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Volumn 2016, Issue , 2016, Pages

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CYTOKINE; ICARIIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MICRORNA; NOTCH RECEPTOR; RESVERATROL; RETINOIC ACID INDUCIBLE PROTEIN I; SIRTUIN; TRANSFORMING GROWTH FACTOR BETA; BIOLOGICAL MARKER;

EID: 84979729473     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/8426874     Document Type: Review
Times cited : (389)

References (89)
  • 3
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • M. De Martinis, C. Franceschi, D. Monti, and L. Ginaldi, "Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity, " FEBS Letters, vol. 579, no. 10, pp. 2035-2039, 2005.
    • (2005) FEBS Letters , vol.579 , Issue.10 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 4
    • 73249118280 scopus 로고    scopus 로고
    • Ageing, Immunosenescence and Inflammageing in the dog and cat
    • M. J. Day, "Ageing, Immunosenescence and Inflammageing in the dog and cat, " Journal of Comparative Pathology, vol. 142, no. 1, pp. S60-S69, 2010.
    • (2010) Journal of Comparative Pathology , vol.142 , Issue.1 , pp. S60-S69
    • Day, M.J.1
  • 5
    • 84950382925 scopus 로고
    • Cell proliferation, cell death and aging
    • C. Franceschi, "Cell proliferation, cell death and aging., " Aging Milano, vol. 1, no. 1, pp. 3-15, 1989.
    • (1989) Aging Milano , vol.1 , Issue.1 , pp. 3-15
    • Franceschi, C.1
  • 6
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: The lesson of centenarians
    • C. Franceschi, D. Monti, P. Sansoni, and A. Cossarizza, "The immunology of exceptional individuals: The lesson of centenarians, " Immunology Today, vol. 16, no. 1, pp. 12-16, 1995.
    • (1995) Immunology Today , vol.16 , Issue.1 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 7
    • 0029175608 scopus 로고
    • Introduction: The reshaping of the immune system with age
    • C. Franceschi and A. Cossarizza, "Introduction: The reshaping of the immune system with age, " International Reviews of Immunology, vol. 12, no. 1, pp. 1-4, 1995.
    • (1995) International Reviews of Immunology , vol.12 , Issue.1 , pp. 1-4
    • Franceschi, C.1    Cossarizza, A.2
  • 8
    • 40949123149 scopus 로고    scopus 로고
    • Activation of innate immunity system during aging: NF-B signaling is the molecular culprit of inflamm-aging
    • A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen, "Activation of innate immunity system during aging: NF-B signaling is the molecular culprit of inflamm-aging, " Ageing Research Reviews, vol. 7, no. 2, pp. 83-105, 2008.
    • (2008) Ageing Research Reviews , vol.7 , Issue.2 , pp. 83-105
    • Salminen, A.1    Huuskonen, J.2    Ojala, J.3    Kauppinen, A.4    Kaarniranta, K.5    Suuronen, T.6
  • 10
    • 70449431387 scopus 로고    scopus 로고
    • An update of the oxidationinflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging
    • M. De La Fuente and J. Miquel, "An update of the oxidationinflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging, " Current Pharmaceutical Design, vol. 15, no. 26, pp. 3003-3026, 2009.
    • (2009) Current Pharmaceutical Design , vol.15 , Issue.26 , pp. 3003-3026
    • De La Fuente, M.1    Miquel, J.2
  • 11
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
    • C. Franceschi, M. Capri, D. Monti et al., "Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans, " Mechanisms of Ageing and Development, vol. 128, no. 1, pp. 92-105, 2007.
    • (2007) Mechanisms of Ageing and Development , vol.128 , Issue.1 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3
  • 12
    • 33845999595 scopus 로고    scopus 로고
    • Is inflammaging an auto[innate]immunity subclinical syndrome
    • S. Giunta, "Is inflammaging an auto[innate]immunity subclinical syndrome" Immunity and Ageing, vol. 3, article 12, 2006.
    • (2006) Immunity and Ageing , vol.3
    • Giunta, S.1
  • 13
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • C. Nathan and A. Ding, "Nonresolving inflammation, " Cell, vol. 140, no. 6, pp. 871-882, 2010.
    • (2010) Cell , vol.140 , Issue.6 , pp. 871-882
    • Nathan, C.1    Ding, A.2
  • 14
    • 3342995295 scopus 로고    scopus 로고
    • Inflamm-aging: Autoimmunity, and the immune-risk phenotype
    • E. Boren and M. E. Gershwin, "Inflamm-aging: Autoimmunity, and the immune-risk phenotype, " Autoimmunity Reviews, vol. 3, no. 5, pp. 401-406, 2004.
