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Volumn 9s2, Issue , 2015, Pages 43-50

Glial tau pathology in tauopathies: Functional consequences

Author keywords

Astrocytes; Functional consequences; Glial tau pathology; Microglia; Neurodegeneration; Oligodendrocytes; Tau; Tauopathy

Indexed keywords

TAU INTERFERON;

EID: 84979283576     PISSN: None     EISSN: 11790695     Source Type: Journal    
DOI: 10.4137/JEN.S25515     Document Type: Review
Times cited : (87)

References (109)
  • 1
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci. 2007;8(9):663-672
    • (2007) Nat Rev Neurosci , vol.8 , Issue.9 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 2
    • 0029879877 scopus 로고    scopus 로고
    • Glial inclusions in CNS degenerative diseases
    • Chin SS, Goldman JE. Glial inclusions in CNS degenerative diseases. J Neuropathol Exp Neurol. 1996;55(5):499-508
    • (1996) J Neuropathol Exp Neurol , vol.55 , Issue.5 , pp. 499-508
    • Chin, S.S.1    Goldman, J.E.2
  • 3
    • 0029790283 scopus 로고    scopus 로고
    • Neurodegenerative disorders with extensive tau pathology: a comparative study and review
    • Feany MB, Dickson DW. Neurodegenerative disorders with extensive tau pathology: a comparative study and review. Ann Neurol. 1996;40(2):139-148
    • (1996) Ann Neurol , vol.40 , Issue.2 , pp. 139-148
    • Feany, M.B.1    Dickson, D.W.2
  • 4
    • 0032886469 scopus 로고    scopus 로고
    • Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease
    • Komori T. Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease. Brain Pathol. 1999;9(4):663-679
    • (1999) Brain Pathol , vol.9 , Issue.4 , pp. 663-679
    • Komori, T.1
  • 5
    • 33748372746 scopus 로고    scopus 로고
    • Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau
    • Williams DR. Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau. Intern Med J. 2006;36(10):652-660
    • (2006) Intern Med J , vol.36 , Issue.10 , pp. 652-660
    • Williams, D.R.1
  • 7
    • 0032191105 scopus 로고    scopus 로고
    • Filamentous nerve cell inclusions in neurodegenerative diseases
    • Goedert M, Spillantini MG, Davies SW. Filamentous nerve cell inclusions in neurodegenerative diseases. Curr Opin Neurobiol. 1998;8(5):619-632
    • (1998) Curr Opin Neurobiol , vol.8 , Issue.5 , pp. 619-632
    • Goedert, M.1    Spillantini, M.G.2    Davies, S.W.3
  • 9
    • 4744372663 scopus 로고    scopus 로고
    • Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition
    • Richter-Landsberg C, Bauer NG. Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition. Int J Dev Neurosci. 2004;22(7):443-451
    • (2004) Int J Dev Neurosci , vol.22 , Issue.7 , pp. 443-451
    • Richter-Landsberg, C.1    Bauer, N.G.2
  • 10
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, Lendon CL, Rizzu P, et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998;393(6686): 702-705
    • (1998) Nature , vol.393 , Issue.6686 , pp. 702-705
    • Hutton, M.1    Lendon, C.L.2    Rizzu, P.3
  • 11
    • 14444284106 scopus 로고    scopus 로고
    • Tau is a candidate gene for chromosome 17.frontotemporal dementia
    • Poorkaj P, Bird TD, Wijsman E, et al. Tau is a candidate gene for chromosome 17. frontotemporal dementia. Ann Neurol. 1998;43(6):815-825
    • (1998) Ann Neurol , vol.43 , Issue.6 , pp. 815-825
    • Poorkaj, P.1    Bird, T.D.2    Wijsman, E.3
  • 12
    • 27644460461 scopus 로고    scopus 로고
    • Hereditary Pick's disease with the G272V tau mutation shows predominant three-repeat tau pathology
    • Bronner IF, ter Meulen BC, Azmani A, et al. Hereditary Pick's disease with the G272V tau mutation shows predominant three-repeat tau pathology. Brain. 2005;128(pt 11):2645-2653
    • (2005) Brain , vol.128 , pp. 2645-2653
    • Bronner, I.F.1    ter Meulen, B.C.2    Azmani, A.3
  • 13
    • 0142062488 scopus 로고    scopus 로고
    • The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy
    • Hogg M, Grujic ZM, Baker M, et al. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. Acta Neuropathol. 2003;106(4):323-336
    • (2003) Acta Neuropathol , vol.106 , Issue.4 , pp. 323-336
    • Hogg, M.1    Grujic, Z.M.2    Baker, M.3
  • 14
    • 0032763203 scopus 로고    scopus 로고
    • Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits
    • Murrell JR, Spillantini MG, Zolo P, et al. Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits. J Neuropathol Exp Neurol. 1999;58(12):1207-1226
    • (1999) J Neuropathol Exp Neurol , vol.58 , Issue.12 , pp. 1207-1226
    • Murrell, J.R.1    Spillantini, M.G.2    Zolo, P.3
  • 15
    • 84937818139 scopus 로고    scopus 로고
