Early Changes in Insulin Receptor Signaling and Pain Sensation in Streptozotocin-Induced Diabetic Neuropathy in Rats

Journal of Pain

Volumn 9, Issue 3, 2008, Pages 237-245

  Sugimoto, Kazuhiro ^a   Rashid, Irena B ^a   Shoji, Masaru ^a   Suda, Toshihiro ^a   Yasujima, Minoru ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Akt; diabetic neuropathy; Insulin signaling; mechanical hyperalgesia; sodium channel; thermal hypoalgesia

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL 1.8;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; EXPERIMENTAL MODEL; HYPERALGESIA; HYPOALGESIA; IMMUNOPRECIPITATION; LATENT PERIOD; MALE; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PERIPHERAL NERVE; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; STREPTOZOCIN DIABETES; TAIL FLICK TEST; THERMAL STIMULATION; WESTERN BLOTTING;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD GLUCOSE; BODY WEIGHT; BRAIN; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERALGESIA; MALE; MUSCLE, SKELETAL; PAIN MEASUREMENT; PAIN THRESHOLD; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SCIATIC NERVE; SIGNAL TRANSDUCTION; STREPTOZOCIN; TIME FACTORS; TYROSINE;

EID: 39449091024     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2007.10.016     Document Type: Article

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