • 84862692484 scopus 로고    scopus 로고
    • Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    • COI: 1:CAS:528:DC%2BC38XpsVWrt70%3D, PID: 22761701
    • Kern M, Kloting N, Niessen HG, Thomas L, Stiller D, Mark M, Klein T, Bluher M (2012) Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity. PLoS One 7:e38744
    • (2012) PLoS One , vol.7
    • Kern, M.1    Kloting, N.2    Niessen, H.G.3    Thomas, L.4    Stiller, D.5    Mark, M.6    Klein, T.7    Bluher, M.8
  • 58
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • COI: 1:CAS:528:DC%2BD2cXmtlGqt7s%3D, PID: 15181022
    • Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 59
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • COI: 1:CAS:528:DC%2BC3sXkvFOqt7g%3D, PID: 23542788
    • Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ (2013a) GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med 19:567–575
    • (2013) Nat Med , vol.19 , pp. 567-575
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3    Quaggin, S.E.4    Backx, P.H.5    Seino, S.6    Simpson, J.A.7    Drucker, D.J.8
  • 60
    • 84885950010 scopus 로고    scopus 로고
    • Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry
    • COI: 1:CAS:528:DC%2BC3sXpsV2ht7Y%3D, PID: 23771499
    • Kim SH, Lee SH, Yim HJ (2013b) Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry. Arch Pharm Res 36:1185–1188
    • (2013) Arch Pharm Res , vol.36 , pp. 1185-1188
    • Kim, S.H.1    Lee, S.H.2    Yim, H.J.3
  • 61
    • 84876498178 scopus 로고    scopus 로고
    • Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXjslehs70%3D, PID: 23344728
    • Kim YG, Hahn S, Oh TJ, Kwak SH, Park KS, Cho YM (2013c) Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis. Diabetologia 56:696–708
    • (2013) Diabetologia , vol.56 , pp. 696-708
    • Kim, Y.G.1    Hahn, S.2    Oh, T.J.3    Kwak, S.H.4    Park, K.S.5    Cho, Y.M.6
  • 62
    • 84950110512 scopus 로고    scopus 로고
    • Hepatic role in an early glucose-lowering effect by a novel dipeptidyl peptidase 4 inhibitor, evogliptin, in a rodent model of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXitVemtb3E, PID: 26621343
    • Kim TH, Kim MK, Cheong YH, Chae YN, Lee Y, Ka SO, Jung IH, Shin CY, Bae EJ, Son MH (2016) Hepatic role in an early glucose-lowering effect by a novel dipeptidyl peptidase 4 inhibitor, evogliptin, in a rodent model of type 2 diabetes. Eur J Pharmacol 771:65–76
    • (2016) Eur J Pharmacol , vol.771 , pp. 65-76
    • Kim, T.H.1    Kim, M.K.2    Cheong, Y.H.3    Chae, Y.N.4    Lee, Y.5    Ka, S.O.6    Jung, I.H.7    Shin, C.Y.8    Bae, E.J.9    Son, M.H.10
  • 63
    • 84867026656 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
    • COI: 1:CAS:528:DC%2BC38XhsFCksbvM, PID: 22989472
    • Kissow H, Hartmann B, Holst JJ, Viby NE, Hansen LS, Rosenkilde MM, Hare KJ, Poulsen SS (2012) Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice. Regul Pept 179:91–100
    • (2012) Regul Pept , vol.179 , pp. 91-100
    • Kissow, H.1    Hartmann, B.2    Holst, J.J.3    Viby, N.E.4    Hansen, L.S.5    Rosenkilde, M.M.6    Hare, K.J.7    Poulsen, S.S.8
  • 64
    • 85007193610 scopus 로고    scopus 로고
    • Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC2cXhsFGls7nI, PID: 24048504
    • Klein T, Fujii M, Sandel J, Shibazaki Y, Wakamatsu K, Mark M, Yoneyama H (2014) Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis. Med Mol Morphol 47:137–149