    • A novel tau mutation, p.K317N, causes globular glial tauopathy
    • Tacik P, DeTure M, Lin WL, et al. A novel tau mutation, p.K317N, causes globular glial tauopathy. Acta Neuropathol. 2015;130(2):199-214
    • (2015) Acta Neuropathol , vol.130 , Issue.2 , pp. 199-214
    • Tacik, P.1    DeTure, M.2    Lin, W.L.3
  • 16
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder LI, Frankfurter A, Rebhun LI. The distribution of tau in the mammalian central nervous system. J Cell Biol. 1985;101(4):1371-1378
    • (1985) J Cell Biol , vol.101 , Issue.4 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 17
    • 77955322042 scopus 로고    scopus 로고
    • Dendritic function of tau mediates amyloidbeta toxicity in Alzheimer's disease mouse models
    • Ittner LM, Ke YD, Delerue F, et al. Dendritic function of tau mediates amyloidbeta toxicity in Alzheimer's disease mouse models. Cell. 2010;142(3):387-397
    • (2010) Cell , vol.142 , Issue.3 , pp. 387-397
    • Ittner, L.M.1    Ke, Y.D.2    Delerue, F.3
  • 18
    • 0034792446 scopus 로고    scopus 로고
    • Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes
    • Gorath M, Stahnke T, Mronga T, Goldbaum O, Richter-Landsberg C. Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes. Glia. 2001;36(1):89-101
    • (2001) Glia , vol.36 , Issue.1 , pp. 89-101
    • Gorath, M.1    Stahnke, T.2    Mronga, T.3    Goldbaum, O.4    Richter-Landsberg, C.5
  • 19
    • 0036469248 scopus 로고    scopus 로고
    • Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau
    • Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J. Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci. 2002;22(3):698-707
    • (2002) J Neurosci , vol.22 , Issue.3 , pp. 698-707
    • Klein, C.1    Kramer, E.M.2    Cardine, A.M.3    Schraven, B.4    Brandt, R.5    Trotter, J.6
  • 20
    • 0028853922 scopus 로고
    • Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes
    • LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI. Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Natl Acad Sci U S A. 1995;92(22):10369-10373
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.22 , pp. 10369-10373
    • LoPresti, P.1    Szuchet, S.2    Papasozomenos, S.C.3    Zinkowski, R.P.4    Binder, L.I.5
  • 21
    • 0030610247 scopus 로고    scopus 로고
    • Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytes
    • Muller R, Heinrich M, Heck S, Blohm D, Richter-Landsberg C. Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytes. Cell Tissue Res. 1997;288(2):239-249
    • (1997) Cell Tissue Res , vol.288 , Issue.2 , pp. 239-249
    • Muller, R.1    Heinrich, M.2    Heck, S.3    Blohm, D.4    Richter-Landsberg, C.5
  • 22
    • 84937767176 scopus 로고    scopus 로고
    • Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes
    • Seiberlich V, Bauer NG, Schwarz L, Ffrench-Constant C, Goldbaum O, Richter-Landsberg C. Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia. 2015;63(9):1621-1635
    • (2015) Glia , vol.63 , Issue.9 , pp. 1621-1635
    • Seiberlich, V.1    Bauer, N.G.2    Schwarz, L.3    Ffrench-Constant, C.4    Goldbaum, O.5    Richter-Landsberg, C.6
  • 23
    • 0023505501 scopus 로고
    • Phosphorylation determines two distinct species of Tau in the central nervous system
    • Papasozomenos SC, Binder LI. Phosphorylation determines two distinct species of Tau in the central nervous system. Cell Motil Cytoskeleton. 1987;8(3): 210-226
    • (1987) Cell Motil Cytoskeleton , vol.8 , Issue.3 , pp. 210-226
    • Papasozomenos, S.C.1    Binder, L.I.2
  • 24
    • 0030267241 scopus 로고    scopus 로고
    • The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules
    • Ilschner S, Brandt R. The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules. Glia. 1996;18(2):129-140
    • (1996) Glia , vol.18 , Issue.2 , pp. 129-140
    • Ilschner, S.1    Brandt, R.2
  • 25
    • 84925867784 scopus 로고    scopus 로고
    • Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy
    • Ferrer I, Legati A, Garcia-Monco JC, et al. Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy. J Neuropathol Exp Neurol. 2015;74(4):370-379
    • (2015) J Neuropathol Exp Neurol , vol.74 , Issue.4 , pp. 370-379
    • Ferrer, I.1    Legati, A.2    Garcia-Monco, J.C.3
  • 26
    • 84891831616 scopus 로고    scopus 로고
    • Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression
    • Ferrer I, Lopez-Gonzalez I, Carmona M, et al. Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression. J Neuropathol Exp Neurol. 2014;73(1):81-97
    • (2014) J Neuropathol Exp Neurol , vol.73 , Issue.1 , pp. 81-97
    • Ferrer, I.1    Lopez-Gonzalez, I.2    Carmona, M.3
