Ageing, Immunosenescence and Inflammageing in the Dog and Cat

Journal of Comparative Pathology

Volumn 142, Issue SUPPL. 1, 2010, Pages

  Day, M J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

ageing; cat; dog; immunosenescence; inflammageing

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANTIBODY TITER; CAT; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DIET SUPPLEMENTATION; DOG; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSENESCENCE; INFLAMMATORY DISEASE; LIFESPAN; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVIEW; VACCINATION; VETERINARY MEDICINE;

AGING; ANIMALS; CATS; CYTOKINES; DOGS; T-LYMPHOCYTES; VACCINATION;

ANIMALIA; CANIS FAMILIARIS; FELIDAE;

EID: 73249118280     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2009.10.011     Document Type: Review

References (85)

1. Adams A.A., Breathnach C.C., Katepalli M.P., Kohler K., and Horohov D.W. Advanced age in horses affects divisional history of T cells and inflammatory cytokine production. Mechanisms of Ageing and Development 129 (2008) 656-664
2. Araujo J.A., Studzinski C.M., Head E., Cotman C.W., and Milgram N.W. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age 27 (2005) 27-37
3. Aspinall R., Del Giudice G., Effros R.B., Grubeck-Loebenstein B., and Sambhara S. Challenges for vaccination in the elderly. Immunity & Ageing 4 (2007) 9
4. Austad S.N. Diverse aging rates in metazoans: targets for functional genomics. Mechanisms of Ageing and Development 126 (2005) 43-49
5. Aw D., Silva A.B., and Palmer D.B. Immunosenescence: emerging challenges for an ageing population. Immunology 120 (2007) 435-446
6. Baum B., Meneses F., Kleinschmidt S., Nolte I., and Hewicker-Trautwein M. Age-related histomorphologic changes in the canine gastrointestinal tract: a histologic and immunohistologic study. World Journal of Gastroenterology 13 (2007) 152-157
7. Billen F., Peeters D., Dehard S., Day M.J., and Clercx C. Distribution of leucocyte subsets in the canine pharyngeal tonsil. Journal of Comparative Pathology 135 (2006) 63-73
8. Blount D.G., Prtichard D.I., and Heaton P.R. Age-related alterations to immune parameters in Labrador retriever dogs. Veterinary Immunology and Immunopathology 108 (2005) 399-407
9. Böhm M., Thompson H., Weir A., Hasted A.M., Maxwell N.S., et al. Serum antibody titres to canine parvovirus, adenovirus and distemper virus in dogs in the UK which had not been vaccinated for at least three years. Veterinary Record 154 (2004) 457-463
10. Bonnett B.N., Egenvall A., Olson P., and Hedhammer A. Mortality in insured Swedish dogs: rates and causes of death in various breeds. Veterinary Record 141 (1997) 40-44
11. Brellou G., Vlemmas I., Lekkas S., and Papaioannou N. Immunohistochemical investigation of amyloid B-protein (A beta) in the brain of aged cats. Histology and Histopathology 20 (2005) 725-731
12. Campbell D.J., Rawlings J.M., Heaton P.R., Blount D.G., Pritchard D.I., et al. Insulin-like growth factor-1 (IGF-1) and its association with lymphocyte homeostasis in the ageing cat. Mechanisms of Ageing and Development 125 (2004) 497-505
13. Campbell D.J., Rawlings J.M., Koelsch S., Wallace J., Strain J.J., et al. Age-related differences in parameters of feline immune status. Veterinary Immunology and Immunopathology 100 (2004) 73-80
14. Canterberry S.C., Greer K.A., Hitte C., Andre C., and Murphy K.E. Aging-associated loci in Canis familiaris. Growth, Development and Aging 69 (2005) 101-113
15. Clarke S.P., Mellor D., Clements D.N., Gemmill T., Farrell, et al. Prevalence of radiographic signs of degenerative joint disease in a hospital population of cats. Veterinary Record 157 (2005) 793-799
16. Clements D.N., Carter S.D., Innes J.F., and Ollier W.E.R. Genetic basis of secondary osteoarthritis in dogs with joint dysplasia. American Journal of Veterinary Research 67 (2006) 909-918
17. Cotman C.W., and Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. Journal of Alzheimer's Disease 15 (2008) 685-707
18. Coyne M.J., Burr J.H.H., Yule T.D., Harding M.J., Tresnan D.B., et al. Duration of immunity in dogs after vaccination or naturally acquired infection. Veterinary Record 149 (2001) 509-515