    • (2014) Med Mol Morphol , vol.47 , pp. 137-149
    • Klein, T.1    Fujii, M.2    Sandel, J.3    Shibazaki, Y.4    Wakamatsu, K.5    Mark, M.6    Yoneyama, H.7
  • 66
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • COI: 1:CAS:528:DC%2BD3sXmtVWhs70%3D, PID: 12892317
    • Lambeir AM, Durinx C, Scharpe S, De Meester I (2003) Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 40:209–294
    • (2003) Crit Rev Clin Lab Sci , vol.40 , pp. 209-294
    • Lambeir, A.M.1    Durinx, C.2    Scharpe, S.3    De Meester, I.4
  • 68
    • 34249741098 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis
    • COI: 1:CAS:528:DC%2BD2sXmtlKhs7g%3D, PID: 17369525
    • Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS (2007) Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. Diabetes 56:1671–1679
    • (2007) Diabetes , vol.56 , pp. 1671-1679
    • Lee, Y.S.1    Shin, S.2    Shigihara, T.3    Hahm, E.4    Liu, M.J.5    Han, J.6    Yoon, J.W.7    Jun, H.S.8
  • 70
    • 80054051051 scopus 로고    scopus 로고
    • Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BC3MXhtl2gu7rP, PID: 21323903
    • Liu WJ, Jin HY, Lee KA, Xie SH, Baek HS, Park TS (2011) Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats. Br J Pharmacol 164:1410–1420
    • (2011) Br J Pharmacol , vol.164 , pp. 1410-1420
    • Liu, W.J.1    Jin, H.Y.2    Lee, K.A.3    Xie, S.H.4    Baek, H.S.5    Park, T.S.6
  • 71
    • 84862944057 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BC38XjtVSltL0%3D, PID: 22025647
    • Liu WJ, Xie SH, Liu YN, Kim W, Jin HY, Park SK, Shao YM, Park TS (2012) Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 340:248–255
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 248-255
    • Liu, W.J.1    Xie, S.H.2    Liu, Y.N.3    Kim, W.4    Jin, H.Y.5    Park, S.K.6    Shao, Y.M.7    Park, T.S.8
  • 72
    • 84918588644 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets
    • COI: 1:CAS:528:DC%2BC2cXhs1Gqt7rJ, PID: 25268763
    • Liu L, Omar B, Marchetti P, Ahren B (2014) Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets. Biochem Biophys Res Commun 453:398–404
    • (2014) Biochem Biophys Res Commun , vol.453 , pp. 398-404
    • Liu, L.1    Omar, B.2    Marchetti, P.3    Ahren, B.4
  • 73
    • 84871685830 scopus 로고    scopus 로고
    • Decreased hepatic glucose production in obese rats by dipeptidyl peptidase-IV inhibitor sitagliptin
    • COI: 1:CAS:528:DC%2BC38XhtV2nsLnF
    • Lu YL, Zhou DQ, Zhai HL, Wu H, Guo ZK (2012) Decreased hepatic glucose production in obese rats by dipeptidyl peptidase-IV inhibitor sitagliptin. Chin Med J (Engl) 125:1690–1694
    • (2012) Chin Med J (Engl) , vol.125 , pp. 1690-1694
    • Lu, Y.L.1    Zhou, D.Q.2    Zhai, H.L.3    Wu, H.4    Guo, Z.K.5
  • 77
    • 84876780409 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes
    • COI: 1:CAS:528:DC%2BC3sXotFykurs%3D, PID: 23386232
    • Matsubara J, Sugiyama S, Akiyama E, Iwashita S, Kurokawa H, Ohba K, Maeda H, Fujisue K, Yamamoto E, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H (2013) Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes. Circ J 77:1337–1344
    • (2013) Circ J , vol.77 , pp. 1337-1344
    • Matsubara, J.1    Sugiyama, S.2    Akiyama, E.3    Iwashita, S.4    Kurokawa, H.5    Ohba, K.6    Maeda, H.7    Fujisue, K.8    Yamamoto, E.9    Kaikita, K.10    Hokimoto, S.11    Jinnouchi, H.12    Ogawa, H.13