  • 27
    • 0029055025 scopus 로고
    • Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders
    • Odawara T, Iseki E, Kosaka K, Akiyama H, Ikeda K, Yamamoto T. Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders. Neurosci Lett. 1995;192(3):145-148
    • (1995) Neurosci Lett , vol.192 , Issue.3 , pp. 145-148
    • Odawara, T.1    Iseki, E.2    Kosaka, K.3    Akiyama, H.4    Ikeda, K.5    Yamamoto, T.6
  • 28
    • 0035011587 scopus 로고    scopus 로고
    • Tau-66: evidence for a novel tau conformation in Alzheimer's disease
    • Ghoshal N, Garcia-Sierra F, Fu Y, et al. Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem. 2001;77(5):1372-1385
    • (2001) J Neurochem , vol.77 , Issue.5 , pp. 1372-1385
    • Ghoshal, N.1    Garcia-Sierra, F.2    Fu, Y.3
  • 29
    • 33749007666 scopus 로고    scopus 로고
    • Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies
    • Arima K. Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. Neuropathology. 2006;26(5):475-483
    • (2006) Neuropathology , vol.26 , Issue.5 , pp. 475-483
    • Arima, K.1
  • 30
    • 84885484879 scopus 로고    scopus 로고
    • Globular glial tauopathies (GGT): consensus recommendations
    • Ahmed Z, Bigio EH, Budka H, et al. Globular glial tauopathies (GGT): consensus recommendations. Acta Neuropathol. 2013;126(4):537-544
    • (2013) Acta Neuropathol , vol.126 , Issue.4 , pp. 537-544
    • Ahmed, Z.1    Bigio, E.H.2    Budka, H.3
  • 31
    • 54449096081 scopus 로고    scopus 로고
    • White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration
    • Kovacs GG, Majtenyi K, Spina S, et al. White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2008;67(10):963-975
    • (2008) J Neuropathol Exp Neurol , vol.67 , Issue.10 , pp. 963-975
    • Kovacs, G.G.1    Majtenyi, K.2    Spina, S.3
  • 32
    • 0028889282 scopus 로고
    • Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles
    • Ikeda K, Akiyama H, Kondo H, et al. Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles. Acta Neuropathol. 1995;90(6): 620-625
    • (1995) Acta Neuropathol , vol.90 , Issue.6 , pp. 620-625
    • Ikeda, K.1    Akiyama, H.2    Kondo, H.3
  • 33
    • 1242316179 scopus 로고    scopus 로고
    • High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
    • Schultz C, Ghebremedhin E, Del Tredici K, Rub U, Braak H. High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging. 2004;25(3):397-405
    • (2004) Neurobiol Aging , vol.25 , Issue.3 , pp. 397-405
    • Schultz, C.1    Ghebremedhin, E.2    Del Tredici, K.3    Rub, U.4    Braak, H.5
  • 34
    • 0036938326 scopus 로고    scopus 로고
    • Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms
    • Tolnay M, Sergeant N, Ghestem A, et al. Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. Acta Neuropathol. 2002;104(4):425-434
    • (2002) Acta Neuropathol , vol.104 , Issue.4 , pp. 425-434
    • Tolnay, M.1    Sergeant, N.2    Ghestem, A.3
  • 35
    • 0029062956 scopus 로고
    • Widespread cytoskeletal pathology characterizes corticobasal degeneration
    • Feany MB, Dickson DW. Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol. 1995;146(6):1388-1396
    • (1995) Am J Pathol , vol.146 , Issue.6 , pp. 1388-1396
    • Feany, M.B.1    Dickson, D.W.2
  • 36
    • 0038268411 scopus 로고    scopus 로고
    • Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain
    • Hattori M, Hashizume Y, Yoshida M, et al. Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain. Acta Neuropathol. 2003;106(2): 143-149
    • (2003) Acta Neuropathol , vol.106 , Issue.2 , pp. 143-149
    • Hattori, M.1    Hashizume, Y.2    Yoshida, M.3
  • 38
    • 7744232563 scopus 로고    scopus 로고
    • Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy
    • Iwasaki Y, Yoshida M, Hattori M, et al. Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy. Acta Neuropathol. 2004; 108(5):399-405
    • (2004) Acta Neuropathol , vol.108 , Issue.5 , pp. 399-405
    • Iwasaki, Y.1    Yoshida, M.2    Hattori, M.3
  • 39
    • 84923006997 scopus 로고    scopus 로고
    • Invited review: Neuropathology of tauopathies: principles and practice
    • Kovacs GG. Invited review: Neuropathology of tauopathies: principles and practice. Neuropathol Appl Neurobiol. 2015;41(1):3-23
    • (2015) Neuropathol Appl Neurobiol , vol.41 , Issue.1 , pp. 3-23
    • Kovacs, G.G.1
  • 40
    • 84928680622 scopus 로고    scopus 로고
    • Diverse subtypes of astrocytes and their development during corticogenesis
    • Tabata H. Diverse subtypes of astrocytes and their development during corticogenesis. Front Neurosci. 2015;9:114
    • (2015) Front Neurosci , vol.9 , pp. 114
