Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process

Acta Neuropathologica

Volumn 104, Issue 4, 2002, Pages 398-402

  Togo, Takashi ^a   Dickson, Dennis W ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Gliosis; Neurofibrillary tangles; Progressive supranuclear palsy; Tufted astrocytes

Indexed keywords

AMYLOID BETA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN INFARCTION; BRAIN REGION; CELL DEGENERATION; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; FEMALE; GLIOSIS; GLOBUS PALLIDUS; HUMAN; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOTOR CORTEX; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN LOCALIZATION; SENILE PLAQUE; SUBTHALAMIC NUCLEUS; VASCULAR LESION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ASTROCYTES; BRAIN INFARCTION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLES; SUPRANUCLEAR PALSY, PROGRESSIVE; TAU PROTEINS;

EID: 0036943019     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0569-x     Document Type: Article

References (24)

1. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
2. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM (1989) Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res 477:90-99
3. Bierrer LM, Hof PR, Purohit DP, Carlin I, Schmeidler J, Davis KL, Perl DP (1995) Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol 52:81-88
4. Bower JH, Maraganore DM, McDonnell SK, Rocca WA (1997) Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976-1990. Neurology 49:1284-1288
5. Braak E, Braak H, Mandelkow EM (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol 87:554-567
6. Braak H, Braak E, Bohl J (1993) Staging of Alzheimer-related cortical destruction. Eur Neurol 33:403-408
7. Collins SJ, Ahlskog JE, Parisi JE, Maraganore DM (1995) Progressive supranuclear palsy: neuropathologically based diagnostic clinical criteria. J Neurol Neurosurg Psychiatry 58:167-173
8. Davis PH, Bergeron C, McLachlan R (1985) Atypical presentation of progressive supranuclear palsy. Ann Neurol 17:337-343
9. Dickson DW (1997) The pathogenesis of senile plaques. J Neuropathol Exp Neurol 56:321-339
10. Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience 54:15-36
11. Feany MB, Dickson DW (1995) Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 146: 1388-1396
12. Gearing M, Olson DA, Watts RL, Mirra SS (1994) Progressive supranuclear palsy: neuropathologic and clinical heterogeneity. Neurology 44:1015-1024
13. Hauw JJ, Verny M, Delaere P, Cervera P, He Y, Duyckaerts C (1990) Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging. Neurosci Lett 119:182-186
14. Hauw JJ, Daniel SE, Dickson DW, Horoupian DS, Jellinger K, Lantos PL, McKee A, Tabaton M, Litvan I (1994) Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology 44:2015-2019
15. Hutton M, Lendon CL, Rizzu P, et al (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP- 17. Nature 393:702-705
16. Ikeda K, Akiyama H, Kondo H, Haga C, Tanno E, Tokuda T, Ikeda S (1995) Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles. Acta Neuropathol 90:620-625
17. Komori T, Arai N, Oda M, Nakayama H, Mori H, Yagishita S, Takahashi T, Amano N, Murayama S, Murakami S, Shibata N, Kobayashi M, Sasaki S, Iwata M (1998) Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol 96:401-408
18. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewki syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1-9
19. Matsusaka H, Ikeda K, Akiyama H, Arai T, Inoue M, Yagishita S (1998) Astrocytic pathology in progressive supranuclear palsy: significance for the neuropathological diagnosis. Acta Neuropathol 96:248-252
20. Spillantini MG, Goedert M (1998) Tau protein pathology in neurodegenerative diseases. Trends Neurosci 21:428-433
21. Steel JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy. Arch Neurol 10:333-359
22. Yamada T, McGeer PL, McGeer EG (1992) Appearance of paired nucleated, tau-positive glia in patients with progressive supranuclear palsy brain tissue. Neurosci Lett 135:99-102
23. Yamada T, Calne DB, Akiyama H, McGeer EG, McGeer PL (1993) Further observations on Tau-positive glia in the brains with progressive supranuclear palsy. Acta Neuropathol 85:308-315
24. Yen SH, Crowe A, Dickson DW (1985) Monoclonal antibodies to Alzheimer neurofibrillary tangles. Am J Pathol 120:282-291