A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research

Paediatric Anaesthesia

Volumn , Issue , 2016, Pages 6-36

  Disma, Nicola ^a   Mondardini, Maria C ^b   Terrando, Niccolò ^c   Absalom, Anthony R ^d   Bilotta, Federico ^e  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

anesthetic related neurotoxicity in the developing age; cognitive behavioral impairment; general anesthetic neurotoxicity

Indexed keywords

ANESTHETIC AGENT; NEUROPROTECTIVE AGENT;

ANIMAL; BRAIN; BRAIN REGION; CLINICAL RESEARCH; COGNITION; COMPARATIVE STUDY; DEVELOPMENTAL STAGE; DISEASE MODEL; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; EXPERIMENTAL ANIMAL; HAPLORHINI; HOMEOSTASIS; HUMAN; METHODOLOGY; MOUSE; NEUROPHYSIOLOGICAL MONITORING; NEUROTOXICITY; NEUROTOXICITY SYNDROMES; NEWBORN; NONHUMAN; PRECLINICAL STUDY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROCEDURES; PUBLICATION; RAT; REVIEW; STUDY DESIGN; SYSTEMATIC REVIEW;

ANESTHETICS; ANIMALS; ANIMALS, NEWBORN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HAPLORHINI; MICE; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; RATS;

EID: 84979938933     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12786     Document Type: Review

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