    • (2004) Autoimmunity Reviews , vol.3 , Issue.5 , pp. 401-406
    • Boren, E.1    Gershwin, M.E.2
  • 15
    • 0034962808 scopus 로고    scopus 로고
    • Neuroinflammation and the genetics of Alzheimer's disease: The search for a proinflammatory phenotype
    • C. Franceschi, S. Valensin, F. Lescai et al., "Neuroinflammation and the genetics of Alzheimer's disease: The search for a proinflammatory phenotype, " Aging Clinical and Experimental Research, vol. 13, no. 3, pp. 163-170, 2001.
    • (2001) Aging Clinical and Experimental Research , vol.13 , Issue.3 , pp. 163-170
    • Franceschi, C.1    Valensin, S.2    Lescai, F.3
  • 16
    • 79751537155 scopus 로고    scopus 로고
    • Inflammaging: The driving force in osteoporosis
    • P. Lencel and D. Magne, "Inflammaging: The driving force in osteoporosis" Medical Hypotheses, vol. 76, no. 3, pp. 317-321, 2011.
    • (2011) Medical Hypotheses , vol.76 , Issue.3 , pp. 317-321
    • Lencel, P.1    Magne, D.2
  • 17
    • 52949126710 scopus 로고    scopus 로고
    • Remodeling of the immunoinflammatory network system in elderly cancer patients: Implications of inflamm-aging and tumor-specific hyperinflammation
    • C. Miki, M. Kusunoki, Y. Inoue et al., "Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation, " Surgery Today, vol. 38, no. 10, pp. 873-878, 2008.
    • (2008) Surgery Today , vol.38 , Issue.10 , pp. 873-878
    • Miki, C.1    Kusunoki, M.2    Inoue, Y.3
  • 18
    • 79960243132 scopus 로고    scopus 로고
    • Effect of ageing on colonic mucosal regeneration
    • F. Sipos, K. Leiszter, and Z. Tulassay, "Effect of ageing on colonic mucosal regeneration, " World Journal of Gastroenterology, vol. 17, no. 25, pp. 2981-2986, 2011.
    • (2011) World Journal of Gastroenterology , vol.17 , Issue.25 , pp. 2981-2986
    • Sipos, F.1    Leiszter, K.2    Tulassay, Z.3
  • 19
    • 13844301902 scopus 로고    scopus 로고
    • Stress responses and innate immunity: Aging as a contributory factor
    • S. K. Butcher and J. M. Lord, "Stress responses and innate immunity: Aging as a contributory factor, " Aging Cell, vol. 3, no. 4, pp. 151-160, 2004.
    • (2004) Aging Cell , vol.3 , Issue.4 , pp. 151-160
    • Butcher, S.K.1    Lord, J.M.2
  • 20
    • 0029954748 scopus 로고    scopus 로고
    • The neuroimmunology of stress from invertebrates to man
    • E. Ottaviani and C. Franceschi, "The neuroimmunology of stress from invertebrates to man, " Progress in Neurobiology, vol. 48, no. 4-5, pp. 421-440, 1996.
    • (1996) Progress in Neurobiology , vol.48 , Issue.4-5 , pp. 421-440
    • Ottaviani, E.1    Franceschi, C.2
  • 22
    • 84880378679 scopus 로고    scopus 로고
    • Resveratrol in mammals: Effects on aging biomarkers, age-related diseases, and life span
    • J. Marchal, F. Pifferi, and F. Aujard, "Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span, " Annals of the New York Academy of Sciences, vol. 1290, no. 1, pp. 67-73, 2013.
    • (2013) Annals of the New York Academy of Sciences , vol.1290 , Issue.1 , pp. 67-73
    • Marchal, J.1    Pifferi, F.2    Aujard, F.3
  • 23
    • 33747172229 scopus 로고    scopus 로고
    • Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
    • S. Salvioli, M. Capri, S. Valensin et al., "Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology, " Current Pharmaceutical Design, vol. 12, no. 24, pp. 3161-3171, 2006.
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.24 , pp. 3161-3171
    • Salvioli, S.1    Capri, M.2    Valensin, S.3
  • 24
    • 33646550890 scopus 로고    scopus 로고
    • Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
    • S. Alberti, E. Cevenini, R. Ostan et al., "Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans, " Mechanisms of Ageing and Development, vol. 127, no. 6, pp. 560-566, 2006.