19. Coyne M.J., Burr J.H.H., Yule T.D., Harding M.J., Tresnan D.B., et al. Duration of immunity in cats after vaccination or naturally acquired infection. Veterinary Record 149 (2001) 545-548
20. Cupp C.J., Kerr W.W., Clementine J.-P., Patil A.R., and Perez-Carnargo G. The role of nutritional interventions in the longevity and maintenance of long-term health in cats. International Journal of Applied Research in Veterinary Medicine 6 (2008) 69-81
21. Deeb B.J., and Wolf N.S. Studying longevity and morbidity in large and small breeds of dogs. Veterinary Medicine 89 (1994) 702-713
22. Dorshkind K., Montecino-Rodriguez E., and Signer R.A.J. The ageing immune system: is it ever too old to become young again?. Nature Reviews Immunology 9 (2009) 57-62
23. Egenvall A., Bonnett B.N., Shoukri M., Olson P., Hedhammar A., et al. Age pattern of mortality in eight breeds of insured dogs in Sweden. Preventative Veterinary Medicine 46 (2000) 1-14
24. Eigenmann J.E., Patterson D.F., and Froesch E.R. Body size parallels insulin-like growth factor 1 levels but not growth hormone secretory capacity. Acta Endocrinologica 106 (1984) 448-453
25. Faldyna M., Leva L., Knotigova P., and Toman M. Lymphocyte subsets in peripheral blood of dogs - a flow cytometric study. Veterinary Immunology and Immunopathology 82 (2001) 23-37
26. Gerber J.D., and Brown A.L. Effect of development and aging on the response of canine lymphocytes to phytohemagglutinin. Infection and Immunity 10 (1974) 695-699
27. German A.J. The growing problem of obesity in dogs and cats. Journal of Nutrition 136 (2006) 1940S-1946S
28. Godfrey D.R. Osteoarthritis in cats: a retrospective radiological study. Journal of Small Animal Practice 46 (2005) 425-429
29. Goy-Thollot I., Decosne-Junot C., and Bonnet J.-M. Influence of aging on adrenal responsiveness in a population of eleven healthy beagles. Research in Veterinary Science 82 (2007) 195-201
30. Greeley E.H., Kealy R.D., Ballam J.M., Lawler D.F., and Segre M. The influence of age on the canine immune system. Veterinary Immunology and Immunopathology 55 (1996) 1-10
31. Greeley E.H., Ballam J.M., Harrison J.M., Kealy R.D., Lawler D.F., et al. The influence of age and gender on the immune system: a longitudinal study in Labrador retriever dogs. Veterinary Immunology and Immunopathology 82 (2001) 57-71
32. Greeley E.H., Spitznagel E., Lawler D.F., Kealy R.D., and Segre M. Modulation of canine immunosenescence by life-long caloric restriction. Veterinary Immunology and Immunopathology 111 (2006) 287-299
33. Greer K.A., Canterberry S.C., and Murphy K.E. Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Research in Veterinary Science 82 (2007) 208-214
34. high regulatory T cells increases with age. Clinical and Experimental Immunology 140 (2005) 540-546
35. Guarente L., and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408 (2000) 255-262
36. Hall J.A., Wander R.C., Gradin J.L., Shi-Hua D., and Jewell D.E. Effect of dietary n-6-to-n-3 fatty acid ratio on complete blood and total white blood cell counts, and T-cell subpopulations in aged dogs. American Journal of Veterinary Research 60 (1999) 319-327
37. Hall J.A., Tooley K.A., Gradin J.L., Jewell D.E., and Wander R.C. Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs. American Journal of Veterinary Research 64 (2003) 762-772
38. Hayek M.G., Massimino S.P., Burr J.R., and Kearns R.J. Dietary vitamin E improves immune function in cats. In: Reinhart G.A., and Carey D.P. (Eds). Recent Advances in Canine and Feline Nutrition Vol. 3 (2000), Iams Company 555-563
39. Head E. Combining an antioxidant-fortified diet with behavioural enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Annals of the New York Academy of Sciences 1114 (2007) 398-406
40. Heaton P.R., Blount D.G., Devlin P., Koelsch S., Mann S.J., et al. Assessing age-related changes in peripheral blood leukocyte phenotypes in domestic short-haired cats using flow cytometry. Journal of Nutrition 132 (2002) 1607S-1609S
41. HogenEsch H., Thompson S., Dunham A., Ceddia M., and Hayek M. Effect of age on immune parameters and the immune response of dogs to vaccines: a cross-sectional study. Veterinary Immunology and Immunopathology 97 (2004) 77-85
