Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

Diabetologia

Volumn 55, Issue 2, 2012, Pages 404-412

  Takeda, Y ^a   Fujita, Y ^a   Honjo, J ^a   Yanagimachi, T ^a   Sakagami, H ^a   Takiyama, Y ^a   Makino, Y ^a   Abiko, A ^a   Kieffer, T J ^b   Haneda, M ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alpha cell proliferation; Beta cell death; Dipeptidyl peptidase 4; Glucagon; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide; Insulin; Streptozotocin

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; SITAGLIPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL EXPANSION; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOARCHITECTURE; DIABETES MELLITUS; DISEASE COURSE; ENZYME INHIBITION; GLUCAGON RELEASE; HYPERGLYCEMIA; INSULIN RELEASE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL PROLIFERATION; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE PROGRESSION; GLUCAGON-SECRETING CELLS; GLUCOSE TOLERANCE TEST; HEMOGLOBINS; IMMUNOHISTOCHEMISTRY; INCRETINS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; STREPTOZOCIN;

EID: 84856711643     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2365-4     Document Type: Article

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