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.6 , pp. 560-566
    • Alberti, S.1    Cevenini, E.2    Ostan, R.3
  • 25
    • 0033793152 scopus 로고    scopus 로고
    • The network and the remodeling theories of aging: Historical background and new perspectives
    • C. Franceschi, S. Valensin, M. Bonafè et al., "The network and the remodeling theories of aging: Historical background and new perspectives, " Experimental Gerontology, vol. 35, no. 6-7, pp. 879-896, 2000.
    • (2000) Experimental Gerontology , vol.35 , Issue.6-7 , pp. 879-896
    • Franceschi, C.1    Valensin, S.2    Bonafè, M.3
  • 26
    • 56949104925 scopus 로고    scopus 로고
    • Advanced age in horses affects divisional history of T cells and inflammatory cytokine production
    • A. A. Adams, C. C. Breathnach, M. P. Katepalli, K. Kohler, and D. W. Horohov, "Advanced age in horses affects divisional history of T cells and inflammatory cytokine production, " Mechanisms of Ageing andDevelopment, vol. 129, no. 11, pp. 656-664, 2008.
    • (2008) Mechanisms of Ageing AndDevelopment , vol.129 , Issue.11 , pp. 656-664
    • Adams, A.A.1    Breathnach, C.C.2    Katepalli, M.P.3    Kohler, K.4    Horohov, D.W.5
  • 29
    • 0037374849 scopus 로고    scopus 로고
    • Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-308 promoter SNP
    • D. Lio, L. Scola, A. Crivello et al., "Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-308 promoter SNP, " Journal of Medical Genetics, vol. 40, no. 4, pp. 296-299, 2003.
    • (2003) Journal of Medical Genetics , vol.40 , Issue.4 , pp. 296-299
    • Lio, D.1    Scola, L.2    Crivello, A.3
  • 30
    • 4544272418 scopus 로고    scopus 로고
    • Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians
    • G. M. Pes, D. Lio, C. Carru et al., "Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians, " Aging Clinical and Experimental Research, vol. 16, no. 3, pp. 244-248, 2004.
    • (2004) Aging Clinical and Experimental Research , vol.16 , Issue.3 , pp. 244-248
    • Pes, G.M.1    Lio, D.2    Carru, C.3
  • 31
    • 48449088578 scopus 로고    scopus 로고
    • Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study
    • M. Sasaki, H. Ikeda, Y. Sato, and Y. Nakanuma, "Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study, " Free Radical Research, vol. 42, no. 7, pp. 625-632, 2008.
    • (2008) Free Radical Research , vol.42 , Issue.7 , pp. 625-632
    • Sasaki, M.1    Ikeda, H.2    Sato, Y.3    Nakanuma, Y.4
  • 32
    • 48649103092 scopus 로고    scopus 로고
    • Cytokine loops driving senescence
    • J. Bartek, Z. Hodny, and J. Lukas, "Cytokine loops driving senescence, " Nature Cell Biology, vol. 10, no. 8, pp. 887-889, 2008.
    • (2008) Nature Cell Biology , vol.10 , Issue.8 , pp. 887-889
    • Bartek, J.1    Hodny, Z.2    Lukas, J.3
  • 33
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • A. Freund, A. V. Orjalo, P.-Y. Desprez, and J. Campisi, "Inflammatory networks during cellular senescence: causes and consequences, " Trends in Molecular Medicine, vol. 16, no. 5, pp. 238-246, 2010.
    • (2010) Trends in Molecular Medicine , vol.16 , Issue.5 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.-Y.3    Campisi, J.4
  • 34
    • 78049243917 scopus 로고    scopus 로고
    • Inflammation, genetic background and longevity
    • G. Candore, C. Caruso, and G. Colonna-Romano, "Inflammation, genetic background and longevity, " Biogerontology, vol. 11, no. 5, pp. 565-573, 2010.
    • (2010) Biogerontology , vol.11 , Issue.5 , pp. 565-573
    • Candore, G.1    Caruso, C.2    Colonna-Romano, G.3
  • 35
    • 34249989400 scopus 로고    scopus 로고
    • Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres
    • A. Meier, H. Fiegler, P. Muñoz et al., "Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres, " The EMBO Journal, vol. 26, no. 11, pp. 2707-2718, 2007.