  • 78
    • 79955480528 scopus 로고    scopus 로고
    • Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis
    • COI: 1:CAS:528:DC%2BC3MXlt1Sgu7c%3D, PID: 21320599
    • Matsui T, Nishino Y, Takeuchi M, Yamagishi S (2011) Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis. Pharmacol Res 63:383–388
    • (2011) Pharmacol Res , vol.63 , pp. 383-388
    • Matsui, T.1    Nishino, Y.2    Takeuchi, M.3    Yamagishi, S.4
  • 81
    • 84904392112 scopus 로고    scopus 로고
    • Macrophages, immunity, and metabolic disease
    • COI: 1:CAS:528:DC%2BC2cXhtFOrsLrJ, PID: 25035952
    • McNelis JC, Olefsky JM (2014) Macrophages, immunity, and metabolic disease. Immunity 41:36–48
    • (2014) Immunity , vol.41 , pp. 36-48
    • McNelis, J.C.1    Olefsky, J.M.2
  • 82
    • 0029876386 scopus 로고    scopus 로고
    • Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice
    • COI: 1:CAS:528:DyaK28Xislyit7Y%3D, PID: 8627002
    • Mentzel S, Dijkman HB, Van Son JP, Koene RA, Assmann KJ (1996) Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice. J Histochem Cytochem 44:445–461
    • (1996) J Histochem Cytochem , vol.44 , pp. 445-461
    • Mentzel, S.1    Dijkman, H.B.2    Van Son, J.P.3    Koene, R.A.4    Assmann, K.J.5
  • 84
    • 84863039515 scopus 로고    scopus 로고
    • Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism
    • COI: 1:CAS:528:DC%2BC38XisFOiu7g%3D, PID: 22179204
    • Miyazaki M, Kato M, Tanaka K, Tanaka M, Kohjima M, Nakamura K, Enjoji M, Nakamuta M, Kotoh K, Takayanagi R (2012) Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Mol Med Rep 5:729–733
    • (2012) Mol Med Rep , vol.5 , pp. 729-733
    • Miyazaki, M.1    Kato, M.2    Tanaka, K.3    Tanaka, M.4    Kohjima, M.5    Nakamura, K.6    Enjoji, M.7    Nakamuta, M.8    Kotoh, K.9    Takayanagi, R.10
  • 86
    • 84921515624 scopus 로고    scopus 로고
    • Teneligliptin: expectations for its pleiotropic action
    • COI: 1:CAS:528:DC%2BC2MXhsF2mt7s%3D, PID: 25597385
    • Morishita R, Nakagami H (2015) Teneligliptin: expectations for its pleiotropic action. Expert Opin Pharmacother 16:417–426
    • (2015) Expert Opin Pharmacother , vol.16 , pp. 417-426
    • Morishita, R.1    Nakagami, H.2
  • 87
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XlsF2rurw%3D, PID: 16731832
    • Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, Feng Y, Zhu L, Li C, Howard AD, Moller DE, Thornberry NA, Zhang BB (2006) Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55:1695–1704
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3    Roy, R.S.4    Li, Z.5    Zycband, E.6    Feng, Y.7    Zhu, L.8    Li, C.9    Howard, A.D.10    Moller, D.E.11    Thornberry, N.A.12    Zhang, B.B.13
  • 89
    • 84877061867 scopus 로고    scopus 로고
    • A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
    • COI: 1:CAS:528:DC%2BC3sXmt1ClsrY%3D, PID: 23501107
    • Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, Kadowaki T (2013) A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site. Biochem Biophys Res Commun 434:191–196
    • (2013) Biochem Biophys Res Commun , vol.434 , pp. 191-196
    • Nabeno, M.1    Akahoshi, F.2    Kishida, H.3    Miyaguchi, I.4    Tanaka, Y.5    Ishii, S.6    Kadowaki, T.7
  • 91
    • 33846670732 scopus 로고    scopus 로고
    • Finding new treatments for diabetes–how many, how fast… how good?