    • Tabata, H.1
  • 41
    • 33748996792 scopus 로고    scopus 로고
    • Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies
    • Yoshida M. Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathology. 2006;26(5):457-470
    • (2006) Neuropathology , vol.26 , Issue.5 , pp. 457-470
    • Yoshida, M.1
  • 42
    • 80855138704 scopus 로고    scopus 로고
    • Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)
    • Dickson DW, Kouri N, Murray ME, Josephs KA. Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau). J Mol Neurosci. 2011;45(3): 384-389
    • (2011) J Mol Neurosci , vol.45 , Issue.3 , pp. 384-389
    • Dickson, D.W.1    Kouri, N.2    Murray, M.E.3    Josephs, K.A.4
  • 43
    • 33645766284 scopus 로고    scopus 로고
    • An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R-and 4R-specific tau monoclonal antibodies
    • de Silva R, Lashley T, Strand C, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R-and 4R-specific tau monoclonal antibodies. Acta Neuropathol. 2006;111(4):329-340
    • (2006) Acta Neuropathol , vol.111 , Issue.4 , pp. 329-340
    • de Silva, R.1    Lashley, T.2    Strand, C.3
  • 44
    • 0029041149 scopus 로고
    • Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy
    • Feany MB, Ksiezak-Reding H, Liu WK, Vincent I, Yen SH, Dickson DW. Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. Acta Neuropathol. 1995;90(1):37-43
    • (1995) Acta Neuropathol , vol.90 , Issue.1 , pp. 37-43
    • Feany, M.B.1    Ksiezak-Reding, H.2    Liu, W.K.3    Vincent, I.4    Yen, S.H.5    Dickson, D.W.6
  • 45
    • 27744484059 scopus 로고    scopus 로고
    • Glial cell inclusions and the pathogenesis of neurodegenerative diseases
    • Miller DW, Cookson MR, Dickson DW. Glial cell inclusions and the pathogenesis of neurodegenerative diseases. Neuron Glia Biol. 2004;1(1):13-21
    • (2004) Neuron Glia Biol , vol.1 , Issue.1 , pp. 13-21
    • Miller, D.W.1    Cookson, M.R.2    Dickson, D.W.3
  • 46
    • 0030996319 scopus 로고    scopus 로고
    • Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene
    • Nishimura T, Ikeda K, Akiyama H, et al. Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene. Neurosci Lett. 1997;224(3): 169-172
    • (1997) Neurosci Lett , vol.224 , Issue.3 , pp. 169-172
    • Nishimura, T.1    Ikeda, K.2    Akiyama, H.3
  • 47
    • 84888015350 scopus 로고    scopus 로고
    • Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury
    • Gao Z, Zhu Q, Zhang Y, et al. Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Mol Neurobiol. 2013;48(3): 690-701
    • (2013) Mol Neurobiol , vol.48 , Issue.3 , pp. 690-701
    • Gao, Z.1    Zhu, Q.2    Zhang, Y.3
  • 48
    • 84921791889 scopus 로고    scopus 로고
    • Astrocyte reactivity and reactive astrogliosis: costs and benefits
    • Pekny M, Pekna M. Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiol Rev. 2014;94(4):1077-1098
    • (2014) Physiol Rev , vol.94 , Issue.4 , pp. 1077-1098
    • Pekny, M.1    Pekna, M.2
  • 49
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med. 2006;12(9):1005-1015
    • (2006) Nat Med , vol.12 , Issue.9 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 50
    • 0028861585 scopus 로고
    • Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease
    • Bierer LM, Hof PR, Purohit DP, et al. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol. 1995;52(1): 81-88
    • (1995) Arch Neurol , vol.52 , Issue.1 , pp. 81-88
    • Bierer, L.M.1    Hof, P.R.2    Purohit, D.P.3
  • 51
    • 0036943019 scopus 로고    scopus 로고
    • Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process
    • Togo T, Dickson DW. Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process. Acta Neuropathol. 2002; 104(4):398-402
    • (2002) Acta Neuropathol , vol.104 , Issue.4 , pp. 398-402
    • Togo, T.1    Dickson, D.W.2
  • 52
    • 0030049067 scopus 로고    scopus 로고
    • Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration
    • Feany MB, Mattiace LA, Dickson DW. Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration. J Neuropathol Exp Neurol. 1996;55(1):53-67
    • (1996) J Neuropathol Exp Neurol , vol.55 , Issue.1 , pp. 53-67
    • Feany, M.B.1    Mattiace, L.A.2    Dickson, D.W.3
  • 53
    • 84885403183 scopus 로고    scopus 로고
    • Expression of Tau40 induces activation of cultured rat microglial cells
    • Wang L, Jiang Q, Chu J, et al. Expression of Tau40 induces activation of cultured rat microglial cells. PLoS One. 2013;8(10):e76057
    • (2013) PLoS One , vol.8 , Issue.10
    • Wang, L.1    Jiang, Q.2    Chu, J.3
  • 54
    • 84938709394 scopus 로고    scopus 로고
    • Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