    • (2007) The EMBO Journal , vol.26 , Issue.11 , pp. 2707-2718
    • Meier, A.1    Fiegler, H.2    Muñoz, P.3
  • 36
    • 84859352385 scopus 로고    scopus 로고
    • Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
    • G. Hewitt, D. Jurk, F. D. Marques et al., "Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence, " Nature Communications, vol. 3, article 708, 2012.
    • (2012) Nature Communications , vol.3
    • Hewitt, G.1    Jurk, D.2    Marques, F.D.3
  • 37
    • 84946829704 scopus 로고    scopus 로고
    • DNA damage response (DDR) and senescence: Shuttled inflamma-miRNAs on the stage of inflamm-aging
    • F. Olivieri, M. C. Albertini, M. Orciani et al., "DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging, " Oncotarget, vol. 6, no. 34, pp. 35509-35521, 2015.
    • (2015) Oncotarget , vol.6 , Issue.34 , pp. 35509-35521
    • Olivieri, F.1    Albertini, M.C.2    Orciani, M.3
  • 38
    • 83555177230 scopus 로고    scopus 로고
    • Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example: Breakdown of the multi-shell cytokine network fuels cancer in aged people
    • M. Bonafè, G. Storci, and C. Franceschi, "Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people, " BioEssays, vol. 34, no. 1, pp. 40-49, 2012.
    • (2012) BioEssays , vol.34 , Issue.1 , pp. 40-49
    • Bonafè, M.1    Storci, G.2    Franceschi, C.3
  • 39
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • N. Mizushima, T. Yoshimori, and B. Levine, "Methods in mammalian autophagy research, " Cell, vol. 140, no. 3, pp. 313-326, 2010.
    • (2010) Cell , vol.140 , Issue.3 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 40
    • 77957299576 scopus 로고    scopus 로고
    • Role of autophagy in-cell function and mass
    • K. Y. Hur, H. S. Jung, and M. S. Lee, "Role of autophagy in-cell function and mass, " Diabetes, Obesity and Metabolism, vol. 12, no. 2, pp. 20-26, 2010.
    • (2010) Diabetes, Obesity and Metabolism , vol.12 , Issue.2 , pp. 20-26
    • Hur, K.Y.1    Jung, H.S.2    Lee, M.S.3
  • 41
    • 64349105425 scopus 로고    scopus 로고
    • Eating to exit: Autophagy-enabled senescence revealed
    • E. White and S. W. Lowe, "Eating to exit: Autophagy-enabled senescence revealed, " Genes and Development, vol. 23, no. 7, pp. 784-787, 2009.
    • (2009) Genes and Development , vol.23 , Issue.7 , pp. 784-787
    • White, E.1    Lowe, S.W.2
  • 42
    • 36849021043 scopus 로고    scopus 로고
    • Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    • G. Juhász, B. érdi, M. Sass, and T. P. Neufeld, "Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila, " Genes and Development, vol. 21, no. 23, pp. 3061-3066, 2007.
    • (2007) Genes and Development , vol.21 , Issue.23 , pp. 3061-3066
    • Juhász, G.1    Érdi, B.2    Sass, M.3    Neufeld, T.P.4
  • 43
    • 84863329778 scopus 로고    scopus 로고
    • Inflammaging: Disturbed interplay between autophagy and inflammasomes
    • A. Salminen, K. Kaarniranta, and A. Kauppinen, "Inflammaging: disturbed interplay between autophagy and inflammasomes, " Aging, vol. 4, no. 3, pp. 166-175, 2012.
    • (2012) Aging , vol.4 , Issue.3 , pp. 166-175
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 44
    • 79955511101 scopus 로고    scopus 로고
    • Emerging models and paradigms for stem cell ageing
    • D. L. Jones and T. A. Rando, "Emerging models and paradigms for stem cell ageing, " Nature Cell Biology, vol. 13, no. 5, pp. 506-512, 2011.
    • (2011) Nature Cell Biology , vol.13 , Issue.5 , pp. 506-512
    • Jones, D.L.1    Rando, T.A.2
  • 46
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • H. Y. Cohen, C. Miller, K. J. Bitterman et al., "Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase, " Science, vol. 305, no. 5682, pp. 390-392, 2004.
    • (2004) Science , vol.305 , Issue.5682 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3
  • 47
    • 53149100858 scopus 로고    scopus 로고
    • SIRT1 longevity factor suppresses NF-B-driven immune responses: Regulation of aging via NF-B acetylation
    • A. Salminen, A. Kauppinen, T. Suuronen, and K. Kaarniranta, "SIRT1 longevity factor suppresses NF-B-driven immune responses: regulation of aging via NF-B acetylation" BioEssays, vol. 30, no. 10, pp. 939-942, 2008.
