Spontaneous regression of hepatocellular carcinoma after improving diabetes mellitus: Possibly responsible for immune system

Kanzo/Acta Hepatologica Japonica

Volumn 53, Issue 3, 2012, Pages 164-174

  Yamamotou, Satoshi ^a   Tokuhara, Taigo ^a   Nishikawa, Masahiro ^a   Nishizawa, Satoshi ^a   Nishioka, Takayosi ^a,b   Nozawa, Akinori ^a,b   Takahashi, Akira ^a   Watanabe, Yoshihisa ^a   Wada, Rikimon ^a   Wakasa, Kenichi ^b   Kubo, Shoji ^b  

^a Asakayama Hospital   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

CD8 positive; Diabetes mellitus; Hepatocellular carcinoma; Immunotherapy; Spontaneous regression; T lymphocyte

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR;

ADULT; ARTICLE; CANCER REGRESSION; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIABETES MELLITUS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LYMPHOCYTE; MALE; MIDDLE AGED; TUMOR VOLUME;

EID: 84922685922     PISSN: 04514203     EISSN: 18813593     Source Type: Journal    
DOI: 10.2957/kanzo.53.164     Document Type: Article

References (44)

1. Cole WH. Efforts to explain spontaneou regression of cancer. J Surg Oncol 1981; 17: 201-209
2. Abiru S, Kato Y, Hamasaki K, et al. Spontaneous regression of hepatocellular carcinoma associated with elevated levels of interleukin 18. Am J Gastroenterol 2002; 97 (3): 774-775
3. Li AJ, Wu MC, Cong WM, et al. Spontaneous complete necrosis of hepatocellular carcinoma:a case report. Hepatobiliary Pancreat Dis Int 2003; 2 (1): 152-154
4. Blondon H, Fritsch L, Cherqui D. Two cases of spontaneous regression of multicentric hepatocel-lular carcinoma after intraperitoneal rupture:possi-bleroleofimmune mechanisms. Eur J Gastroen-terol Hepatol 2004; 16 (12): 1355-1359
5. Cheng HM, Tsai MC. Regression of hepatocellular carcinoma spontaneous or herbal medicine related? Am J Chin Med 2004; 32 (4): 579-585
6. Jeon SW, Lee MK, Lee YD, et al. Clear cell hepato-cellular carcinoma with spontaneous regression of primary and metastaticlesions. Korean J Intern Med 2005; 20 (3): 268-273
7. Kojima H, Tanigawa N, Kariya S, et al. A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases. Radiat Med 2006; 24 (2): 139-142
8. Vardhana HG, Panda M. Spontaneous regression of hepatocellular carcinoma: potential promise for the future. South Med J 2007; 100 (2): 223-224
9. Arakawa Y, Mori H, Ikegami T, et al. Hepatocellu-lar carcinoma with spontaneous regression: report of the rare case. Hepatogastroenterology 2008; 55 (86-87): 1770-1772
10. Del Poggio P, Mattiello M, Gilardoni L, et al. The mysterious case of spontaneous disappearance of hepatocellular carcinoma. Dig Liver Dis 2009; 41 (7): e21-25
11. Park HS, Jang KY, Kim YK, et al. Hepatocellular carcinoma with massive lymphoid infiltration: a regressing phenomenon? Pathol Res Pract 2009; 205 (9): 648-652
12. Matsuo R, Ogata H, Tsuji H, et al. Spontaneous regression of hepatocellular carcinoma-a case report. Hepatogastroenterology 2001; 48 (42): 1740-1742
13. Randolph AC, Tharalson EM, Gilani N. Spontaneous regression of hepatocellular carcinoma is possible and might have implications for future therapies. Eur J Gastroenterol Hepatol 2008; 20 (8): 804-809
14. Morimoto Y, Tanaka Y, Itoh T, et al. Spontaneous necrosis of hepatocellular carcinoma: a case report. Dig Surg 2002; 19 (5): 413-418
15. Iiai T, Sato Y, Nabatame N, et al. Spontaneous complete regression of hepatocellular carcinoma with portal vein tumor thrombus. Hepatogastroenterology 2003; 50 (53): 1628-1630
16. Feo CF, Marrosu A, Scanu AM, et al. Spontaneous regression of hepatocellular carcinoma: report of a case. Eur J Gastroenterol Hepatol 2004; 16 (9): 933-936
17. Nakajima T, Moriguchi M, Watanabe T, et al. Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression. World J Gas-troenterol 2004 Nov 15; 10 (22): 3385-3387
18. Ohta H, Sakamoto Y, Ojima H, et al. Spontaneous regression of hepatocellular carcinoma with complete necrosis: case report. Abdom Imaging 2005; 30 (6): 734-737
19. Ohtani H, Yamazaki O, Matsuyama M, et al. Spontaneous regression of hepatocellular carcinoma: report of a case. Surg Today 2005; 35 (12): 1081-1086