    • Maphis N, Xu G, Kokiko-Cochran ON, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138(pt 6):1738-1755
    • (2015) Brain , vol.138 , pp. 1738-1755
    • Maphis, N.1    Xu, G.2    Kokiko-Cochran, O.N.3
  • 55
    • 84945474523 scopus 로고    scopus 로고
    • Depletion of microglia and inhibition of exosome synthesis halt tau propagation
    • Asai H, Ikezu S, Tsunoda S, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18(11):1584-1593
    • (2015) Nat Neurosci , vol.18 , Issue.11 , pp. 1584-1593
    • Asai, H.1    Ikezu, S.2    Tsunoda, S.3
  • 56
    • 55049084760 scopus 로고    scopus 로고
    • The mystery and magic of glia: a perspective on their roles in health and disease
    • Barres BA. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron. 2008;60(3):430-440
    • (2008) Neuron , vol.60 , Issue.3 , pp. 430-440
    • Barres, B.A.1
  • 57
    • 0141533210 scopus 로고    scopus 로고
    • New roles for astrocytes (stars at last)
    • Ransom B, Behar T, Nedergaard M. New roles for astrocytes (stars at last). Trends Neurosci. 2003;26(10):520-522
    • (2003) Trends Neurosci , vol.26 , Issue.10 , pp. 520-522
    • Ransom, B.1    Behar, T.2    Nedergaard, M.3
  • 58
    • 70049084419 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration
    • Bartels AL, Kortekaas R, Bart J, et al. Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration. Neurobiol Aging. 2009;30(11):1818-1824
    • (2009) Neurobiol Aging , vol.30 , Issue.11 , pp. 1818-1824
    • Bartels, A.L.1    Kortekaas, R.2    Bart, J.3
  • 59
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57(2):178-201
    • (2008) Neuron , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 60
    • 84944903063 scopus 로고    scopus 로고
    • Tau depletion prevents progressive bloodbrain barrier damage in a mouse model of tauopathy
    • Blair LJ, Frauen HD, Zhang B, et al. Tau depletion prevents progressive bloodbrain barrier damage in a mouse model of tauopathy. Acta Neuropathol Commun. 2015;3:8
    • (2015) Acta Neuropathol Commun , vol.3 , pp. 8
    • Blair, L.J.1    Frauen, H.D.2    Zhang, B.3
  • 61
    • 0035287432 scopus 로고    scopus 로고
    • GLIA: listening and talking to the synapse
    • Haydon PG. GLIA: listening and talking to the synapse. Nat Rev Neurosci. 2001; 2(3):185-193
    • (2001) Nat Rev Neurosci , vol.2 , Issue.3 , pp. 185-193
    • Haydon, P.G.1
  • 62
    • 0035105962 scopus 로고    scopus 로고
    • Glutamate transporters in neurologic disease
    • Maragakis NJ, Rothstein JD. Glutamate transporters in neurologic disease. Arch Neurol. 2001;58(3):365-370
    • (2001) Arch Neurol , vol.58 , Issue.3 , pp. 365-370
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 63
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
    • Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 1996;16(3):675-686
    • (1996) Neuron , vol.16 , Issue.3 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3
  • 64
    • 0030812843 scopus 로고    scopus 로고
    • Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    • Tanaka K, Watase K, Manabe T, et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 1997;276(5319): 1699-1702
    • (1997) Science , vol.276 , Issue.5319 , pp. 1699-1702
    • Tanaka, K.1    Watase, K.2    Manabe, T.3
  • 65
    • 84870493318 scopus 로고    scopus 로고
    • Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP
    • Pita-Almenar JD, Zou S, Colbert CM, Eskin A. Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP. Learn Mem. 2012;19(12): 615-626
    • (2012) Learn Mem , vol.19 , Issue.12 , pp. 615-626
    • Pita-Almenar, J.D.1    Zou, S.2    Colbert, C.M.3    Eskin, A.4
  • 66
    • 32544448946 scopus 로고    scopus 로고
    • Impaired glutamate transport in a mouse model of tau pathology in astrocytes
    • Dabir DV, Robinson MB, Swanson E, et al. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. J Neurosci. 2006;26(2):644-654
    • (2006) J Neurosci , vol.26 , Issue.2 , pp. 644-654
    • Dabir, D.V.1    Robinson, M.B.2    Swanson, E.3
  • 67
    • 84863058838 scopus 로고    scopus 로고
    • Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment
    • Yang W, Strong MJ. Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment. Amyotroph Lateral Scler. 2012; 13(2):178-193
    • (2012) Amyotroph Lateral Scler , vol.13 , Issue.2 , pp. 178-193
    • Yang, W.1    Strong, M.J.2
  • 68
    • 84908176097 scopus 로고    scopus 로고
    • Glial cells in amyotrophic lateral sclerosis
    • Philips T, Rothstein JD. Glial cells in amyotrophic lateral sclerosis. Exp Neurol. 2014;262 Pt B:111-120
    • (2014) Exp Neurol , vol.262 , pp. 111-120