    • COI: 1:CAS:528:DC%2BD2sXht1ekurg%3D, PID: 17267901
    • Nathan DM (2007) Finding new treatments for diabetes–how many, how fast… how good? N Engl J Med 356:437–440
    • (2007) N Engl J Med , vol.356 , pp. 437-440
    • Nathan, D.M.1
  • 94
    • 84879914429 scopus 로고    scopus 로고
    • Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model
    • COI: 1:CAS:528:DC%2BC3sXhtVyrurzM
    • Omar BA, Vikman J, Winzell MS, Voss U, Ekblad E, Foley JE, Ahren B (2013) Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model. Diabetologia 56:1752–1760
    • (2013) Diabetologia , vol.56 , pp. 1752-1760
    • Omar, B.A.1    Vikman, J.2    Winzell, M.S.3    Voss, U.4    Ekblad, E.5    Foley, J.E.6    Ahren, B.7
  • 95
    • 84905576401 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhtVSgsrnK, PID: 24939431
    • Omar BA, Liehua L, Yamada Y, Seino Y, Marchetti P, Ahren B (2014) Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes. Diabetologia 57:1876–1883
    • (2014) Diabetologia , vol.57 , pp. 1876-1883
    • Omar, B.A.1    Liehua, L.2    Yamada, Y.3    Seino, Y.4    Marchetti, P.5    Ahren, B.6
  • 96
    • 84925748891 scopus 로고    scopus 로고
    • Comparison of treatment with sitagliptin or sulfonylurea in patients with type 2 diabetes mellitus and mild renal impairment: a post hoc analysis of clinical trials
    • COI: 1:CAS:528:DC%2BC2MXitVCnt7s%3D, PID: 25633134
    • Ommen ES, Xu L, O’Neill EA, Goldstein BJ, Kaufman KD, Engel SS (2015) Comparison of treatment with sitagliptin or sulfonylurea in patients with type 2 diabetes mellitus and mild renal impairment: a post hoc analysis of clinical trials. Diabetes Ther 6:29–40
    • (2015) Diabetes Ther , vol.6 , pp. 29-40
    • Ommen, E.S.1    Xu, L.2    O’Neill, E.A.3    Goldstein, B.J.4    Kaufman, K.D.5    Engel, S.S.6
  • 97
    • 44349163999 scopus 로고    scopus 로고
    • Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
    • COI: 1:CAS:528:DC%2BD1cXnsVCkurs%3D, PID: 18522833
    • Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D (2008) Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7:520–532
    • (2008) Cell Metab , vol.7 , pp. 520-532
    • Oyadomari, S.1    Harding, H.P.2    Zhang, Y.3    Oyadomari, M.4    Ron, D.5
  • 99
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE (–/–) mice
    • COI: 1:CAS:528:DC%2BC3sXlt1eqtg%3D%3D, PID: 23183176
    • Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ (2013) GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE (–/–) mice. Endocrinology 154:127–139
    • (2013) Endocrinology , vol.154 , pp. 127-139
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3    Yusta, B.4    Campbell, J.E.5    Brown, T.J.6    Streutker, C.7    Holland, D.8    Cao, X.9    Baggio, L.L.10    Drucker, D.J.11
  • 100
    • 34047205064 scopus 로고    scopus 로고
    • Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice
    • COI: 1:CAS:528:DC%2BD2sXkslSrsb8%3D, PID: 17360951
    • Park CW, Kim HW, Ko SH, Lim JH, Ryu GR, Chung HW, Han SW, Shin SJ, Bang BK, Breyer MD, Chang YS (2007) Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice. J Am Soc Nephrol 18:1227–1238
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1227-1238
    • Park, C.W.1    Kim, H.W.2    Ko, S.H.3    Lim, J.H.4    Ryu, G.R.5    Chung, H.W.6    Han, S.W.7    Shin, S.J.8    Bang, B.K.9    Breyer, M.D.10    Chang, Y.S.11