    • (2008) BioEssays , vol.30 , Issue.10 , pp. 939-942
    • Salminen, A.1    Kauppinen, A.2    Suuronen, T.3    Kaarniranta, K.4
  • 48
    • 42449142360 scopus 로고    scopus 로고
    • Interaction of aging-associated signaling cascades: Inhibition of NF-B signaling by longevity factors FoxOs and SIRT1
    • A. Salminen, J. Ojala, J. Huuskonen, A. Kauppinen, T. Suuronen, and K. Kaarniranta, "Interaction of aging-associated signaling cascades: inhibition of NF-B signaling by longevity factors FoxOs and SIRT1, " Cellular and Molecular Life Sciences, vol. 65, no. 7-8, pp. 1049-1058, 2008.
    • (2008) Cellular and Molecular Life Sciences , vol.65 , Issue.7-8 , pp. 1049-1058
    • Salminen, A.1    Ojala, J.2    Huuskonen, J.3    Kauppinen, A.4    Suuronen, T.5    Kaarniranta, K.6
  • 49
    • 84874727130 scopus 로고    scopus 로고
    • Characteristics of lymphocyte nuclear factor-B signal transduction kinase expression in aging process and regulatory effect of Epimedium flavonoids
    • X.-Y. Liu, Q. Wang, S.-J. Xia, J.-H. Huang, Z.-Y. Shen, and H. Xu, "Characteristics of lymphocyte nuclear factor-B signal transduction kinase expression in aging process and regulatory effect of Epimedium flavonoids, " Chinese Journal of Integrative Medicine, vol. 17, no. 9, pp. 704-709, 2011.
    • (2011) Chinese Journal of Integrative Medicine , vol.17 , Issue.9 , pp. 704-709
    • Liu, X.-Y.1    Wang, Q.2    Xia, S.-J.3    Huang, J.-H.4    Shen, Z.-Y.5    Xu, H.6
  • 50
    • 33947581886 scopus 로고    scopus 로고
    • TOR and aging: Less is more
    • S. M. Schieke and T. Finkel, "TOR and aging: less is more, " Cell Metabolism, vol. 5, no. 4, pp. 233-235, 2007.
    • (2007) Cell Metabolism , vol.5 , Issue.4 , pp. 233-235
    • Schieke, S.M.1    Finkel, T.2
  • 51
    • 77953014263 scopus 로고    scopus 로고
    • The role of mTOR signaling in controlling mammalian life Span: What a fungicide teaches us about longevity
    • Z. D. Sharp and R. Strong, "The role of mTOR signaling in controlling mammalian life Span: what a fungicide teaches us about longevity, " Journals of Gerontology-Series A: Biological Sciences and Medical Sciences, vol. 65, no. 6, pp. 580-589, 2010.
    • (2010) Journals of Gerontology-Series A: Biological Sciences and Medical Sciences , vol.65 , Issue.6 , pp. 580-589
    • Sharp, Z.D.1    Strong, R.2
  • 52
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • P. Kapahi, B. M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer, "Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, " Current Biology, vol. 14, no. 10, pp. 885-890, 2004.
    • (2004) Current Biology , vol.14 , Issue.10 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 53
    • 80051637832 scopus 로고    scopus 로고
    • MTORC1 signaling: What we still don't know
    • X. Wang and C. G. Proud, "mTORC1 signaling: what we still don't know, " Journal of Molecular Cell Biology, vol. 3, no. 4, pp. 206-220, 2011.
    • (2011) Journal of Molecular Cell Biology , vol.3 , Issue.4 , pp. 206-220
    • Wang, X.1    Proud, C.G.2
  • 55
    • 79952281150 scopus 로고    scopus 로고
    • Klotho suppresses RIGI-mediated senescence-associated inflammation
    • F. Liu, S. Wu, H. Ren, and J. Gu, "Klotho suppresses RIGI-mediated senescence-associated inflammation, " Nature Cell Biology, vol. 13, no. 3, pp. 254-262, 2011.
    • (2011) Nature Cell Biology , vol.13 , Issue.3 , pp. 254-262
    • Liu, F.1    Wu, S.2    Ren, H.3    Gu, J.4
  • 56
    • 84875459250 scopus 로고    scopus 로고
    • Impact of Notch signaling on inflammatory responses in cardiovascular disorders
    • T. Quillard and B. Charreau, "Impact of Notch signaling on inflammatory responses in cardiovascular disorders, " International Journal of Molecular Sciences, vol. 14, no. 4, pp. 6863-6888, 2013.