    • Philips, T.1    Rothstein, J.D.2
  • 69
    • 0029657947 scopus 로고    scopus 로고
    • Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration
    • Dickson DW, Feany MB, Yen SH, Mattiace LA, Davies P. Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration. J Neural Transm Suppl. 1996; 47:31-46
    • (1996) J Neural Transm Suppl , vol.47 , pp. 31-46
    • Dickson, D.W.1    Feany, M.B.2    Yen, S.H.3    Mattiace, L.A.4    Davies, P.5
  • 70
    • 26844433190 scopus 로고    scopus 로고
    • Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
    • Higuchi M, Zhang B, Forman MS, Yoshiyama Y, Trojanowski JQ, Lee VM. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. J Neurosci. 2005; 25(41):9434-9443
    • (2005) J Neurosci , vol.25 , Issue.41 , pp. 9434-9443
    • Higuchi, M.1    Zhang, B.2    Forman, M.S.3    Yoshiyama, Y.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 71
    • 84875443717 scopus 로고    scopus 로고
    • Axonal transport deficits and neurodegenerative diseases
    • Millecamps S, Julien JP. Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci. 2013;14(3):161-176
    • (2013) Nat Rev Neurosci , vol.14 , Issue.3 , pp. 161-176
    • Millecamps, S.1    Julien, J.P.2
  • 72
    • 17044411592 scopus 로고    scopus 로고
    • Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration
    • Forman MS, Lal D, Zhang B, et al. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. J Neurosci. 2005;25(14): 3539-3550
    • (2005) J Neurosci , vol.25 , Issue.14 , pp. 3539-3550
    • Forman, M.S.1    Lal, D.2    Zhang, B.3
  • 73
    • 0036685608 scopus 로고    scopus 로고
    • Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    • Higuchi M, Ishihara T, Zhang B, et al. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. 2002;35(3): 433-446
    • (2002) Neuron , vol.35 , Issue.3 , pp. 433-446
    • Higuchi, M.1    Ishihara, T.2    Zhang, B.3
  • 74
    • 78649723354 scopus 로고    scopus 로고
    • Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy
    • Colodner KJ, Feany MB. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010;30(48):16102-16113
    • (2010) J Neurosci , vol.30 , Issue.48 , pp. 16102-16113
    • Colodner, K.J.1    Feany, M.B.2
  • 75
    • 0344874553 scopus 로고    scopus 로고
    • Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes
    • Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM. Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. J Neurosci. 2003;23(33):10662-10671
    • (2003) J Neurosci , vol.23 , Issue.33 , pp. 10662-10671
    • Yoshiyama, Y.1    Zhang, B.2    Bruce, J.3    Trojanowski, J.Q.4    Lee, V.M.5
  • 77
    • 4944247976 scopus 로고    scopus 로고
    • Astrocytic degeneration relates to the severity of disease in frontotemporal dementia
    • Broe M, Kril J, Halliday GM. Astrocytic degeneration relates to the severity of disease in frontotemporal dementia. Brain. 2004;127(pt 10):2214-2220
    • (2004) Brain , vol.127 , pp. 2214-2220
    • Broe, M.1    Kril, J.2    Halliday, G.M.3
  • 78
    • 12844271615 scopus 로고    scopus 로고
    • Correlation between astrocyte apoptosis and Alzheimer changes in gray matter lesions in Alzheimer's disease
    • discussion 673-681
    • Kobayashi K, Hayashi M, Nakano H, Shimazaki M, Sugimori K, Koshino Y. Correlation between astrocyte apoptosis and Alzheimer changes in gray matter lesions in Alzheimer's disease. J Alzheimers Dis. 2004;6(6):623-632; discussion 673-681
    • (2004) J Alzheimers Dis , vol.6 , Issue.6 , pp. 623-632
    • Kobayashi, K.1    Hayashi, M.2    Nakano, H.3    Shimazaki, M.4    Sugimori, K.5    Koshino, Y.6
  • 79
    • 0034073966 scopus 로고    scopus 로고
    • DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia
    • Su JH, Nichol KE, Sitch T, et al. DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. Exp Neurol. 2000;163(1):9-19
    • (2000) Exp Neurol , vol.163 , Issue.1 , pp. 9-19
    • Su, J.H.1    Nichol, K.E.2    Sitch, T.3
  • 80
    • 1842576566 scopus 로고    scopus 로고
    • Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice
    • Zehr C, Lewis J, McGowan E, et al. Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice. Neurobiol Dis. 2004;15(3):553-562
    • (2004) Neurobiol Dis , vol.15 , Issue.3 , pp. 553-562
    • Zehr, C.1    Lewis, J.2    McGowan, E.3
  • 81
    • 0035958642 scopus 로고    scopus 로고
    • Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
    • Wittmann CW, Wszolek MF, Shulman JM, et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001;293(5530): 711-714
    • (2001) Science , vol.293 , Issue.5530 , pp. 711-714