  • 101
    • 0024436374 scopus 로고
    • Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix
    • COI: 1:CAS:528:DyaL1MXltlWgu7s%3D, PID: 2573346
    • Piazza GA, Callanan HM, Mowery J, Hixson DC (1989) Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Biochem J 262:327–334
    • (1989) Biochem J , vol.262 , pp. 327-334
    • Piazza, G.A.1    Callanan, H.M.2    Mowery, J.3    Hixson, D.C.4
  • 102
    • 84938932103 scopus 로고    scopus 로고
    • A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond
    • PID: 26213556
    • Prasad-Reddy L, Isaacs D (2015) A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond. Drugs Context 4:212283
    • (2015) Drugs Context , vol.4 , pp. 212283
    • Prasad-Reddy, L.1    Isaacs, D.2
  • 103
    • 34247362355 scopus 로고    scopus 로고
    • Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXlsVylsrs%3D, PID: 17407649
    • Pratley RE, Salsali A (2007) Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes. Curr Med Res Opin 23:919–931
    • (2007) Curr Med Res Opin , vol.23 , pp. 919-931
    • Pratley, R.E.1    Salsali, A.2
  • 104
    • 33750010094 scopus 로고    scopus 로고
    • Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats
    • COI: 1:CAS:528:DC%2BD28XhtFSrtbzN, PID: 16935517
    • Romanovsky D, Cruz NF, Dienel GA, Dobretsov M (2006) Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats. Neurobiol Dis 24:384–394
    • (2006) Neurobiol Dis , vol.24 , pp. 384-394
    • Romanovsky, D.1    Cruz, N.F.2    Dienel, G.A.3    Dobretsov, M.4
  • 105
    • 84865246554 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-gamma expression
    • COI: 1:CAS:528:DC%2BC38XhtFahsbzF, PID: 22819773
    • Rosmaninho-Salgado J, Marques AP, Estrada M, Santana M, Cortez V, Grouzmann E, Cavadas C (2012) Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-gamma expression. Peptides 37:49–54
    • (2012) Peptides , vol.37 , pp. 49-54
    • Rosmaninho-Salgado, J.1    Marques, A.P.2    Estrada, M.3    Santana, M.4    Cortez, V.5    Grouzmann, E.6    Cavadas, C.7
  • 106
    • 84964027413 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor use in patients with type 2 diabetes and cardiovascular disease or risk factors
    • PID: 26436470
    • Ryan G (2015) Dipeptidyl peptidase-4 inhibitor use in patients with type 2 diabetes and cardiovascular disease or risk factors. Postgrad Med 127:842–854
    • (2015) Postgrad Med , vol.127 , pp. 842-854
    • Ryan, G.1
  • 107
    • 0027759367 scopus 로고
    • Decrease of nerve Na+, K(+)-ATPase activity in the pathogenesis of human diabetic neuropathy
    • COI: 1:STN:280:DyaK2c7os1yisQ%3D%3D, PID: 8138805
    • Scarpini E, Bianchi R, Moggio M, Sciacco M, Fiori MG, Scarlato G (1993) Decrease of nerve Na+, K(+)-ATPase activity in the pathogenesis of human diabetic neuropathy. J Neurol Sci 120:159–167
    • (1993) J Neurol Sci , vol.120 , pp. 159-167
    • Scarpini, E.1    Bianchi, R.2    Moggio, M.3    Sciacco, M.4    Fiori, M.G.5    Scarlato, G.6
  • 111
    • 84879919203 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization
    • COI: 1:CAS:528:DC%2BC3sXhtFChsr%2FL, PID: 23633194
    • Shah P, Ardestani A, Dharmadhikari G, Laue S, Schumann DM, Kerr-Conte J, Pattou F, Klein T, Maedler K (2013) The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization. J Clin Endocrinol Metab 98:E1163–E1172