42. Horiuchi Y., Nakajima Y., Nariai Y., Asanuma H., Kuwabara M., et al. Th1/Th2 balance in canine peripheral blood lymphocytes: a flow cytometric study. Veterinary Immunology and Immunopathology 118 (2007) 179-185
43. Kearns R.J., Hayek M.G., Turek J.J., Meydani M., Burr J.R., et al. Effect of age, breed and dietary omega-6 (n-6):omega-3 (n-3) fatty acid ratio on immune function, eicosanoid production, and lipid peroxidation in young and aged dogs. Veterinary Immunology and Immunopathology 69 (1999) 165-183
44. Kearns R.J., Hayek M.G., and Sunvold G.D. Microbial changes in aged dogs. In: Reinhart G.A., and Carey D.P. (Eds). Recent Advances in Canine and Feline Nutrition (2000), Iams Company 337-351
45. Kennedy L.J., Lunt M., Barnes A., McElhinney L., Fooks A.R., et al. Factors influencing the antibody response of dogs vaccinated against rabies. Vaccine 25 (2007) 8500-8507
46. Kipar A., Baptiste K., Meli M.L., Barth A., Knietsch M., et al. Age-related dynamics of constitutive cytokine transcription levels of feline monocytes. Experimental Gerontology 40 (2005) 243-248
47. Kirkness E.F., Bafna V., Halpern A.L., Levy S., Remington K., et al. The dog genome, survey sequencing and comparative analysis. Science 301 (2003) 1898-1903
48. Kleinschmidt S., Meneses F., Nolte I., and Hewicker-Trautwein M. Distribution of mast cell subtypes and immune cell populations in canine intestines: evidence for age-related decline in T cells and macrophages and increase of IgA-positive plasma cells. Research in Veterinary Science 84 (2008) 41-48
49. Kraft W. Geriatrics in canine and feline internal medicine. European Journal of Medical Research 3 (1998) 31-41
50. Kumar R., and Burns E.A. Age-related decline in immunity: implications for vaccine responsiveness. Expert Review of Vaccines 7 (2008) 467-469
51. Lawler D.F., Evans R.H., Chase K., Ellersieck M., Li Q.H., et al. The aging feline kidney: a model mortality antagonist?. Journal of Feline Medicine and Surgery 8 (2006) 363-371
52. Lawler D.F., Evans R.H., Larson B.T., Sptiznagel E.L., Ellersieck M.R., et al. Influence of lifetime food restriction on causes, time, and predictors of death in dogs. Journal of the American Veterinary Medical Association 226 (2005) 225-231
53. Lawler D.F., Larson B.T., Ballam J.M., Smith G.K., Biery D.N., et al. Diet restriction and ageing in the dog: major observations over two decades. British Journal of Nutrition 99 (2008) 793-805
54. Li Y., Deeb B., Pendergrass W., and Wolf N. Cellular proliferative capacity and life span in small and large dogs. Journals of Gerontology Series A: Biological Sciences 51 (1996) B403-B408
55. Mansfield K.L., Burr P.D., Snodgrass D.R., Sayers R., and Fooks A.R. Factors affecting the serological response of dogs and cats to rabies vaccination. Veterinary Record 154 (2004) 423-426
56. Massimino S., Kearns R.J., Loos K.M., Burr J., Park J.S., et al. Effects of age and dietary beta-carotene on immunological variables in dogs. Journal of Veterinary Internal Medicine 17 (2003) 835-842
57. McKevitt T.P., Nasir L., Devlin P., and Argyle D.J. Telomere lengths in dogs decrease with increasing donor age. Journal of Nutrition 132 (2002) 1604S-1606S
58. McKevitt T.P., Nasir L., Wallis C.V., and Argyle D.J. A cohort study of telomere and telomerase biology in cats. American Journal of Veterinary Research 64 (2003) 1496-1499
59. Meydani S.N., Hayek M.G., Wu D., and Meydani M. Vitamin E and immune response in aged dogs. In: Reinhart G.A., and Carey D.P. (Eds). Recent Advances in Canine and Feline Nutrition Vol. 3 (2000), Iams Company 295-303
60. Michell A.R. Longevity of British breeds of dog and its relationship with sex, size, cardiovascular variables and disease. Veterinary Record 145 (1999) 625-629
61. Mouzin D.E., Lorenzen M.J., Haworth J.D., and King V.L. Duration of serologic response to five viral antigens in dogs. Journal of the American Veterinary Medical Association 224 (2004) 55-60
62. Mouzin D.E., Lorenzen M.J., Haworth J.D., and King V.L. Duration of serologic response to three viral antigens in cats. Journal of the American Veterinary Medical Association 224 (2004) 61-66