    • Wittmann, C.W.1    Wszolek, M.F.2    Shulman, J.M.3
  • 82
    • 84899944338 scopus 로고    scopus 로고
    • A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
    • Ahmed Z, Cooper J, Murray TK, et al. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta Neuropathol. 2014;127(5): 667-683
    • (2014) Acta Neuropathol , vol.127 , Issue.5 , pp. 667-683
    • Ahmed, Z.1    Cooper, J.2    Murray, T.K.3
  • 83
    • 67650077008 scopus 로고    scopus 로고
    • Transmission and spreading of tauopathy in transgenic mouse brain
    • Clavaguera F, Bolmont T, Crowther RA, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009;11(7):909-913
    • (2009) Nat Cell Biol , vol.11 , Issue.7 , pp. 909-913
    • Clavaguera, F.1    Bolmont, T.2    Crowther, R.A.3
  • 84
    • 84857275902 scopus 로고    scopus 로고
    • Propagation of tau pathology in a model of early Alzheimer's disease
    • de Calignon A, Polydoro M, Suarez-Calvet M, et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012;73(4):685-697
    • (2012) Neuron , vol.73 , Issue.4 , pp. 685-697
    • de Calignon, A.1    Polydoro, M.2    Suarez-Calvet, M.3
  • 85
    • 84918576232 scopus 로고    scopus 로고
    • Connecting the dots between tau dysfunction and neurodegeneration
    • Frost B, Gotz J, Feany MB. Connecting the dots between tau dysfunction and neurodegeneration. Trends Cell Biol. 2015;25(1):46-53
    • (2015) Trends Cell Biol , vol.25 , Issue.1 , pp. 46-53
    • Frost, B.1    Gotz, J.2    Feany, M.B.3
  • 86
    • 84883503648 scopus 로고    scopus 로고
    • Are tau aggregates toxic or protective in tauopathies?
    • Cowan CM, Mudher A. Are tau aggregates toxic or protective in tauopathies? Front Neurol. 2013;4:114
    • (2013) Front Neurol , vol.4 , pp. 114
    • Cowan, C.M.1    Mudher, A.2
  • 87
    • 84868677556 scopus 로고    scopus 로고
    • Biochemistry and cell biology of tau protein in neurofibrillary degeneration
    • Mandelkow EM, Mandelkow E. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med. 2012;2(7):a006247
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.7
    • Mandelkow, E.M.1    Mandelkow, E.2
  • 88
    • 49149126973 scopus 로고    scopus 로고
    • The last tangle of tau
    • Ding H, Johnson GV. The last tangle of tau. J Alzheimers Dis. 2008;14(4):441-447
    • (2008) J Alzheimers Dis , vol.14 , Issue.4 , pp. 441-447
    • Ding, H.1    Johnson, G.V.2
  • 89
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005;309(5733):476-481
    • (2005) Science , vol.309 , Issue.5733 , pp. 476-481
    • Santacruz, K.1    Lewis, J.2    Spires, T.3
  • 90
    • 31944434543 scopus 로고    scopus 로고
    • TORmediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
    • Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TORmediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006;16(3):230-241
    • (2006) Curr Biol , vol.16 , Issue.3 , pp. 230-241
    • Khurana, V.1    Lu, Y.2    Steinhilb, M.L.3    Oldham, S.4    Shulman, J.M.5    Feany, M.B.6
  • 91
    • 34248219026 scopus 로고    scopus 로고
    • S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila
    • Steinhilb ML, Dias-Santagata D, Mulkearns EE, et al. S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res. 2007; 85(6):1271-1278
    • (2007) J Neurosci Res , vol.85 , Issue.6 , pp. 1271-1278
    • Steinhilb, M.L.1    Dias-Santagata, D.2    Mulkearns, E.E.3
  • 92
    • 84945963946 scopus 로고    scopus 로고
    • Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration
    • Richter-Landsberg C. Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration. Biol Chem. 2015
    • (2015) Biol Chem
    • Richter-Landsberg, C.1
  • 93
    • 84925500787 scopus 로고    scopus 로고
    • Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance
    • Leyk J, Goldbaum O, Noack M, Richter-Landsberg C. Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol Neurosci. 2015;55(4):1031-1046
    • (2015) J Mol Neurosci , vol.55 , Issue.4 , pp. 1031-1046
    • Leyk, J.1    Goldbaum, O.2    Noack, M.3    Richter-Landsberg, C.4
  • 94
    • 84893803744 scopus 로고    scopus 로고
    • HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes
    • Noack M, Leyk J, Richter-Landsberg C. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. Glia. 2014;62(4):535-547
    • (2014) Glia , vol.62 , Issue.4 , pp. 535-547
    • Noack, M.1    Leyk, J.2    Richter-Landsberg, C.3
  • 95
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • Min SW, Cho SH, Zhou Y, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67(6):953-966
    • (2010) Neuron , vol.67 , Issue.6 , pp. 953-966
    • Min, S.W.1    Cho, S.H.2    Zhou, Y.3
  • 96
    • 84880638106 scopus 로고    scopus 로고