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1163-E1172
    • Shah, P.1    Ardestani, A.2    Dharmadhikari, G.3    Laue, S.4    Schumann, D.M.5    Kerr-Conte, J.6    Pattou, F.7    Klein, T.8    Maedler, K.9
  • 112
    • 84927640087 scopus 로고    scopus 로고
    • Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC2cXhs1GntrnO, PID: 25215436
    • Sharkovska Y, Reichetzeder C, Alter M, Tsuprykov O, Bachmann S, Secher T, Klein T, Hocher B (2014) Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy. J Hypertens 32:2211–2223
    • (2014) J Hypertens , vol.32 , pp. 2211-2223
    • Sharkovska, Y.1    Reichetzeder, C.2    Alter, M.3    Tsuprykov, O.4    Bachmann, S.5    Secher, T.6    Klein, T.7    Hocher, B.8
  • 113
    • 84877839950 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity
    • COI: 1:CAS:528:DC%2BC3sXosFGjs7k%3D, PID: 23696840
    • Shimasaki T, Masaki T, Mitsutomi K, Ueno D, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H (2013) The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity. PLoS One 8:e63626
    • (2013) PLoS One , vol.8
    • Shimasaki, T.1    Masaki, T.2    Mitsutomi, K.3    Ueno, D.4    Gotoh, K.5    Chiba, S.6    Kakuma, T.7    Yoshimatsu, H.8
  • 114
    • 79960387066 scopus 로고    scopus 로고
    • Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased beta cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes
    • COI: 1:CAS:528:DC%2BC3MXovFCktrw%3D, PID: 21613229
    • Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y (2011a) Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased beta cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem 286:25467–25476
    • (2011) J Biol Chem , vol.286 , pp. 25467-25476
    • Shirakawa, J.1    Amo, K.2    Ohminami, H.3    Orime, K.4    Togashi, Y.5    Ito, Y.6    Tajima, K.7    Koganei, M.8    Sasaki, H.9    Takeda, E.10    Terauchi, Y.11
  • 117
    • 84859103180 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide 1 on cardiovascular risk
    • COI: 1:CAS:528:DC%2BC38XksVKmsbs%3D, PID: 22290234
    • Sivertsen J, Rosenmeier J, Holst JJ, Vilsboll T (2012) The effect of glucagon-like peptide 1 on cardiovascular risk. Nat Rev Cardiol 9:209–222
    • (2012) Nat Rev Cardiol , vol.9 , pp. 209-222
    • Sivertsen, J.1    Rosenmeier, J.2    Holst, J.J.3    Vilsboll, T.4
  • 119
    • 0030748773 scopus 로고    scopus 로고
    • Aberrant dipeptidyl peptidase IV (DPP IV/CD26) expression in human hepatocellular carcinoma
    • COI: 1:CAS:528:DyaK2sXlvFarsLg%3D, PID: 9288609
    • Stecca BA, Nardo B, Chieco P, Mazziotti A, Bolondi L, Cavallari A (1997) Aberrant dipeptidyl peptidase IV (DPP IV/CD26) expression in human hepatocellular carcinoma. J Hepatol 27:337–345
    • (1997) J Hepatol , vol.27 , pp. 337-345
    • Stecca, B.A.1    Nardo, B.2    Chieco, P.3    Mazziotti, A.4    Bolondi, L.5    Cavallari, A.6
  • 120
    • 84857425029 scopus 로고    scopus 로고
    • Incretin-based therapies. J
    • COI: 1:CAS:528:DC%2BC38XltV2rt7Y%3D
    • Stonehouse AH, Darsow T, Maggs DG (2012) Incretin-based therapies. J. Diabetes 4:55–67
    • (2012) Diabetes , vol.4 , pp. 55-67
    • Stonehouse, A.H.1    Darsow, T.2    Maggs, D.G.3
  • 121
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: principles of pathogenesis and therapy
