Anesthetic neurotoxicity - Clinical implications of animal models

New England Journal of Medicine

Volumn 372, Issue 9, 2015, Pages 796-797

  Rappaport, Bob A ^a   Suresh, Santhanam ^b   Hertz, Sharon ^a   Evers, Alex S ^c   Orser, Beverley A ^d  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANESTHETIC AGENT; DESFLURANE; ETOMIDATE; GLUTAMATE RECEPTOR; ISOFLURANE; KETAMINE; PROPOFOL; SEDATIVE AGENT; SEVOFLURANE; HYPNOTIC SEDATIVE AGENT;

AMNESIA; ANESTHESIOLOGICAL PROCEDURE; APOPTOSIS; ATTENTION DISTURBANCE; CELL DEATH; FOOD AND DRUG ADMINISTRATION; HIPPOCAMPUS; HUMAN; MEDICAL SOCIETY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; UNCONSCIOUSNESS; ANIMAL; ANIMAL MODEL; BRAIN; CHEMICALLY INDUCED; DRUG EFFECTS; LEARNING DISORDER; POSTOPERATIVE COMPLICATION; PRACTICE GUIDELINE; PRESCHOOL CHILD; SURGERY;

ANESTHETICS; ANIMALS; BRAIN; CHILD, PRESCHOOL; HUMANS; HYPNOTICS AND SEDATIVES; LEARNING DISORDERS; MODELS, ANIMAL; POSTOPERATIVE COMPLICATIONS; PRACTICE GUIDELINES AS TOPIC; RECEPTORS, GABA; RECEPTORS, GLUTAMATE; SURGICAL PROCEDURES, OPERATIVE;

EID: 84923813545     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp1414786     Document Type: Article

References (5)

1. Rappaport B, Mellon RD, Simone A, Woodcock J. Defining safe use of anesthesia in children. N Engl J Med 2011;364:1387-90.
2. Jevtovic-Todorovic V, Absalom AR, Blomgren K, et al. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth 2013;111:143-51.
3. Creeley C, Dikranian K, Dissen G, Martin L, Olney J, Brambrink A. Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. Br J Anaesth 2013;110:Suppl 1:i29-i38.
4. Brambrink AM, Evers AS, Avidan MS, et al. Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology 2012;116:372-84.
5. Flick RP, Katusic SK, Colligan RC, et al. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 2011;128(5):e1053-e1061. [Erratum, Pediatrics 2012;129:595.]