63. Ostan R., Bucci L., Capri M., Salvioli S., Scurti M., et al. Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation 15 (2008) 224-240
64. Patronek G.J., Waters D.J., and Glickman L.T. Comparative longevity of pet dogs and humans: implications for gerontology research. Journal of Gerontology Series A: Biological Science 52A (1997) B171-B178
65. Peeters D., Day M.J., Farnir F., Moore P., and Clercx C. Distribution of leucocyte subsets in the canine respiratory tract. Journal of Comparative Pathology 132 (2005) 261-272
66. Peeters D., Peters I.R., Farnir F., Clercx C., and Day M.J. Real-time RT-PCR quantification of mRNA encoding cytokines and chemokines in histologically normal canine nasal, bronchial and pulmonary tissue. Veterinary Immunology and Immunopathology 104 (2005) 195-204
67. Pereira M.B.C., Traverse M.C.F., Barros D.A., Bianchini A., and Martinez P.E. The effects of aging on leukocyte glucocorticoid receptor concentration and response to dexamethasone in dogs. Experimental Gerontology 38 (2003) 989-995
68. Pomeroy M.J., and Robertson J.L. The relationship of age, sex, and glomerular location to the development of spontaneous lesions in the canine kidney: analysis of a life-span study. Toxicologic Pathology 32 (2004) 237-242
69. Proschowsky H.F., Rugbjerg H., and Ersboll A.K. Mortality of purebred and mixed-breed dogs in Denmark. Preventative Veterinary Medicine 58 (2003) 63-74
70. Reis A.B., Carneiro C.M., Carvalho M.D.G., Teixeira-Carvalho A., Giunchetti R.C., et al. Establishment of a microplate assay for flow cytometric assessment and its use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes. Veterinary Immunology and Immunopathology 103 (2005) 173-185
71. Richards S.E., Wang Y., Lawler D., Kochhar S., Holmes E., et al. Self modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs. Analytical Chemistry 80 (2008) 4876-4885
72. Rosato E., and Salsano F. Immunity, autoimmunity and autoimmune diseases in older people. Journal of Biological Regulators and Homeostatic Agents 22 (2008) 217-224
73. Sako T., Uchida E., Kagawa Y., Hirayama K., Takahashi T., et al. Immunohistochemical detection of apolipoprotein B-100 and immunoglobulins (IgA, IgM, IgG) in the splenic arteries of aging dogs. Veterinary Pathology 38 (2001) 407-413
74. Scott F.W., and Geissinger C.M. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. American Journal of Veterinary Research 60 (1999) 652-658
75. Sharma S., Dominguez A.L., and Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. Journal of Immunology 177 (2006) 8348-8355
76. Speakman J.R., van Acker A., and Harper E.J. Age-related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy. Aging Cell 2 (2003) 265-275
77. Strasser A., Teltscher A., May B., Sanders C., and Niedermuller H. Age-associated changes in the immune system of German shepherd dogs. Journal of Veterinary Medicine Series A: Physiology and Pathology 47 (2000) 181-192
78. Sutter N.B., Bustamante C.D., Chase K., Gray M.M., Zhao K., et al. A single IGF1 allele is a major determinant of size in dogs. Science 316 (2007) 112-115
79. Sutter N.B., and Ostrander E.A. Dog star rising: the canine genetic system. Nature Reviews Genetics 5 (2004) 900-910
80. Tani Y., Uchida K., Uetsuka K., Nakamura S., Nakayama H., et al. Amyloid deposits in the gastrointestinal tract of aging dogs. Veterinary Pathology 34 (1997) 415-420
81. Targonski P.V., Jacobson R.M., and Poland G.A. Immunosenescence: role and measurement in influenza vaccine response amongst the elderly. Vaccine 25 (2007) 3066-3069
82. Tone C.M., Cardoza D.M., Carpenter R.H., and Draghia-Akli R. Long-term effects of plasmid-mediated growth hormone releasing hormone in dogs. Cancer Gene Therapy 11 (2004) 389-396
83. Twark L., and Dodds W.J. Clinical use of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. Journal of the American Veterinary Medical Association 217 (2000) 1021-1024
84. Wang Y.L., Lawler D., Larson B., Ramadan Z., Kochlar S., et al. Metabonomic investigations of aging and caloric restriction in a life-long study. Journal of Proteome Research 6 (2007) 1846-1854
85. Woodruff-Pak D. Animal models of Alzheimer's disease: therapeutic implications. Journal of Alzheimer's Disease 15 (2008) 507-521