    • COI: 1:CAS:528:DC%2BD2MXjtF2iu7g%3D, PID: 15823385
    • Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 122
    • 39449091024 scopus 로고    scopus 로고
    • Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats
    • COI: 1:CAS:528:DC%2BD1cXitlKrsbw%3D, PID: 18331706
    • Sugimoto K, Rashid IB, Shoji M, Suda T, Yasujima M (2008) Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats. J Pain 9:237–245
    • (2008) J Pain , vol.9 , pp. 237-245
    • Sugimoto, K.1    Rashid, I.B.2    Shoji, M.3    Suda, T.4    Yasujima, M.5
  • 124
    • 84856711643 scopus 로고    scopus 로고
    • Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice
    • COI: 1:CAS:528:DC%2BC3MXhs1yntbbF, PID: 22072158
    • Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M (2012) Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia 55:404–412
    • (2012) Diabetologia , vol.55 , pp. 404-412
    • Takeda, Y.1    Fujita, Y.2    Honjo, J.3    Yanagimachi, T.4    Sakagami, H.5    Takiyama, Y.6    Makino, Y.7    Abiko, A.8    Kieffer, T.J.9    Haneda, M.10
  • 125
    • 84862128306 scopus 로고    scopus 로고
    • Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice
    • COI: 1:CAS:528:DC%2BC38XosVaksbk%3D, PID: 22225957
    • Terasaki M, Nagashima M, Watanabe T, Nohtomi K, Mori Y, Miyazaki A, Hirano T (2012) Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice. Metabolism 61:974–977
    • (2012) Metabolism , vol.61 , pp. 974-977
    • Terasaki, M.1    Nagashima, M.2    Watanabe, T.3    Nohtomi, K.4    Mori, Y.5    Miyazaki, A.6    Hirano, T.7
  • 127
    • 85008347137 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once-weekly dipeptidyl peptidase-4 inhibitor, in healthy Japanese male subjects
    • Tsuchiya S, Friedman E, Addy C, Wakana A, Tatosian D, Matsumoto Y, Suzuki H, Kauh E (2016) Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once-weekly dipeptidyl peptidase-4 inhibitor, in healthy Japanese male subjects. J Diabetes Investig
    • (2016) J Diabetes Investig
    • Tsuchiya, S.1    Friedman, E.2    Addy, C.3    Wakana, A.4    Tatosian, D.5    Matsumoto, Y.6    Suzuki, H.7    Kauh, E.8
  • 128
    • 84901462249 scopus 로고    scopus 로고
    • Cardiovascular actions of incretin-based therapies
    • COI: 1:CAS:528:DC%2BC2cXotlOjsbs%3D, PID: 24855202
    • Ussher JR, Drucker DJ (2014) Cardiovascular actions of incretin-based therapies. Circ Res 114:1788–1803
    • (2014) Circ Res , vol.114 , pp. 1788-1803
    • Ussher, J.R.1    Drucker, D.J.2
  • 129
    • 83455230039 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence
    • PID: 21752172
    • van Genugten RE, van Raalte DH, Diamant M (2012) Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence. Diabetes Obes Metab 14:101–111
    • (2012) Diabetes Obes Metab , vol.14 , pp. 101-111
    • van Genugten, R.E.1    van Raalte, D.H.2    Diamant, M.3
  • 130
    • 83455230038 scopus 로고    scopus 로고
    • Vildagliptin improves endothelium-dependent vasodilatation in type 2 diabetes
    • PID: 21788633
    • van Poppel PC, Netea MG, Smits P, Tack CJ (2011) Vildagliptin improves endothelium-dependent vasodilatation in type 2 diabetes. Diabetes Care 34:2072–2077
    • (2011) Diabetes Care , vol.34 , pp. 2072-2077
    • van Poppel, P.C.1    Netea, M.G.2    Smits, P.3    Tack, C.J.4
  • 131
    • 84866356839 scopus 로고    scopus 로고
    • Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (–/–) mice
    • COI: 1:CAS:528:DC%2BC38XhtVWjt73L, PID: 22648661
    • Vittone F, Liberman A, Vasic D, Ostertag R, Esser M, Walcher D, Ludwig A, Marx N, Burgmaier M (2012) Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (–/–) mice. Diabetologia 55:2267–2275
    • (2012) Diabetologia , vol.55 , pp. 2267-2275
    • Vittone, F.1    Liberman, A.2    Vasic, D.3    Ostertag, R.4    Esser, M.5    Walcher, D.6    Ludwig, A.7    Marx, N.8    Burgmaier, M.9
  • 133
    • 84938918533 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity in the United States, 2007-2012
    • PID: 26098405
    • Yang L, Colditz GA (2015) Prevalence of overweight and obesity in the United States, 2007-2012. JAMA Intern Med 175:1412–1413
    • (2015) JAMA Intern Med , vol.175 , pp. 1412-1413
    • Yang, L.1    Colditz, G.A.2
  • 134
    • 84971654976 scopus 로고    scopus 로고
    • Association of Sitagliptin with cardiovascular outcome in diabetic patients: a nationwide cohort study
    • Yang TY, Liaw YP, Huang JY, Chang HR, Chang KW, Ueng KC (2016) Association of Sitagliptin with cardiovascular outcome in diabetic patients: a nationwide cohort study. Acta Diabetol 53:461–468
    • (2016) Acta Diabetol , vol.53 , pp. 461-468
    • Yang, T.Y.1    Liaw, Y.P.2    Huang, J.Y.3    Chang, H.R.4    Chang, K.W.5    Ueng, K.C.6
  • 135
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    • COI: 1:CAS:528:DC%2BD1MXhtlCku7zJ, PID: 19837468
    • Yazbeck R, Howarth GS, Abbott CA (2009) Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol Sci 30:600–607
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 600-607
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 138
    • 84958154465 scopus 로고    scopus 로고
    • Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study
    • PID: 26821795
    • Zheng T, Liu Y, Qin S, Liu H, Zhang X, Zhao H (2016) Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study. Diab Vasc Dis Res 13:127–136
    • (2016) Diab Vasc Dis Res , vol.13 , pp. 127-136
    • Zheng, T.1    Liu, Y.2    Qin, S.3    Liu, H.4    Zhang, X.5    Zhao, H.6
  • 140
    • 84872424922 scopus 로고    scopus 로고
    • An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease
    • COI: 1:CAS:528:DC%2BC38XhsFClu73N, PID: 23083681
    • Zhong J, Rao X, Rajagopalan S (2013b) An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease. Atherosclerosis 226:305–314
    • (2013) Atherosclerosis , vol.226 , pp. 305-314
    • Zhong, J.1    Rao, X.2    Rajagopalan, S.3
  • 141
    • 84982082392 scopus 로고    scopus 로고
    • Metabolic role of dipeptidyl peptidase 4 (DPP4) in primary human (pre)adipocytes
    • COI: 1:CAS:528:DC%2BC28XktlKmsb8%3D, PID: 26983599
    • Zillessen P, Celner J, Kretschmann A, Pfeifer A, Racke K, Mayer P (2016) Metabolic role of dipeptidyl peptidase 4 (DPP4) in primary human (pre)adipocytes. Sci Rep 6:23074
    • (2016) Sci Rep , vol.6 , pp. 23074
    • Zillessen, P.1    Celner, J.2    Kretschmann, A.3    Pfeifer, A.4    Racke, K.5    Mayer, P.6
  • 142
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • COI: 1:CAS:528:DC%2BD38Xhtlymtg%3D%3D, PID: 11742409
    • Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782–787
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3


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