CRISPR-Cas9-mediated modification of the NOD mouse genome with Ptpn22R619W mutation increases autoimmune diabetes

Diabetes

Volumn 65, Issue 8, 2016, Pages 2134-2138

  Lin, Xiaotian ^a   Pelletier, Stephane ^b   Gingras, Sebastien ^b,c   Rigaud, Stephanie ^a   Maine, Christian J ^a   Marquardt, Kristi ^a   Dai, Yang D ^a   Sauer, Karsten ^a   Rodriguez, Alberto R ^a   Martin, Greg ^a   Kupriyanov, Sergey ^a   Jiang, Ling ^d   Yu, Liping ^d   Green, Douglas R ^b   Sherman, Linda A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR CAS 9 PROTEIN; INSULIN ANTIBODY; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; UNCLASSIFIED DRUG; PTPN22 PROTEIN, MOUSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENOTYPE; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION SITE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYGOTE; ANIMAL; CRISPR CAS SYSTEM; GENETIC PREDISPOSITION; GENETICS; GENOME; HUMAN; KNOCKOUT MOUSE; METABOLISM; MUTATION; NONOBESE DIABETIC MOUSE; PATHOPHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; BLOTTING, WESTERN; CRISPR-CAS SYSTEMS; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84980324645     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0061     Document Type: Article

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