    • (2013) International Journal of Molecular Sciences , vol.14 , Issue.4 , pp. 6863-6888
    • Quillard, T.1    Charreau, B.2
  • 57
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • M. C. Haigis and L. P. Guarente, "Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction, " Genes and Development, vol. 20, no. 21, pp. 2913-2921, 2006.
    • (2006) Genes and Development , vol.20 , Issue.21 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 58
    • 84873151285 scopus 로고    scopus 로고
    • SIRT1, a class III histone deacetylase, regulates TNF-induced inflammation in human chondrocytes
    • M.-H. Moon, J.-K. Jeong, Y.-J. Lee, J.-W. Seol, C. J. Jackson, and S.-Y. Park, "SIRT1, a class III histone deacetylase, regulates TNF-induced inflammation in human chondrocytes, " Osteoarthritis and Cartilage, vol. 21, no. 3, pp. 470-480, 2013.
    • (2013) Osteoarthritis and Cartilage , vol.21 , Issue.3 , pp. 470-480
    • Moon, M.-H.1    Jeong, J.-K.2    Lee, Y.-J.3    Seol, J.-W.4    Jackson, C.J.5    Park, S.-Y.6
  • 59
    • 13844280837 scopus 로고    scopus 로고
    • The G/C915 polymorphism of transforming growth factor 1 is associated with human longevity: A study in Italian centenarians
    • G. Carrieri, E. Marzi, F. Olivieri et al., "The G/C915 polymorphism of transforming growth factor 1 is associated with human longevity: A study in Italian centenarians, " Aging Cell, vol. 3, no. 6, pp. 443-448, 2004.
    • (2004) Aging Cell , vol.3 , Issue.6 , pp. 443-448
    • Carrieri, G.1    Marzi, E.2    Olivieri, F.3
  • 60
    • 0242361641 scopus 로고    scopus 로고
    • Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis
    • T. Minamino, T. Yoshida, K. Tateno et al., "Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis, " Circulation, vol. 108, no. 18, pp. 2264-2269, 2003.
    • (2003) Circulation , vol.108 , Issue.18 , pp. 2264-2269
    • Minamino, T.1    Yoshida, T.2    Tateno, K.3
  • 61
    • 84888197753 scopus 로고    scopus 로고
    • MicroRNAs linking inflamm-aging, cellular senescence and cancer
    • F. Olivieri, M. R. Rippo, V. Monsurrò et al., "MicroRNAs linking inflamm-aging, cellular senescence and cancer, " Ageing Research Reviews, vol. 12, no. 4, pp. 1056-1068, 2013.
    • (2013) Ageing Research Reviews , vol.12 , Issue.4 , pp. 1056-1068
    • Olivieri, F.1    Rippo, M.R.2    Monsurrò, V.3
  • 64
    • 48749126012 scopus 로고    scopus 로고
    • Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan
    • W. Cai, J. C. He, L. Zhu et al., "Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan, " The American Journal of Pathology, vol. 173, no. 2, pp. 327-336, 2008.
    • (2008) The American Journal of Pathology , vol.173 , Issue.2 , pp. 327-336
    • Cai, W.1    He, J.C.2    Zhu, L.3
  • 66
    • 84883462446 scopus 로고    scopus 로고
    • Recent advances in calorie restriction research on aging
    • K. W. Chung, D. H. Kim, M. H. Park et al., "Recent advances in calorie restriction research on aging, " Experimental Gerontology, vol. 48, no. 10, pp. 1049-1053, 2013.
    • (2013) Experimental Gerontology , vol.48 , Issue.10 , pp. 1049-1053
    • Chung, K.W.1    Kim, D.H.2    Park, M.H.3
  • 67
    • 0035040549 scopus 로고    scopus 로고
    • The inflammation hypothesis of aging: Molecular modulation by calorie restriction
    • H. Y. Chung, H. J. Kim, J. W. Kim, and B. P. Yu, "The inflammation hypothesis of aging: molecular modulation by calorie restriction, " Annals of the New York Academy of Sciences, vol. 928, pp. 327-335, 2001.