    • Acetylated tau neuropathology in sporadic and hereditary tauopathies
    • Irwin DJ, Cohen TJ, Grossman M, et al. Acetylated tau neuropathology in sporadic and hereditary tauopathies. Am J Pathol. 2013;183(2):344-351
    • (2013) Am J Pathol , vol.183 , Issue.2 , pp. 344-351
    • Irwin, D.J.1    Cohen, T.J.2    Grossman, M.3
  • 97
    • 33847369469 scopus 로고    scopus 로고
    • The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    • Dickey CA, Kamal A, Lundgren K, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest. 2007;117(3):648-658
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 648-658
    • Dickey, C.A.1    Kamal, A.2    Lundgren, K.3
  • 98
    • 77955957517 scopus 로고    scopus 로고
    • The small heat shock protein HSP25/27 (HspB1) is abundant in cultured astrocytes and associated with astrocytic pathology in progressive supranuclear palsy and corticobasal degeneration
    • Schwarz L, Vollmer G, Richter-Landsberg C. The small heat shock protein HSP25/27 (HspB1) is abundant in cultured astrocytes and associated with astrocytic pathology in progressive supranuclear palsy and corticobasal degeneration. Int J Cell Biol. 2010;2010:717520
    • (2010) Int J Cell Biol , vol.2010
    • Schwarz, L.1    Vollmer, G.2    Richter-Landsberg, C.3
  • 99
    • 1542574213 scopus 로고    scopus 로고
    • Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology
    • Dabir DV, Trojanowski JQ, Richter-Landsberg C, Lee VM, Forman MS. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. Am J Pathol. 2004;164(1):155-166
    • (2004) Am J Pathol , vol.164 , Issue.1 , pp. 155-166
    • Dabir, D.V.1    Trojanowski, J.Q.2    Richter-Landsberg, C.3    Lee, V.M.4    Forman, M.S.5
  • 100
    • 0028297910 scopus 로고
    • Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia
    • Renkawek K, Bosman GJ, de Jong WW. Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia. Acta Neuropathol. 1994;87(5):511-519
    • (1994) Acta Neuropathol , vol.87 , Issue.5 , pp. 511-519
    • Renkawek, K.1    Bosman, G.J.2    de Jong, W.W.3
  • 102
    • 84925740928 scopus 로고    scopus 로고
    • Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes
    • Filipcik P, Cente M, Zilka N, et al. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochim Biophys Acta. 2015;1852(7):1219-1229
    • (2015) Biochim Biophys Acta , vol.1852 , Issue.7 , pp. 1219-1229
    • Filipcik, P.1    Cente, M.2    Zilka, N.3
  • 103
    • 0032476645 scopus 로고    scopus 로고
    • Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease
    • Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J Cell Biol. 1998;143(3):777-794
    • (1998) J Cell Biol , vol.143 , Issue.3 , pp. 777-794
    • Ebneth, A.1    Godemann, R.2    Stamer, K.3    Illenberger, S.4    Trinczek, B.5    Mandelkow, E.6
  • 104
    • 0030770987 scopus 로고    scopus 로고
    • Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesin
    • Carson JH, Worboys K, Ainger K, Barbarese E. Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesin. Cell Motil Cytoskeleton. 1997;38(4):318-328
    • (1997) Cell Motil Cytoskeleton , vol.38 , Issue.4 , pp. 318-328
    • Carson, J.H.1    Worboys, K.2    Ainger, K.3    Barbarese, E.4
  • 105
    • 84896719812 scopus 로고    scopus 로고
    • Tau promotes neurodegeneration through global chromatin relaxation
    • Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci. 2014;17(3):357-366
    • (2014) Nat Neurosci , vol.17 , Issue.3 , pp. 357-366
    • Frost, B.1    Hemberg, M.2    Lewis, J.3    Feany, M.B.4
  • 106
    • 84866151476 scopus 로고    scopus 로고
    • Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease
    • Ke YD, Dramiga J, Schutz U, et al. Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PLoS One. 2012; 7(4):e35678
    • (2012) PLoS One , vol.7 , Issue.4
    • Ke, Y.D.1    Dramiga, J.2    Schutz, U.3
  • 107
    • 34347383021 scopus 로고    scopus 로고
    • Nitric oxide and nitroxidative stress in Alzheimer's disease
    • Malinski T. Nitric oxide and nitroxidative stress in Alzheimer's disease. J Alzheimers Dis. 2007;11(2):207-218
    • (2007) J Alzheimers Dis , vol.11 , Issue.2 , pp. 207-218
    • Malinski, T.1
  • 109
    • 0031952714 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy
    • Komori T, Shibata N, Kobayashi M, Sasaki S, Iwata M. Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy. Acta Neuropathol. 1998;95(4):338-344
    • (1998) Acta Neuropathol , vol.95 , Issue.4 , pp. 338-344
    • Komori, T.1    Shibata, N.2    Kobayashi, M.3    Sasaki, S.4    Iwata, M.5


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