20. Yano Y, Yamashita F, Kuwaki K, et al. Partial spontaneous regression of hepatocellular carcinoma: a case with high concentrations of serum lens culi-naris agglutinin-reactive alpha fetoprotein. Ku-rume Med J 2005; 52 (3): 97-103
21. Kondo S, Okusaka T, Ueno H, et al. Spontaneous regression of hepatocellular carcinoma. Int J ClinOn-col 2006; 11 (5): 407-411
22. Meza-Junco J, Montaño-Loza AJ, Martinez-Benitez B, et al. Spontaneous partial regression of hepato-cellular carcinoma inacirrhoticpatient. Ann Hepa-tol 2007; 6 (1): 66-69
23. Sibartie V, Moriarty J, Crowe J. Spontaneous regression of hepatocellular carcinoma. Am J Gastroenterol 2008; 103 (4): 1050-1051
24. Peddu P, Huang D, Kane PA, et al. Vanishing liver tumours. Clin Radiol 2008; 63 (3): 329-339
25. Nouso K, Uematsu S, Shiraga K, et al. Regression of hepatocellular carcinoma during vitamin K administration. World J Gastroenterol 2005; 11 (42): 6722-6724
26. Oquiñena S, Inarrairaegui M, Vila JJ, et al. Spontaneous regression of hepatocellular carcinoma: three case reports and a categorized review of the literature. DigDisSci 2009; 54 (5): 1147-1153
27. Ikeda M, Okada S, Ueno H, et al. Spontaneous regression of hepatocellular carcinoma with multiple lung metastases: a case report. Jpn J ClinOncol 2001; 31 (9): 454-458
28. Lin TJ, Liao LY, Lin CL, et al. Spontaneous regression of hepatocellular carcinoma: a case report and literature review. Hepatogastroenterology 2004; 51 (56): 579-582
29. Nam SW, Han JY, Kim JI, et al. Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol Hepatol 2005; 20 (3): 488-492
30. Nishijima N, Marusawa H, Kita R, et al. Education and Imaging. Hepatobiliary and pancreatic: spontaneous regression of hepatocellular cancer demonstrated by contrast-enhanced ultrasonography. J Gastroenterol Hepatol 2009; 24 (6): 1153
31. Oquiñena S, Guillen-Grima F, Iñarrairaegui M, et al. Spontaneous regression of hepatocellular carcinoma: a systematicreview. Eur J Gastroenterol He-patol 2009; 21 (3): 254-257
32. O'Beirne JP, Harrison PM. The role of the immune system in the control of hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2004; 16 (12): 1257-1260
33. Bortolami M, Venturi C, Giacomelli L, et al. Cy-tokine, infiltrating macrophage and T cell-mediated response to development of primary and secondary human liver cancer. Dig Liver Dis 2002; 34(11): 794-801
34. Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007; 117 (5): 1137-1146
35. Canning C, O'Brien M, Hegarty JM, et al. Immunol Lett 2006; 107 (2): 83-88
36. Geerlings SE, Hoepelman AI. Immune dysfunction inpatients with diabetes mellitus (DM). FEMS Immunol Med Microbiol 1999; 26 (3-4): 259-265
37. Sakowicz-Burkiewicz M, Kocbuch K, Grden M, et al. Diabetes-induced decrease of adenosine kinase expression impairs the proliferation potential of diabeticrat T lymphocytes. Immunology 2006; 118 (3): 402-412
38. Moulin CM, Marguti I, Peron JPS, et al. Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment in-ducedby morbidobesity. Obes Surg 2011; 21:112-118
39. Lamas O, Martinez JA, Marti A. Energy restriction restores the impaired immune response inover-weight(cafeteria)rats. J Nutr Biochem 2004; 15: 418-425
40. Nieman DC, Henson DA, Nehlsen-Cannarella SL, et al. Physical activity and immune function ineld-erly women. Med Sci Sports Exerc 1993; 25: 823-831
41. Ronchetti A, Rovere P, Iezzi G, et al. Immunogenicity of apototic cells invivo: Role of antigen load, antigen-presenting cells, and cytokines. J Immunol 1999; 163 (1): 130-136
42. Ferlazzo G, Semino C, Spaggiari GM, et al. Dendritic cells efficiently cross-prime HLA class I-restricted cytolytic Tlymphocytes when pulsed with both apoptotic and necrotic cells but not with soluble cell-derived lysates. Int Immunol 2000; 12 (12): 1741-1747
43. Pang B, Neijssen J, Qiao X, et al. Direct antigen presentation and gap junction mediated cross-presentation during apoptosis. J Immunol 2009; 183(2): 1083-1090
44. Nakamoto Y, Mizukoshi E, Tsuji H, et al. Combined therapy of transcatheter hepaticarterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma:clinical safety. Clin Exp Immunol 2007; 147 (2): 296-305