    • (2001) Annals of the New York Academy of Sciences , vol.928 , pp. 327-335
    • Chung, H.Y.1    Kim, H.J.2    Kim, J.W.3    Yu, B.P.4
  • 68
    • 33646128026 scopus 로고    scopus 로고
    • Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response
    • E. Mocchegiani, L. Costarelli, R. Giacconi et al., "Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response, " Mechanisms of Ageing and Development, vol. 127, no. 6, pp. 517-525, 2006.
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.6 , pp. 517-525
    • Mocchegiani, E.1    Costarelli, L.2    Giacconi, R.3
  • 70
    • 84958880844 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)
    • R. S. Said, E. El-Demerdash, A. S. Nada, and M. M. Kamal, "Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1), " Biochemical Pharmacology, vol. 103, pp. 140-150, 2016.
    • (2016) Biochemical Pharmacology , vol.103 , pp. 140-150
    • Said, R.S.1    El-Demerdash, E.2    Nada, A.S.3    Kamal, M.M.4
  • 71
    • 84960096455 scopus 로고    scopus 로고
    • Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells
    • C. Buhrmann, P. Shayan, B. Popper, A. Goel, andM. Shakibaei, "Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells, " Nutrients, vol. 8, no. 3, p. E145, 2016.
    • (2016) Nutrients , vol.8 , Issue.3 , pp. E145
    • Buhrmann, C.1    Shayan, P.2    Popper, B.3    Goel, A.4    Shakibaei, M.5
  • 72
    • 80055113353 scopus 로고    scopus 로고
    • Activation of Sirt1 by resveratrol inhibits TNF-induced inflammation in fibroblasts
    • X. Zhu, Q. Liu, M. Wang et al., "Activation of Sirt1 by resveratrol inhibits TNF-induced inflammation in fibroblasts, " PloS one, vol. 6, no. 11, article e27081, 2011.
    • (2011) PloS One , vol.6 , Issue.11
    • Zhu, X.1    Liu, Q.2    Wang, M.3
  • 73
    • 84979785740 scopus 로고    scopus 로고
    • Study onmechanism and intervention of inflamm-aging in rats
    • S. Xia, Y. Shen, W. Yu et al., "Study onmechanism and intervention of inflamm-aging in rats, " Chinese Journal of Gerontology, vol. 29, no. 20, pp. 2595-2598, 2009.
    • (2009) Chinese Journal of Gerontology , vol.29 , Issue.20 , pp. 2595-2598
    • Xia, S.1    Shen, Y.2    Yu, W.3
  • 74
    • 84979790905 scopus 로고    scopus 로고
    • Infalmm-aging related genes expression in aged rat hippocampus and Icariin intervention outcome
    • S. Xia, Y. Shen, W. Yu et al., "Infalmm-aging related genes expression in aged rat hippocampus and Icariin intervention outcome, " Geriatrics & Health Care, vol. 14, no. 6, pp. 340-344, 2008.
    • (2008) Geriatrics & Health Care , vol.14 , Issue.6 , pp. 340-344
    • Xia, S.1    Shen, Y.2    Yu, W.3
  • 75
    • 79959564452 scopus 로고    scopus 로고
    • If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
    • V. N. Anisimov, L. M. Berstein, I. G. Popovich et al., "If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice, " Aging, vol. 3, no. 2, pp. 148-157, 2011.
    • (2011) Aging , vol.3 , Issue.2 , pp. 148-157
    • Anisimov, V.N.1    Berstein, L.M.2    Popovich, I.G.3
  • 76
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. Elegans healthspan via AMPK, LKB1, and SKN-1
    • B. Onken and M. Driscoll, "Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1, " PLoS ONE, vol. 5, no. 1, Article IDe8758, 2010.
    • (2010) PLoS ONE , vol.5 , Issue.1
    • Onken, B.1    Driscoll, M.2
  • 77
    • 84942882207 scopus 로고    scopus 로고
    • A trial for the ages
    • S. S. Hall, "A trial for the ages, " Science, vol. 349, no. 6254, pp. 1274-1278, 2015.
    • (2015) Science , vol.349 , Issue.6254 , pp. 1274-1278
    • Hall, S.S.1
  • 79
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and aging: An update
    • E. J. Masoro, "Caloric restriction and aging: An update, " Experimental Gerontology, vol. 35, no. 3, pp. 299-305, 2000.
    • (2000) Experimental Gerontology , vol.35 , Issue.3 , pp. 299-305
    • Masoro, E.J.1
  • 80
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. Elegans by altering microbial folate and methionine metabolism
    • F. Cabreiro, C. Au, K.-Y. Leung et al., "Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism, " Cell, vol. 153, no. 1, pp. 228-239, 2013.
    • (2013) Cell , vol.153 , Issue.1 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.-Y.3
  • 81
    • 84877822086 scopus 로고    scopus 로고
    • Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation
    • O. Moiseeva, X. Desch?enes-Simard, E. St-Germain et al., "Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation, " Aging Cell, vol. 12, no. 3, pp. 489-498, 2013.
    • (2013) Aging Cell , vol.12 , Issue.3 , pp. 489-498
    • Moiseeva, O.1    Deschenes-Simard, X.2    St-Germain, E.3
  • 82
    • 34248206078 scopus 로고    scopus 로고
    • The immunebody cytokine network defines a social architecture of cell interactions
    • Z. Frankenstein, U. Alon, and I. R. Cohen, "The immunebody cytokine network defines a social architecture of cell interactions, " Biology Direct, vol. 1, article 32, 2006.
    • (2006) Biology Direct , vol.1
    • Frankenstein, Z.1    Alon, U.2    Cohen, I.R.3
  • 83
    • 33846491758 scopus 로고    scopus 로고
    • Interferon-induced depressive symptoms are related to changes in the cytokine network but not to cortisol
    • M. C. Wichers, G. Kenis, G. H. Koek, G. Robaeys, N. A. Nicolson, andM. Maes, "Interferon-induced depressive symptoms are related to changes in the cytokine network but not to cortisol, " Journal of Psychosomatic Research, vol. 62, no. 2, pp. 207-214, 2007.
    • (2007) Journal of Psychosomatic Research , vol.62 , Issue.2 , pp. 207-214
    • Wichers, M.C.1    Kenis, G.2    Koek, G.H.3    Robaeys, G.4    Nicolson, N.A.5    Maes, M.6
  • 84
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • H. Kitano, "Systems biology: A brief overview, " Science, vol. 295, no. 5560, pp. 1662-1664, 2002.
    • (2002) Science , vol.295 , Issue.5560 , pp. 1662-1664
    • Kitano, H.1
  • 85
    • 38949145803 scopus 로고    scopus 로고
    • Asystematic look at an old problem
    • T. B. L. Kirkwood, "Asystematic look at an old problem, " Nature, vol. 451, no. 7179, pp. 644-647, 2008.
    • (2008) Nature , vol.451 , Issue.7179 , pp. 644-647
    • Kirkwood, T.B.L.1
  • 86
    • 33947247395 scopus 로고    scopus 로고
    • Is benign prostatic hyperplasia (BPH) an immune inflammatory disease
    • G. Kramer, D. Mitteregger, and M. Marberger, "Is benign prostatic hyperplasia (BPH) an immune inflammatory disease" European Urology, vol. 51, no. 5, pp. 1202-1216, 2007.
    • (2007) European Urology , vol.51 , Issue.5 , pp. 1202-1216
    • Kramer, G.1    Mitteregger, D.2    Marberger, M.3
  • 87
    • 84880571356 scopus 로고    scopus 로고
    • The role of the T cell in age-related inflammation
    • R. Macaulay, A. N. Akbar, and S. M. Henson, "The role of the T cell in age-related inflammation, " Age, vol. 35, no. 3, pp. 563-572, 2013.
    • (2013) Age , vol.35 , Issue.3 , pp. 563-572
    • Macaulay, R.1    Akbar, A.N.2    Henson, S.M.3
  • 88
    • 84876407781 scopus 로고    scopus 로고
    • Polymorphisms in immune/ inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population
    • K. Nie, Y. Zhang, R. Gan et al., "Polymorphisms in immune/ inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population, " Neuroscience Letters, vol. 541, pp. 111-115, 2013.
    • (2013) Neuroscience Letters , vol.541 , pp. 111-115
    • Nie, K.1    Zhang, Y.2    Gan, R.3
  • 89
    • 77952347333 scopus 로고    scopus 로고
    • Gender-related immune-inflammatory factors, age-related diseases, and longevity
    • G. Candore, C. R. Balistreri, G. Colonna-Romano et al., "Gender-related immune-inflammatory factors, age-related diseases, and longevity, " Rejuvenation Research, vol. 13, no. 2-3, pp. 292-297, 2010.
    • (2010) Rejuvenation Research , vol.13 , Issue.2-3 , pp. 292-297
    • Candore, G.1    Balistreri, C.R.2    Colonna-Romano, G.3


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